CN206671035U - A kind of cambered surface magnetic bead separating device - Google Patents
A kind of cambered surface magnetic bead separating device Download PDFInfo
- Publication number
- CN206671035U CN206671035U CN201720978498.8U CN201720978498U CN206671035U CN 206671035 U CN206671035 U CN 206671035U CN 201720978498 U CN201720978498 U CN 201720978498U CN 206671035 U CN206671035 U CN 206671035U
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- test tube
- cambered surface
- pedestal
- magnetic bead
- separating device
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Abstract
The utility model discloses a kind of cambered surface magnetic bead separating device, including upper cover plate, lower shoe, the pedestal between upper cover plate and lower shoe, the top of the pedestal to be connected with the upper cover plate, and the bottom of the pedestal is connected with the lower shoe；The upper cover plate is provided with 2 test tube holes placed for test tube, and test tube is fixed jointly with lower shoe for the test tube hole；The both sides of the pedestal are equipped with cambered surface, 2 test tube holes are respectively positioned at the both sides of the pedestal and close to the pedestal, so that the cambered surface for the adjacent pedestal of test tube placed, the cambered surface is provided with magnetosphere, middle part and/or top distribution of the magnetosphere along the cambered surface, magnetic bead separating device is enabled firmly to hold more magnetic beads, the effect for separating magnetic bead is more preferable.
Description
Technical field
Separator technical field is the utility model is related to, more particularly, to a kind of cambered surface magnetic bead separating device.
Background technology
Immuno magnetic cell separation technology is the nanometer or micron order magnetic bead for having antigen or antibody using surface coupling as separation Jie
Matter, reacted by the high specific between antigen-antibody and capture target substance, then the effect by externally-applied magnetic field, promote object
Matter separates with the other materials in mixture, so as to reach the purpose of separation, enrichment, purifying.The technology has simple and easy, anti-
Short, the specific high, many merits such as loss is small, are widely used to medical diagnosis, bio-separation, drug screening, ring between seasonable
The numerous areas such as border detection.
Magnetic microparticle chemiluminescence immune assay is by magnetic separation technique, chemiluminescence and immuno analytical method three
A kind of emerging analysis method combined.The technology takes full advantage of the high specific of immunoassay, chemiluminescence
The quick easily automation property of high sensitivity and magnetic separation technique, irreplaceable work is presented in biomedical diagnostic field
With.
In magnetic microparticle chemiluminescence immune assay detection kit, the magnetic particle of antigen or antibody is coupled containing surface
Reagent be one of essential constituent.When producing the reagent, it usually needs cleaned by multiple Beads enrichment
Step, in the process, it is necessary to magnetic bead is adsorbed in the tube wall of glass tube using magnetic bead separating device, then with pipettor by test tube
Interior solution takes out.
At present, the contact surface of the additional magnet and test tube of most magnetic bead separating device is plane, and the outer wall of test tube
For arc-shaped surface, for magnet when attracting magnetic bead, it is smaller firmly to hold the effective area of magnetic bead, the magnetic that can firmly hold
Pearl is less so that magnetic bead separating device separation magnetic bead effect it is poor, particularly large-scale production when magnetic bead usage amount it is larger, point
It is very undesirable from effect.
Utility model content
The utility model is the defects of overcoming described in above-mentioned prior art, there is provided a kind of cambered surface magnetic bead separating device.
In order to solve the above technical problems, the technical solution adopted in the utility model is：
A kind of cambered surface magnetic bead separating device, including upper cover plate, lower shoe, the pedestal between upper cover plate and lower shoe,
The top of the pedestal is connected with the upper cover plate, and the bottom of the pedestal is connected with the lower shoe；The upper cover plate is provided with 2
Test tube is fixed jointly with lower shoe for the individual test tube hole placed for test tube, the test tube hole；The both sides of the pedestal are all provided with
There is cambered surface, 2 test tube holes are respectively positioned at the both sides of the pedestal and close to the pedestal, so that the adjacent institute of test tube placed
The cambered surface of pedestal is stated, the cambered surface is provided with magnetosphere, middle part and/or top distribution of the magnetosphere along the cambered surface.
The pedestal both sides are cambered surface, and the magnetosphere of cambered surface is capable of the side wall of portion envelops test tube to a certain extent,
When holding magnetic bead and being attached on test tube madial wall, the effective area increase of magnetic bead can be firmly held, can firmly be held more
Magnetic bead so that the effect of above-mentioned magnetic bead separating device separation magnetic bead is more preferable.
Preferably, middle part distribution of the magnetosphere along the cambered surface.
It is highly preferred that the cambered surface where the magnetosphere matches with test tube side wall.
When being operated using the test tube to match with test tube hole size, the side wall of the magnetosphere and test tube matches,
It can be bonded completely with test tube side wall, it is bigger now firmly to hold the effective area of magnetic bead, can firmly hold more magnetic beads,
So that the effect of above-mentioned magnetic bead separating device separation magnetic bead is more preferable.The magnetosphere is alnico magnets.
Preferably, the upper cover plate, lower shoe and pedestal are made up of PMMA materials.Preferably, but it is not limited to, the pedestal
Size be long 8.0cm × wide 5.5cm × high 4.5cm；The size of the upper cover plate is long 18.5cm × wide 8.0cm × thickness
0.5cm；The size of the lower shoe is long 18.5cm × wide 8.0cm × thick 0.5cm.
Preferably, the lower shoe is provided with cylindric neck, and the cylindric neck can hold test tube, and with the examination
Test tube is fixed jointly for pore.It is highly preferred that the cylindric neck is hollow cylindrical neck.It is further preferred that
The cylindric neck protrudes from lower shoe.Still further preferably, the center of circle of the cylindric neck is located at the test tube hole
Center underface.Preferably, but it is not limited to, the cylindric high 0.5cm of neck, hollow, Inner circular diameters are 3cm, cylindrical
The wide 0.4cm between Inner circles.
Cylindric neck on the cambered surface magnetic bead separating device lower shoe, particularly hollow cylindrical neck, can be very well
The sharp bottom of fixation or round bottom test tube bottom, and there is anti-skidding effect, the glass round bottom tube manipulation larger to volume is especially square
Just.The specification of test tube hole and cylindric neck on test tube fixed mount can need to design according to practical application, then coordinate various rule
The test tube of lattice uses, flexibly and easily.
Preferably, the magnetic bead separating device supports the use with test tube, and the volume of the test tube is 10 ~ 100mL.
A kind of tubular type magnetic bead separating device suitable for volume for 10 ~ 100ml is provided, reaction tube can be sharp bottom or circle
Bottom, the material of test tube can solve most of commercially available prod at present well and are only capable of being below 10ml to volume with plastics or glass
The limitation that is operated of plastic test tube.Be particularly suitable for use in the reagent containing magnetic bead in magnetic microparticle chemiluminescence detection kit
Large-scale production, can also be widely used in the numerous areas such as bio-separation, drug screening, environment measuring, reach separation, rich
The purpose of collection, purification.
Compared with prior art, the beneficial effects of the utility model are：
The both sides of the pedestal of cambered surface magnetic bead separating device of the present utility model are equipped with cambered surface, 2 test tube holes difference
Positioned at the both sides of the pedestal and close to the pedestal, so that the cambered surface for the adjacent pedestal of test tube placed, in the cambered surface
Provided with magnetosphere, middle part and/or top distribution of the magnetosphere along the cambered surface.
The cambered surface of pedestal both sides can be partly bonded with test tube side wall, so magnetosphere can be wrapped partly to a certain extent
The side wall of test tube is wrapped up in, when holding magnetic bead and being attached on test tube madial wall, can firmly hold the effective area increase of magnetic bead, energy
It is enough firmly to hold more magnetic beads so that the effect of above-mentioned magnetic bead separating device separation magnetic bead is more preferable.
Further, test tube fixed mount lower shoe is provided with cylindric neck, can fix sharp bottom or round bottom test tube well
Bottom, and there is anti-skidding effect.
The utility model is simple in construction, and cost is cheap, easy to carry, not easy to wear, practical flexible；Magnetic particle can be met
The large-scale production of reagent containing magnetic bead in chemiluminescence detection kit, can also be widely used in bio-separation, drug sieve
The numerous areas such as choosing, environment measuring, reaches the purpose of separation, enrichment, purification.
Brief description of the drawings
Fig. 1 is the structural representation of the cambered surface magnetic bead separating device of embodiment 1.
Fig. 2 is the top view of the cambered surface magnetic bead separating device of embodiment 1.
Fig. 3 is the top view of the cambered surface magnetic bead separating device of embodiment 2.
Fig. 4 is the structural representation of the cambered surface magnetic bead separating device of embodiment 3.
Embodiment
The utility model is further described with reference to embodiment.
Embodiment 1
Fig. 1 is a kind of structural representation of cambered surface magnetic bead separating device of the present utility model, and Fig. 2 is the present embodiment magnetic bead point
From the top view of device.As depicted in figs. 1 and 2, a kind of cambered surface magnetic bead separating device, including pedestal 1, upper cover plate 2 and lower shoe
3, between upper cover plate 2 and lower shoe 3, the top of pedestal 1 is connected pedestal 1 with upper cover plate 2, and the bottom of pedestal 1 connects with lower shoe 3
Connect；Upper cover plate 2 is provided with two test tube holes 5, and test tube is fixed jointly with lower shoe 3 for test tube hole 5；The both sides of pedestal 1 are all provided with
There is cambered surface, test tube hole 5 is located at the both sides of pedestal 1 and close to pedestal 1, so that the adjacent pedestal 1 of test tube placed, pedestal 1 are provided with
Magnetosphere 4, the middle part distribution of cambered surface of the magnetosphere 4 along the both sides of pedestal 1.Magnetosphere 4 can partly be bonded test tube outer wall, certain
Test tube outer wall is wrapped up in degree, can firmly hold the effective area increase of magnetic bead.When being put into test tube in test tube hole 5, relatively
In the magnet with both ends for plane, magnetosphere 4 can hold more magnetic beads so that above-mentioned magnetic bead separating device separates magnetic bead
Effect it is more preferable.
In use, it is respectively charged into Magnetic Isolation reagent and biological sample to be coupled in glass round bottom heavy wall pressure bottle
（Antigen/antibody etc.）, glass round bottom heavy wall pressure bottle shape can be put into the magnetic bead separating device that size matches similar to test tube
In, when Magnetic Isolation reagent and after coupling target substance fully reacts, target substance is by by the magnetic bead in Magnetic Isolation reagent
Absorption, heavy wall pressure bottle is inserted in the test tube hole 5 of magnetic bead separating device, stand 5min, the magnetic of cambered surface magnetic bead separating device
It is firm in madial wall, and very that layer 4 can hold more magnetic bead.
Embodiment 2
As different from Example 1, as Fig. 3 shows, magnetosphere 4 is round tube wall-like curved surface, the radius of the circular arc of magnetosphere 4
Identical with the radius of test tube hole 5, the center of circle of the circular arc of magnetosphere 4 is located at the underface in the center of circle of test tube hole 5, the circle of magnetosphere 4
Arc is semi arch.During using the test tube to match with the size of test tube hole 5, magnetosphere 4 matches with test tube side wall.
Miscellaneous part and annexation are same as Example 1.
When being operated using the test tube to match with the size of test tube hole 5, magnetosphere 4 matches with test tube side wall to be matched,
Magnetosphere 4 can perfect fitting test tube side wall, it is bigger now firmly to hold the effective area of magnetic bead, magnetic bead separating device separation magnetic
The effect of pearl is more preferable.
Embodiment 3
As different from Example 1, as Fig. 4 shows, lower shoe 3 is provided with two cylindric necks 6, during cylindric neck 6 is
Hollow cylinder shape neck, cylindric neck 6 protrudes from lower shoe, and the center of circle of cylindric neck 6 is being located at the center of test tube hole 5 just
Lower section.
Miscellaneous part and annexation are same as Example 1.
Hollow cylindrical neck can fix the bottom at sharp bottom or round bottom test tube well, and have anti-skidding effect, to volume
Larger glass round bottom tube manipulation is particularly convenient.Test tube hole 5 and the specification of cylindric neck 6 can be according to realities on test tube fixed mount
Border application needs to design, then coordinates the test tube of variously-shaped specification to use, flexibly and easily.
Obviously, above-described embodiment of the present utility model is only intended to clearly illustrate the utility model example, and
It is not the restriction to embodiment of the present utility model.For those of ordinary skill in the field, in described above
On the basis of can also make other changes in different forms.There is no need and unable to give all embodiments
It is exhaustive.All made within spirit of the present utility model and principle all any modification, equivalent and improvement etc., should be included in
Within the protection domain of the utility model claims.
Claims (5)
1. a kind of cambered surface magnetic bead separating device, it is characterised in that including upper cover plate（2）, lower shoe（3）, positioned at upper cover plate（2）With
Lower shoe（3）Between pedestal（1）, the pedestal（1）Top and the upper cover plate（2）Connection, the pedestal（1）Bottom
With the lower shoe（3）Connection；The upper cover plate（2）Provided with 2 test tube holes placed for test tube（5）, the test tube hole（5）With
Lower shoe（3）Test tube is fixed jointly；The pedestal（1）Both sides be equipped with cambered surface, 2 test tube holes（5）Respectively
Positioned at the pedestal（1）Both sides and close to the pedestal（1）, so that the adjacent pedestal of test tube placed（1）Cambered surface, institute
State cambered surface and be provided with magnetosphere（4）, the magnetosphere（4）It is distributed along the middle part of the cambered surface and/or top.
2. cambered surface magnetic bead separating device according to claim 1, it is characterised in that the magnetosphere（4）Along the cambered surface
Middle part distribution.
3. cambered surface magnetic bead separating device according to claim 2, it is characterised in that the magnetosphere（4）The cambered surface at place
Match with test tube side wall.
4. cambered surface magnetic bead separating device according to claim 1, it is characterised in that the lower shoe（3）Provided with cylindrical shape
Neck（6）, the cylindric neck（6）Can hold test tube, and with the test tube hole（5）Test tube is fixed jointly.
5. cambered surface magnetic bead separating device according to claim 4, it is characterised in that the cylindric neck（6）To be hollow
Cylindric neck.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720978498.8U CN206671035U (en) | 2017-08-07 | 2017-08-07 | A kind of cambered surface magnetic bead separating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720978498.8U CN206671035U (en) | 2017-08-07 | 2017-08-07 | A kind of cambered surface magnetic bead separating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206671035U true CN206671035U (en) | 2017-11-24 |
Family
ID=60369992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720978498.8U Active CN206671035U (en) | 2017-08-07 | 2017-08-07 | A kind of cambered surface magnetic bead separating device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206671035U (en) |
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2017
- 2017-08-07 CN CN201720978498.8U patent/CN206671035U/en active Active
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