CN213527173U - Iodine-125 particle chain and source bin for brachytherapy - Google Patents
Iodine-125 particle chain and source bin for brachytherapy Download PDFInfo
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- CN213527173U CN213527173U CN202021018685.XU CN202021018685U CN213527173U CN 213527173 U CN213527173 U CN 213527173U CN 202021018685 U CN202021018685 U CN 202021018685U CN 213527173 U CN213527173 U CN 213527173U
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Abstract
A brachytherapy iodine-125 seed chain and source capsule, wherein the seed chain is composed of the following structures: an iodine-125 particle source, a bio-based fiber braided tube, an hourglass-shaped spacer; in the weaving process of the biological-based fiber woven tube, a plurality of iodine-125 particles are woven into the tube to form long chains, and spacers with the same length are arranged among the particles; weaving a plurality of iodine-125 particles together through biological fibers to form particle chains, embedding biodegradable materials among the particles and forming an hourglass shape to prevent migration and movement of the iodine-125 particles; the iodine-125 particle source bin is matched with the implanted needle to realize automatic and rapid needle installation under radiation shielding, and extra radiation irradiation of workers and patients is reduced.
Description
Technical Field
The utility model relates to a nuclear medicine technical field, concretely relates to brachytherapy iodine-125 particle chain still relates to the source storehouse of storing this brachytherapy iodine-125 particle chain.
Background
Sealed radioactive sources are radioactive materials that are sealed in an envelope or tightly bound in a covering and are in a solid form. With the rapid development of economy and the accelerated promotion of industrialization process after 40 years of reform and opening, the sealed radioactive source is gradually applied to the fields of industry, agriculture, medicine, environmental protection and the like, forms a certain industrial scale and obtains remarkable economic and social benefits. One of the major directions of application of sealed radioactive sources in the medical field is tumor radiotherapy, which is a local treatment technology for treating malignant tumors by utilizing rays generated by radioactive sources, and is called three major core means of tumor clinical treatment at present with operations and chemotherapy, and is the field with the most intensive and most potential nuclear technology in medicine.
125The I-particle is generally used for implantation therapy, is an intertissue interventional radiotherapy and belongs to the field of brachytherapy. Radioactive particle sources with certain specifications and activity are implanted into target areas (lesions) in a human body in a minimally invasive mode, and the particle sources emit continuous low-energy gamma rays to play a therapeutic role. The diseased cells being in the cell cycleThe particle source is continuously irradiated for a long time in different stages, so that the influence of the cell cycle on the curative effect can be overcome, and the curative effect is obviously improved. Because radioactive particles are implanted according to the size and shape of the focus and the internal irradiation treatment dosage, the radioactive distribution ratio of the focus position and the surrounding normal tissues can be provided to the maximum extent, the curative effect is improved, and the side effect is reduced. However, the existing iodine-125 particle source for implantation radiotherapy has some technical defects, such as displacement and migration of the iodine-125 particles after implantation, which results in insufficient radiation dose in tumor area, and large radiation dose in normal tissue, which affects the overall treatment effect. In addition, the iodine-125 particles need to be manually loaded into the implantation needle during the implantation process, the whole implantation time is long, and the extra radiation dose to workers and patients is large.
Disclosure of Invention
The present invention aims to solve the above problems of the prior art and provide a brachytherapy iodine-125 particle chain and source bin, wherein a plurality of iodine-125 particles are woven together by using biological fibers to form a particle chain, and biodegradable materials are embedded between the particles and have an hourglass shape to prevent the migration and movement of the iodine-125 particles; the iodine-125 particle source bin is matched with the implanted needle to realize automatic and rapid needle installation under radiation shielding, and extra radiation irradiation of workers and patients is reduced.
The utility model discloses a solve above-mentioned technical problem through following technical scheme:
a brachytherapy iodine-125 seed chain consisting of the structure: an iodine-125 particle source, a bio-based fiber braided tube, an hourglass-shaped spacer; in the weaving process of the biological-based fiber woven tube, a plurality of iodine-125 particles are woven into the tube to form long chains, and spacers with the same length are arranged among the particles; the iodine-125 particle source comprises a source core and a titanium alloy shell; the biodegradable material is embedded between the iodine-125 particle sources and is in an hourglass shape; the titanium alloy shell is in a capsule shape, and two ends of the titanium alloy shell are sealed by laser welding; the source core is formed by a layer of Ag on the surface through chemical reaction125The silver wire of I or the middle part is a gold wire which is coated with Ag125The porous ceramic of I.
Preferably, the activity of the iodine-125 particle source is 0.1 mCi-6 mCi.
Preferably, the bio-based fiber braided tube is formed by braiding one of bio-based carbon fiber, soybean protein fiber or biodegradable polybutylene terephthalate-co-butylene succinate (PBST) fiber.
Preferably, the hourglass-shaped spacer is a biodegradable material.
Preferably, the hourglass-shaped spacer is one of a starch-based material or a bio-based polyethylene terephthalate (PET for short).
A source bin for storing the brachytherapy iodine-125 particle chain, wherein the source bin adopts a 'tape measure' principle, and the iodine-125 particle chain is controlled to enter or exit the source bin through a knob outside the bin; the source bin shell is divided into 3 layers, the inner layer and the outer layer are made of stainless steel, and the middle layer is made of lead and used for shielding radiation of iodine-125 particles.
Compared with the prior art, the utility model discloses an actively progress the effect and lie in:
(1) the hourglass-shaped spacer is embedded between the particle sources of the iodine-125 particle chain for the brachytherapy of the utility model, and after the iodine-125 particle chain is implanted into a tumor part of a human body, the migration and the displacement of the iodine-125 particles can be effectively prevented, and the treatment precision is high;
(2) the source bin of the iodine-125 particle chain for the brachytherapy of the utility model has the radiation shielding function, and can be well matched with the implanting needle to quickly load the iodine-125 particles into the implanting needle, thereby reducing the whole implanting time of the particles, reducing the extra radiation dose of the working personnel and the patient, and improving the radiation safety;
(3) the fiber tube and the particle spacer of the iodine-125 particle chain for brachytherapy of the utility model are bio-based materials, have good biocompatibility with human body and improve the safety.
(4) The utility model discloses the source core silver silk or the gold wire of brachytherapy iodine-125 particle are as the marker, can form images under equipment such as X ray, fluoroscopy, CT or MR, can realize carrying out iodine-125 particle implantation operation under visual, have improved the precision of treatment.
Drawings
FIG. 1 is a schematic diagram of the structure of the iodine-125 particle chain for brachytherapy of the present invention;
FIG. 2 is a schematic diagram of a brachytherapy iodine-125 source of the present invention;
FIG. 3 is a schematic view of another embodiment of the brachytherapy iodine-125 source of the present invention;
fig. 4 is a schematic structural diagram of the brachytherapy iodine-125 particle source chamber of the present invention.
1. Chains of iodine-125 particles; 2. an iodine-125 particle source; 3. an hourglass-shaped spacer; 4. a bio-based fiber braided tube; 5. ag125I; 6. a titanium alloy housing; 7. silver wire; 8. adsorb Ag125The porous ceramic of I; 9. gold wire; 10. a source bin; 11. a source bin knob; 12. a bin body; 13. and a source bin outlet and inlet.
Detailed Description
For a better understanding of the present invention, its objects are further attained by the technology disclosed in the appended claims, and its advantages and features are easily understood by those skilled in the art. It should be noted that the following description is only a preferred embodiment of the present invention, but the present invention is not limited to the following embodiment. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the scope or spirit of the invention. For instance, features illustrated or described as part of one embodiment, can be used with another embodiment to yield a still further embodiment. Therefore, it is intended that the present invention cover such modifications and variations as come within the scope of the appended claims and their equivalents.
As shown in fig. 1, the utility model provides a brachytherapy iodine-125 particle chain, including iodine-125 particle chain 1, the particle chain 1 is formed by weaving a plurality of iodine-125 particle sources 2 into a tube 4 by using bio-based fiber silk threads to form a long chain, the iodine-125 particle sources 2 are evenly distributed in the bio-based fiber woven tube 4 at the same interval, and hourglass-shaped spacers 3 are arranged between the adjacent iodine-125 particle sources 2.
Due to the hourglass-shaped spacers 3 arranged between the iodine-125 particle sources 2, the migration and displacement of the iodine-125 particle sources can be effectively prevented, the accuracy and the effectiveness of radiation dose absorption of a focus region are improved, normal tissues are prevented from being damaged by radiation, and the effect of iodine-125 particle brachytherapy is optimized.
The biological-based fiber braided tube 4 is formed by braiding PBST fibers, the hourglass-shaped spacer 3 is made of a starch-based material, the PBST fibers and the hourglass-shaped spacer are both made of a biological-based material, so that the particle chain 1 and human tissues have good biocompatibility, and the number of the iodine-125 particle sources 2 in the particle chain 1 is less than or equal to 75.
Shown in FIG. 2 is a source 2 of iodine-125 particles, comprising Ag on the surface of a silver filament 7125I5, titanium alloy tube 6 and silver wire 7, wherein the Ag is125I5 is the surface layer of the silver wire 7, passing through the silver wire 7 and Na125And I, preparing the titanium alloy pipe 6 in a capsule shape by chemical reaction, and sealing by laser welding.
As shown in FIG. 3, another iodine-125 particle source 2 includes a titanium alloy tube 6 having Ag adsorbed thereon125I, porous ceramic 8 and gold wires 9, wherein the porous ceramic 8 is Ag125A vector of I.
The source core of the iodine-125 particle source 2 adopts a silver wire or a gold wire as a marker, and the particle source 2 can image under X-ray, fluoroscopy, CT or MR, so that the whole visual operation can be realized in the implantation process of the iodine-125 particle source 2, and the implantation accuracy and convenience are greatly improved.
As shown in fig. 4, the source bin 10 comprises a source bin knob 11, a bin body 12 and a source bin access 13, wherein the knob 11 can rotate clockwise and anticlockwise, the iodine-125 particle chain 1 is controlled to enter and exit the source bin 10 through rotation, and the bin body 12 is composed of an inner stainless steel layer and an outer stainless steel layer, the middle of which is filled with lead.
As the bin body 12 is filled with the lead layer with good radiation shielding effect, the source bin 10 has good radiation shielding effect, the source bin 10 is matched with the implanted needle, the needle can be rapidly and safely installed, the needle installing time is greatly shortened, the extra radiation irradiation of workers and patients can be greatly reduced due to the good radiation shielding property of the source bin 10, and the radiation safety of iodine-125 particle radiotherapy is improved.
The above-mentioned embodiments further explain the objects, technical solutions and advantages of the present invention in detail. It should be understood that the above description is only exemplary of the present invention and is not intended to limit the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (6)
1. A brachytherapy iodine-125 seed chain, comprising the structure: an iodine-125 particle source (2), a bio-based fiber braided tube (4) and an hourglass spacer (3); the particle chain (1) is formed by weaving a plurality of iodine-125 particle sources (2) into a biological-based fiber woven pipe (4) through biological-based fiber silk threads to form a long chain, the iodine-125 particle sources (2) are evenly distributed in the biological-based fiber woven pipe (4) at the same interval, and hourglass-shaped spacers (3) are arranged between the adjacent iodine-125 particle sources (2); the iodine-125 particle source (2) comprises a source core and a titanium alloy shell; the titanium alloy shell is in a capsule shape, and two ends of the titanium alloy shell are sealed by laser welding; the source core is formed by a layer of Ag on the surface through chemical reaction125The silver wire of I or the middle part is a gold wire which is coated with Ag125The porous ceramic of I.
2. The brachytherapy iodine-125 particle chain of claim 1, wherein the source activity of the iodine-125 particles is 0.1mCi to 6 mCi.
3. The brachytherapy iodine-125 particle chain of claim 1, wherein the bio-based fiber braided tube is braided from one of bio-based carbon fiber or soy protein fiber or biodegradable polybutylene terephthalate-co-succinate fiber.
4. A brachytherapy iodine-125 particle chain according to claim 1, wherein the hourglass shaped spacer (3) is a biodegradable material.
5. The brachytherapy iodine-125 particle chain of claim 1, wherein the hourglass shaped spacer is one of a starch based material or a bio-based polyethylene terephthalate material.
6. A source chamber for storing a brachytherapy iodine-125 particle chain as defined in any one of claims 1-5, comprising a source chamber knob (11), a chamber body (12), and a source chamber access opening (13), wherein the source chamber knob (11) can rotate clockwise and counterclockwise, the iodine-125 particle chain (1) is controlled to enter and exit the source chamber (10) by rotation, the housing of the source chamber (10) is divided into three layers, the inner and outer layers are made of stainless steel, and the middle layer is made of lead, so as to shield the radiation of the iodine-125 particle source.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202021018685.XU CN213527173U (en) | 2020-06-05 | 2020-06-05 | Iodine-125 particle chain and source bin for brachytherapy |
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| CN202021018685.XU CN213527173U (en) | 2020-06-05 | 2020-06-05 | Iodine-125 particle chain and source bin for brachytherapy |
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| CN213527173U true CN213527173U (en) | 2021-06-25 |
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| CN202021018685.XU Active CN213527173U (en) | 2020-06-05 | 2020-06-05 | Iodine-125 particle chain and source bin for brachytherapy |
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