CN112522088B - Multifunctional intelligent virus detection specimen sampling and storing integrated system - Google Patents
Multifunctional intelligent virus detection specimen sampling and storing integrated system Download PDFInfo
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- CN112522088B CN112522088B CN202110016605.XA CN202110016605A CN112522088B CN 112522088 B CN112522088 B CN 112522088B CN 202110016605 A CN202110016605 A CN 202110016605A CN 112522088 B CN112522088 B CN 112522088B
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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Abstract
A multifunctional intelligent virus detection sample sampling and storing integrated system comprises a sampling gun nozzle, a sample storage bottle, a sample storage stack and a sample storage box, wherein the sample storage box comprises a box cover, a cover heat-insulating layer, a box body, a battery, a base plate, a plate rod, a box contact piece, a box heat-insulating layer and a storage bin; the sampling gun nozzle is placed in the sample storage box, the sample storage bottle is stored in the sample storage stack, and the sample storage stack is placed in the accommodating bin. The device can obtain a sample which is always stored in an aseptic environment, and realizes real pollution-free aseptic sampling and aseptic storage integrated device and intelligent management thereof through the sterilization of a special liquid transfer gun sampling gun nozzle in the sampling process.
Description
Technical Field
The invention belongs to the field of virus sampling and storing devices, and particularly relates to a multifunctional intelligent virus detection specimen sampling and storing integrated system.
Background
The virus is a non-cell type organism which is small in individual and simple in structure, only contains a nucleic acid, must be parasitic in living cells and proliferated in a replication mode, is a non-cell life form and is composed of a nucleic acid long chain and a protein shell, and has no own metabolic mechanism and no enzyme system. The virus thus leaves the host cell and becomes an organism which does not have any vital activity and which is not able to self-propagate independently. Its ability to replicate, transcribe, and translate is performed in the host cell, and when it enters the host cell, it can use the materials and energy in the cell to perform life activities, generating a new generation of virus as it does according to the genetic information contained in its own nucleic acid.
Basic sampling and storage problems are encountered in biochemical studies of microorganisms, where the procedure is carried out under conditions that ensure the absence of contamination, otherwise unpredictable increases in test results are caused. In traditional biochemical reactions, especially in high-risk viral pathology research experiments, a sterile environment needs to be involved. Generally, the operation is carried out in a sterile chamber or a plurality of leaching measures are carried out to enter the experimental area for operation. The high cost makes the general scientific research institutions and the experiment centers have no experiment conditions. The virus mixed liquid is always required to be maintained at a specific temperature to keep the activity of the virus mixed liquid in the storage process, and the existing virus sampling equipment is relatively complicated in storage operation and relatively inconvenient to use.
In the prior art, the acceptable miniaturized device is considered, the sterile condition is created from experimental equipment to sampling and testing links, and the specific temperature is realized to keep the virus activity.
Chinese patent document CN205672946U considers the sterilization and storage of the pipette tips of the pipetting devices for sampling from the sampling stage. The sterilization of the head of the liquid-transfering gun is realized by uniformly distributing a plurality of ultraviolet lamp tubes at the lower end and arranging a plurality of heating vent ultraviolet lamp mounting plates on the upper surface of the plate. However, the method only allows the pipette tip to exist in an environment with possible sterilization effect, and does not consider direct sterilization on the surface of the pipette tip, and the sterilization effect of the pipette tip is to be further tested.
Although the chinese patent document CN111089444A considers the preservation of the sample itself, it also provides that the top end inside the box body is provided with a temperature sensor, the bottom of the box body is provided with a refrigerator, and both sides inside the box body are provided with ultraviolet disinfection lamps to ensure the sterility and proper storage temperature of the sample. And set up division board central point and put and be equipped with well core rod perpendicularly, well core rod connects in the reduction gear and the motor of placing incasement portion and realizes that the convenient search of sample obtains. However, the manufacture of a sterile environment during sampling and storage, i.e. during handling, is not achieved.
Although the chinese patent document CN108239599A combines the three processes of sampling, culturing and testing into an integrated device, no sterility guarantee is provided on the sampling gun nozzle, and therefore, undesirable contaminants may be mixed in the culturing process, which affects the subsequent biochemical test results. Although the test chamber portion in this integrated apparatus is provided with a sterilization pot, since provision of a sterile environment has not been previously taken into consideration in sampling and incubation processes, other side effects on the sample may have been caused before the test, and sterilization may be performed later at the test stage in the test chamber.
Therefore, it is considered that sterilization is started from the sampling process, and it is also required to ensure long-term preservation of the collected sample in a sterile environment. This is so that even when the sampling is completed and the sample is transferred to the test device, there is a very small probability of contamination occurring, but is more recommended than if a sample that has been subjected to the adverse effects of a sterile environment for some time is taken for testing. In addition, the intelligent management of sample storage is also an approach which is not considered in the prior art.
The prior art needs a portable multifunctional intelligent virus detection specimen sampling and storing integrated system which can ensure pollution-free virus adoption and storage.
Disclosure of Invention
In view of the technical problems in the prior art, an object of the present invention is to provide a multifunctional intelligent integrated system for sampling and storing a virus detection specimen, which can obtain a sample stored in an aseptic environment all the time, and can achieve a real sampling system for aseptic sampling and aseptic storage without contamination and intelligent management thereof by sterilizing a sampling gun nozzle of a specially-made pipette in a sampling process, so as to solve the problems in the background art.
The front face is defined as the direction perpendicular to the paper surface and towards the viewer, and the back face is defined as the direction perpendicular to the paper surface and away from the viewer.
Specifically, according to a first aspect of the invention, the invention provides a multifunctional intelligent virus detection specimen sampling and storing integrated system, which is characterized by comprising a sampling gun nozzle, a specimen storage bottle, a specimen storage stack, a specimen storage box, a sterile parameter controller, a periodic sterilization device and a storage unit with a built-in intelligent program;
the sample storage box comprises a box cover, a cover heat-insulating layer, a box body, a battery, a base plate, a plate rod, a box contact piece, a box heat-insulating layer and a storage bin;
the sampling gun nozzle is placed in the sample storage box, the sample storage bottle is stored in the sample storage stack, and the sample storage stack is placed in the accommodating bin.
Preferably, the cover heat preservation layer is arranged in the inner space of the box cover, the box heat preservation layer is arranged in the inner space of the box body, the box cover is hinged to the box body through a hinge, the battery is arranged at the bottom of the inner space of the box body, a base plate is arranged above the battery and is a PCB (printed Circuit Board), a plate bar is arranged above the base plate, box contact pieces are arranged at the tops of the plate bar, a containing bin distributed in a rectangular array is arranged inside the box heat preservation layer, and two box contact pieces are arranged at the bottom of the inner space of the containing bin.
Preferably, the sampling gun nozzle is made of metal material or polytetrafluoroethylene,
preferably, the sample storage bottle comprises a bottle body and a bottle cap, the bottle cap is provided with a label plate extending in the horizontal direction and a hole for inserting the sampling gun nozzle, a membrane made of flexible materials is fixedly arranged on the hole, the center of the membrane is coincided with the center of the hole, and the membrane is cut through in the center in a cross mode so that the sampling gun nozzle can be inserted into the bottle body of the sample storage bottle for sampling;
preferably, the sample storage stack comprises an L-shaped shell, a core cover is in threaded connection with the lower end of the bottom of the shell, a core plate is embedded in the middle of the core cover, two arc-shaped sheet-shaped plate contact pieces are bonded to the lower end of the core plate, a plurality of sample storage compartments which are arranged in a linear direction in the shell, and a first compartment storage position which is located in the leftmost compartment or the rightmost compartment are arranged in the shell, each compartment is placed in a respective storage drawer, and any compartment which is not stored in the first compartment storage position can be drawn out in a direction perpendicular to the front face direction of the shell through all the drawers of the compartments except the compartment to generate an escape space, so that the compartment can be linearly translated to the first compartment storage position, and the top of each compartment is provided with only one through hole for a sampling gun nozzle to pass through; a binding opening which is also provided by a flexible material film which is cut through in a cross shape at the center and is arranged above the first compartment storage position in a vertical protruding mode in the straight line direction, and a corresponding protective cover for covering the binding opening, wherein a channel for the sampling gun nozzle to enter is arranged below the binding opening, two sterilization positions are arranged in the channel from top to bottom, a short-time heating position is arranged above the channel, an ultraviolet radiation area is arranged below the channel, at least two work stations for placing the sample storage bottles are arranged at the bottom of each compartment, the bottom of each compartment further comprises a rotary disc which can rotate through a rotary piece at the top of the compartment, and the work stations are arranged on the rotary disc; when one compartment is in the first compartment storage position, each sample storage bottle can rotate the rotating disc through the rotating piece to a position that the tying center, the hole center of the sample storage bottle and the perforation center are overlapped in a top view direction; when the sample storage bottle rotates to reach the overlapped position, the center of the channel is over against the center of the hole of the sample storage bottle, and each sterilization position is provided with an infrared sensor for sensing the passing of a sampling gun nozzle; the bottom surface of the rotary table is provided with a guide sheet which can form an electric loop when being abutted against the plate contact sheet.
In one embodiment, the station is provided as a loop extending vertically upward from the base for stably supporting the vial. Also preferably, the channels are connected between the two sterilization sites by an insulating ceramic.
Preferably, the infrared sensor is mounted in the thermally insulating ceramic of the channel.
In one embodiment, a mutually slidable translation device is mounted on each compartment and on the front and back of the L-shaped housing. Preferably the translating means are tracks on the front and back of the L-shaped housing and translating wheels mounted on the front and back of each compartment. And a gate is mounted at the linear end of the L-shaped housing opposite to the first compartment storage position for opening to push and translate the compartment stored in any one of the non-first compartment storage positions, and a hook portion for pulling back the compartment stored in any one of the non-first compartment storage positions is arranged on one side of the compartment stored in any one of the non-first compartment storage positions.
Preferably, the sampling gun nozzle and the channel are both made of food-grade stainless steel, and the sampling gun nozzle is provided with a scale for indicating that the penetration depth reaches a heating position H or an ultraviolet radiation area UV sterilization position so as to stay for corresponding pyrolysis surface pollutants and sterilization treatment. The element device of the heating position is an electromagnetic heating device.
Preferably, when the sampling gun nozzle is positioned at any position between the heating position or the radiation area, the maximum gap between the inner wall of the channel and the sampling gun nozzle is not more than 0.5mm, and the end part of the sampling gun nozzle can penetrate into the bottle body to contact with the inner surface of the bottom of the bottle body.
Preferably, both the L-shaped housing and the sample holding compartment are made of a transparent organic material.
The sample storage box also comprises a socket, a controller, a microprocessor, a color touch screen for displaying the use state of each parameter and setting by a user, an operation table, a plurality of ultraviolet radiation devices, a semiconductor refrigerator and a temperature sensor, the box is sterilized and insulated, and a plurality of sample storage stack support frames are hung on the inner wall of the storage bin; the operation panel is located the outer horizontal surface of box, the operation panel set up with the spliced pole that the socket corresponds, when the stock sample stack is placed on the operation panel, the socket docks and leads to spliced pole switch-on component device to according to the position of disinfecting that corresponding sampling rifle mouth reached, trigger corresponding infrared sensor, let microprocessor trigger corresponding component device work for controller work, disinfect, and further pass the stock sample bottle fixed membrane that is provided with flexible material on the hole gets into the body sampling, after opening the case lid and close the case lid once more, a plurality of ultraviolet radiation devices start, to the inside sterilization of box.
Preferably, the starting time is 20s-1 min.
In one embodiment, a pipette sampling gun nozzle rack and a sterile glove rack are also stored in the sample storage box, and the sample storage stack support rack is provided with position numbers.
In one embodiment, the sample stack includes a syringe, a plunger, a plug seal, a frit, an electrical heater, a tip gasket, a rubber cylinder, a core plate, a plate contact, and a core cover.
Preferably, the contour of the sintered part is in a circular column shape, a needle cylinder is arranged inside the upper portion of the sintered part, a piston is arranged inside the needle cylinder, a plug sealing ring is arranged in a groove in the outer circular surface of the piston, a head gasket is arranged on the lower end of the needle cylinder, the head gasket is fixedly bonded with the sintered part, a cylindrical cavity is arranged in the middle of the lower end of the sintered part, a cylindrical cavity is formed in the sintered part outside the cylindrical cavity, the cylindrical cavity is communicated with the cylindrical cavity through a through hole, a core cover is connected to the lower end of the sintered part in a threaded mode, a core plate is embedded in the middle of the core cover, two arc-shaped sheet contact pieces are bonded to the lower end of the core plate, a spiral electric heating pipe is arranged on the inner side of the outer circle of the sintered part, the lower.
Preferably, the connecting wire between the controller and the electrothermal tube passes through a wire hole at the lower side of the sintered part, and the controller is connected with the sintered part through a screw.
Preferably, the excircle of the core plate is provided with an annular bulge, and the annular bulge on the excircle of the core plate is embedded into the groove of the adjacent core cover.
As a further aspect of the present invention, the core plate is provided with two funnel-shaped holes, and the positions of the funnel-shaped holes correspond to the positions of the plate contact pieces.
In one embodiment, the controller is further used for commanding the controller to control and operate the temperature, the heating and the ultraviolet sterilization in the box body by the microprocessor according to the parameters set by the user. When each sterilization process is finished, the microprocessor controls the controller to cut off the power supply at the corresponding compartment, and the heating and ultraviolet sterilization functions are stopped.
Preferably, the temperature in the box body is between 0 ℃ and 40 ℃.
Preferably, the connecting column is arranged on a lifting rod capable of lifting, when the lifting rod is not used, the lifting rod falls down to hide the connecting column into the accommodating groove in the back of the box body, and the connecting column is sealed through a flip cover. The microprocessor and the controller are used for controlling the lifting rod to start lifting or descending through the mobile phone or the color touch screen.
In one embodiment, the sampling system of the present invention can further adjust the heating temperature, the heating time, the heating mode, and the ultraviolet light intensity through a mobile phone or a color touch screen. Preferably, the heating mode comprises single-step heating, step heating and heating in a preset curve mode.
Preferably, the user can set the operation of temperature in the box, heating parameters (including heating temperature, heating time and heating mode), ultraviolet sterilization (including the ultraviolet lamp of ultraviolet sterilization position and the time and intensity of sterilization of a plurality of ultraviolet sterilization devices in the box) and the time of predetermined sampling or saving by mobile phone app online with the sampling system, and the user can also set through the colored touch screen and edit the storage position list of the stored sample, so that the storage sample stack support frame position number can be found out quickly by searching through the colored touch screen or the mobile phone during sampling. The user can also check the setting parameters, the working state, the preset sampling or stored time information and the list of the sampling system through the color touch screen or the mobile phone.
Preferably, the user is reminded by a mobile app short message or on a color touch screen before the predetermined sampling or saving time comes.
Preferably, when the user is reminded on the color touch screen, screen flashing and/or voice reminding is adopted. Therefore, intelligent management of sampling and storage is realized.
Preferably, the predetermined profile mode comprises profile selection for each heating stage in a single step or in steps.
Preferably, the curve includes a straight line having a certain slope, a power function curve, an exponential function curve, and the like. The heating element is electromagnetically heated, the heating temperature is in the range of 90-200 ℃, the heating time is selected from 1s-10s, preferably less than 5s, more preferably 2s, and most preferably 1 s.
In one embodiment, the sampling system further comprises a periodic sterilization device ultraviolet gun for irradiating sterilization of the protective cover periodically or experimentally.
Preferably, said plurality of ultraviolet radiation means may also be used for regular irradiation sterilization purposes during closure of the lid.
Preferably, the user is reminded of regular sterilization through a mobile app short message or a colored touch screen, and preferably, when the user is reminded by selecting the colored touch screen, screen flashing and/or voice reminding are adopted. Thereby realizing the intelligent management of regular sterilization.
When a sample is stored, a user can set a storage temperature and customize sterilization time on a mobile phone or a color touch screen, a sample storage bottle is placed on a station on a turntable at the bottom of a sample storage stack compartment, the sample storage stack is placed on a sample storage stack support frame with a corresponding number, sample information is edited and recorded in the list and the pH value of the sample through the mobile phone or the color touch screen, and when the pH value is within a range of +/-0.3 near a neutral value of 7, a sampling gun nozzle made of a metal material is recommended. And the sampling gun nozzle made of polytetrafluoroethylene is adopted for other pH values.
During sampling, a user can independently or after receiving a short message notice of a mobile phone, search the position number of the sample storage stack support frame stored by the sample by using the mobile phone or the color touch screen, find the sample storage stack with the corresponding number after the box cover is opened according to the position indicated on the screen, take out the sample storage stack from the sample storage stack support frame and close the box cover. At this time, the ultraviolet radiation devices are turned on to perform sterilization treatment in the tank. The lifting rod is lifted by using a mobile phone or a color touch screen, and the connecting column is inserted into the jack to be connected with the heating position and the radiation area element device interface. Connecting the pipette with the sampling gun nozzle, inserting the sampling gun nozzle into the binding hole to the H scale mark, triggering the heating position infrared sensor at the moment, enabling the microprocessor to command the controller to start the electromagnetic heater, automatically stopping at the preset time, prompting the completion of heating on the mobile phone or the color touch screen, then continuously downwards inserting the pipette into the UV scale mark, and similarly prompting the completion of ultraviolet sterilization on the mobile phone or the color touch screen after the preset time. And continuously inserting the sample bottle downwards through the cross-cut film at the center of the hole of the sample storage bottle to penetrate into the bottle body, so as to collect the sample and pull out the tying opening. At the moment, the box cover can be opened to put the sample storage stack back to the sample storage stack support frame, and the box cover is closed. At this time, the ultraviolet radiation devices are turned on again to sterilize the inside of the box.
According to the invention, sampling and saving can be combined in one device.
According to the invention, the sterile environment is provided during the sampling process and during the real-time period of preservation, ensuring that the sampling and the sample themselves are free of contamination.
According to the invention, the sampling process can carry out comprehensive thermal decomposition and sterilization treatment on surface pollutants of the sampling gun nozzle with the position scales before sampling through continuous heating and ultraviolet sterilization treatment.
According to the invention, the color touch screen and the mobile phone are interconnected, so that the intelligent management of storage, sampling and regular sterilization can be realized.
According to the multifunctional intelligent virus detection sample sampling and storing integrated system, the sample storage stacks are used for containing virus mixed liquid, the storage boxes are used for containing a plurality of sample storage stacks, the power supply batteries are arranged in the storage boxes, the electric heating tubes are powered and heated through the contact of the plate contact pieces and the box contact pieces, the temperature is controlled through the temperature sensors, the storage temperature of viruses can be well controlled, and the multifunctional intelligent virus detection sample sampling and storing integrated system is suitable for being generally popularized and used; a plurality of sample storage stacks can be mounted in the container, viruses of different types can be stored, and the work of the sample storage stacks is independent and cannot interfere with each other.
Drawings
FIG. 1 is a schematic view showing a sampling nozzle with heating position H and UV sterilization position scale of a multifunctional intelligent virus detection specimen sampling and preservation integrated system according to an embodiment of the present invention;
FIG. 2 is a front view of a sample bottle of the integrated multifunctional intelligent virus detection sample sampling and storing system according to an embodiment of the present invention;
FIG. 3 is a top view of a sample bottle of the integrated multifunctional intelligent virus detection sample sampling and storage system according to an embodiment of the present invention;
FIG. 4 is a front view of a sample storage stack of the multifunctional intelligent virus detection sample sampling and storage integrated system according to the embodiment of the present invention;
FIG. 5 is a top view of a sample storage stack of the integrated multifunctional intelligent virus detection sample sampling and storage system according to an embodiment of the present invention;
FIG. 6 is a right side view of a sample storage stack of the integrated multifunctional intelligent virus detection sample sampling and storage system according to an embodiment of the present invention;
FIG. 7 is a front view of a sample storage box of the integrated multifunctional intelligent virus detection sample sampling and storage system according to the embodiment of the present invention;
FIG. 8 is a top view of a sample storage box of the integrated multifunctional intelligent virus detection sample sampling and storage system according to the embodiment of the present invention;
FIG. 9 is a schematic view showing the structure of a sample storage box of the integrated multifunctional intelligent virus detection specimen sampling and storing system according to another embodiment of the present invention;
FIG. 10 is a front view of a sample stack of the integrated multifunctional intelligent virus detection sample sampling and storage system according to another embodiment of the present invention;
FIG. 11 is a schematic diagram of the structure at A in FIG. 10 showing the sample storage stack of the integrated multifunctional intelligent virus detection sample sampling and storage system according to another embodiment of the present invention;
FIG. 12 is a schematic view showing an upper side structure of a sample storage stack of the multifunctional intelligent virus detection sample sampling and storing integrated system according to the embodiment of the present invention in a combined state of a core plate, a plate contact piece and a core cover;
fig. 13 is a schematic view showing a lower side structure of a sample storage stack of the multifunctional intelligent virus detection sample sampling and storing integrated system according to the embodiment of the present invention in a combined state of a core plate, a plate contact piece and a core cover.
The bottle comprises a bottle body, a bottle cap, a label plate, a hole 4, a flexible material membrane penetrated by a central cross cut 5, an L-shaped shell of a sample storage stack 6, a sample storage compartment 7, a drawer 8, a perforation 9, a binding hole 10, a channel 11, a heating position 12, an ultraviolet radiation area 13, a rotating part 14, a rotating disc 15, a sample storage box 16, a box body 17, a microprocessor and a controller 18, a color touch screen 19, a semiconductor refrigerating sheet 20, an operation table 21, a temperature sensor 22, a sample stack support frame 23, a connecting column 24, a lifting rod 25, a sampling nozzle frame 26, a sterile glove frame 27, a sterile glove frame 31 and a containing box, wherein the sample storage stack is provided with a sample storage box; 32. a box cover; 33. covering an insulating layer; 34. a box body; 35. a battery; 36. a base plate; 37. a plate bar; 38. a case contact; 39. a box insulating layer; 40. containing a bin; 41. an accommodating unit; 42. a needle cylinder; 43. a piston; 44. plugging a seal ring; 45. sintering the part; 4501. a wire hole; 46. an electric heating tube; 47. a head gasket; 48. a rubber cylinder; 49. a temperature sensor; 50. a controller; 51. a core board; 52. a plate contact; 53. and (4) covering the core. H heating position scale, UV sterilization position scale, a B ring, C heat insulation ceramic, a G gate and an H hook.
Detailed Description
The present invention now will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown.
Fig. 1 is a schematic view showing a sampling nozzle having heating positions H and UV sterilization positions UV scales of a multifunctional intelligent virus detection specimen sampling and storing integrated system according to an embodiment of the present invention.
As shown in figure 1, a food-grade stainless steel sampling nozzle is prepared, and the length of the sampling nozzle is 5-10cm, so that the sampling nozzle can penetrate into the bottle body 1 to contact the inner surface of the bottom of the bottle body 1. And the surface of the sampling nozzle is engraved with an H heating position and an ultraviolet sterilization position UV scale.
FIG. 2 is a front view of a sample bottle of the integrated multifunctional intelligent virus detection sample sampling and storing system according to an embodiment of the present invention; fig. 3 is a plan view.
As shown in fig. 2 and 3, the sample storage bottle comprises a bottle body 1, a bottle cap 2, wherein the bottle cap 1 is provided with a label plate 3 extending in the horizontal direction and a hole 4 for inserting the sampling nozzle, a membrane 5 made of flexible material is fixedly arranged on the hole 4, the center of the membrane 5 is coincided with the center of the hole 4, and the membrane 5 is crossly cut through to enable the sampling nozzle to be inserted into the bottle body 1 for sampling.
FIG. 4 is a front view of a sample storage stack of the multifunctional intelligent virus detection sample sampling and storage integrated system according to the embodiment of the present invention; FIG. 5 is a top view; fig. 6 is a right side view.
As shown in fig. 4-6, the sample stack comprises an L-shaped shell 6 made of transparent organic material, a core cover is screwed on the lower end of the bottom of the shell, a core plate is embedded in the middle of the core cover, and two arc-shaped sheet-shaped plate contact pieces (as the structure of the core plate is the same as that of another embodiment, the structure is marked and explained in fig. 11). A plurality of sample storage compartments 7 made of transparent organic materials are arranged in a straight line in the shell 6, and a first compartment storage position is arranged at the leftmost compartment, each compartment is placed in a respective storage drawer 8, and any compartment which is not stored in the first compartment storage position can be withdrawn towards the direction vertical to the front surface of the shell (see fig. 5) through the drawers 8 of all compartments except the compartment to form a clearance space, so that the compartment can be translated to the first compartment storage position along the straight line trans direction as shown in fig. 5, and the top of each compartment is provided with a single perforation 9 for a sampling nozzle to pass through.
Above the first compartment storage position, perpendicularly projecting in said rectilinear direction, there is provided a binding 10, also provided by a membrane of flexible material cut crosswise in the centre, and a corresponding protective cover (not shown) covering the binding 10.
A channel 11 made of food-grade stainless steel for the sampling nozzle to enter is arranged below the tying port 10, the channel 11 is provided with two sterilization positions from top to bottom, the upper part is a short-time heating position 12 provided with an electromagnetic heating device, and the lower part is an ultraviolet radiation area 13 provided with an ultraviolet lamp. The two sterilization positions are connected by a heat insulation ceramic C.
At least two rings B extending vertically upwards from the bottom are present at the bottom of each compartment, where the sample vials are placed, as stations, and the bottom further comprises a turntable 15 rotatable by a compartment top rotating member 14, and the stations are provided on the turntable 15. When a compartment is in the first compartment storage position, each vial is able to rotate the carousel 15 by the rotating member 14 to a position such that the centre of the opening 10, the centre of the well 4 of the vial, and the centre of the perforation 9 coincide in plan view. The bottom surface of the rotary table 15 is provided with a guide piece which can form an electric circuit when abutting against the plate contact piece.
The sample storage bottle is rotated to reach when the position of coincidence, the center of passageway 11 is just to the sample storage bottle 4 centers in the hole, every is disinfected and is installed infrared sensor (not shown) that the induction sampling mouth passes through and in the corresponding thermal-insulated ceramic circle that heats the position passageway of infrared sensor installation (not shown) that the induction heating position sampling mouth passes through on the position.
The front and back of the shaped housing is provided with a guide rail, and the front and back of each compartment is provided with a translation wheel. And a gate G (see fig. 6) is installed at the end of the linear direction of the L-shaped housing with respect to the first compartment storage position for opening to push and translate the compartment stored in any one of the non-first compartment storage positions, and a hook h for pulling back the compartment stored in any one of the non-first compartment storage positions is provided at one side of the compartment stored in any one of the non-first compartment storage positions.
When the sampling nozzle is positioned at any position between the heating position or the radiation area, the maximum gap between the inner wall of the channel and the sampling nozzle is 0.2-0.5 mm.
FIG. 7 is a front view of a sample storage box of the integrated multifunctional intelligent virus detection sample sampling and storage system according to the embodiment of the present invention; fig. 8 is a plan view.
As shown in fig. 7 and 8, the sample storage box 16 includes a box body 17, a box cover (not shown), a controller and a microprocessor 18, a color touch screen 19 for displaying the use state of each parameter and user setting, a semiconductor cooling sheet 20, and an operation panel 21.
A plurality of ultraviolet radiation devices 13, a semiconductor refrigerating sheet 20 and a temperature sensor 22 are arranged in the box body 17. The box body 17 is internally divided into a plurality of sample storage stack support frames 23; the console 21 is located at the outer horizontal surface of the box 17. The console 21 is provided with a connection post 24 corresponding to the socket. When the storage stack is placed on operation panel 21, socket butt joint switch-on spliced pole 24 switch-on electromagnetic heating device and ultraviolet lamp to according to the position of disinfecting that corresponding sampling rifle mouth reached, trigger corresponding infrared sensor, let microprocessor for the work of controller trigger corresponding component device work, disinfect, and further pass the storage bottle membrane 5 that the fixed flexible material that is provided with on hole 4 gets into body 1 sampling, after opening the case lid and closing the case lid once more, a plurality of ultraviolet radiation device 13 start 30s, to the inside sterilization of box 17.
The sample storage box is also stored with a pipette sampling nozzle rack 26 and a sterile glove rack 27, and the sample storage stack support rack 23 has position numbers.
The controller is also used for commanding the controller to control the operation of the temperature (between 0 and 40 ℃) in the box body, heating and ultraviolet sterilization by the microprocessor according to parameters set by a user. When each sterilization process is finished, the microprocessor controls the controller to cut off the power supply at the corresponding compartment, and the heating and ultraviolet sterilization functions are stopped.
The connecting column 24 is arranged on a lifting rod 25 capable of lifting, when the connecting column is not used, the lifting rod 25 falls down to hide the connecting column 24 into a containing groove (not shown) in the back of the box body, and the connecting column is sealed and closed through a flip cover (not shown). The microprocessor and controller 18 is also used for controlling the lifting rod 25 to start lifting or descending through a mobile phone or a color touch screen.
The integrated device can also adjust the heating temperature, the heating time, the heating mode and the ultraviolet intensity of the heating position H. The heating pattern comprises a predetermined curve pattern heating. The curves include straight lines having a slope of 1-100, quadratic and cubic curves, and e is an exponential, quadratic, cubic function curve with a base.
The user can set the operation of sterilization of the temperature, the heating time, the heating mode, the ultraviolet lamps of the ultraviolet sterilization positions 13 and the ultraviolet sterilization devices 13 in the box body 17 and preset sampling or storage time by connecting the mobile phone app with the integrated device. The user can also set through the color touch screen 19 and edit the storage position list of the stored samples, so that the position numbers of the stored sample stack support frames 23 can be quickly found through searching through the color touch screen 19 or a mobile phone during sampling. The user can also check the setting parameters, the working state, the preset sampling or stored time information and the list of the sampling system through the color touch screen or the mobile phone. The sampling system also comprises an ultraviolet gun for irradiating and sterilizing the protective cover at regular intervals or during experiments.
When the user is reminded on the color touch screen, the user is reminded of the sampling test time by voice. The heating temperature was set at 200 ℃ for 1s by electromagnetic heating, and the ultraviolet sterilization was 30s at both the ultraviolet lamp and the plurality of ultraviolet sterilization units 13.
When the sample is stored, a user firstly sets the storage temperature of 4 ℃ on a mobile phone, places the sample on a station on a turntable at the bottom of a sample storage stack compartment, places the sample storage stack on a sample storage stack support frame 23 with a corresponding number, edits and records sample information on the list through the mobile phone, keeps the pH value of the sample at a neutral value of 7, and uses a sampling nozzle made of a metal material.
During sampling, a user can independently use the mobile phone to search the position number of the sample storage stack support frame for storing samples, find the sample storage stack with the corresponding number after the box cover is opened according to the schematic position on the screen of the mobile phone, and take out the sample storage stack from the sample storage stack support frame 23 to close the box cover. At this time, the ultraviolet irradiation devices 13 were turned on to perform sterilization treatment for 30 seconds.
The sample storage stack is placed on the operation table 21, the flip cover is opened, the lifting rod 25 is lifted by using a mobile phone, and the connecting column 25 is inserted into the jack to be connected with the interfaces of the electronic heating device and the ultraviolet lamp. Connecting the pipette with a sampling nozzle made of a metal material, inserting the sampling nozzle into the binding port 10 to an H scale mark, triggering the heating position infrared sensor at the moment, and enabling the microprocessor to instruct the controller to start the electromagnetic heating device and stop heating after 1 s. Heating completion is prompted on the mobile phone, then the mobile phone continues to be inserted to the UV scale mark, and similarly, ultraviolet sterilization completion is prompted on the mobile phone screen after the preset time of 30 s. And is inserted downwards continuously through the membrane 5 which is crossly cut through the center of the hole 4 of the sample storage bottle to penetrate into the bottle body 1, so that a sample is collected and the tying opening 10 is pulled out. At this time, the box cover is opened, the sample storage stack is placed back to the sample storage stack support frame 23, and the box cover is closed. At this time, the ultraviolet irradiation devices 13 are turned on again to perform the sterilization process for 30 seconds. Therefore, pollution-free sampling and storage of the sample are realized, and intelligent management can be performed on the storage and sampling of the sample.
Fig. 9 is a schematic diagram showing a configuration of a sample storage box of the integrated multifunctional intelligent virus detection specimen sampling and storage system according to another embodiment of the present invention.
As shown in fig. 9, the multifunctional intelligent virus detection specimen sampling and storing integrated system of the present embodiment includes a container 31 and a plurality of specimen storage stacks 11 inserted therein. The container 31 comprises a container cover 32, a cover insulating layer 33, a container body 34, a battery 35, a backing plate 36, a plate rod 37, a container contact piece 38, a container insulating layer 39 and a container 40. The sample storage stack 11 is hung in the storage 40 through a sample storage stack support frame (not shown) arranged on the inner wall of the storage 40. The cover heat preservation layer 33 is arranged in the inner space of the box cover 32, the box heat preservation layer 39 is arranged in the inner space of the box body 34, the box cover 32 is hinged to the box body 34 through hinges, the battery 35 is arranged at the bottom of the inner space of the box body 34, a base plate 36 is arranged above the battery 35 and is a PCB, in a preferred embodiment, a semiconductor refrigerating sheet is arranged on the base plate 36, a plate rod 37 is arranged above the base plate 36, a box contact sheet 38 is arranged at the top of the plate rod 37, a containing bin 40 distributed in a rectangular array is arranged in the box heat preservation layer 39, two box contact sheets 38 are arranged at the bottom of the inner space of the containing bin 40, one of the two box contact sheets 38 is connected with the positive pole of the battery 35, the other box contact sheet is connected with the negative pole of the battery 35, the two box contact sheets 38 in the containing bin 40 are regarded.
Fig. 10 is a front view showing a sample storage stack of the integrated multifunctional intelligent virus detection sample sampling and storage system according to another embodiment of the present invention. Fig. 11 is a schematic view showing a structure at a of fig. 10.
As shown in fig. 10 and 11, the sample storage stack 41 comprises a syringe 42, a piston 43, a plug seal 44, a sintered part 45, an electrothermal tube 46, a head gasket 47, a rubber cylinder 48, a temperature sensor 49, a controller 50, a core plate 51, a plate contact piece 52 and a core cover 53, wherein the preferred model of the temperature sensor 49 is PT100, and the preferred model of the controller 50 is STC89C52 RC.
The profile of the sintered piece 45 is in a circular column shape, a needle cylinder 42 is arranged inside the upper part of the sintered piece 45, a piston 43 is arranged inside the needle cylinder 42, a plug sealing ring 44 is arranged in a groove on the outer circular surface of the piston 43, a head gasket 47 is arranged on the lower end top of the needle cylinder 42, the head gasket 47 is fixedly bonded with the sintered piece 45, a cylindrical cavity is arranged in the middle of the lower end of the sintered piece 45, a cylindrical cavity is formed in the sintered piece 45 outside the cylindrical cavity, the cylindrical cavity is communicated with the cylindrical cavity through a through hole 4501, a controller 50 is arranged inside the cylindrical cavity, a temperature sensor 49 in contact with the needle cylinder 42 is arranged above the controller 50, a core cover 53 is in threaded connection with the lower end of the sintered piece 45, a core 51 is embedded in the middle of the core cover 53, two arc-shaped sheet contact pieces 52 are bonded on the lower end of the core 51, and a, the lower end of the electric heating tube 46 is arranged in a cylindrical cavity at the lower end of the sintering piece 45, a rubber cylinder 48 is filled in the cylindrical cavity, the controller 50 is respectively connected with the electric heating tube 46, the temperature sensor 49 and the plate contact piece 52 through leads, the sintering piece 45 is of an integrated structure for 3D printing, and the electric heating tube 46 is arranged in a thread groove in the sintering piece 45.
Specifically, the connection wire between the controller 50 and the electrical heating tube 46 passes through the wire hole 4501 on the lower side of the sintered part 45, and the controller 50 is connected with the sintered part 45 through a screw.
Specifically, the multifunctional intelligent virus detection sample sampling and storing integrated system is characterized in that bolts are screwed into threaded holes in the middle of a piston 43, a needle cylinder 42 with bolts is designed like an injector, mixed liquid with viruses is extracted, the bolts are detached from the piston 43 after extraction is finished, the mixed liquid is stored in the needle cylinder 42, the needle cylinder 42 is inserted into a sintering piece 45, a box cover 32 is opened to open the upper part of a box body 34, the sintering piece 45 is inserted into a containing bin 40, two plate contact pieces 52 below the sintering piece 45 are respectively contacted with two box contact pieces 38 in the containing bin 40, at the moment, a battery 35 supplies power to a controller 50, the controller 50 supplies power to an electric heating tube 46 and a temperature sensor 49, the electric heating tube 46 is powered to heat the needle cylinder 42, the temperature sensor 49 detects the temperature of the needle cylinder 42, the controller 50 limits the temperature threshold, if the temperature sensor 49 detects that the temperature is higher than the threshold, the controller 50 stops sending power to the electric heating tube 46 to cool the syringe 42, and it should be noted that the sample storage stack 11 is subjected to plastic sealing treatment before use.
Fig. 12 and 13 show the upper side and the lower side of the core plate, the plate contact piece, and the core cover of the sample storage stack in combination. As shown in fig. 12 and 13, the outer circle of the core plate 51 is provided with an annular protrusion, and the annular protrusion of the outer circle of the core plate 51 is embedded into the groove of the adjacent core cover 53, so that the design can reduce the maintenance difficulty. The core plate 51 is provided with two funnel-shaped holes, and the positions of the funnel-shaped holes correspond to the positions of the plate contact pieces 52, so that the welding of the wires and the plate contact pieces 52 is facilitated.
The integrated device can also adjust the heating temperature, the heating time and the heating mode of the electric heating tube. The heating pattern comprises a predetermined curve pattern heating. The curves include straight lines having a slope of 1-100, quadratic and cubic curves, and e is an exponential, quadratic, cubic function curve with a base.
The user can be online with the sampling system through the mobile phone app to perform temperature, heating time, heating mode in the box 34, and predetermined sampling or storage time. The user can also set through a color touch screen 19 (see fig. 8) arranged at the top of the box cover 32, and edit a storage position list of the stored samples, so that the position numbers of the stored sample storage stack supports can be quickly found through searching through the color touch screen 19 or a mobile phone during sampling. The user can also check the setting parameters, the working state, the preset sampling or stored time information and the list of the integrated device through the color touch screen or the mobile phone. The sampling system also includes an ultraviolet gun for sterilizing the sintered part 45 by irradiation at regular intervals or during experiments.
When the sample is stored, a user sets the storage temperature of the mobile phone to be 4 ℃, puts the sample storage stack on the sample storage stack support frame with the corresponding number, and edits and records the sample information in the list through the mobile phone. Therefore, pollution-free sampling and storage of the sample are realized, and intelligent management can be performed on the storage and sampling of the sample.
In summary, the present invention has been described in detail with reference to the specific embodiments, and it will be apparent to those skilled in the art that modifications can be made to the technical solutions described in the embodiments or equivalent substitutions for some technical features, and any modifications, equivalent substitutions, improvements and the like made without departing from the spirit and scope of the present invention shall fall within the protection scope of the present invention. The scope of the invention is defined by the appended claims.
Claims (9)
1. A multifunctional intelligent virus detection specimen sampling and storing integrated system,
the sampling device is characterized by comprising a sampling gun nozzle, a sample storage bottle, a sample storage stack and a sample storage box;
the sample storage box comprises a box cover, a cover heat-insulating layer, a box body, a battery, a base plate, a plate rod, a box contact piece, a box heat-insulating layer and a storage bin;
the sampling gun nozzle is placed in the sample storage box, the sample storage bottle is stored in the sample storage stack, and the sample storage stack is placed in the accommodating bin; wherein the content of the first and second substances,
the sample storage stack comprises an L-shaped shell, the lower end of the bottom of the shell is in threaded connection with a core cover, a core plate is embedded in the middle of the core cover, two arc-shaped sheet-shaped plate contact pieces are bonded at the lower end of the core plate, a plurality of sample storage compartments which are arranged in a linear direction in the shell and a first compartment storage position which is positioned at the leftmost compartment or the rightmost compartment are arranged in the shell, each compartment is placed in a drawer for storing the compartment, and the compartments which are not stored in the first compartment storage position can be drawn out in the direction vertical to the front face of the shell through the drawers of all the compartments except the compartments to generate an avoidance space, so that the compartments can be translated to the first compartment storage position in a linear mode, and the top of each compartment is provided with only one through hole for a sampling gun; a binding opening which is also provided by a flexible material film which is cut through in a cross shape at the center and is arranged above the first compartment storage position in a vertical protruding mode in the straight line direction, and a corresponding protective cover for covering the binding opening, wherein a channel for the sampling gun nozzle to enter is arranged below the binding opening, two sterilization positions are arranged in the channel from top to bottom, a short-time heating position is arranged above the channel, an ultraviolet radiation area is arranged below the channel, at least two work stations for placing the sample storage bottles are arranged at the bottom of each compartment, the bottom of each compartment further comprises a rotary disc which can rotate through a rotary piece at the top of the compartment, and the work stations are arranged on the rotary disc; when one compartment is in the first compartment storage position, each sample storage bottle can rotate the rotating disc through the rotating piece to a position where the tying center, the sample storage bottle hole center and the perforation center are overlapped in a top view direction; when the sample storage bottle rotates to reach the overlapped position, the center of the channel is over against the center of the hole of the sample storage bottle, and each sterilization position is provided with an infrared sensor for sensing the passing of a sampling gun nozzle; the bottom surface of the rotary table is provided with a guide sheet which can form an electric loop when being abutted against the plate contact sheet.
2. The integrated multifunctional intelligent virus detection specimen sampling and storing system according to claim 1, wherein the cover heat preservation layer is arranged in the inner space of the case cover, the case heat preservation layer is arranged in the inner space of the case body, the case cover and the case body are hinged through hinges, the battery is arranged at the bottom of the inner space of the case body, a base plate is arranged above the battery, the base plate is a PCB (printed circuit board), a plate bar is arranged above the base plate, case contact pieces are arranged at the top of the plate bar, the case heat preservation layer is internally provided with the bins distributed in a rectangular array, and two case contact pieces are arranged at the bottom of the inner space of each bin.
3. The integrated multifunctional intelligent virus detection specimen sampling and storing system according to claim 1, wherein the sample storage bottle comprises a bottle body and a bottle cap, the bottle cap is provided with a label plate extending horizontally and a hole for inserting the sampling gun nozzle, a membrane made of flexible material is fixedly arranged on the hole, the center of the membrane is coincident with the center of the hole, and the membrane is cut through in the center of the membrane in a cross manner so that the sampling gun nozzle can be inserted into the bottle body of the sample storage bottle for sampling.
4. The integrated multifunctional intelligent virus detection specimen sampling and preserving system of claim 1, wherein each compartment and the front and back surfaces of the L-shaped housing are respectively provided with a mutually slidable translation device, the translation devices are a guide rail on the front and back surfaces of the L-shaped housing and a translation wheel mounted on the front and back surfaces of each compartment, and a gate is mounted at the linear end of the L-shaped housing relative to the first compartment storage position and used for opening so as to push and translate the compartment stored in any non-first compartment storage position, and a hook portion for pulling back the compartment stored in any non-first compartment storage position is arranged on one side of the compartment stored in any non-first compartment storage position.
5. The multifunctional intelligent virus detection specimen sampling and storing integrated system according to claim 1, wherein the sample storage box further comprises a socket, a controller, a microprocessor, a color touch screen for displaying the use state of each parameter and setting by a user, an operation panel, a plurality of ultraviolet radiation devices, a semiconductor refrigerator, and a temperature sensor, and a plurality of sample storage stack supports are hung on the inner wall of the storage bin; the operation panel is located the outer horizontal surface of box, the operation panel set up with the spliced pole that the socket corresponds, when the storehouse of depositing the appearance was placed on the operation panel, socket butt joint spliced pole to according to the position of disinfecting that corresponding sampling rifle mouth reached, trigger corresponding infrared sensor, let microprocessor for controller work trigger corresponding component device work, disinfect, and further pass the fixed membrane that is provided with flexible material on the bottle hole of depositing the appearance and get into the body sampling, after opening the case lid and closing the case lid once more, a plurality of ultraviolet radiation devices start, to the inside sterilization treatment of box.
6. The integrated multifunctional intelligent virus detection specimen sampling and storing system of claim 1, wherein the sample storage stack comprises a syringe, a piston, a plug seal ring, a sintered part, an electrothermal tube, a head gasket, a rubber cylinder, a core plate, a plate contact piece and a core cover.
7. The integrated multifunctional intelligent virus detection specimen sampling and storing system of claim 6, wherein the sintered part has a cylindrical contour, a needle cylinder is disposed inside the sintered part, a piston is disposed inside the needle cylinder, a plug seal ring is disposed in a groove on the outer circumferential surface of the piston, a head gasket is disposed on the lower end of the needle cylinder, the head gasket is bonded and fixed to the sintered part, a cylindrical cavity is disposed in the middle of the lower end of the sintered part, a cylindrical cavity is formed in the sintered part outside the cylindrical cavity, the cylindrical cavity and the cylindrical cavity are communicated through a thread hole, a core cover is screwed to the lower end of the sintered part, a core plate is embedded in the middle of the core cover, two arc-shaped plate contact pieces are bonded to the lower end of the core plate, a spiral electric heating tube is disposed inside the outer circumferential surface of the sintered part, and the lower end of the electric heating tube is disposed in the, the cylindrical cavity is filled with a rubber cylinder.
8. The integrated system for sampling and storing a multifunctional intelligent virus detection specimen according to any one of claims 1 to 7, wherein a user is reminded by a mobile app short message or a color touch screen before a predetermined sampling or storing time comes; when the user is reminded by selecting the colorful touch screen, screen flashing and/or voice reminding are adopted.
9. The integrated multifunctional intelligent virus detection specimen sampling and preservation system according to any one of claims 1 to 7, further comprising a periodic sterilization device ultraviolet gun for irradiating and sterilizing the protective cover periodically or during an experiment.
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| CN113308364A (en) * | 2021-06-09 | 2021-08-27 | 北京京东方技术开发有限公司 | Nucleic acid extraction substrate, nucleic acid extraction apparatus, and nucleic acid extraction method |
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