CN206527969U - Semiconductor microactuator needle assemblies and its manufacture mould based on gene therapy - Google Patents
Semiconductor microactuator needle assemblies and its manufacture mould based on gene therapy Download PDFInfo
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- CN206527969U CN206527969U CN201621208405.5U CN201621208405U CN206527969U CN 206527969 U CN206527969 U CN 206527969U CN 201621208405 U CN201621208405 U CN 201621208405U CN 206527969 U CN206527969 U CN 206527969U
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- fixed plate
- needle assemblies
- semiconductor microactuator
- gene
- side fixed
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Abstract
The utility model discloses a kind of semiconductor microactuator needle assemblies based on gene therapy and its manufacture mould, semiconductor microactuator needle assemblies include the conduit of endoscope, microneedle unit and connection endoscope and microneedle unit, the microneedle unit is prepared by semi-conducting material, microneedle unit includes matrix and some micropins positioned at matrix surface, described matrix one end is connected with conduit, the other end is set for closing, and micropin is used to puncture biliary tract cell so that medicament or gene enter intracellular.The utility model uses microneedle component collocation endoscope, and its is simple in construction, and micropin, which pats biliary tract or coat of the stomach etc., to be needed the position for the treatment of and puncture cell, you can is reached the effect of gene delivery, be can be used to treat the cancer cell of the organ inwall such as stomach.
Description
Technical field
The utility model is related to gene therapy technology field, more particularly to a kind of semiconductor micropin based on gene therapy
Component and its manufacture mould.
Background technology
The method for the treatment of malignant tumour has direct excision, chemotherapy etc. at present, and simultaneously not all tissue is suitable in human body
Directly cut off, and chemotherapy then has sequelae.Domestic gene therapy (Gene Therapy) it is not yet ripe with it is legal but existing
Considerable research is carried out.Gene delivery is entered intracellular and should not to injure cell be considerable one of gene therapy
Part.There is doubt for security using viral Transgene, other method also has squeezes into surface texture with gases at high pressure by gene
Cell membrane (Electroporation) is opened such as particle bombardment (Gene Gun), to shock by electricity or cell is pierced through with micro- spicule
Film is with transfer gene etc..This patent pierces through cell membrane to transmit simultaneously transgene gene using micro- spicule, and exploitation microneedle component is simultaneously
Endoscope operation is coordinated to treat the cancer cell of stomach wall or biliary tract wall.Human body cell size is about at 30~100 μm, through two or three
Confluent monolayer cells need to use about 70~80 μm of micro- spicules of height.
MEMS is exactly that the manufacturing technology of film and thick film is widely used in into electronics and the design in mechanical industry
Device, general is often base material using silicon.Although siliceous material has integration IC circuits and good engineering properties, if demand has light
, toughness, not chemical impedance, the characteristic such as adsorbed proteins or micro-structural volume production, then must select plastics model technology.The modern designs of plastics
The technology of making common are hot-forming (Hot Embossing), ejection formation (Injection Molding) or penetrate molded
(Injection Compression Molding) etc..But carrying out volume production plastics micro-structural using plastics model technology must have
Metal die (Mold Insert), the manufacture of die substantially has two methods, and one is direct processing die, and another is first to process
Master mold, after reuse electroforming (Electrodeposition or Electroforming) overmolded produce metal die.Electroforming
The technology of overmolded is applied has quite long history, such as glass lens, car light lid on optical plastic product.Because electroforming is
By the upper master tool surface of metallic atom deposition, therefore can the suitable intactly feature of replicating master molds.Its die precision can definitely reach
Below secondary micron, therefore the precision of die depends primarily on the precision of master mold.Based on this background, develop the master mold of micro- plastics model
Process technology turns into an important subject under discussion.
Domestic and international micropin feature ejection formation research is not also common, and Michael et al. was once used<100>Monocrystalline silicon and
KOH etching solutions carry out anisotropic etching, and height about 80 μm, the needle-like feature array of 250 μm of spacing, its end are produced in silicon substrate
Point is quite sharp, and end points radius of curvature is less than 0.1 μm.Its preparation method is silica of first growing up in silicon substrate, by square
Array figure (pattern) soaks etching solution after replicating, and cusp is etched using undercutting (undercutting) effect.Excessively erosion
The height that (overetching) will shorten acicular texture is carved, the control of etching period is quite crucial.Figure on silicon has
Natural inhomogeneities, over etching but can ensure that the acicular texture in all planes has all been formed.Once the use of height it is 140 μm
Silicon substrate microprobes pierce through tissue, and can effectively incoming DNA or medicament.Liwei Lin et al. are once entered using silicon substrate die
Row is hot-forming, is etched with KOH<100>Monocrystalline silicon formation taper groove, is carried out by die of the silicon substrate of taper groove micro-structural herein
Acryl (PMMA) is hot-forming, produces the high about 21 μm, acicular texture of 30 μm of bottom width.
Therefore, for above-mentioned technical problem, it is necessary to provide a kind of semiconductor microactuator needle assemblies based on gene therapy and system
Make method and manufacture mould.
The content of the invention
In view of this, the purpose of this utility model be to provide a kind of semiconductor microactuator needle assemblies based on gene therapy and its
Manufacture mould.
To achieve these goals, the technical scheme that the utility model embodiment is provided is as follows：
A kind of semiconductor microactuator needle assemblies based on gene therapy, the semiconductor microactuator needle assemblies include endoscope, micropin list
The conduit of member and connection endoscope and microneedle unit, the microneedle unit is prepared by semi-conducting material, and microneedle unit includes matrix
And positioned at some micropins of matrix surface, described matrix one end is connected with conduit, the other end is set for closing, and micropin is used to pierce
Intimidating road cell is so that medicament or gene enter intracellular.
As further improvement of the utility model, the micropin is distributed in matrix surface in sharp pyramid.
As further improvement of the utility model, the conduit is flexible silica gel catheter, and silica gel catheter is used for will be interior
The swing of sight glass is converted into the swing of microneedle unit.
As further improvement of the utility model, described matrix surface is provided with gene tap hole.
The technical scheme that another embodiment of the utility model is provided is as follows：
A kind of manufacture mould of the semiconductor microactuator needle assemblies based on gene therapy, the mould include affixed side fixed plate,
Drawer at movable side fixed plate and affixed side pattern plate between affixed side fixed plate and drawer at movable side fixed plate, drawer at movable side pattern plate,
Space bar, is also sequentially provided with sliding block, stripper plate, cardioid fixed plate, ejector pin fixed between affixed side fixed plate and drawer at movable side fixed plate
It is formed with cardioid fixed plate on the inside of position plate and ejector pin fixed plate, sliding block on cardioid, space bar and is installed with elevating lever,
It is installed with affixed side fixed plate in locating ring, locating ring and sprue bushing is installed, die is locked on the inside of sliding block
Row plastic injection compression forming, produces the groove relative with micropin on die.
The beneficial effects of the utility model are：
Microneedle component collocation endoscope is used, its is simple in construction, micropin pats the position that biliary tract or coat of the stomach etc. need to treat
Put and puncture cell, you can reach the effect of gene delivery, can be used to treat the cancer cell of the organ inwall such as stomach；
Micropin is produced using anisotropic etching monocrystalline silicon, is turned over as a master mold nickel electroforming of progress and die is made, then
Die is bumped into progress plastic injection compression forming in mould, micropin is prepared simply, prepares precision higher.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
Or the accompanying drawing used required in description of the prior art is briefly described, it should be apparent that, drawings in the following description are only
It is some embodiments described in the utility model, for those of ordinary skill in the art, is not paying creative work
On the premise of, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the semiconductor microactuator needle assemblies based on gene therapy in the embodiment of the utility model one
Figure；
Fig. 2 is the structural representation of microneedle unit in the embodiment of the utility model one；
Fig. 3 is the close-up schematic view of microneedle unit in the embodiment of the utility model one；
Fig. 4 is the manufacture mould structure schematic diagram in the embodiment of the utility model one.
Embodiment
In order that those skilled in the art more fully understand the technical scheme in the utility model, below in conjunction with this reality
With the accompanying drawing in new embodiment, the technical scheme in the utility model embodiment is clearly and completely described, it is clear that
Described embodiment is only a part of embodiment of the utility model, rather than whole embodiments.Based on the utility model
In embodiment, the every other implementation that those of ordinary skill in the art are obtained under the premise of creative work is not made
Example, should all belong to the scope of the utility model protection.
The utility model devises the gene therapy microneedle component that collocation endoscope is used, and can be used to treat the devices such as stomach
The cancer cell of official's inwall.On the other hand micropin array is produced using anisotropic etching monocrystalline silicon, one is carried out as master mold
Secondary nickel electroforming, which is turned over, is made die, then die is bumped into progress plastic injection compression forming in mould, and sharp micropin is provided in manufacture
Construction package.Experimentation carries out micropin feature Outshooting compression shaping using high fluidity PC and general PP respectively.
Join shown in Fig. 3, a kind of semiconductor micropin group based on gene therapy in the embodiment of the utility model one
Part, the semiconductor microactuator needle assemblies include the conduit 103 of endoscope 101, microneedle unit 102 and connection endoscope and microneedle unit.
With reference to shown in Fig. 1, Fig. 2, microneedle unit 102 is prepared by semi-conducting material, microneedle unit 102 include matrix 1021 and
Positioned at some micropins 1022 of matrix surface, the one end of matrix 1021 is connected with conduit, and the other end is set for closing, micropin 1022
For puncturing biliary tract cell so that medicament or gene enter intracellular.
Preferably, micropin 1022 is distributed in matrix surface in sharp pyramid shape in present embodiment, certainly at other
Micropin 1022 no longer can also one by one be illustrated herein for other sharp shapes, such as triangular pyramid in embodiment.
Further, the surface of matrix 1021 is provided with gene tap hole 1023.
Wherein, conduit 103 is flexible silica gel catheter, and silica gel catheter is used to the swing of endoscope being converted into microneedle unit
Swing.
The utility model devises the microneedle component that collocation endoscope is used, and the dynamic of gene delivery is carried out to enter in body cavity
Make.In addition use and be not required to endoscope guiding and body cavity caliber larger opportunity.In order to be able to a large amount of productions, select with ejection formation
Mode manufactures simplified microneedle component, and designs the mould of microneedle component, treats after the completion of finished product again with bore mode processed gene
Tap hole.Diameter about 0.3mm bit bore can be used in gene tap hole, using artificial due to gene viscous force less
Be injected to microneedle component surface, general gene is all dissolved in medium, injection gene when and need not too great can be by gene
Transmission.
Gene therapy microneedle component is driven also and then to swing because endoscope is swung, while by gene injection to micropin table
Face, when micropin pats the position of the needs treatment such as biliary tract or coat of the stomach and punctures cell, you can reach the effect of gene delivery.By
The action of swing can be produced in itself in endoscope, therefore eliminates the parts such as copper cash in the prior art and steel disc pats dynamic to produce
Make.
In view of such scheme, semiconductor microactuator needle assemblies of the utility model based on gene therapy need to have following functions：
(1) gene therapy microneedle component enters biliary tract together with endoscope, catheter combination；
(2) gene therapy with microneedle component have hundreds of or even thousands of micropins can puncture biliary tract cell simultaneously, make medicament or
Gene enters intracellular；
(3) from external injection medicament or gene to gene therapy microneedle surface；
(4) tool pats the action of biliary tract wall.
A kind of manufacture mould in the utility model a further embodiment, this mould holes of mould one is the stripping of two template die sliding blocks
Flitch is stripped the mould of pattern.
Join shown in Fig. 4, the mould includes affixed side fixed plate 1, drawer at movable side fixed plate 6 and positioned at the and of affixed side fixed plate 1
Affixed side pattern plate 2, drawer at movable side pattern plate 4, space bar 5, affixed side fixed plate 1 and drawer at movable side between drawer at movable side fixed plate 6
Sliding block 3, stripper plate 9, cardioid fixed plate 10, ejector pin location-plate 7 and ejector pin fixed plate 8 are also sequentially provided between fixed plate 6.
It is formed with the cardioid fixed plate 10 of the inner side of sliding block 3 on cardioid 16, space bar 5 and is installed with elevating lever 15, Gu
Determine to be installed with locating ring 11 in side fixed plate 1, sprue bushing 12 is installed in locating ring 11, die is locked in sliding block 3
Side produces the groove relative with micropin to carry out plastic injection compression forming on die.
Due to produce micropin structure of arrays in gene therapy micropin both sides, therefore micropin electrocasting mould must be locked in cunning
On the inside of block.Microneedle configuration array is gone out as master mold using silicon-based etch, rear electroforming turn over metal die be made, produced on this metal die
Raw micropin shape groove structure.
Further, pilot pin 13 and leader pin bushing 14, affixed side fixed plate 1 are also correspondingly provided with affixed side pattern plate 2
Keeper 19 is additionally provided between drawer at movable side fixed plate 6, the lower section of cardioid 16 is provided with knock-pin 22, and the lower section of sliding block 3 is provided with return pin
27。
In addition, be additionally provided with present embodiment it is some be used for fixed screws, including for fix affixed side screw 17,
Screw 18 for fixed positioning piece, the screw 20 for fixing drawer at movable side, the screw 21 for fixing rationed marketing plate, for fixing
The screw 23 of locating ring, the screw 24 for fixing cardioid fixed plate, the screw 25 for fixing sliding block and risen for fixed
The screw 26 of bar drops.
The utility model has the advantages that it can be seen from above-mentioned technical proposal：
Microneedle component collocation endoscope is used, its is simple in construction, micropin pats the position that biliary tract or coat of the stomach etc. need to treat
Put and puncture cell, you can reach the effect of gene delivery, can be used to treat the cancer cell of the organ inwall such as stomach；
Micropin is produced using anisotropic etching monocrystalline silicon, is turned over as a master mold nickel electroforming of progress and die is made, then
Die is bumped into progress plastic injection compression forming in mould, micropin is prepared simply, prepares precision higher.
It is obvious to a person skilled in the art that the utility model is not limited to the details of above-mentioned one exemplary embodiment, and
And in the case of without departing substantially from spirit or essential attributes of the present utility model, can realize that this practicality is new in other specific forms
Type.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and is nonrestrictive, this practicality is new
The scope of type limits by appended claims rather than described above, it is intended that the equivalency fallen in claim is contained
All changes in justice and scope are included in the utility model.Any reference in claim should not be considered as limitation
Involved claim.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (5)
1. a kind of semiconductor microactuator needle assemblies based on gene therapy, it is characterised in that the semiconductor microactuator needle assemblies include interior peep
The conduit of mirror, microneedle unit and connection endoscope and microneedle unit, the microneedle unit is prepared by semi-conducting material, microneedle unit
Including matrix and positioned at some micropins of matrix surface, described matrix one end is connected with conduit, and the other end is set for closing, micro-
Pin is used to puncture biliary tract cell so that medicament or gene enter intracellular.
2. semiconductor microactuator needle assemblies according to claim 1, it is characterised in that the micropin is distributed in sharp pyramid
In matrix surface.
3. semiconductor microactuator needle assemblies according to claim 1, it is characterised in that the conduit is flexible silica gel catheter,
Silica gel catheter is used for the swing that the swing of endoscope is converted into microneedle unit.
4. semiconductor microactuator needle assemblies according to claim 1, it is characterised in that flowed out provided with gene on described matrix surface
Hole.
5. a kind of manufacture mould of the semiconductor microactuator needle assemblies based on gene therapy, it is characterised in that the mould includes fixing
It is side fixed plate, drawer at movable side fixed plate and affixed side pattern plate between affixed side fixed plate and drawer at movable side fixed plate, movable
Side pattern plate, space bar, are also sequentially provided with sliding block, stripper plate, cardioid and fix between affixed side fixed plate and drawer at movable side fixed plate
It is formed with cardioid, space bar and is fixedly mounted in cardioid fixed plate on the inside of plate, ejector pin location-plate and ejector pin fixed plate, sliding block
Have to be installed with locating ring, locating ring in elevating lever, affixed side fixed plate and sprue bushing is installed, die is locked in sliding block
Inner side produces the groove relative with micropin to carry out plastic injection compression forming on die.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621208405.5U CN206527969U (en) | 2016-11-09 | 2016-11-09 | Semiconductor microactuator needle assemblies and its manufacture mould based on gene therapy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621208405.5U CN206527969U (en) | 2016-11-09 | 2016-11-09 | Semiconductor microactuator needle assemblies and its manufacture mould based on gene therapy |
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|---|---|
| CN206527969U true CN206527969U (en) | 2017-09-29 |
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| CN201621208405.5U Expired - Fee Related CN206527969U (en) | 2016-11-09 | 2016-11-09 | Semiconductor microactuator needle assemblies and its manufacture mould based on gene therapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106426729A (en) * | 2016-11-09 | 2017-02-22 | 江苏信息职业技术学院 | Semiconductor microneedle assembly based on gene therapy, manufacturing method and manufacturing mold |
-
2016
- 2016-11-09 CN CN201621208405.5U patent/CN206527969U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106426729A (en) * | 2016-11-09 | 2017-02-22 | 江苏信息职业技术学院 | Semiconductor microneedle assembly based on gene therapy, manufacturing method and manufacturing mold |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170929 Termination date: 20201109 |