CN206594103U - A kind of blood vessel cavitation effect experimental provision - Google Patents
A kind of blood vessel cavitation effect experimental provision Download PDFInfo
- Publication number
- CN206594103U CN206594103U CN201720212543.9U CN201720212543U CN206594103U CN 206594103 U CN206594103 U CN 206594103U CN 201720212543 U CN201720212543 U CN 201720212543U CN 206594103 U CN206594103 U CN 206594103U
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- Prior art keywords
- blood vessel
- cavitation effect
- conduit
- interface
- experimental provision
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Abstract
The utility model is related to a kind of blood vessel cavitation effect experimental provision, support fixed shell, and the top of support sets high-speed camera and ultrasonic probe, and the port of high-speed camera and ultrasonic probe is towards housing；Housing is medium altitude groove shape, and inside is provided with first interface and second interface, and first interface is connected to reservoir by the first conduit, and second interface is connected to liquid trap by the second conduit；The inside of reservoir is provided with bar is performed, and the end for performing bar is provided with the execution plate fitted with reservoir inwall, performs bar and is provided with rack-and-pinion, rack-and-pinion is driven by motor connection.The utility model gathers blood vessel cavitation effect procedural image, convenient analysis and observation.
Description
Technical field
The utility model is related to technical field of experiment equipment, particularly a kind of collection blood vessel cavitation effect procedural image, side
Just the blood vessel cavitation effect experimental provision with observation is analyzed.
Background technology
Low frequency ultrasound is one of focus of current ultrasonic investigation.The mechanism of action of low frequency ultrasound is mainly cavitation effect.Such as
What can reach that Real Time Observation cavitation effect is current Research Challenges, be also the research of acoustics cavitation effect face it is topmost
Medical problem.Cavitation is that under certain sound field conditions, the pulsation of micro-bubble experience, expansion, contraction, collapse in liquid are vanished
Phenomenon, a series of physical, chemical effect can be triggered --- destruction biological cell membrane, increase cell permeability, accelerate chemistry
Reaction speed, production sonoluminescence etc..Cavitation effect is mainly used in treatment in clinic, particularly in the treatment of tumour.Utilize microvesicle
Cavitation effect, destroys tumor-microvessel, reduces tumour blood supply, suppresses the growth of tumour.Further investigate intravascular bubble cavitation effect
The effect of injury of blood vessel should be caused, pathogenesis is illustrated, explore effective prophylactico-therapeutic measures, it is empty as clinical medicine, particularly ultrasound
Change the emphasis of effect medical research.The research to bubble cavitation effect and mechanism is mostly injected into by simulating in capilary at present
Single microbubble, can truly simulate the generation of single microvesicle cavitation effect, but in clinical position, microvesicle is largely present,
Due to being disposable intravascular to be injected into a large amount of microvesicles, such as contrast agent, the cavitation effect of single microvesicle in tumor therapeutic procedure
The cavitation effect result under time of day can not be reacted.
If it is possible in the case of in vitro for a large amount of microvesicles ultrasound cavitation effect, carry out in situ study, in real time
It was observed that microvesicle cavitation effect under additional ultrasonic sound field, the mechanism of action of the ultrasound cavitation effect for understanding microvesicle group, tool
There is important meaning.In the prior art, the process that blood vessel ruptures in cavitation effect is difficult to observe, and lacks a kind of blood vessel cavitation effect
Answer experimental provision.
Utility model content
The purpose of this utility model is to provide a kind of collection blood vessel cavitation effect procedural image, the convenient blood analyzed with observation
Pipe cavitation effect experimental provision.
A kind of blood vessel cavitation effect experimental provision, including：
Support, the support fixed shell, the top of the support sets high-speed camera and ultrasonic probe, the high speed
The port of video camera and ultrasonic probe is towards housing；
The housing is medium altitude groove shape, and inside is provided with first interface and second interface, and the first interface passes through first
Conduit is connected to reservoir, and the second interface is connected to liquid trap by the second conduit；
The inside of the reservoir is provided with the execution fitted with reservoir inwall provided with bar, the end of the execution bar is performed
Plate, the execution bar is provided with rack-and-pinion, and the rack-and-pinion is driven by motor connection.
The high-speed camera is connected to support by the first moving block, the first sliding shoe, the second sliding shoe and spill spin block
On.
The ultrasonic probe is provided with the second moving block, and second moving block connects adjusting rod, and the adjusting rod is in cunning
Slided in groove, the adjusting rod is provided with screw thread, the height of adjusting rod is adjusted by being arranged on the nut above chute.
The bottom conducting of first conduit and reservoir, the bottom conducting of second conduit and liquid trap.
The housing is transparent pane body shape groove.
The frame upper is horizontal stand, and bottom is vertical cylinder.
The conduit of high-speed camera distance first and the second conduit line are 12-15cm.
The conduit of ultrasonic probe distance first and the second conduit line are 5-8mm.
The first interface and the external diameter of second interface are 2-6mm.
The utility model support fixed shell, the top of support sets high-speed camera and ultrasonic probe, high-speed camera
With the port of ultrasonic probe towards housing；Housing is medium altitude groove shape, and inside is provided with first interface and second interface, first interface
Reservoir is connected to by the first conduit, second interface is connected to liquid trap by the second conduit；The inside of reservoir is provided with and held
Row bar, the end for performing bar is provided with execution plate fit with reservoir inwall, performs bar provided with rack-and-pinion, rack-and-pinion by
Motor connection drives.First interface and second interface fix blood vessel, and the liquid for driving reservoir by motor flows, and forms path,
Ultrasonic probe carries out cavitation to blood vessel, and high-speed camera is recorded to blood vessel cavitation effect, can effectively record microvesicle
Situation of change, conveniently visually observes whole process, is that further research lays the foundation.The utility model collection blood vessel cavitation effect
Answer procedural image, convenient analysis and observation.
Brief description of the drawings
Fig. 1 be the utility model overlook to structural representation；
Fig. 2 is structural representation of the present utility model；
In figure：1st, support, 11, first interface, the 12, first conduit, 13, reservoir, 14, perform bar, 15, rack-and-pinion,
16th, motor, 17, second interface, the 18, second conduit, 19, liquid trap, 21, high-speed camera, the 22, first moving block, 23, first
Sliding shoe, 24, the second sliding shoe, 25, spill spin block, 31, ultrasonic probe, the 32, second moving block, 33, adjusting rod, 34, chute, 4,
Housing.
Embodiment
Below in conjunction with the drawings and specific embodiments, the utility model is described further.
Embodiment 1：
A kind of blood vessel cavitation effect experimental provision, including：Support 1, the fixed shell 4 of support 1, the top of support 1 sets high
The port of fast video camera 21 and ultrasonic probe 31, high-speed camera 21 and ultrasonic probe 31 is towards housing 4；Housing 4 is hollow recessed
Channel-shaped, inside is provided with first interface 11 and second interface 17, and first interface 11 is connected to reservoir 13 by the first conduit 12, the
Two interfaces 17 are connected to liquid trap 19 by the second conduit 18；The inside of reservoir 13 performs the end of bar 14 provided with bar 14 is performed
Portion is provided with the execution plate fitted with the inwall of reservoir 13, performs bar 14 and is provided with rack-and-pinion 15, rack-and-pinion 15 is by motor 16
Connection driving.
High-speed camera 21 is connected by the first moving block 22, the first sliding shoe 23, the second sliding shoe 24 and spill spin block 25
Onto support 1.Ultrasonic probe 31 is provided with the second moving block 32, and the second moving block 32 connects adjusting rod 33, and adjusting rod 33 is in cunning
Slided in groove 34, adjusting rod 33 is provided with screw thread, the height of adjusting rod 33 is adjusted by being arranged on the nut of the top of chute 34.The
The bottom of one conduit 12 and reservoir 13 is turned on, and the bottom of the second conduit 18 and liquid trap 19 is turned on.Housing 4 is transparent pane body
Shape groove.The top of support 1 is horizontal stand, and bottom is vertical cylinder.Distance the first conduit 12 of high-speed camera 21 and the second conduit
18 lines are 12-15cm.Distance the first conduit 12 of ultrasonic probe 31 and the line of the second conduit 18 are 5-8mm.The He of first interface 11
The external diameter of second interface 17 is 2-6mm.
It when carrying out Vascular Ultrasonography cavitation research, it is necessary to build extracorporal circulatory system, and can effectively control, and be remembered
Record, remains analysis.New Zealand's experimental rabbit is put to death in anesthesia, and rabbit arteria carotis is dissected immediately, is separated, two ends are ligatured.Tool
Gymnastics uses first interface 11 slowly to insert as arteria carotis one end, and arteria carotis is enclosed on outside flexible pipe, then, and ligation is fixed,
Path is constituted, arteria carotis other end does same operation using second interface 17, constitutes a path.During experiment, reservoir 13
Interior acoustic contrast agent microvesicle, is connected by motor 16 and driven, and rack-and-pinion 15 drives execution bar 14 to decline, and performs the end of bar 14
The execution plate compression acoustic contrast agent microvesicle in portion.Rack-and-pinion 15 drives acoustic contrast agent microvesicle when performing the rising of bar 14 to flow to phase
It is counter to may be constructed an extracorporal circulatory system.Physiological saline is put into housing 4, and blood vessel is soaked in physiological saline.
Physiological saline is placed in housing, acoustic contrast agent is conventional use of contrast agent sound Novi.1 59mg of sound Novi,
Injecting normal saline, is made into microbubble contrast agent suspension, is 5ml；Microbubble diameter is 2-8 μm, and microbubble concentration is 1.8 × 109/ml。
Microvesicle fluid drip has the dyeing of methylene blue dyeing liquor, is easy to observation liquid during angiorrhoxis to flow out.
General principle of the present utility model, principal character and advantage has been shown and described above.The technical staff of the industry
It should be appreciated that the utility model is not restricted to the described embodiments, the simply explanation described in above-described embodiment and specification is originally
The principle of utility model, on the premise of the utility model spirit and scope are not departed from the utility model also have various change and
Improve, these changes and improvements are both fallen within the range of claimed the utility model.The utility model be claimed scope by
Appended claims and its equivalent are defined.
Claims (9)
1. a kind of blood vessel cavitation effect experimental provision, it is characterised in that including：
Support (1), support (1) fixed shell (4), the top of the support (1) sets high-speed camera (21) and ultrasound
Pop one's head in (31), the port of the high-speed camera (21) and ultrasonic probe (31) is towards housing (4)；
The housing (4) is medium altitude groove shape, and inside is provided with first interface (11) and second interface (17), the first interface
(11) reservoir (13) is connected to by the first conduit (12), the second interface (17) is connected to collection by the second conduit (18)
Liquid device (19)；
The inside of the reservoir (13) is provided with interior with reservoir (13) provided with bar (14), the end for performing bar (14) is performed
The execution plate of wall laminating, the execution bar (14) is provided with rack-and-pinion (15), and the rack-and-pinion (15) is connected by motor (16)
Connect driving.
2. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the high-speed camera
(21) by the first moving block (22), the first sliding shoe (23), the second sliding shoe (24) and spill spin block (25) are connected to support (1)
On.
3. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the ultrasonic probe (31)
The second moving block (32) is provided with, second moving block (32) connects adjusting rod (33), and the adjusting rod (33) is in chute
(34) slided in, the adjusting rod (33) is provided with screw thread, adjusting rod is adjusted by being arranged on the nut above chute (34)
(33) height.
4. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that first conduit (12)
Turned on the bottom of reservoir (13), second conduit (18) and the bottom of liquid trap (19) are turned on.
5. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the housing (4) is
Bright rectangular-shape groove.
6. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that support (1) top
For horizontal stand, bottom is vertical cylinder.
7. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the high-speed camera
(21) conduit of distance first (12) and the second conduit (18) line are 12-15cm.
8. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the ultrasonic probe (31)
The conduit of distance first (12) and the second conduit (18) line are 5-8mm.
9. a kind of blood vessel cavitation effect experimental provision according to claim 1, it is characterised in that the first interface (11)
External diameter with second interface (17) is 2-6mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720212543.9U CN206594103U (en) | 2017-03-06 | 2017-03-06 | A kind of blood vessel cavitation effect experimental provision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720212543.9U CN206594103U (en) | 2017-03-06 | 2017-03-06 | A kind of blood vessel cavitation effect experimental provision |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206594103U true CN206594103U (en) | 2017-10-27 |
Family
ID=60127206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720212543.9U Expired - Fee Related CN206594103U (en) | 2017-03-06 | 2017-03-06 | A kind of blood vessel cavitation effect experimental provision |
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| Country | Link |
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| CN (1) | CN206594103U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021093762A1 (en) * | 2019-11-12 | 2021-05-20 | 清华大学 | Vortexed-acoustic-field method for creating cell permeability and vortexed-acoustic-field method for opening blood-brain barrier |
-
2017
- 2017-03-06 CN CN201720212543.9U patent/CN206594103U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021093762A1 (en) * | 2019-11-12 | 2021-05-20 | 清华大学 | Vortexed-acoustic-field method for creating cell permeability and vortexed-acoustic-field method for opening blood-brain barrier |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171027 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |