CN206428270U - Automatic dose control device for cell irradiation experiment - Google Patents
Automatic dose control device for cell irradiation experiment Download PDFInfo
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- CN206428270U CN206428270U CN201720065589.2U CN201720065589U CN206428270U CN 206428270 U CN206428270 U CN 206428270U CN 201720065589 U CN201720065589 U CN 201720065589U CN 206428270 U CN206428270 U CN 206428270U
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- 238000002474 experimental method Methods 0.000 title claims abstract description 37
- 238000004113 cell culture Methods 0.000 claims abstract description 14
- 230000007246 mechanism Effects 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 13
- 230000033001 locomotion Effects 0.000 claims description 10
- 238000011534 incubation Methods 0.000 claims description 9
- 230000005855 radiation Effects 0.000 claims description 8
- 239000012930 cell culture fluid Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 230000003750 conditioning effect Effects 0.000 claims description 5
- 239000000941 radioactive substance Substances 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 2
- 230000002285 radioactive effect Effects 0.000 description 7
- 230000006378 damage Effects 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000006872 improvement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The utility model discloses an automatic dose control device for cell irradiation experiment, which comprises an irradiation source, a cell culture device and a box body, wherein the box body is provided with a cavity for accommodating the cell culture device and is provided with a box body opening; the first shielding module comprises a first baffle plate so as to adjust the position of the first shielding module for shielding the irradiation source; the second shielding module comprises a second baffle and an adjusting plate, the second baffle is provided with a grid-shaped opening matched with the opening of the box body, the second baffle is movably arranged above the opening of the box body in the horizontal plane so as to adjust the position of the second baffle for shielding the opening of the box body, and the adjusting plate is movably arranged above the grid-shaped opening in the horizontal plane so as to adjust the position of the adjusting plate for shielding the grid-shaped opening; the first module that shelters from still in the setting of vertical plane liftable, first module, the second of sheltering from shelters from the module and connects in control module respectively. The utility model discloses have following advantage at least: the irradiation dose is automatically adjusted and controlled, and the method is safe, convenient and accurate and standard.
Description
Technical field
The utility model is related to experiment apparatus technical field, more particularly to a kind of cell irradiation experiment automatic dosage control dress
Put.
Background technology
During modern age radiology develops, radioactive substance reflects for the influence of human skin and whole body with injury
Subject in fixed and scientific research is gradually replaced from experimental animal by experimental cell, therefore radioactive ray pass through whole body
Irradiation damage experiment also by Cell irradiation experiment replace complete.Past Cell irradiation experiment uses radioactive ray direct irradiation
The experimental cell of culture, experiment operator wears the simple and crude protective garment of comparison and protector carries out autoprotection, root after the completion of irradiation
According to the change of cell, influence and injury of the radioactive ray for cell are determined according to the Comparison of standards of pertinent regulations, so as to reason out
The influence and injury being likely to result in for human skin or whole body.The irradiation dose and irradiation intensity of radioactive ray all can not be controlled accurately
System and measure, irradiation position is not accurate, thus irradiation experiment result it cannot be guaranteed that accurate credible.And in radiation mistake
Cheng Zhong, experiment operator can also touch radioactive ray because operating condition is simple and crude and come to harm, and section is have impact on to a certain extent
The quality and safety of experimental implementation are learned, the deep development of correlative study is hindered.In order to overcome above-mentioned difficulties, fundamentally solve
The safe, automatic of cell irradiation experiment, standard and it is accurate the problem of, research and develop a kind of cell irradiation experiment automatic dosage control device
Just turn into inevitable and urgent demand.
Utility model content
In order to solve the above technical problems, the utility model purpose is to provide a kind of cell irradiation experiment automatic dosage control
Device, accurately can not control and measure to solve the irradiation dose and irradiation intensity of radioactive ray of the prior art, irradiate position
Not accurate, big to operating personnel's injury the problem of.
A kind of cell irradiation experiment automatic dosage control device of the present utility model, including irradiation bomb and it is arranged on the spoke
According to the cell culture apparatus below source, in addition to casing, it has the chamber for housing the cell culture apparatus, the roof of the chamber
Insertion, which is provided with, makes the light of the irradiation bomb pass through and irradiate in the box opening on the cell culture apparatus；First blocks mould
Block, it includes first baffle, and the first baffle is rotatably arranged at the outer circumferential of the irradiation bomb in perpendicular,
To adjust the position that it blocks the irradiation bomb；Second blocks module, and it includes second baffle and adjustable plate, the second baffle
On offer the lattice-shaped opening matched with the box opening, the second baffle is movably arranged in the horizontal plane
The top of the box opening, to adjust the position that it blocks the box opening, the adjustable plate may move in the horizontal plane
The top for being arranged at the lattice-shaped opening, to adjust the position that it blocks the lattice-shaped opening；Wherein, described first hide
Keep off module liftable top for being arranged at the box opening also in perpendicular, described first blocks module, described the
Two, which block module, is electrically connected in control module.
Further, the cell culture apparatus includes the culture liquid pool of culture experiment cell and the culture liquid pool is entered
The incubation pond body of row temperature control, the culture liquid pool is placed in the incubation pond body.
Further, the cell culture fluid for being used for cultivating the experimental cell and bottom leaching are provided with the culture liquid pool
Cell storage unit not in the cell culture fluid, the cell storage unit includes the cell training that several are uniformly arranged
Support ware and the culture dish retaining frame of the Tissue Culture Dish is fixedly mounted；Temperature conditioning unit, the temperature control are provided with the incubation pond body
Unit includes heating wire and the temperature sensor to the heating wire temperature detection.
Further, the irradiation bomb is the hollow circular-tube that uviol lamp or accommodated inside have specific radioactive substance.
Further, described first block module and drive it to move up and down by the first driver element, first driving
Unit include the first motor, be fixed on first motor output shaft first gear, engaged with the first gear the
One rack, guiding described first block the first guiding mechanism of module, the electromagnetic lock pin of module locking, institute are blocked to described first
State the first rack and block module with described first and be relatively fixed.
Further, the first baffle drives it to rotate by the second driver element, and second driver element includes
Second motor, the second gear for being fixed on second motor output shaft, the second tooth of the arc engaged with the second gear
Bar and the second guiding mechanism for being oriented to the first baffle, second rack are relatively fixed with the first baffle.
Further, the second baffle drives its horizontal movement, the 3rd driver element by the 3rd driver element
Including the 3rd motor, the thread spindle for the output shaft for being fixed on the 3rd motor, the thread bush with thread spindle socket, guiding
3rd guiding mechanism of the second baffle, the thread bush is on the second baffle.
Further, the adjustable plate drives its horizontal movement, the 4th driver element bag by the 4th driver element
Include the 4th motor, be fixed on the 4th motor output shaft the 4th gear, the 4th rack that is engaged with the 4th gear,
And the 4th guiding mechanism of the adjustable plate is oriented to, the 4th rack is relatively fixed with the adjustable plate.
Further, the second baffle is provided with the irradiation bomb for the intensity of radiation for being used to detect the irradiation bomb transmitting
Irradiation dose sensor, the irradiation dose sensor and the Tissue Culture Dish are provided with sensor, the cabinet wall
In same level.
By such scheme, the utility model at least has advantages below：
1st, by blocking module provided with first, can automatically adjust above and below between irradiation bomb and cell culture apparatus it is relative away from
From while the radiation heat input that irradiation bomb is sent can be automatically adjusted, accurately realizing the purpose of control irradiation dose；
2nd, by blocking module provided with second, casing opening, the size in the visual field of lattice-shaped opening can be automatically adjusted, is entered
And automatically control the irradiation dose of irradiation bomb；
3rd, by provided with irradiation bomb sensor and irradiation dose sensor, can in real time be monitored and tested by control module
The parameters of journey, with driving part in fast adjuster, it is ensured that experimental cell receives automatic dosage in stable environment
The Radiation of control, it is ensured that the accurate and security of experiment.
Described above is only the general introduction of technical solutions of the utility model, in order to better understand skill of the present utility model
Art means, and being practiced according to the content of specification, with preferred embodiment of the present utility model and coordinate accompanying drawing detailed below
Describe in detail bright as after.
Brief description of the drawings
Fig. 1 is the overall structure diagram of utility model.
In the figures above：1st, irradiation bomb；2nd, casing；3rd, first baffle；4th, second baffle；5th, adjustable plate；6th, lattice-shaped is opened
Mouthful；7th, liquid pool is cultivated；8th, pond body is incubated；9th, cell storage unit；10th, heating wire；11st, temperature sensor；12nd, the first driving is single
Member；13rd, electromagnetic lock pin；14th, the second driver element；15th, the 3rd driver element；16th, the 3rd guiding mechanism；17th, the 4th driving is single
Member；18th, the 4th guiding mechanism；19th, irradiation bomb sensor；20th, irradiation dose sensor.
Embodiment
With reference to the accompanying drawings and examples, embodiment of the present utility model is described in further detail.Below
Embodiment is used to illustrate the utility model, but is not limited to scope of the present utility model.
With reference to shown in Fig. 1, a kind of cell irradiation experiment automatic dosage control device of this real utility model, including irradiation bomb
1 and it is arranged on the cell culture apparatus of the lower section of the irradiation bomb 1.The irradiation bomb 1 is that uviol lamp or accommodated inside have specific radiation
Property material hollow circular-tube, be preferably that accommodated inside has the hollow circular-tube of specific radioactive substance in the utility model.It is described thin
Born of the same parents' incubator includes the culture liquid pool 7 of culture experiment cell and the incubation pond body 8 of temperature control is carried out to the culture liquid pool 7, described
Culture liquid pool 7 is placed in the incubation pond body 8.The cell for being used for cultivating the experimental cell is provided with the culture liquid pool 7
The cell storage unit 9 of nutrient solution and lower submerged in the cell culture fluid, to ensure that cell being capable of normal existence.Institute
Stating cell storage unit 9 includes the culture of several Tissue Culture Dish and the fixed installation Tissue Culture Dish that are uniformly arranged
Ware retaining frame.Temperature conditioning unit is provided with the incubation pond body 8, the temperature conditioning unit includes heating wire 10 and to the heating wire 10
The temperature sensor 11 of temperature detection.
The cell irradiation experiment automatic dosage control device also blocks module and second including casing 2, first and blocks mould
Block.The casing 2 has the chamber for housing the cell culture apparatus, and the roof insertion of the chamber, which is provided with, makes the irradiation bomb 1
Light pass through and irradiate in the box opening on the cell culture apparatus.Irradiation dose biography is provided with the inwall of casing 2
Sensor 20, the irradiation dose sensor 20 and the Tissue Culture Dish are in same level, for test experience cell
The irradiation dose being subject to.
Described first blocks module drives it to move up and down by the first driver element 12, and first driver element 12 is wrapped
Include the first motor, be fixed on first motor output shaft first gear, engaged with the first gear the first rack,
It is oriented to the described first electromagnetic lock pin 13 for blocking the first guiding mechanism of module, module locking being blocked to described first, described the
One rack blocks module with described first and is relatively fixed.Described first, which blocks module, includes first baffle 3, the first baffle 3
The outer circumferential of the irradiation bomb 1 is arranged in perpendicular, drives it to rotate by the second driver element 14, to adjust it
Block the position of the irradiation bomb 1.Second driver element 14 includes the second motor, is fixed on second motor output shaft
Second gear, the second rack of the arc engaged with the second gear and the second Guiding machine for being oriented to the first baffle 3
Structure, second rack is relatively fixed with the first baffle 3.
Second blocks module, and it includes second baffle 4 and adjustable plate 5.The surface of second baffle 4 is smooth and easy to clean disappears
The lattice-shaped opening 6 matched with the box opening is further opened with poison, the second baffle 4.The second baffle 4 is in water
The top of the box opening is arranged in plane, its horizontal movement is driven by the 3rd driver element 15, blocked with adjusting it
The position of the box opening.3rd driver element 15 includes the 3rd motor, is fixed on the output shaft of the 3rd motor
Thread spindle, be socketed with the thread spindle thread bush, be oriented to the 3rd guiding mechanism 16 of the second baffle 4, the screw thread
It is sheathed on the second baffle 4.3rd guiding mechanism 16 include with the second baffle 4 be connected chute dead axle and
The slip elongated slot being slidably connected with the chute dead axle.The 3rd motor in the utility model selects stepper motor, with higher
Accuracy, it is ensured that realize that resultant error is small.The second baffle 4 is provided with the radiation for being used for detecting that the irradiation bomb 1 is launched
The irradiation bomb sensor 19 of line strength, the radioactive ray energy intensity that the irradiation bomb 1 for detecting by control is emitted, then
The knot detected is crossed and is sent to control module.The adjustable plate 5 is arranged at the upper of the lattice-shaped opening 6 in the horizontal plane
Side, drives its horizontal movement, to adjust the position that it blocks the lattice-shaped opening 6, the tune by the 4th driver element 17
The size for saving plate 5 is more than the size of the lattice-shaped opening 6.4th driver element 17 includes the 4th motor, is fixed on institute
The 4th gear for stating the output shaft of the 4th motor, the 4th rack engaged with the 4th gear, and it is oriented to the adjustable plate 5
4th guiding mechanism 18.4th guiding mechanism 18 includes the regulation dead axle of the connected adjustable plate 5 and fixed with the regulation
The regulation chute that axle is slidably connected, the 4th rack is relatively fixed with the adjustable plate 5.Wherein, described first block module,
Described second, which blocks module, is electrically connected in control module.
Embodiment
During experimental implementation, experimental cell is inoculated into each Tissue Culture Dish (such as transwell Membrance cuitures ware) first
Via membrane upper surface culture it is qualified after, then appropriate cell culture fluid injected in culture pond, then will be inoculated with experiment
The Tissue Culture Dish of cell is put into culture pond 7 and is uniformly arranged in culture dish retaining frame, the size and location of culture dish retaining frame
Ensure each Tissue Culture Dish can homogeneous immersion in appropriate cell culture fluid, to ensure that experimental cell can be normal
Existence；Specific radioactive substance required for experiment is fitted into irradiation bomb 1, starts control module, regulation and the control mould
The component of block electrical connection is in reset state, is then preset according to the requirement of cell irradiation experiment regulation and startup optimization
Good irradiation dose and operation program.
Operation principle of the present utility model is as follows
Experimentation：
(1) first driver element 12 driving irradiation bomb 1 is moved down, when the distance between irradiation bomb 1 and cell culture apparatus
When meeting the requirements, electromagnetic lock pin 13 locks the first driver element 12；
(2) the 3rd driver elements 15 driving second baffle 4 is moved forward, when lattice-shaped opening 6 is directed at box opening, the
Two baffle plates 4 stop movement；
(3) the 4th driver elements 17 driving adjustable plate 5 is moved forward, and lattice-shaped opening 6 is hidden by adjustable plate 5
Gear, when reaching the irradiation dose of requirement of experiment, adjustable plate 5 stops movement；
(4) second driver elements 14 driving first baffle 3 is circumferentially rotated, and is rotated by first baffle 3 and irradiation bomb 1 is sent
Transmitting heat input blocked, when reaching the irradiation dose of requirement of experiment, the stop motion of first baffle 3；
(5) irradiation experiment is started, control module monitors irradiation bomb sensor 19, irradiation dose sensor 20 and temperature in real time
The detection data of sensor 11 are spent, the fine setting to each driver element is carried out, it is ensured that experimental cell is received in stable environment
The Radiation of automatic dosage control.
Reseting procedure：
(1) second driver element 14 driving first baffle 3 is circumferentially rotated, and completely obscured irradiation is rotated by first baffle 3
Source 1；
(2) electromagnetic lock pin 13 discharges the first driver element 12, and motion is multiple upwards for the first driver element 12 driving irradiation bomb 1
Position；
(3) the 3rd driver elements 15 driving second baffle 4 is moved rearwards by so that lattice-shaped opening 6 deviates box opening；
(4) the 4th driver elements 17 driving adjustable plate 5 is moved rearwards by, and passes through the completely obscured lattice-shaped opening 6 of adjustable plate 5；
(5) experimental cell after irradiation bomb 1 and irradiation is removed, experiment terminates.
Described above is only preferred embodiment of the present utility model, is not limited to the utility model, it is noted that
For those skilled in the art, on the premise of the utility model technical principle is not departed from, it can also do
Go out some improvement and modification, these improvement and modification also should be regarded as protection domain of the present utility model.
Claims (9)
1. a kind of cell irradiation experiment automatic dosage control device, including irradiation bomb and the cell being arranged on below the irradiation bomb
Incubator, it is characterised in that：
- casing, it has the chamber for housing the cell culture apparatus, and the roof insertion of the chamber, which is provided with, makes the irradiation bomb
Light is passed through and irradiated in the box opening on the cell culture apparatus；
- the first blocks module, and it includes first baffle, and the first baffle is rotatably arranged at the spoke in perpendicular
According to the outer circumferential in source, to adjust the position that it blocks the irradiation bomb；
- the second blocks module, and it includes offering on second baffle and adjustable plate, the second baffle and the box opening phase
The lattice-shaped opening of matching, the second baffle is movably arranged at the top of the box opening in the horizontal plane, to adjust
Its position for blocking the box opening is saved, the adjustable plate is movably arranged at the lattice-shaped opening in the horizontal plane
Top, to adjust the position that it blocks the lattice-shaped opening；
Wherein, described first module liftable top for being arranged at the box opening also in perpendicular is blocked, it is described
First blocks module, described second blocks module and be electrically connected in control module.
2. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The cell culture
Device includes the culture liquid pool of culture experiment cell and the incubation pond body of temperature control, the culture liquid pool is carried out to the culture liquid pool
It is placed in the incubation pond body.
3. cell irradiation experiment automatic dosage control device according to claim 2, it is characterised in that：The culture liquid pool
The interior cell storage for being provided with the cell culture fluid and lower submerged that are used for cultivating the experimental cell in the cell culture fluid
Unit, the cell storage unit includes the Tissue Culture Dish and the fixed installation Tissue Culture Dish that several are uniformly arranged
Culture dish retaining frame；Temperature conditioning unit is provided with the incubation pond body, the temperature conditioning unit includes heating wire and to the heating wire
The temperature sensor of temperature detection.
4. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The irradiation bomb is
Uviol lamp or accommodated inside have the hollow circular-tube of specific radioactive substance.
5. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：Described first blocks
Module drives it to move up and down by the first driver element, and first driver element includes the first motor, is fixed on described the
The first gear of the output shaft of one motor, the first rack engaged with the first gear, guiding described first block module
First guiding mechanism, the electromagnetic lock pin that module locking is blocked to described first, first rack and described first block module
It is relatively fixed.
6. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The first baffle
It is driven to rotate by the second driver element, second driver element includes the second motor, to be fixed on second motor defeated
The second gear of shaft, the second rack of the arc engaged with the second gear and it is oriented to the second of the first baffle and leads
To mechanism, second rack is relatively fixed with the first baffle.
7. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The second baffle
Its horizontal movement is driven by the 3rd driver element, the 3rd driver element includes the 3rd motor, is fixed on the 3rd electricity
The thread spindle of the output shaft of machine, the thread bush being socketed with the thread spindle, the 3rd guiding mechanism for being oriented to the second baffle, institute
Thread bush is stated on the second baffle.
8. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The adjustable plate leads to
Cross the 4th driver element and drive its horizontal movement, the 4th driver element includes the 4th motor, is fixed on the 4th motor
Output shaft the 4th gear, the 4th rack that is engaged with the 4th gear, and be oriented to the 4th Guiding machine of the adjustable plate
Structure, the 4th rack is relatively fixed with the adjustable plate.
9. cell irradiation experiment automatic dosage control device according to claim 1, it is characterised in that：The second baffle
It is provided with the irradiation bomb sensor for the intensity of radiation for being used to detect the irradiation bomb transmitting, the cabinet wall and is provided with spoke
According to dose sensor, the irradiation dose sensor and the Tissue Culture Dish are in same level.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720065589.2U CN206428270U (en) | 2017-01-19 | 2017-01-19 | Automatic dose control device for cell irradiation experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720065589.2U CN206428270U (en) | 2017-01-19 | 2017-01-19 | Automatic dose control device for cell irradiation experiment |
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| Publication Number | Publication Date |
|---|---|
| CN206428270U true CN206428270U (en) | 2017-08-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720065589.2U Active CN206428270U (en) | 2017-01-19 | 2017-01-19 | Automatic dose control device for cell irradiation experiment |
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| Country | Link |
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| CN (1) | CN206428270U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112697953A (en) * | 2020-11-27 | 2021-04-23 | 中国矿业大学 | Cable combustion and pyrolysis characteristic test system and test method under multi-variable-parameter environment condition |
-
2017
- 2017-01-19 CN CN201720065589.2U patent/CN206428270U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112697953A (en) * | 2020-11-27 | 2021-04-23 | 中国矿业大学 | Cable combustion and pyrolysis characteristic test system and test method under multi-variable-parameter environment condition |
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