CN206410940U - A kind of surgical operation sealing agent BURSTING STRENGTH detection means - Google Patents
A kind of surgical operation sealing agent BURSTING STRENGTH detection means Download PDFInfo
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- CN206410940U CN206410940U CN201621312611.0U CN201621312611U CN206410940U CN 206410940 U CN206410940 U CN 206410940U CN 201621312611 U CN201621312611 U CN 201621312611U CN 206410940 U CN206410940 U CN 206410940U
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Abstract
The utility model discloses a kind of surgical operation sealing agent BURSTING STRENGTH detection means, including matrix lock chamber（1）, matrix retainer ring（2）, piston（3）, pressure sensor（4）, recorder（6）And booster pump（7）；Wherein, matrix retainer ring（2）It is fixed on matrix lock chamber（1）On；Matrix lock chamber（1）Upper end open, inside sets piston（3）, bottom passes through thribble road（5）Respectively with pressure sensor（4）And booster pump（7）Connection, pressure sensor（4）With recorder（6）It is connected.Surgical operation sealing agent BURSTING STRENGTH detection means described in the utility model can be detected to the mechanical property of surgical operation sealing agent gel liquid soaking conditionses, simple in construction, easy to use, with it is safer, reliable, environmentally friendly, facilitate the features such as.
Description
Technical field
The utility model belongs to material property testing equipment field, and in particular to a kind of surgical operation sealing agent BURSTING STRENGTH
Detection means.
Background technology
Hydrogel, as a kind of biocompatible materials, is the three-dimensional net structure polymer that a class has hydrophilic radical,
Because the physical crosslinking between polymer chain and chemical crosslinking are acted on, hydrogel can be water-swellable but water insoluble and keep certain
Shape.Medically, hydrogel can be used for Wound dressing, Post operation to prevent adhesion, perform the operation in hemostasis, tissue filling, prevent tissue
Liquid seepage or gas leakage etc..When hydrogel is used as tissue fluid seepage or the closure of gas leakage mechanical, also referred to as surgery hand
Art sealing agent.
Sealing agent of performing the operation has many potential medical applications, including closes wound, suture is aided in surgical operation
Or suturing nail, it is used as barrier for preventing post-operation adhesion and as hemostasis sealing agent etc..Current Fibrin Glue is commonly used for outer
Section's operation sealing agent, it is made up of human or animal's fibrinogen, fibrin ferment and gel accelerator.Bonded as a kind of two-component
Agent, rapid reaction forms gel after mixing.The gel formed can adhere to tissue, stop blooding, bridge tissue surface of a wound etc. directly
Untill healing.
The hydrogel material gel time of two-component can be adjusted according to composition, such as glutaraldehyde/bovine serum albumin(BSA)
The gel time is more than 30 seconds, Bard companies Progel（Albumin/polyethylene glycol gel）Gel time is less than 15 seconds,
Baxter companies Coseal（Two-component polyethylene glycol gel）Gel time is less than 10 seconds.It is very fast for gelation rate（Such as gel
Time is less than the gel of 20 seconds）Two-component gel be difficult to by rheometer detect gel modulus of elasticity.Burst by detection
Intensity can be evaluated the intensity of surgical operating sealing agent.
Chinese patent application 201610194316.8 provides a kind of surgical operation sealing agent BURSTING STRENGTH detection means, can
The sealing strength that detection surgical operation sealing agent is sprayed to after material surface.During clinical practice use, surgical operation envelope
The gel formed after mixture spraying, will be swelled with absorbing moisture after bioresorbable, with the soak time in body fluid
Extension, the sealing strength of gel will likely change, and research gel strength is as the change of the extension of soak time is to clinic
Using with directive significance.
Accordingly, it would be desirable to develop a kind of BURSTING STRENGTH detection means of hydrogel in liquid immersion, can be to surgical operation
Mechanical property after sealing agent use is evaluated.
The content of the invention
The utility model provides a kind of surgical operation sealing agent BURSTING STRENGTH detection means easy to operate, can be to surgery hand
The mechanical property of art sealing agent gel liquid soaking conditionses is detected.
Material BURSTING STRENGTH detection means described in the utility model, including matrix lock chamber（1）, matrix retainer ring（2）、
Piston（3）, pressure sensor（4）, recorder（6）And booster pump（7）；Wherein, matrix retainer ring (2) is fixed on matrix and fixed
On chamber (1)；Matrix lock chamber (1) upper end open, inside sets piston（3）, bottom is passed with pressure respectively by thribble road (5)
Sensor (4) and booster pump (7) connection, pressure sensor (4) are connected with recorder (6).
In above-mentioned intensity detecting device, matrix lock chamber is by hard material systems such as stainless steel, polyformaldehyde or polyether-ether-ketones
Into.Its shape can be cylinder, cube or other arbitrary shapes, preferably cylinder.It is preferred that matrix lock chamber be
External diameter 20-80mm, internal diameter 18-78mm, high 5-50mm cavity.
In above-mentioned intensity detecting device, piston is set inside matrix lock chamber, can be moved freely, piston inner diameter is 18-
78mm, height h are 1-10mm.The effect of piston is to isolate the liquid in matrix lock chamber with bottom, prevents liquid from matrix
Flowed in lock chamber in thribble road.
In above-mentioned intensity detecting device, matrix retainer ring is fixed on matrix lock chamber by screw thread, screw or fastener
On, preferably it is threadably secured.The effect of matrix retainer ring is that matrix membrane is fixed on matrix chamber, and matrix membrane is casing, pig
The uncrosslinked albuminous membranae material such as skin or pericardium, so that simulated human tissue seals the contact of agent material with surgical operating
State.Matrix membrane when in use, is first covered on matrix lock chamber by intensity detecting device, by matrix retainer ring by matrix membrane
Fixed, matrix center membrane is punched with card punch, and pore diameter range is preferably 2-5mm.
In above-mentioned intensity detecting device, booster pump can be gas boosting pump or liquid booster pump.Booster pump pressure limit
Preferably 0-50kPa.
In above-mentioned intensity detecting device, preferably a liquid crystal display recorder is connected with pressure sensor, in favor of note
Record Strength Changes.Pressure sensor preferred scope is in 0-100kPa, accuracy rating ± 0.1%-0.5%.
As a kind of preferred embodiment, the utility model provides a kind of intensity detecting device, including matrix is fixed
Chamber（1）, matrix retainer ring（2）, piston（3）, pressure sensor（4）, recorder（6）, booster pump（7）With piston limit device（8）；
Wherein, matrix retainer ring (2) is fixed by snap on matrix lock chamber (1)；Matrix lock chamber (1) upper end open, inside is set
Put piston（3）With piston limit device（8）, bottom is connected with pressure sensor (4) and booster pump (7) respectively by thribble road (5)
Connect, pressure sensor (4) is connected with recorder (6).
In above-mentioned intensity detecting device, piston limit device is set inside matrix lock chamber.The effect of piston limit device is anti-
Only in pressurization, piston removes matrix lock chamber.
Material BURSTING STRENGTH detection means described in the utility model, it is simple in construction, it is easy to use, material is can detect in liquid
BURSTING STRENGTH under body soaking conditionses.The utility model also demonstrates described detection means and burst by force in surgical operation sealing agent
Application in degree detection.When in use, piston is first slided into matrix lock chamber bottom, injects liquid into matrix lock chamber
In, fill after liquid, matrix membrane is covered on matrix lock chamber, matrix membrane is fixed on into matrix by matrix retainer ring fixes
On chamber.Liquid can be physiological saline or isotonic phosphate buffer liquid, in favor of simulation human body fluid.Matrix membrane is casing, pigskin
Or the uncrosslinked albuminous membranae material such as pericardium, so that simulated human tissue seals the contact shape of agent material with surgical operating
State.After fixing, matrix center membrane is punched with card punch, and pore diameter range is preferably 2-5mm.Then by material to be detected as outside
Section sprays to stromal surface with operation sealing agent, and after after surgical operation sealing agent gel, a small amount of physiology salt is injected on gel upper strata
Water, gel is submerged.Soak after a period of time, open booster pump, recorder record Strength Changes.Surgical operation sealing agent
Gel breaks, or sealing agent are peeled off with matrix, and intensity reduces.The maximum that intensity reaches is that surgical operation sealing agent bursts
Intensity.It is adapted to the surgical operating sealing agent such as hydrogel material of detection, Progel sealing agents (the white egg of such as Bard companies
In vain/polyethylene glycol gel), Coseal sealing agents (two-component polyethylene glycol gel), the Confluent of Baxter companies
Surgical companies DuraSeal sealing agents, HyperBranch Medical Technology company's Adherus sealing agents and
Ocuseal sealing agents, CryoLife companies BioGlue surgical adhesives etc..In addition, the device is also applied for tissue adhesion
Agent (such as Ethicon DERMABOND surgical appliance adhesives) and the sealing strength inspection of styptic (such as lyophilized condition of human blood fibrin glue)
Survey.Surgical operation sealing agent BURSTING STRENGTH detection means described in the utility model, it is simple in construction, it is easy to use.
The maximum of intensity that recorder is recorded when surgical operation sealing agent bursts is Pmax, immersion liquid density is ρLiquid, leaching
Bubble liquid height is HLiquid, acceleration of gravity is g, and piston density is ρPiston, depth pistion is hPiston, surgical operation is calculated as follows
Sealing agent BURSTING STRENGTH P：
P=Pmax-ρLiquid×g×HLiquid-ρPiston×g×hPiston
Described material BURSTING STRENGTH detection means of the present utility model, preferably can also be used to detect seralbumin gel
BURSTING STRENGTH, the specific preparation technology of the gel may be referred to the .0 of Chinese patent application 201510960917, herein all
It is incorporated herein by reference.Described seralbumin gel can be prepared by following preferred method：
(1) the first liquid component, is prepared：Seralbumin is dissolved in pH scopes in 6 .0-10 .0 cushioning liquid to match somebody with somebody
The serum albumin solution that concentration is 5%-45% (w/v) is made；It is preferred that, described serum albumin solution can be via radiation
Processing, irradiation dose scope is between 5kGy-45kGy；
(2) second liquid component, is prepared：Hydrophilic polymer solid constituent containing electrophilic functional group is dissolved in pH
Scope is in 6 .0-10 .0 cushioning liquid, it is the hydrophilic containing electrophilic functional group of 5%~45% (w/v) that preparation, which obtains concentration,
Property polymers compositions solution, wherein the blood in the described hydrophilic polymer components and the first liquid component containing electrophilic functional group
The mass ratio of pure albumen is 0 .3-2；
(3), the first liquid component is mixed with second liquid component, seralbumin gel is cross-linked to form.
Hydrophilic polymer containing electrophilic functional group can be selected from double amber imide propionic acid ester group polyethylene glycol, double ambers
Amber acid imide butanedioic acid ester group polyethylene glycol, double amber imide glutaric acid ester group polyethylene glycol, double amber imide decanedioic acid
Ester group polyethylene glycol, the succinimidyl glutarate of pentaerythritol polyethylene glycol ether four, the succinyl of pentaerythritol polyethylene glycol ether four
One or more in imines succinic acid, the succinimide decanedioic acid of pentaerythritol polyethylene glycol ether four, molecular weight is 1000-
100000, preferably 2000-50000, more preferably 3000-20000.It is preferred that double amber imide butanedioic acid ester group polyethylene glycol,
Molecular weight is 1000-100000, preferably 2000-50000, more preferably 3000-20000.
Described seralbumin gel can be used for the bonding of wound in the various surgical operations of human body, hemostasis, antiseep or
Application in preventing adhesion, for example, medically can be used for angiocarpy, department of general surgery, department of plastic surgery, neurosurgery, ophthalmology, bone surgery
Or defective tissue is sealed during pulmonary surgery.
BURSTING STRENGTH detection means described in the utility model be particularly suitable for use in organize the surgical operation sealing agent that contacts or
Sealing strength detection of the person tissue adhesive under liquid soaking conditionses.The device is economical and practical, convenient, high performance-price ratio, detection
It is light and flexible, the operation of convenient use personnel, with it is safer, reliable, environmentally friendly, facilitate the features such as.
Brief description of the drawings
Fig. 1 is material BURSTING STRENGTH detection means schematic diagram described in the utility model.1 is matrix lock chamber in figure, and 2 be base
Matter retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be thribble road, and 6 be liquid crystal display recorder, and 7 be booster pump.
Fig. 2 is material BURSTING STRENGTH detection means schematic diagram described in the utility model.1 is matrix lock chamber in figure, and 2 be base
Matter retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be thribble road, and 6 be liquid crystal display recorder, and 7 be booster pump, and 8 be work
Fill in limiter.
Embodiment
Preferred embodiment of the present utility model is described in detail below in conjunction with the accompanying drawings, so that advantage of the present utility model
It can be easier to be readily appreciated by one skilled in the art with feature, so as to make apparent bright to protection domain of the present utility model
Really.
Embodiment 1
As shown in figure 1, in figure 1 be matrix lock chamber, 2 be matrix retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be three
Union road, 6 be liquid crystal display recorder, and 7 be booster pump.
Matrix lock chamber is external diameter 35mm, and internal diameter 30mm, high 50mm cavity is made up of aluminium alloy.Piston diameter 30mm,
Height h is 10mm, is made up of aluminium alloy, density is 2.7g/cm3.Piston is first slided into matrix lock chamber bottom, by physiology salt
Water is injected into matrix lock chamber, and cavity fills physiological saline.Host material is casing membrane material, and a diameter of 80mm, center is used
Card punch is punched, aperture 3mm.Host material is fixed on matrix lock chamber by matrix retainer ring, matrix retainer ring and base
Matter lock chamber is fixed by fastener or screw.
.4 grams of gelatin 0 (20%, w/v) is taken to be dissolved in 2mL phosphate buffers (10mM, the pH prepared by deionized water
7 .4).37 DEG C of occasional agitations 1 hour, dissolve it, after after gelatin, thoroughly dissolving turns into transparence liquid, are evacuated with vavuum pump
Make it that within 30 minutes that bubble is quickly eliminated in solution.
The .2g of double amber imide butanedioic acid ester group polyethylene glycol 0 that molecular weight is 5000 is weighed, is dissolved in by deionization
The 2ml phosphate buffers (10mM, pH 8.6) that water is prepared, vortex makes its dissolving turn into transparence liquid.
Under room temperature condition, gelatin solution is well mixed in equal volume with double amber imide succinate polyglycol solution
Afterwards, stromal surface is sprayed to, after after gel, opening booster pump, recorder records Strength Changes.Gelatin/double amber imide amber
Amber perester radical polyethylene glycol surgical operation sealing agent gel breaks, the maximum P that the intensity of record reachesmaxIt is bright for 15.9kPa
At once BURSTING STRENGTH is 9.2kPa to glue/double amber imide butanedioic acid ester group polyethylene glycol section operation sealing agent（P=Pmax-ρLiquid×
g×HLiquid-ρAluminium alloy×g×hAluminium alloy= 15.9×103Pa -1×103×10×0.4Pa-2.7×103×10×0.1Pa=9.2
×103Pa）.
Embodiment 2
As shown in figure 1, in figure 1 be matrix lock chamber, 2 be matrix retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be three
Union road, 6 be liquid crystal display recorder, and 7 be booster pump.
Matrix lock chamber is external diameter 35mm, and internal diameter 30mm, high 50mm cavity is made up of aluminium alloy.Piston diameter 30mm,
Height h is 10mm, is made up of aluminium alloy, density is 2.71g/cm3.Piston is first slided into matrix lock chamber bottom, by physiology
Salt solution is injected into matrix lock chamber, and cavity fills physiological saline.Host material is casing membrane material, a diameter of 80mm, center
Punched with card punch, aperture 3mm.Host material is fixed on matrix lock chamber by matrix retainer ring, matrix retainer ring and
Matrix lock chamber is fixed by fastener or screw.
.4 grams of gelatin 0 (20%, w/v) is taken to be dissolved in 2mL phosphate buffers (10mM, the pH prepared by deionized water
7 .4).37 DEG C of occasional agitations 1 hour, dissolve it, after after gelatin, thoroughly dissolving turns into transparence liquid, are evacuated with vavuum pump
Make it that within 30 minutes that bubble is quickly eliminated in solution.
The .2g of double amber imide butanedioic acid ester group polyethylene glycol 0 that molecular weight is 5000 is weighed, is dissolved in by deionization
The 2ml phosphate buffers (10mM, pH 8.6) that water is prepared, vortex makes its dissolving turn into transparence liquid.
Under room temperature condition, gelatin solution is well mixed in equal volume with double amber imide succinate polyglycol solution
Afterwards, stromal surface is sprayed to, after after gel, a small amount of physiological saline is injected on gel upper strata, gel is submerged.After immersion 1 hour,
Open booster pump, recorder record Strength Changes.Gelatin/double amber imide butanedioic acid ester group polyethylene glycol surgical operation sealing
Agent gel breaks, the maximum P that the intensity of record reachesmaxFor 12.4kPa, the gelatin/poly- second of double amber imide butanedioic acid ester group
BURSTING STRENGTH is 5.7kPa after glycol surgical operation sealing agent physiological saline soaks 30 minutes（P=Pmax-ρLiquid×g×HLiquid-ρAluminium alloy
×g×hAluminium alloy= 12.4×103Pa -1×103×10×0.4 Pa -2.7×103×10×0.1 Pa =5.7×103
Pa）.
Embodiment 3
As shown in Fig. 2 in figure 1 be matrix lock chamber, 2 be matrix retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be three
Union road, 6 be liquid crystal display recorder, and 7 be booster pump, and 8 be piston limit device.
Matrix lock chamber is external diameter 35mm, and internal diameter 30mm, high 50mm cavity is made up of aluminium alloy.Piston diameter 30mm,
Height h is 5mm, is made up of aluminium alloy, density is 2.71g/cm3.Piston is first slided into matrix lock chamber bottom, by physiology salt
Water is injected into matrix lock chamber, and cavity fills physiological saline.Host material is casing membrane material, and a diameter of 80mm, center is used
Card punch is punched, aperture 3mm.Host material is fixed on matrix lock chamber by matrix retainer ring, matrix retainer ring and base
Matter lock chamber is fixed by fastener.
.4 grams of the human serum albumins 0 (20%, w/v) for taking blood plasma to originate, is dissolved in the 2mL phosphorus prepared by deionized water
Phthalate buffer (.4 of 10mM, pH 7).37 DEG C of occasional agitations 1 hour, dissolve it, treat that thoroughly dissolving turns into transparence to albumen
After liquid, it is evacuated with vavuum pump and make it that within 30 minutes that bubble is quickly eliminated in solution.The human serum albumin solution that blood plasma is originated
Through electron beam irradiation, irradiation dose is 20kGy.
The .3g of double amber imide butanedioic acid ester group polyethylene glycol 0 that molecular weight is 5000 is weighed, is dissolved in by deionization
The 2ml phosphate buffers (10mM, pH 8.4) that water is prepared, vortex makes its dissolving turn into transparence liquid.
Under room temperature condition, the human serum albumin solution that blood plasma is originated and double amber imide succinate polyethylene glycol
After solution is well mixed in equal volume, sprays to host surface and be cross-linked to form seralbumin gel.Open booster pump, record
Instrument records Strength Changes.Human serum albumins/double amber imide butanedioic acid ester group polyethylene glycol surgical operation sealing agent gel
Rupture, the maximum P that the intensity of record reachesmaxFor 21.6kPa, human serum albumins/double amber imide butanedioic acid ester group gathers
At once BURSTING STRENGTH is 15.8kPa to ethylene glycol section operation sealing agent（P=Pmax-ρLiquid×g×HLiquid-ρAluminium alloy×g×hAluminium alloy= 21.6
×103 Pa -1×103×10×0.45 Pa -2.7×103×10×0.05 Pa =15.8×103Pa）.
Embodiment 4
As shown in Fig. 2 in figure 1 be matrix lock chamber, 2 be matrix retainer ring, 3 be piston, and 4 be pressure sensor, and 5 be three
Union road, 6 be liquid crystal display recorder, and 7 be booster pump, and 8 be piston limit device.
Matrix lock chamber is external diameter 35mm, and internal diameter 30mm, high 50mm cavity is made up of aluminium alloy.Piston diameter 30mm,
Height h is 5mm, is made up of aluminium alloy, density is 2.71g/cm3.Piston is first slided into matrix lock chamber bottom, by physiology salt
Water is injected into matrix lock chamber, and cavity fills physiological saline.Host material is casing membrane material, and a diameter of 80mm, center is used
Card punch is punched, aperture 3mm.Host material is fixed on matrix lock chamber by matrix retainer ring, matrix retainer ring and base
Matter lock chamber is fixed by fastener.
.4 grams of the human serum albumins 0 (20%, w/v) for taking blood plasma to originate, is dissolved in the 2mL phosphorus prepared by deionized water
Phthalate buffer (.4 of 10mM, pH 7).37 DEG C of occasional agitations 1 hour, dissolve it, treat that thoroughly dissolving turns into transparence to albumen
After liquid, it is evacuated with vavuum pump and make it that within 30 minutes that bubble is quickly eliminated in solution.The human serum albumin solution that blood plasma is originated
Through electron beam irradiation, irradiation dose is 20kGy.
The .3g of double amber imide butanedioic acid ester group polyethylene glycol 0 that molecular weight is 5000 is weighed, is dissolved in by deionization
The 2ml phosphate buffers (10mM, pH 8.4) that water is prepared, vortex makes its dissolving turn into transparence liquid.
Under room temperature condition, the human serum albumin solution that blood plasma is originated and double amber imide succinate polyethylene glycol
After solution is well mixed in equal volume, sprays to host surface and be cross-linked to form seralbumin gel.After after gel, in gel
A small amount of physiological saline is injected on upper strata, and gel is submerged.After immersion 4 hours, booster pump, recorder record Strength Changes are opened.People
Seralbumin/double amber imide butanedioic acid ester group polyethylene glycol surgical operation sealing agent gel breaks, the intensity of record reaches
The maximum P arrivedmaxFor 18.5kPa, human serum albumins/double amber imide butanedioic acid ester group polyethylene glycol section operation sealing
BURSTING STRENGTH is 12.7kPa after agent is soaked 4 hours（P=Pmax-ρLiquid×g×HLiquid-ρAluminium alloy×g×hAluminium alloy= 18.5×103 Pa
-1×103×10×0.45 Pa -2.7×103×10×0.05 Pa =12.7×103kPa）.
Claims (9)
1. a kind of surgical operation sealing agent BURSTING STRENGTH detection means, including matrix lock chamber (1), matrix retainer ring (2), piston
(3), pressure sensor (4), recorder (6) and booster pump (7)；Wherein, matrix retainer ring (2) is fixed on matrix lock chamber (1)
On；Matrix lock chamber (1) upper end open, inside set piston (3), bottom by thribble road (5) respectively with pressure sensor
(4) connected with booster pump (7), pressure sensor (4) is connected with recorder (6).
2. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 1, it is characterised in that：In described device
Matrix lock chamber is shaped as cylinder or cube.
3. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 2, it is characterised in that：In described device
Matrix lock chamber is external diameter 20-80mm, internal diameter 18-78mm, high 5-50mm cylinder.
4. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 1, it is characterised in that：Piston is in matrix
It can be moved freely in lock chamber.
5. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 1, it is characterised in that：Described device bag
Containing a matrix membrane, the matrix membrane is covered on matrix lock chamber, is fixed matrix membrane by matrix retainer ring, matrix center membrane
Punched with card punch；The matrix membrane is casing, pigskin or pericardium.
6. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 5, it is characterised in that：In described device
Matrix membrane punching back aperture scope is 2-5mm.
7. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 1, it is characterised in that：Described device
In, booster pump is gas boosting pump or liquid booster pump.
8. surgical operation sealing agent BURSTING STRENGTH detection means according to claim 1, it is characterised in that：In described device
Liquid crystal display recorder is connected with pressure sensor, in favor of record Strength Changes.
9. a kind of surgical operation sealing agent BURSTING STRENGTH detection means, including matrix lock chamber (1), matrix retainer ring (2), piston
(3), pressure sensor (4), recorder (6), booster pump (7) and piston limit device (8)；Wherein, matrix retainer ring (2) passes through card
Button is fixed on matrix lock chamber (1)；Matrix lock chamber (1) upper end open, inside sets piston (3) and piston limit device (8),
Bottom is connected with pressure sensor (4) and booster pump (7) respectively by thribble road (5), pressure sensor (4) and recorder
(6) it is connected.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621312611.0U CN206410940U (en) | 2016-12-02 | 2016-12-02 | A kind of surgical operation sealing agent BURSTING STRENGTH detection means |
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