CN206444019U - A kind of radiation intraluminal stent - Google Patents

Abstract

The utility model is related to the technical field of medical instruments containing radioactive substance, discloses a kind of radiation intraluminal stent, and it includes body, the support flank of branch shape, the laminar radiation core for being loaded with radionuclide being sealed in the tube wall of body.The support flank of branch shape is used to secure a bracket to ad-hoc location in tube chamber, prevents displacement；Core is radiated in addition to carrying radionuclide, the effect of x-ray marker is also acted as；Beta ray therapy tumour is discharged during radionuclide decay.The utility model is simple in construction, with good pliability, maintains the smooth of surface, facilitates and is implanted into, takes out and changes under scope, has the effect of support, drainage and treatment concurrently；Its " radiation core " structure being arranged on body can avoid radionuclide from revealing, and radiation core is very thin, and very little is influenceed on stent size；Radiated and designed using segmental, realized 360 degree without blind spot irradiation, active area domain sizes, nucleic species, the position on support and nucleic activity can be adjusted according to Clinical symptoms such as position, the sizes of tumour, realize that individuation is precisely treated.

Description

A kind of radiation intraluminal stent

Technical field

The utility model belongs to the technical field of medical instruments containing radioactive substance, and in particular to a kind of radiation intraluminal Support, can be used for treatment cholangiocarcinoma and cancer of pancreas, can be used for treating other tube chamber malignant tumours.

Background technology

Luminal organs are the important compositions of human body, such as esophagus, enteron aisle, tracheae, bile duct, blood vessel, and tube chamber malignant tumour is tight Weight is unhealthful, and luminal stenosis caused by tube chamber malignant tumour and obstruction also annoying the mankind always.

Luminal stenosis caused by tube chamber malignant tumour and obstruction generally by be implanted into support alleviate, can reach in a short time compared with Good effect, but support has no meaning to oncotherapy in itself, and as tumor proliferative generally occurs narrow again, lead Cause needs to be implanted into support again.

The treatment of tube chamber malignant tumour mainly has the methods such as operation, chemotherapy, radiotherapy, in recent years, utilizes¹²⁵I、¹⁰³Pd、¹³¹Cs Etc. low energy radionuclide, Interstitial brachytherapy malignant tumour is carried out, is clinically widely used, and take Obtained good clinical effectiveness.

Intraluminal stent is combined with the radionuclide of close-range treatment, radiant stand is made, not only can be with Alleviate various luminal stenosis and obstruction using the mechanical support effect of support, can also be killed using the ray of radionuclide Hinder tumour cell, reach the purpose for the treatment of or control malignant tumour, therefore radiant stand controlling for tube chamber malignant tumour Treat significant.

Support can be generally divided into network and entity support according to structure, both can carry radionuclide, Prepare radiant stand.

Network is generally metal or alloy material, and the radiant stand of the structure generally has three kinds of forms or preparation sides Method：

(1) radiant stand of radioactive particle is carried, for example, Jin Anqin etc. is in " memory alloy stent binding iodine-125 In the text of the clinical practice of the particle therapy cancer of the esophagus " one, a kind of carrying is described¹²⁵The radiant stand of I particles, selection band film note Recall alloy bracket, sheath special, for containing radioactive particle is fixed in periphery, according to the length of lesion and the feature of lesion, It is preoperative to be encased in radioactive particle with tweezers in special sheath, support loaded into propeller using preceding, then by stenter to implant Oesophagus, support is swelling, is fixed in oesophagus；In another example, Hai-Dong Zhu etc. are in " A novel biliary stent loaded with ¹²⁵I seeds in patients with malignant biliary obstruction: In the texts of Preliminary results versus a conventional biliary stent " one, describe one kind and take Band¹²⁵The radiant stand of I particles, is divided into two parts, and outside self-expandable stent is that several parallel wires connect the netted knot in two ends Structure, wire is used to bundle¹²⁵I particles, internal self-expandable stent is full mesh structure, first by outside carrying when using¹²⁵I particles Self-expandable stent implantation, then internal self-expandable stent is implanted into, allows both to overlap, after internal self-expandable stent is swelling, will Outside is carried¹²⁵The support of I particles is fixed in tube chamber.

(2) coat radioactive thin films radiant stand, for example, Chen Zhen etc. "¹²⁵It is prepared by I polyurethane overlay films esophageal stents In the text of technique study " one, the radiant stand that surface is covered with radiant polyurethane film is described, by Na¹²⁵I adds polyurethane DMF solution in and be well mixed, prepare¹²⁵I polyurethane solutions, support is immersed, and then takes out baking and curing, is obtained Arrive¹²⁵I polyurethane overlay film radiant stands.

(3) radiant stand of deposited activity indissoluble thing, such as Chinese patent ZL201410323239.2 discloses one kind Radiant stand, Ag is deposited on network surface¹²⁵I or¹⁰³The slightly solubility radioactive substance such as Pd, then surface coating polyurethane Film, obtains radiant stand.

Entity support is generally nonmetallic materials, it can also be used to prepare radiant stand.

For example, Chinese patent ZL200610116321.3 disclose it is a kind of can bearing micro radioactive particle source pipeline branch Frame, particle duct is provided with the drainage wall of entity support, for inserting radioactive particle, radiant stand is prepared.

Either network, or entity support, when preparing radiant stand by carrying radioactive particle, advantage is Method is fairly simple, but there is also more shortcoming, such as：

First, because network wire is relatively thin compared with thin, entity cradle wall, although radioactive particle size is smaller (outer Footpath 0.8mm, length 4.5mm), but relative to network wire, entity cradle wall, radioactive particle external diameter is still larger, because This fixes or loaded¹²⁵The operation of I particles is more difficult；

Second, the motion of matter easily causes radioactive particle and come off in tube chamber or tube chamber, so as to migrate, is likely to result in The damage of normal lumina tissue or other tissues；

3rd, for the tube chamber that esophagus uniform internal diameter is larger,¹²⁵I particles will not take more cavity space, but for courage The less tube chamber of road uniform internal diameter,¹²⁵The introducing of I particles increases the overall volume of support, and it is empty that implantation cavity takes larger cavity Between, influence normal physiological activity；

4th, the important feature of support is but the introducing of radioactive particle with pliability, reduces the flexible of support Property, inserting implanting device or implantation tube chamber becomes difficult, and can change the physical slot of tube chamber in vivo, extruding surrounding tissue or Organ, has undesirable effect.

When preparing radiant stand by coating radioactive thin films, radionuclide typically exists with ionic formses, although Solidify in film, but with the extension of time, the phenomenons such as migration, seepage easily occur for radionuclide, be readily soluble in body Liquid, so as to be absorbed by the body and be distributed in vivo everywhere with metabolism, causes body radioactivity to pollute, may damage normal group loom Can, so as to cause adverse consequences.Such as¹²⁵I, if seepage, can be enriched with Thyreoidine, so as to cause thyroid function not Reversible damage, this is clinically not intended to see.

When preparing radiant stand by deposited activity indissoluble thing, galvanoplastic or chemical deposition, plating are generally used Processes and apparatus is typically complex, and the radioactivity indissoluble thing of chemical deposition formation is typically poor with basal body binding force.

In addition, network is generally self-expandable stent, it can not take out or change after implantation.

Cholangiocarcinoma and cancer of pancreas be one group the state of an illness be dangerous, cure rate is low, poor prognosis malignant tumor of digestive tract, and its cause of disease is still Indefinite, early diagnosis is more difficult, and most during discovery to be in middle and advanced stage, treatment is also more difficult, and radical surgery is cut Except rate is low, with disease progression, tumour can usually cause the narrow or obstruction of bile duct, ductus pancreaticus, now be typically implanted intraluminal stent, Tube chamber that is narrow or blocking can be strutted in a short time, and relief of symptoms extends life span, quality of making the life better.

Clinically being usually used in the support of cholangiocarcinoma and cancer of pancreas mainly has metallic support and plastic stent.Metallic support is general For network, mostly self-inflated；Plastic stent is generally entity support.The advantage of plastic stent be periodically to take out or Person changes, and plastic stent generally sets opposite hangnail in outside, for fixed support position, prevents displacement.

On the basis of implantation support, how effectively to treat tumour or control tumour progression turns into the pass for improving curative effect Key.The local treatments such as endovenous radiofrequency, light power, radionuclide irradiation turn into the focus of Recent study.Compared to traditional Radiotherapy, chemotherapy, using radionuclide close-range treatment technology, carry out local treatment in tube chamber, with target more accurate positioning, Curative effect more precisely, the advantage such as light to the small and general reaction of normal surrounding tissue infringement.Therefore by intraluminal stent with closely controlling Treatment technology is combined, and has important value in the treatment of cholangiocarcinoma, cancer of pancreas and other tube chamber malignant tumours.

Now, how to design support becomes particularly significant.

Chinese patent ZL200610116321.3 disclose it is a kind of be used to treating cholangiocarcinoma and cancer of pancreas can bearing micro Have parallel and isometric with drainage lumens tiny in tube wall outside the support of pipelines in radioactive particle source, the drainage lumens of the support of pipelines Particle duct, for placing radioactive particle, the support of pipelines is to the plastic entity support in existing bile duct and stents of pancreatic duct The improvement of progress, is a kind of important trial, but also has the shortcomings that its own, such as：

First, tube wall outside the drainage lumens of support of pipelines it is general it is most thick be no more than several millimeters, some even only 0.5-1mm Left and right, although and radioactive particle is smaller (external diameter 0.8mm, length 4.5mm), relative to the thickness of tube wall, radioactivity grain After the external diameter of son but seems larger so that the realization of the design is more difficult, or the design is realized, the support sheet near particle Body thickness becomes very thin, may be easily damaged；

Second, particle shell is hard titanium tube, is inserted after tube wall, support reduction of pliability, the particle inserted is more, is influenceed It is bigger so that the implantation of support becomes difficult, and pipeline is easy with support deformation after implantation, rather than support is with pipeline Deformation, so as to can change lumen organization's natural form in vivo or position, extruding surrounding tissue or organ cause bad shadow Ring；

3rd, radioactive particle is point source, the dosage of forming region to be distributed, it usually needs the multiple particles of implantation, so that Above-mentioned the first and second two shortcomings can be amplified.

In view of drawbacks described above, it is new that the utility model creator obtains this practicality finally by prolonged research and practice Type.In the utility model, based on the plastic entity support in existing bile duct and stents of pancreatic duct, it is improved, overcomes above-mentioned Defect, design prepares novel radioactive intraluminal stent, has unique advantage in the treatment of cholangiocarcinoma and cancer of pancreas, but originally Utility model is not limited to the treatment of cholangiocarcinoma and cancer of pancreas, can also prepare the radioactivity branch for other tube chamber treating malignant tumors Frame, for other tube chamber treating malignant tumors.

Utility model content

(1) utility model purpose

The purpose of this utility model be in order to overcome the deficiencies in the prior art there is provided a kind of novel radioactive intraluminal stent, It can be used for treatment cholangiocarcinoma and cancer of pancreas, can be used for treating other tube chamber malignant tumours.

(2) technical scheme

To achieve the above object, the utility model provides following technical scheme：

A kind of radiation intraluminal stent, it includes body, the support flank of branch shape and is loaded with the thin of radionuclide The radiation core of sheet；Support flank is integrally formed at the outer surface of body or is arranged on the outer surface for being fixed on body；Radiation Core is arranged on body.

Radiation intraluminal stent can have different ways of realization,

For example：Outer surface of tube body sets fluted, and groove is circumferentially disposed along body at least in part；Radiation core is arranged on recessed In groove, core environmental sealing will be radiated on body using sleeve pipe.

For example：Radiation core is embedded in the tube wall of body, circumferentially disposed along body at least in part.Here " embedding " be Refer to radiation core directly to be coated by the structural pipe wall of body.

For example：Radiation core is circumferentially covered in outer surface of tube body along body at least in part, and will radiate core using sleeve pipe wraps up It is sealed on body.

Further：Inboard wall of tube body is smooth；Support flank at least one, support flank be arranged on body end and/or Radiate near core；Each support flank have wing at least one wing, each support flank towards same direction or It is respectively facing different directions；When the wing on each support flank is towards same direction, the direction of wing is support-side The direction of the wing, and the direction of multiple support flanks on same support is identical or different.

Further：Casing thickness is 20-500 μm, preferably 50-200 μm, more preferably 100-150 μm, radiates core thickness 10-500 μm, more preferably preferably 20-100 μm, 20-50 μm.10 μm can be less than or more than 500 μm by radiating core thickness, but When being less than 10 μm, radiation core is easily broken, during more than 500 μm, and the increase of support body volume, thickness are larger, are unfavorable for using, Therefore do not use typically.

Further：Radionuclide is¹²⁵I、¹⁰³Pd、³²P、¹³¹Cs、⁹⁰Y、¹⁹⁸Au、¹⁶⁹Yb、²⁴¹One kind or many in Am Kind；Radionuclide is not limited to above-mentioned nucleic, and other nucleic available for Interstitial brachytherapy tumour may be selected.Radiation The radionuclide that core is loaded with can have different species or activity, can be according to the species of tumour, growth rate, differentiation The different nucleic of the selections such as degree and biological property or activity, that is, select different therapeutic schemes, carry out appropriate treatment, from And tumour is more effectively controlled, improve treatment or suppress the effect of tumour.

The radionuclide that above-mentioned radiation core is loaded with can be two or more and with different proportionings, some nucleic half Declining, the phase is shorter, dosage release is very fast, such as¹⁰³Pd, may lead to not the slower tumour of effective Inhibit proliferaton or can not effectively suppress The recurrence of some tumours, some nucleic half-life period are longer, dosage release is slower, such as¹²⁵I, may lead to not effectively suppress some Breed faster tumour, different half-life period or two or more nucleic use in conjunction of various dose release rate can be obtained More suitably dosage release rate or action time to adapt to the actual conditions of tumour, can according to the species of tumour, growth rate, Differentiation degree and biological property etc. select two or more different nucleic and activity proportioning, that is, select different treatments Scheme, carries out appropriate treatment, so as to more effectively control tumour, improves treatment or suppresses the effect of tumour.

Further：It is the sheet metal or nonmetallic slices for being loaded with radionuclide to radiate core；Sheet metal is preferably Silver foil, goldleaf, palladium paper tinsel, copper foil or other soft nontoxic metal paper tinsels；Nonmetallic slices are preferably plastic tab, resin flake, gathered Urethane thin slice or other soft nontoxic nonmetallic slices.Sheet metal can not only carry radionuclide, also with X rays The effect of marker, when in stenter to implant body or after implanting, it is possible to use the X-ray apparatus such as X-ray machine are observed or tracked The position of support.Nonmetallic slices can be plastic tab, resin flake, sheet of polyurethane or other soft nontoxic nonmetallic thin Piece, when in stenter to implant body or after implanting, possibly can not be observed or be tracked the position of support using equipment, therefore typically Do not select, from when typically in position introduce X-ray marker, the position for marking active area.X-ray is identified Thing can be annular metal thin slice hoop, or thin metal layer of the uniform fold on nonmetallic slices surface.

In the technical scheme, described sleeve pipe is film, and single or multiple lift film will radiate core environmental sealing on body.

In the technical scheme, the radiation intraluminal stent is used to treat cholangiocarcinoma and cancer of pancreas, it can also be used to treat Other tube chamber malignant tumours, such as cancer of the esophagus, tracheocarcinoma, colorectal cancer, it can also be used to treat the pernicious of other class lumen organizations Tumour, such as nasopharyngeal carcinoma, the malignant tumour are preferably cholangiocarcinoma and cancer of pancreas.

(3) beneficial effect

In the utility model, the radiation intraluminal stent and the technical scheme provided have advantages below：Structure is closed Reason is simple, it is easy to prepares or realizes, with good pliability, maintains the smooth of surface, easy to use, can realize implantation Visualization after process and implantation, can take out or regularly replace as needed, have the effect of support, drainage and treatment concurrently, put Penetrating property support is fixed in tube chamber, and the structure of the support flank of branch shape can prevent displacement, especially close to radiation core Proximal end sets support flank, with obvious advantage, specifically, after radionuclide plays therapeutic action, tumour can occur Necrosis or apoptosis etc., therefore luminal stenosis can be alleviated, now still can be with the support flank set close to radiation core proximal end Good fixation is played, prevents support or active area from shifting, in addition, the radioactivity pipe provided in the utility model Chamber support presss from both sides " radiation core " structure using sandwich, and the seepage of "dead" nucleic is safe, and radiation core is very thin, to support Size influences very little, does not change drainage tube chamber diameter, can keep drainage effect, is radiated and designed using segmental, realizes 360 degree Without blind spot irradiation, the radiation core for being loaded with radionuclide being sealed in body can be special according to the position of tumour, size, propagation Property etc. Clinical symptoms adjustment size, nucleic species, the position on support and nucleic activity, realize the individuation and precisely for the treatment of Change, both kept the therapeutic action to local tumor, and avoided normal structure from sustaining damage again.

Brief description of the drawings

Drawings below of the present utility model is used to understand the utility model in this as a part of the present utility model.Accompanying drawing In show embodiment of the present utility model and its description, for explaining principle of the present utility model.In the accompanying drawings,

Fig. 1 is the overall schematic of the radiation intraluminal stent of embodiment one.

Fig. 2 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment one.

Fig. 3 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment two.

Fig. 4 is the overall schematic of the radiation intraluminal stent of embodiment three.

Fig. 5 is the overall schematic of the radiation intraluminal stent of example IV.

Fig. 6 is the overall schematic of the radiation intraluminal stent of embodiment five.

Fig. 7 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment five.

Fig. 8 is the cross section enlarged diagram of the radiation intraluminal stent of embodiment five.

Fig. 9 is the support flank schematic diagram of the branch shape with sleeve structure of embodiment six.

Figure 10 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment eight.

Figure 11 is the cross section enlarged diagram of the radiation intraluminal stent of embodiment eight.

Figure 12 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment ten.

Figure 13 is the partial longitudinal section enlarged diagram of the radiation intraluminal stent of embodiment 13.

In figure, 1. radiation intraluminal stents, 10. bodys, 11. drainage lumens, 20. support flanks, 21. wings, 30. radiation Property region, 31. radiation cores, 32. sleeve pipes, 40.X ray markers.

Embodiment

The technical program is described further below in conjunction with specific embodiments.

Below in conjunction with accompanying drawing and specific embodiment, to the utility model and the technical scheme provided, technology in addition Feature, advantage and concrete methods of realizing, are described in detail.

Embodiment one

As shown in Figure 1-2：A kind of radiation intraluminal stent 1, includes support flank 20, the sealing of body 10, branch shape In the radiation core 31 in body 10, radiation core 31 is the silver foil for being loaded with radionuclide.The inner wall smooth of body 10, the body 10 Outer wall is located smooth in addition to the support flank 20 and groove of branch shape.

The outside of body 10 has parcel in the middle part of annular recess, groove to be loaded with¹²⁵I silver foil, silver foil outer wrap sleeve pipe is simultaneously filled Sleeve surface after whole groove, parcel groove is smooth and contour with the outer surface of body 10, forms smooth surface.

Two ends of body 10 and close to being loaded with¹²⁵There is the branch of branch shape the side for the radioactive area proximal end that I silver foil is produced Flank 20 is supportted, the structure of support flank 20 of each branch shape there are 4 wings 21.

To realize the present embodiment, there is provided following preparation scheme：

Step one, prepare body 10, epidermis is swept in relevant position, the support flank 20 of branch shape is formed, corresponding Epidermis is removed in position, forms annular recess.

Step 2, prepares the silver foil of 20 μ m-thicks, in silver foil surface deposition¹²⁵I, specifically, by 51.5mg sodium bromides, 0.2mg sodium iodides, 0.04mg sodium hydroxides, 3.5mCi Na¹²⁵I is soluble in water, and adjusts volume 4ml, silver foil is added above-mentioned In solution, then add 41.2mg/ml potassium ferricyanide solution 1ml and be well mixed, after oscillating reactions 30min, take out silver foil, Cleaned, be loaded with after drying with 5g/L IodineSodium Solutions, water and acetone successively¹²⁵I silver foil, activity 3.2mCi.

Step 3, will be loaded with¹²⁵I silver foil is placed in the middle part of annular recess, and is sticked with medical glue on body 10, then With medical glue by the suitable tight of big and small sheath 32 in outside silver foil, and fill up groove.

By above-mentioned steps, radiation intraluminal stent is obtained.

Embodiment two

The implementation be the same as Example one of embodiment two, difference part is as shown in Figure 3：There is annular recess in the outside of body 10, Parcel is loaded with outside the silver foil of radionuclide, the thick film such as groove other parts parcel and silver foil, silver foil and film in the middle part of groove Wrap up sleeve pipe and fill whole groove in portion.

Embodiment three

The implementation be the same as Example one of embodiment three, difference part is as shown in Figure 4：The two ends of body 10 and close load There is the support flank of branch shape the both sides for the proximal end of active area 30 that the silver foil for having radionuclide is produced.

Example IV

The implementation be the same as Example one of example IV, difference part is as shown in Figure 5：Radiation core 31 is nonmetallic slices, Such as sheet of polyurethane, body (both sides) at active area 30 has X-ray marker 40, and X-ray marker 40 is Ring-type silver foil hoop.

To realize the present embodiment, it is necessary to carry radionuclide on nonmetallic slices (such as sheet of polyurethane), such as¹²⁵I, It is loaded with to prepare¹²⁵There is provided following preparation scheme for I sheet of polyurethane：

Preparation scheme one

The tetrahydrofuran solution 10ml of the polyurethane of configuration 10%, adds 0.2ml Na¹²⁵I (200mCi) solution, mixing is equal It is even, take 0.25ml mixed solutions to drip on the sheet glass of given shape, and make mixed solution evenly laid out on the glass sheet, treat molten After agent volatilization, it is loaded with¹²⁵I sheet of polyurethane (5mCi), it is taken off from sheet glass, you can for preparing described put Penetrating property intraluminal stent 1.

Preparation scheme two

In the first reaction solution that sheet of polyurethane is added to 2ml, the first reaction solution composition is：2g/L silver nitrates, 40g/L disodium ethylene diamine tetraacetates, 17% ammoniacal liquor, 0.5% hydrazine hydrate, stirring reaction 60 minutes are formed in sheet of polyurethane Uniform silver layer, then the sheet of polyurethane of surface coverage silver layer is cleaned, add 2ml the second reaction solution with deionized water In, the second reaction solution composition is 10g/L sodium bromides, 0.05g/L sodium iodides, 0.01g/L sodium hydroxides, 8.5g/L iron cyanidings Potassium, 2.5mCi/ml Na¹²⁵I, stirring reaction 20 minutes, the silver layer that sheet of polyurethane surface is covered is converted into Ag¹²⁵I, is obtained It is loaded with¹²⁵I sheet of polyurethane (4.5mCi), after being cleaned and dried with deionized water, you can for preparing the radiation intraluminal Support 1.

Embodiment five

A kind of radiation intraluminal stent, includes support flank 20, the radiation being sealed in body of body 10, branch shape Core 31, the radiation core 31 is to be loaded with¹²⁵I silver foil.

As shown in figs 6-8：

It is described to be loaded with¹²⁵I silver foil is directly embedded in the tube wall of body 10, so as to be sealed in body 10.

50 μm of the silver foil thickness.

The inner wall smooth of body 10, its in addition to the support flank region of branch shape of the outer wall of body 10 Its region is smooth.

To realize the present embodiment, there is provided following preparation scheme：

Step one, deposited on silver foil surface¹²⁵I, specifically, by 51.5mg sodium bromides, 0.2mg sodium iodides, 0.04mg hydrogen The Na of sodium oxide molybdena, 3.5mCi¹²⁵I is soluble in water, and adjusts volume 4ml, and silver foil is added in above-mentioned solution, then added 41.2mg/ml potassium ferricyanide solution 1ml is simultaneously well mixed, after oscillating reactions 30min, takes out silver foil, 5g/L iodate is used successively Sodium solution, water and acetone cleaning, are loaded with after drying¹²⁵I silver foil, activity 3.2mCi.

Step 2, will be loaded with¹²⁵The correct position that I silver foil is placed in bracket casting mould, will prepare the material of support body Mould is poured into after material hot melt, then cools and solidifies, i.e., is loaded with surface¹²⁵I silver foil is directly embedded in the tube wall of body 10, So as to be sealed in body 10.

Step 3, in the pipe wall embedding is loaded with¹²⁵The support body two ends correct position of I silver foil, branch is respectively facing with cutter Frame cutaway tip section tubular wall, forms the support flank 20 of branch shape.

By above-mentioned steps, radiation intraluminal stent 1 is obtained.

Embodiment six

The implementation be the same as Example one or five of embodiment six, difference part is as shown in Figure 9：The support flank of branch shape 20 structures are sheathed on body 10, and are pasted fixed with medical glue and formed.

Embodiment seven

The implementation be the same as Example one or five of embodiment seven, difference part is：The support flank 20 of branch shape is each There are 3 wings 21.

Embodiment eight

The implementation be the same as Example five of embodiment eight, difference part is as shown in figs. 10-11：It is sealed in putting in body 10 Core shooting 31 is not around the circumferential one week of body 10.

Embodiment nine

The implementation be the same as Example one or five of embodiment nine, difference part is：10 μm of silver foil thickness.The body is only There is the support flank of branch shape one end, and the support flank 20 of branch shape has the wing 21 of 5 wing 21,3 dorsad residing end End, 2 wings 21 are towards residing end.

Embodiment ten

A kind of radiation intraluminal stent, includes support flank 20, the load being sealed in body 10 of body 10, branch shape There is the laminar radiation core 31 of radionuclide, the radiation core 31 is to be loaded with¹⁰³Pd palladium paper tinsel.

The implementation be the same as Example one of embodiment ten, difference part is as shown in figure 12：The outside of body 10 is fluted, carries Have¹⁰³Pd palladium paper tinsel is placed in groove and wraps up body 10 at this, palladium paper tinsel and the outer wrap sleeve pipe 32 of body 10, sleeve pipe 32 and pipe Body 10 is tightly combined, the whole palladium paper tinsels of parcel, and wraps up whole body portions in the flank of two ends.

30 μm of the palladium paper tinsel thickness, and the inner wall smooth of body 10.

To realize the present embodiment, there is provided following preparation scheme：

Step one, deposited on palladium paper tinsel surface¹⁰³Pd, specifically, by 10mg palladium bichlorides, 0.8ml ammoniacal liquor (28%), 150mg Ammonium chloride, 5.5mCi¹⁰³PdCl₂It is soluble in water, and volume 4ml is adjusted, palladium paper tinsel is added in above-mentioned solution, then added 60mg/ml sodium hypophosphite solution 1ml is simultaneously well mixed, after 50 DEG C of oscillating reactions 120min, takes out palladium paper tinsel, 1g/L chlorine is used successively Change palladium solution, water and acetone cleaning, be loaded with after drying¹⁰³Pd palladium paper tinsel, activity 5.0mCi.

Step 2, prepares the insertion diameter stainless steel consistent with duct in the reeded body 10 in outside, the duct of body 10 Rod, will be loaded with¹⁰³Pd palladium paper tinsel sticks the groove in body with medical glue, then uniform on body 10 and palladium paper tinsel to smear doctor With glue, the sleeve pipe 32 by internal diameter slightly larger than body is placed on body 10, so as to be loaded with¹⁰³Pd palladium paper tinsel is also placed in sleeve pipe 32, And be sandwiched between body 10 and sleeve pipe 32, with alcolhol burner flame baking sleeve pipe, it is shunk because of heating power, be firmly enclosed on body 10 On, stainless steel bar is taken out after cooling.

Step 3, at active area, installs the support flank 20 of branch shape, specifically, taking outside body 10 The support flank 20 of branch shape is placed at active area, and is sticked with medical glue on body.

By above-mentioned steps, radiation intraluminal stent 1 is obtained.

Embodiment 11

The implementation be the same as Example ten of embodiment 11, difference part is：The outside of body 10 is fluted not to be surround Body, is loaded with¹⁰³Pd palladium paper tinsel is placed in groove and covers groove at this, therefore is also only positioned at side not around body.

Palladium paper tinsel and surrounding tube body outer wrap sleeve pipe 32, sleeve pipe is tightly combined with body, the whole palladium paper tinsels of parcel, and wraps up palladium Paper tinsel peripheral part body.

Embodiment 12

The implementation be the same as Example ten of embodiment 12, difference part is：100 μm of palladium paper tinsel thickness.On body 10 The support flank 20 of branch shape respectively has 2 wings 21, and wing 21 is towards same direction.

Embodiment 13

The implementation be the same as Example one of embodiment 13, difference part is as shown in figure 13：The outer wall of body 10 removes branch shape Locate beyond the support flank 20 of shape it is smooth, without annular recess, radiation core is is loaded with³²P goldleaf.It is loaded with³²P goldleaf is direct The outside of body 10 is wrapped in, and around body, one layer of sleeve pipe 10 of goldleaf and body outer wrap, sleeve pipe 10 is individual layer or many The film of layer, the film is tightly combined with body 10, the whole goldleaf of parcel, whole tube bodies in parcel two ends support flank 20 Point.

50 μm of the goldleaf thickness, the inner wall smooth of body 10.

To realize the present embodiment, there is provided following preparation scheme：

Step one, 20mCi Na³²PO₄Solution is added in the tetrahydrofuran solution of 1ml 5% polyurethane, with 5% poly- ammonia The tetrahydrofuran solution regulation volume 2ml of ester is simultaneously well mixed, and goldleaf is immersed into above-mentioned solution and taken out, is dried, then immerse State solution and take out, dry, be repeated several times to activity and reach 1mCi, then immerse the tetrahydrofuran solution of 5% polyurethane again simultaneously Take out, dry, be repeated twice, be loaded with³²P goldleaf.

Step 2, prepares the insertion diameter stainless steel bar consistent with duct in body 10, the duct of body 10, will be loaded with³²P Goldleaf stick the correct position on the outside of body with medical glue, then uniformly smear medical glue on goldleaf and body 10, will Medical glue is also equably smeared in the inner side of sleeve pipe 32, then wraps up on goldleaf and body 10 sleeve pipe 32, is loaded with³²P goldleaf folder Between body 10 and sleeve pipe 32, with alcolhol burner flame baking sleeve pipe 32, it is shunk because of heating power, be firmly enclosed on and be loaded with³²P's On goldleaf and body 10, stainless steel bar is taken out after cooling.

Step 3, at active area, installs the support flank 20 of branch shape, specifically, taking outside body 10 The support flank 20 of branch shape is sheathed near active area, and is sticked with medical glue on body 10.

By above-mentioned steps, radiation intraluminal stent 1 is obtained.

Embodiment 14

The implementation be the same as Example 13 of embodiment 14, difference part is：It is loaded with³²P goldleaf is directly coated in The outside of body 10, but it does not surround body 10 1 weeks.The support flank 20 at the two ends of body 10 respectively has 3 wings 21, and wing 21 is equal Dorsad respective residing end, two ends wing 21 is opposite.

Embodiment 15

The implementation be the same as Example 13 of embodiment 15, difference part is：100 μm of goldleaf thickness.Body 10 1 The support flank 20 at end has 2 wings 21, and the direction of two wing 21 is identical, and the support flank 20 of other end branch shape has 4 Wing 21, four directions of wing 21 are different, 2 towards the end, 2 the dorsad ends, the branch positioned at the middle part of body 10 Support flank 20 has 3 21,3 wing of wing, 21 directions identical.

Embodiment 16

The implementation be the same as Example one of embodiment 16, difference part is：Radionuclide is¹³¹Cs。

Above content is with reference to illustrating that preferred embodiment is done to the utility model, it is impossible to assert that this practicality is new The embodiment of type is only limitted to these explanations.For the utility model person of an ordinary skill in the technical field, On the premise of not departing from the utility model design, some simple deductions and conversion can also be made, this reality should be all considered as belonging to With new protection domain.

Claims (10)

1. a kind of radiation intraluminal stent, it is characterised in that including body, the support flank of branch shape and be loaded with radioactive nucleus The laminar radiation core of element；Support flank, which is integrally formed at the outer surface of the body or is arranged, is fixed on the body Outer surface on；The radiation core is arranged on the body.

2. a kind of radiation intraluminal stent according to claim 1, it is characterised in that：Outer surface of tube body sets fluted, The groove is circumferentially disposed along body at least in part；The radiation core is set in a groove, and will radiate core using sleeve pipe wraps up It is sealed on body.

3. a kind of radiation intraluminal stent according to claim 1, it is characterised in that：The radiation core is embedded in body In tube wall, the radiation core is circumferentially disposed along body at least in part.

4. a kind of radiation intraluminal stent according to claim 1, it is characterised in that：It is described to radiate core edge at least in part Body is circumferentially covered in the outer surface of tube body, and core environmental sealing will be radiated on body using sleeve pipe.

5. a kind of radiation intraluminal stent according to claim any one of 1-4, it is characterised in that：The radiation core is load There are the sheet metal or nonmetallic slices of radionuclide；Nonmetallic slices are equipped with X-ray marker, the X-ray mark Thing is the thin metal layer of annular metal thin slice hoop or uniform fold on nonmetallic slices surface；The radiation core thickness 10-500 μ m。

6. a kind of radiation intraluminal stent according to claim 5, it is characterised in that：The sheet metal is silver foil, gold Paper tinsel, palladium paper tinsel or copper foil；The nonmetallic slices are plastic tab；The radiation core thickness is 20-100 μm.

7. a kind of radiation intraluminal stent according to claim any one of 1-4, it is characterised in that：The inboard wall of tube body light It is sliding；It is described support flank at least one, it is described support flank be arranged near body end and/or the radiation core；Each Support flank that there is the wing at least one wing, each support flank towards same direction or to be respectively facing not Tongfang To；When the wing on each support flank is towards same direction, the direction of wing is the direction for supporting flank, and is located at The direction of multiple support flanks on same support is identical or different.

8. a kind of radiation intraluminal stent according to claim any one of 1-4, it is characterised in that：The radionuclide For¹²⁵I、¹⁰³Pd、³²P、¹³¹Cs、⁹⁰Y、¹⁹⁸Au、¹⁶⁹Yb、²⁴¹One or more in Am.

9. a kind of radiation intraluminal stent according to claim 2 or 4, it is characterised in that：Described sleeve pipe thickness is 20- 500μm。

10. a kind of radiation intraluminal stent according to claim 2 or 4, it is characterised in that：Described sleeve pipe is film, single Layer or the film of multilayer will radiate core environmental sealing on body.