CN206496841U - Spatial spectral for motion artifact correction encodes parallel OCT systems - Google Patents
Spatial spectral for motion artifact correction encodes parallel OCT systems Download PDFInfo
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Abstract
Parallel OCT systems are encoded the utility model discloses a kind of spatial spectral for motion artifact correction.The utility model adds spatial spectral coding module between wideband light source and parallel OCT systems, and the module carries out spatial spectral coding along light beam scanning direction to the broadband spectral of wideband light source outgoing；The utility model is utilized in adjacent two steps scanning process, and the data corresponding to the overlapping region of two rectangular illuminating areas carry out the motion artifact correction based on cross correlation algorithm, to compute and compensate for the random motion amount of sample in adjacent scanning process.To the different coding spectrum of same position in the multi-frame interferometry spectrum obtained using adjacent multistep scanning process, the complete spectrum of the position is spliced into, spatial spectral decoding is completed, so as to recover the theoretical lateral resolution and axial resolution of parallel OCT systems.The utility model can there is provided high accuracy, the correction of the sample random motion amount of high accuracy while original parallel OCT systemic resolutions are ensured.
Description
Technical field
The utility model belongs to optical coherence fields of measurement, and in particular to a kind of spatial spectral for motion artifact correction
Encode parallel OCT systems.
Technical background
In OCT detection light beam scanning processes, and random motion that sample is present (respiratory movement of such as living body biological, it is electronic flat
Randomized jitter of moving stage etc.) inevitably OCT image will be caused motion artifacts occur, and then to subsequently being quantified based on image
Analysis has adverse effect on.Thus, the influence for how suppressing the random motion is always the key issue in OCT technology.
At present, mainly there are two class methods in OCT technology to suppress sample random motion amount：1. improve OCT image taking speed；
2. examine and determine and compensate the random motion amount.It is to use whole audience OCT image technology to improve OCT image speed most efficient method, should
Technology uses frequency sweep wideband light source and area array CCD, so as to avoid the use of light beam sweep mechanism, it is thus possible to realize MHz's
OCT image speed, greatly inhibits influence of the random motion amount of sample in imaging cycle to OCT image quality.However, should
Whole audience OCT image technology has the intrinsic of the mutual crosstalk of signal between probe unit, thus cause image resolution ratio and
The reduction of signal sensitivity.Therefore, in order to take into account OCT image speed and signal sensitivity, using the parallel OCT skills of linear scan
Art will be more suitably applied to suppress the random motion amount of sample.Signals of the parallel OCT due to simply obtaining single B-Scan simultaneously,
Therefore adjacent B-Scan is still needed and examines and determine and compensate sample random motion amount.Examine and determine at present and compensate sample random motion amount
Method be broadly divided into two kinds：In calibrating in real time and compensation in 1.OCT detection light beam scanning processes, 2. subsequent algorithm processing procedures
Algorithm is examined and determine and compensated.The random motion amount of the extra laser beam real-time tracing sample of introducing is needed in method 1, and by multiple
Miscellaneous feedback device, the random motion amount is compensated by improving the scan pattern of sweep mechanism.It this method increase system
Complexity and system cost.Method 2 is by the cross-correlation calculation between adjacent over-sampling data, to ask for OCT detection light beams
The random motion amount of sample in scanning process, and compensate.But this method needs more highdensity data sampling point, and
Need to assume sample surfaces relative smooth.
The content of the invention
The utility model in view of the shortcomings of the prior art, proposes a kind of spatial spectral coding for motion artifact correction simultaneously
Row OCT systems.
A kind of spatial spectral for motion artifact correction encodes parallel OCT systems, and the system includes wideband light source, space
Optical spectrum encoded module and parallel OCT modules.Broadband light from wideband light source outgoing is after spatial spectral coding module, broadband
Light forms spatial spectral encoded light along whole system light beam scanning direction (x-axis direction), and spatial spectral encoded light is subsequently entered
Parallel OCT modules, focusing illumination forms the rectangular illuminating area of spatial spectral coding on testing sample, anti-via testing sample
The flashlight penetrated reenters parallel OCT modules, is interfered with the reference light in parallel OCT modules, interferes the interference formed
Light carries out spectral resolution and parallel detecting by the probe unit in parallel OCT modules, surveys the final incoming parallel OCT modules of data
Computer in carry out follow-up algorithm process.
The spatial spectral coding module includes：Dispersing prism, the first achromatic lens, edge of a knife prism, the first plane are anti-
Penetrate mirror, the second plane mirror, the first depolarization Amici prism, the second achromatic lens and the 3rd plane mirror.Dispersion rib
Mirror into the broadband light of spatial spectral coding module along whole system light beam scanning direction (x-axis direction) to carrying out spatial linear
Dispersion, the broadband light after dispersion is by occurring the symmetrical of left half of and right half of spectrum after the first achromatic lens and edge of a knife prism
Separation, the broadband light after the separation of left and right reflects via the first plane mirror, the second plane mirror respectively, is again incident on first
Collect again after depolarization Amici prism, then collimated via the second achromatic lens, now the half of spectrum in left and right is spatially complete
Full weight is closed, and dispersion direction is on the contrary, so as to form spatial spectral encoded light.Finally, spatial spectral encoded light is anti-via the 3rd plane
Penetrate outgoing spatial spectral coding module after mirror.
The parallel OCT modules include：First cylindrical lens, the second depolarization Amici prism, neutral density attenuator,
Two cylindrical lenses, the 3rd achromatic lens, fourth plane speculum, the 4th achromatic lens, motorized precision translation stage, compound lens,
Slit, the 5th achromatic lens, transmission grating, the 6th achromatic lens, face battle array CMOS, high speed image acquisition board, electric translation
Platform controller and computer.Enter parallel OCT modules from the spatial spectral encoded light of spatial spectral coding module outgoing, first
Via cylindrical wave beam exit is changed into after the first cylindrical lens, the cylindrical wave light beam is then divided into by the second depolarization Amici prism
First light beam and the second light beam.First light beam is via neutral density attenuator, the second cylindrical lens and the 3rd achromatic lens
After focus on fourth plane speculum, the subsequent another mistake of the light beam to via the 3rd achromatic lens, the second cylindrical lens and in
Property density decay piece returns to the second depolarization Amici prism.Second light beam focused on via the 4th achromatic lens be positioned over it is electronic
On the testing sample of translation stage, the light beam another mistake returned from testing sample to via the 4th achromatic lens returns to the second depolarization
Amici prism.The first light beam and the second light beam returned is interfered in the second depolarization Amici prism, then saturating via combination
By face, battle array CMOS carries out spectral resolution and parallel after mirror, slit, the 5th achromatic lens, transmission grating, the 6th achromatic lens
Detection.Detection the data obtained in the incoming computer of high speed image acquisition board via carrying out follow-up algorithm process.
Compared with background technology, the utility model has an advantageous effect in that：
1. compared to whole audience OCT image technology, the utility model employs spatial spectral coding module and parallel OCT modules
The system architecture being combined, thus higher OCT image speed and higher Signal-to-Noise have been taken into account simultaneously.
2. the utility model laser beam extra due to not needing and the feedback device of complexity are used for correcting sample
Random motion amount, therefore system will seem more succinct, so as to effectively reduce system cost.
Brief description of the drawings
Fig. 1 is that spatial spectral of the present utility model encodes parallel OCT system schematics；
Fig. 2 is spatial spectral coding of the present utility model and scanning schematic diagram；
Fig. 3 is that motion artifacts correction of the present utility model and spatial spectral decode schematic diagram.
In Fig. 1：1st, wideband light source, 2, dispersing prism, the 3, first achromatic lens, 4, edge of a knife prism, the 5, first plane is anti-
Penetrate mirror, the 6, second plane mirror, the 7, first depolarization Amici prism, the 8, second achromatic lens, the 9, the 3rd plane mirror,
10th, the first cylindrical lens, the 11, second depolarization Amici prism, 12, neutral density attenuator, the 13, second cylindrical lens, 14,
Three achromatic lens, 15, fourth plane speculum, the 16, the 4th achromatic lens, 17, testing sample, 18, motorized precision translation stage,
19th, compound lens, 20, slit, the 21, the 5th achromatic lens, 22, transmission grating, the 23, the 6th achromatic lens, 24, face battle array
CMOS, 25, high speed image acquisition board, 26, computer, 27, motorized precision translation stage controller, 28, spatial spectral coding module, 29,
Parallel OCT modules.
Embodiment
The purpose of this utility model is that providing a kind of spatial spectral for motion artifact correction encodes parallel OCT systems
System.The utility model adds spatial light compared to traditional parallel OCT systems between wideband light source and parallel OCT systems
Spectral encoding module, the module carries out spatial spectral coding along light beam scanning direction to the broadband spectral of wideband light source outgoing, so that
Realize the rectangular area illumination of spatial spectral coding.Then, using in adjacent two steps scanning process, two rectangular illuminating areas
Data corresponding to overlapping region carry out the motion artifact correction based on cross correlation algorithm, scanned to compute and compensate for adjacent time
The random motion amount of sample in journey.In the multi-frame interferometry spectrum obtained using adjacent multistep scanning process to same position not
With coding spectrum, the complete spectrum of the position is spliced into, spatial spectral decoding is completed, so as to recover the theory of parallel OCT systems
Lateral resolution and axial resolution.Thus, the utility model can ensure original parallel OCT systemic resolutions while,
High accuracy, the correction of the sample random motion amount of high accuracy are provided.
The purpose of this utility model is achieved by the following technical solution：
A kind of spatial spectral for motion artifact correction encodes parallel OCT systems：
The system includes wideband light source, spatial spectral coding module and parallel OCT modules.From the width of wideband light source outgoing
Band light is after spatial spectral coding module, and broadband light forms spatial light along whole system light beam scanning direction (x-axis direction)
Spectral encoding light, spatial spectral encoded light subsequently enters parallel OCT modules, and focusing illumination forms spatial spectral volume on testing sample
The rectangular illuminating area of code, the flashlight reflected via testing sample reenters parallel OCT modules, and in parallel OCT modules
Reference light interfere, interfere the interference light formed to carry out spectral resolution and parallel by the probe unit in parallel OCT modules
In detection, the computer for surveying the final incoming parallel OCT modules of data.
The spatial spectral coding module includes：Dispersing prism, the first achromatic lens, edge of a knife prism, the first plane are anti-
Penetrate mirror, the second plane mirror, the first depolarization Amici prism, the second achromatic lens and the 3rd plane mirror.Dispersion rib
Mirror into the broadband light of spatial spectral coding module along whole system light beam scanning direction (x-axis direction) to carrying out spatial linear
Dispersion, the broadband light after dispersion is by occurring the symmetrical of left half of and right half of spectrum after the first achromatic lens and edge of a knife prism
Separation, the broadband light after the separation of left and right is respectively via the first plane mirror, the second plane mirror and the first depolarization light splitting
Collect again after prism, then collimated via the second achromatic lens, now the half of spectrum in left and right is spatially completely superposed, dispersion
In the opposite direction, so as to form spatial spectral encoded light.Finally, spatial spectral encoded light is empty via outgoing after the 3rd plane mirror
Between optical spectrum encoded module.
The parallel OCT modules include：First cylindrical lens, the second depolarization Amici prism, neutral density attenuator,
Two cylindrical lenses, the 3rd achromatic lens, fourth plane speculum, the 4th achromatic lens, motorized precision translation stage, compound lens,
Slit, the 5th achromatic lens, transmission grating, the 6th achromatic lens, face battle array CMOS, high speed image acquisition board, electric translation
Platform controller and computer.Enter parallel OCT modules from the spatial spectral encoded light of spatial spectral coding module outgoing, first
Via cylindrical wave beam exit is changed into after the first cylindrical lens, the cylindrical wave light beam is then divided into by the second depolarization Amici prism
First light beam and the second light beam.First light beam is via neutral density attenuator, the second cylindrical lens and the 3rd achromatic lens
After focus on fourth plane speculum, the subsequent another mistake of the light beam to via the 3rd achromatic lens, the second cylindrical lens and in
Property density decay piece returns to the second depolarization Amici prism.Second light beam focused on via the 4th achromatic lens be positioned over it is electronic
On the testing sample of translation stage, the light beam another mistake returned from testing sample to via the 4th achromatic lens returns to the second depolarization
Amici prism.The first light beam and the second light beam returned is interfered in the second depolarization Amici prism, then saturating via combination
By face, battle array CMOS carries out spectral resolution and parallel after mirror, slit, the 5th achromatic lens, transmission grating, the 6th achromatic lens
Detection.The data obtained is detected via in the incoming computer of high speed image acquisition board.
The utility model is further described with implementation example below in conjunction with the accompanying drawings：
As shown in figure 1, a kind of spatial spectral for motion artifact correction encodes parallel OCT systems, including wideband light source
1st, dispersing prism 2, the first achromatic lens 3, edge of a knife prism 4, the first plane mirror 5, the second plane mirror 6, first disappear
Polarization splitting prism 7, the second achromatic lens 8, the 3rd plane mirror 9, the first cylindrical lens 10, the second depolarization light splitting rib
Mirror 11, neutral density attenuator 12, the second cylindrical lens 13, the 3rd achromatic lens 14, fourth plane speculum the 15, the 4th disappear
Aberration lens 16, testing sample 17, motorized precision translation stage 18, compound lens 19, slit 20, the 5th achromatic lens 21, transmitted light
Grid 22, the 6th achromatic lens 23, face battle array CMOS24, high speed image acquisition board 25, computer 26, motorized precision translation stage controller
27th, spatial spectral coding module 28, parallel OCT modules 29.
The broadband light sent from wideband light source 1, into spatial spectral coding module 28.In spatial spectral coding module 28
In, the broadband light that wideband light source 1 is sent occurs after dispersing prism 2 along whole system light beam scanning direction (x-axis direction)
Spatial linear dispersion, broadband light after dispersion by occur after the first achromatic lens 3 and edge of a knife prism 4 it is left it is half of (k-m~
K0) and right half of (k0~km) spectrum symmetrical separation, as shown in hollow arrow in Fig. 1 and filled arrows.After the separation of left and right
Broadband light respectively via collecting again after the first plane mirror 5, the second plane mirror 6 and the first depolarization Amici prism 7,
Collimated again via the second achromatic lens 8, now the half of spectrum in left and right is spatially completely superposed, dispersion direction on the contrary, so as to
Form spatial spectral encoded light.Finally, spatial spectral encoded light encodes mould via outgoing spatial spectral after the 3rd plane mirror 9
Block 28.
Enter parallel OCT modules 29 from the broadband light of the outgoing of spatial spectral coding module 28, it is saturating via the first cylinder first
Be changed into cylindrical wave beam exit after mirror 10, the cylindrical wave light beam then by the second depolarization Amici prism 11 be divided into the first light beam and
Second light beam.First light beam gathers via after neutral density attenuator 12, the second cylindrical lens 13 and the 3rd achromatic lens 14
Jiao is on fourth plane speculum 15, and the subsequent another mistake of the light beam is to via the 3rd achromatic lens 14, the and of the second cylindrical lens 13
Neutral density attenuator 12 returns to the second depolarization Amici prism 11.Second light beam is focused on via the 4th achromatic lens 16 and put
It is placed on the testing sample 17 of motorized precision translation stage 18, the light beam another mistake from the return of testing sample 17 is to via the 4th achromatic lens
16 return to the second depolarization Amici prism 11.The first light beam and the second light beam returned occurs in the second depolarization Amici prism 11
Interference, then via after compound lens 19, slit 20, the 5th achromatic lens 21, transmission grating 22, the 6th achromatic lens 23
By face, battle array CMOS24 carries out spectral resolution and parallel detecting.The data obtained is detected via the incoming computer of high speed image acquisition board 25
Follow-up algorithm process is carried out in 26.
As shown in Fig. 2 schematic diagram is encoded and scanned for spatial spectral of the present utility model.Y-axis shown in figure, which corresponds to, to be passed
The parallel detecting direction for parallel OCT systems of uniting.Because spatial spectral coding module is scanned to broadband light along whole system light beam
Spatial spectral coding occurs for direction (x directions), produces that left and right half of spectrum is spatially completely superposed but dispersion direction is opposite
Spatial spectral encoded light, therefore along the x-axis direction, testing sample diverse location will be irradiated by different spectrum segment, but be irradiated any
The average wave number of two spectrum segments of position is identical again, that is, realizes the spatial spectral coding to testing sample.Interference light
The interference spectrum formed in probe unit by spectral resolution battle array CMOS24 detections in face shown in Fig. 1.By described above
The mode of spatial spectral coding, have recorded the information of x position in illumination region simultaneously in an interference spectrum, and with spectrum segment
It is different as distinguishing.For the purpose of simplifying the description, so that scanning step is 1/3rd of illumination region width as an example, only listed in figure
K-3、k-2、k-1、k0、k1、k2、k3, 7 spectrum coordinates.As when the n-th step is scanned in Fig. 2, the coordinate of the region of illumination in x-axis
Respectively xn-1、xn、xn+1, corresponding spectrum segment is respectively (k-3~k-2、k2~k3)、(k-2~k-1、k1~k2) and (k-1~
k0、k0~k1), average wave number is k0.Identical x and k corresponding relation are also embodied in face battle array CMOS24 and detect interference light
In spectrum.Fig. 1 Computers 26 send control signal, after motorized precision translation stage controller 27, send motorized precision translation stage 18 to, from
And realize that x-axis scans the movement that stepping n scans stepping n+1 to x-axis in Fig. 2.N-th step and the (n+1)th step scan illuminated region
Coordinate in x-axis is respectively xn-1、xn、xn+1And xn、xn+1、xn+2, overlapping region is xn、xn+1。
As shown in figure 3, being that motion artifacts correction and spatial spectral decode schematic diagram.It includes step II and step III,
In step II, choose two steps in Fig. 2 respectively using window function H ' and H " and scan obtained data InAnd In+1In, correspond to
The partial data of overlapping region, and Fast Fourier Transform (FFT) processing is carried out to it respectivelyTo the number after Fast Fourier Transform (FFT)
According to cross-correlation calculation is done 1., the Pixel-level offsetting amount in the adjacent sub-beams scanning process of sample is obtained by the magnitude calculation of resultTo data In+1Compensate the Pixel-level offsetting amount 2..Then InWith the I for correcting Pixel-level offsetting amountn+1It is divided into two portions
Divide and do Fourier transformation respectively, obtain resultWithWithWithDo respectively mutually
Algorithm process is closed, then 3. summation operation is carried out to the result obtained by processing, so as to eliminate the phase mass relevant with depth location, is entered
And ask for phase level offsetting amountAnd to its In+1Carry out the phase level offsetting amount compensation 4. so that corrected sample with
The data I' of machine amount of exercisen+1.In step III, the data I scanned to adjacent 3 step for correcting motion artifactsn-1、InAnd In+1,
Extract respectively and encode position xnDiscrete spectrum data (k-1~k1)、(k-2~k-1、k1~k2) and (k-3~k-2、k2~
k3), so as to be spliced into corresponding light beam scanning position xnComplete spectrum (the k at place-3~k3), and then recover the theory of parallel OCT systems
Lateral resolution and axial resolution.
Claims (3)
1. the spatial spectral for motion artifact correction encodes parallel OCT systems, it is characterised in that：The system includes broadband light
Source, spatial spectral coding module and parallel OCT modules；Pass through spatial spectral coding module from the broadband light of wideband light source outgoing
Afterwards, broadband light forms spatial spectral encoded light along whole system light beam scanning direction, and spatial spectral encoded light is subsequently entered simultaneously
Row OCT modules, focusing illumination forms the rectangular illuminating area of spatial spectral coding on testing sample, is reflected via testing sample
Flashlight reenter parallel OCT modules, interfered with the reference light in parallel OCT modules, interfere formed interference light
Spectral resolution and parallel detecting are carried out by the probe unit in parallel OCT modules, the final incoming parallel OCT modules of data are surveyed
In computer.
2. the spatial spectral for motion artifact correction encodes parallel OCT systems as claimed in claim 1, it is characterised in that：
The spatial spectral coding module includes：Dispersing prism, the first achromatic lens, edge of a knife prism, the first plane mirror, second
Plane mirror, the first depolarization Amici prism, the second achromatic lens and the 3rd plane mirror；Dispersing prism is empty to entering
Between optical spectrum encoded module broadband light along whole system light beam scanning direction carry out spatial linear dispersion, the broadband light after dispersion
By the way that the symmetrical separation of left half of and right half of spectrum, the width after the separation of left and right occur after the first achromatic lens and edge of a knife prism
Band light reflects via the first plane mirror, the second plane mirror respectively, is again incident on weight after the first depolarization Amici prism
Newly collect, then collimated via the second achromatic lens, now the half of spectrum in left and right is spatially completely superposed, dispersion direction phase
Instead, so as to form spatial spectral encoded light；Finally, spatial spectral encoded light is via outgoing spatial spectral after the 3rd plane mirror
Coding module.
3. the spatial spectral for motion artifact correction encodes parallel OCT systems as claimed in claim 1, it is characterised in that：
The parallel OCT modules include：First cylindrical lens, the second depolarization Amici prism, neutral density attenuator, the second cylinder are saturating
Mirror, the 3rd achromatic lens, fourth plane speculum, the 4th achromatic lens, motorized precision translation stage, compound lens, slit, the 5th
Achromatic lens, transmission grating, the 6th achromatic lens, face battle array CMOS, high speed image acquisition board, motorized precision translation stage controller with
And computer；Enter parallel OCT modules from the spatial spectral encoded light of spatial spectral coding module outgoing, first via the first post
Be changed into cylindrical wave beam exit after the lens of face, the cylindrical wave light beam then by the second depolarization Amici prism be divided into the first light beam and
Second light beam；First light beam is via focusing on after neutral density attenuator, the second cylindrical lens and the 3rd achromatic lens
On four plane mirrors, the subsequent another mistake of the light beam decays to via the 3rd achromatic lens, the second cylindrical lens and neutral density
Piece returns to the second depolarization Amici prism；Second light beam focuses on via the 4th achromatic lens and is positioned over treating for motorized precision translation stage
On test sample product, the light beam another mistake returned from testing sample to via the 4th achromatic lens returns to the second depolarization Amici prism；
The first light beam and the second light beam returned is interfered in the second depolarization Amici prism, then via compound lens, slit, the
By face, battle array CMOS carries out spectral resolution and parallel detecting after five achromatic lens, transmission grating, the 6th achromatic lens；Detection institute
Data are obtained via the incoming computer of high speed image acquisition board.
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| CN106895917A (en) * | 2017-02-14 | 2017-06-27 | 浙江大学 | Spatial spectral for motion artifact correction encodes parallel OCT system and method |
| CN106895917B (en) * | 2017-02-14 | 2018-09-28 | 浙江大学 | Spatial spectral for motion artifact correction encodes parallel OCT system and method |
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