CN206635348U - Embryo Culture device for drug toxicity detection evaluation - Google Patents
Embryo Culture device for drug toxicity detection evaluation Download PDFInfo
- Publication number
- CN206635348U CN206635348U CN201720381946.6U CN201720381946U CN206635348U CN 206635348 U CN206635348 U CN 206635348U CN 201720381946 U CN201720381946 U CN 201720381946U CN 206635348 U CN206635348 U CN 206635348U
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- China
- Prior art keywords
- culture dish
- culture
- waste liquid
- embryo
- tube body
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Abstract
The utility model discloses a kind of Embryo Culture device for drug toxicity detection evaluation, including insulating box and some culture units, described culture unit includes being used for the outer culture dish for filling nutrient solution, for placing the interior culture dish of culture embryo, for exporting the waste liquid ware of nutrient solution waste liquid, Miniature negative pressure pump and the buret for filling drug solvent to be detected, described interior culture dish and waste liquid ware is arranged in outer culture dish, the utility model is reasonable in design, under identical environment, multiple embryos are cultivated, the amount of the drug solvent to be detected of different culture unit titration is controlled, influence of the embryo to the cell differentiation and cytoactive of the drug solvent to be detected of the different amounts of drawing is different, harmfulness of the drug toxicity to each system of human body is evaluated by contrasting the differentiation and development situation of embryo.
Description
Technical field
It the utility model is related to a kind of Embryo Culture device for drug toxicity detection evaluation.
Background technology
Drug safety always receives much attention in the clinical practice of medicine, due to conventional medicament, such as Chinese medicine, Tibetan medicine,
The materials such as natural animals and plants, mineral are come from, and are often appeared in the form of compound in medicinal application, thus its chemical substance basis
And the mechanism of action of the medicine in human body is sufficiently complex, the difficulty of its security evaluation and test is very big, and this is also conventional medicament (as in
Medicine, Tibetan medicine etc.) enter international market, especially into one of the major obstacle in hospital of western countries prescription market, conventional medicament
Toxicity research and evaluation and test be at home and abroad weak link, to the toxicity assessment of conventional medicament, generally use it is a large amount of artificial and
Laboratory techniques, substantial contribution and time are consumed, turn into and hinder conventional medicament modernization and international important bottleneck.At present
The means of detection poisonous side effect of medicine mainly pass through zoopery, such as mouse, rabbit, dog, monkey, the reality of zebra fish living animal
Test, but it is expensive, and general survival dose is bigger, and living animal is low to the susceptibility of medicine, the evaluation effect of toxicity detection
Accuracy has much room for improvement.
Utility model content
The purpose of this utility model is to overcome above shortcomings in the prior art, and provides a kind of structure design and close
Reason, the Embryo Culture device for drug toxicity detection evaluation.
The technical scheme in the invention for solving the above technical problem is：A kind of embryo for drug toxicity detection evaluation
Tire culture apparatus, including insulating box and some culture units, described culture unit include being used for the outer training for filling nutrient solution
Support ware, the interior culture dish for placing culture embryo, the waste liquid ware for exporting nutrient solution waste liquid, Miniature negative pressure pump and fill
The buret of drug solvent to be detected, described interior culture dish and waste liquid ware are arranged in outer culture dish, described interior culture
Ware and waste liquid ware are sealed by closure respectively, and described interior culture dish is connected by the first check valve and outer culture dish
Logical, described waste liquid ware is connected by the second check valve with waste liquid ware, and described waste liquid ware connects with Miniature negative pressure pump so that micro-
Type negative pressure pump exports the nutrient solution waste liquid in waste liquid ware, and described buret is fixed on the outside of insulating box, described buret
Liquid outlet be arranged on the top of outer culture dish, described outer culture dish is connected with filling the culture liquid container of sufficient nutrient solution.
Further：Interior culture dish is divided into four cultivation regions by described interior culture dish by section in criss-cross dividing plate
Domain.
Further：Described buret includes air bag, helical tube body, only liquid valve and inside extending tube body are formed, described
Air bag, helical tube body and inside extending tube body are sequentially connected, and the wall of described helical tube body is provided with graduation mark, and described Inner stretches
Body is arranged in the casing of insulating box, and the liquid outlet that described Inner stretches body is arranged on the top of outer culture dish so that titration
Drug solvent to be detected in pipe instills outer culture dish by liquid outlet, and described only liquid valve is arranged on the downside of helical tube body.
Further：Described Inner stretches the internal diameter of the internal diameter small fish helical tube body of body.
The utility model compared with prior art, has advantages below and effect：It is reasonable in design, in identical environment
Under, multiple embryos are cultivated, the amount of the drug solvent to be detected of different culture units titration is controlled, and embryo is not to
It is different with the influence of the cell differentiation and cytoactive of the drug solvent to be detected for the amount of drawing, sent out by the differentiation for contrasting embryo
Educate situation and then evaluate harmfulness of the drug toxicity to each system of human body.
Brief description of the drawings
Fig. 1 is the structural representation for the Embryo Culture device that the utility model embodiment is used for drug toxicity detection evaluation.
Fig. 2 is the structural representation of the utility model embodiment culture unit.
Embodiment
Below in conjunction with the accompanying drawings and the utility model is described in further detail by embodiment, and following examples are pair
It is of the present utility model explanation and the utility model is not limited to following examples.
Referring to Fig. 1-Fig. 2, a kind of Embryo Culture device for drug toxicity detection evaluation of the present embodiment, including insulating box
1 and it is some culture unit 2, described culture unit 2 include be used for fill nutrient solution outer culture dish 21, for place culture
The interior culture dish 22 of embryo, the waste liquid ware 23 for exporting nutrient solution waste liquid, Miniature negative pressure pump 232 and fill medicine to be detected
The buret 24 of solvent, described interior culture dish 22 and waste liquid ware 23 are arranged in outer culture dish 21, described interior culture dish
22 and waste liquid ware 23 sealed respectively by closure, described interior culture dish 22 passes through the first check valve 221 and outer training
Support ware 21 connect, described waste liquid ware 23 is connected by the second check valve 231 with waste liquid ware 23, described waste liquid ware 23 with it is miniature
Negative pressure pump 232 connects so that Miniature negative pressure pump 232 exports the nutrient solution waste liquid in waste liquid ware 23, and described buret 24 is solid
The outside of insulating box 1 is scheduled on, the liquid outlet of described buret 24 is arranged on the top of outer culture dish 21, described outer culture dish 21
It is connected with the culture liquid container for filling sufficient nutrient solution, described interior culture dish 22 is in criss-cross dividing plate 223 is incited somebody to action by section
Culture dish 22 be divided into four culture regions, described buret 24 include air bag 241, helical tube body 242, only liquid valve 243 and
Inside extending tube body 244 is formed, and described air bag 241, helical tube body 242 and inside extending tube body 244 are sequentially connected, described helix tube
The wall of body 242 is provided with graduation mark, and described Inner stretches body and is arranged in the casing of insulating box 1, and described Inner stretches body
Liquid outlet is arranged on the top of outer culture dish 21 so that the drug solvent to be detected in buret 24 instills outer cultivate by liquid outlet
Ware 21, described only liquid valve 243 are arranged on the downside of helical tube body 242, and described Inner stretches the internal diameter small fish helical tube body of body
242 internal diameter, the utility model is reasonable in design, and under identical environment, multiple embryos are cultivated, different culture lists
The amount of the drug solvent to be detected of the titration of member 2 is controlled, cell point of the embryo to the drug solvent to be detected of the different amounts of drawing
Change and the influence of cytoactive is different, it is each to human body to evaluate drug toxicity by contrasting the differentiation and development situation of embryo
The harmfulness of system., detected compared to living animals such as existing conventionally employed small white mouses, greatly smaller living animal
The influence of body factor (build, health status and innate factor etc.), while embryo is higher to the susceptibility of medicine, differentiation degree
Low, in foetus organ atomization, influence of the medicine to it, which has, preferably to be shown.
Above content described in this specification is only to the utility model example explanation.The utility model
Person of ordinary skill in the field can make various modifications or supplement to described specific embodiment or using class
As mode substitute, content without departing from the utility model specification or surmount model defined in the claims
Enclose, the scope of protection of the utility model all should be belonged to.
Claims (4)
- A kind of 1. Embryo Culture device for drug toxicity detection evaluation, it is characterised in that：Including insulating box and some trainings Support unit, described culture unit include be used for fill nutrient solution outer culture dish, for place cultivate embryo interior culture dish, For exporting the waste liquid ware, Miniature negative pressure pump and the buret for filling drug solvent to be detected of nutrient solution waste liquid, described is interior Culture dish and waste liquid ware are arranged in outer culture dish, and described interior culture dish and waste liquid ware is carried out close by closure respectively Envelope, described interior culture dish are connected by the first check valve with outer culture dish, and described waste liquid ware is by the second check valve with giving up Liquid ware connects, and described waste liquid ware connects with Miniature negative pressure pump so that Miniature negative pressure pump leads the nutrient solution waste liquid in waste liquid ware Go out, described buret is fixed on the outside of insulating box, and the liquid outlet of described buret is arranged on the top of outer culture dish, described Outer culture dish be connected with filling the culture liquid container of sufficient nutrient solution.
- 2. the Embryo Culture device according to claim 1 for drug toxicity detection evaluation, it is characterised in that：Described Interior culture dish is divided into four culture regions by interior culture dish by section in criss-cross dividing plate.
- 3. the Embryo Culture device according to claim 1 for drug toxicity detection evaluation, it is characterised in that：Described Buret includes air bag, helical tube body, only liquid valve and inside extending tube body are formed, described air bag, helical tube body and inside extending tube Body is sequentially connected, and the wall of described helical tube body is provided with graduation mark, and described Inner stretches the casing that body is arranged on insulating box Interior, the liquid outlet that described Inner stretches body is arranged on the top of outer culture dish so that drug solvent to be detected in buret by Liquid outlet instills outer culture dish, and described only liquid valve is arranged on the downside of helical tube body.
- 4. the Embryo Culture device according to claim 3 for drug toxicity detection evaluation, it is characterised in that：Described Inner stretches the internal diameter of the internal diameter small fish helical tube body of body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720381946.6U CN206635348U (en) | 2017-04-12 | 2017-04-12 | Embryo Culture device for drug toxicity detection evaluation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720381946.6U CN206635348U (en) | 2017-04-12 | 2017-04-12 | Embryo Culture device for drug toxicity detection evaluation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206635348U true CN206635348U (en) | 2017-11-14 |
Family
ID=60247874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720381946.6U Expired - Fee Related CN206635348U (en) | 2017-04-12 | 2017-04-12 | Embryo Culture device for drug toxicity detection evaluation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206635348U (en) |
-
2017
- 2017-04-12 CN CN201720381946.6U patent/CN206635348U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171114 Termination date: 20180412 |
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| CF01 | Termination of patent right due to non-payment of annual fee |