CN205620240U - Intensity detection device is burst with involution agent to surgery operation - Google Patents

Abstract

The utility model discloses an intensity detection device is burst with involution agent to surgery operation, including matrix fixed chamber (1), matrix solid fixed ring (2), booster pump (3), pressure sensor (4) and record appearance (6), wherein, matrix solid fixed ring (2) are fixed in matrix fixed chamber (1), chamber (1) upper end opening is fixed to matrix, and the bottom is passed through trigeminy pipeline (5) and is connected with booster pump (3) and pressure sensor (4) respectively, and pressure sensor (4) are with to write down appearance (6) continuous. Intensity detection device is burst with involution agent to surgery operation simple structure, convenient to use has characteristics such as safer, reliable, environmental protection, convenience.

Description

A kind of surgical operation sealing agent BURSTING STRENGTH detects device

Technical field

This utility model belongs to material property detection apparatus field, is specifically related to a kind of surgical operation Device is detected with sealing agent BURSTING STRENGTH.

Background technology

Hydrogel as a kind of biocompatible materials, is the class three dimensional network with hydrophilic group Network structural polymer, due to the physical crosslinking between polymer chain and chemical crosslinking effect, hydrogel Can be water-swellable but water insoluble and keep certain shape.Medically, hydrogel can be used for Wound dressing, Post operation anti, operation in hemostasis, tissue filling, prevent tissue fluid seepage Or gas leakage etc..When hydrogel is used as tissue fluid seepage or the closure of gas leakage mechanical, also It is referred to as surgical operation sealing agent.

Operation sealing agent has the most potential medical applications, including Guan Bi wound, at surgery Operation assists stitching thread or suturing nail, stops as the barrier and conduct preventing tissue adhesion Blood sealing agent etc..Fibrin Glue is commonly used for surgical operation sealing agent at present, and it is by human or animal Fibrinogen, thrombin and gel accelerator composition.As a kind of two-component adhesive, mixed After conjunction, reaction forms gel rapidly.The gel formed can adhere to tissue, hemostasis, bridge Connect tissue wound surface etc. till healing.

The hydrogel material gel time of double-component can be adjusted according to composition, such as glutaraldehyde The gel time of/bovine serum albumin white gel is more than 30 seconds, Bard company Progel (white egg In vain/polyethylene glycol gel) gel time less than 15 seconds, Baxter company Coseal (double groups Part polyethylene glycol gel) gel time is less than 10 seconds.Very fast (such as gel for gelation rate Time was less than the gel of 20 seconds) double-component gel be difficult to the bullet by flow graph detection gel Property modulus.

Accordingly, it would be desirable to develop a kind of new simple and feasible hydrogel intensity detection device, pass through The mechanical property of surgical operating sealing agent can be evaluated by detection BURSTING STRENGTH.

Summary of the invention

The purpose of this utility model is to provide a kind of material BURSTING STRENGTH easy and simple to handle to detect Device.

Material BURSTING STRENGTH described in the utility model detection device, including substrate lock chamber (1), Substrate retainer ring (2), booster pump (3), pressure transducer (4) and monitor (6)；Wherein, Substrate retainer ring (2) is fixed on substrate lock chamber (1)；Substrate lock chamber (1) upper end Opening, bottom by thribble road (5) respectively with booster pump (3) and pressure transducer (4) Connecting, pressure transducer (4) is connected with monitor (6).

In above-mentioned intensity detecting device, substrate lock chamber is by rustless steel, polyformaldehyde or polyethers ether The hard materials such as ketone are made.Its shape can be cylinder, cube or other arbitrary shapes, It is preferably cylinder.Preferably substrate lock chamber is external diameter 20-80mm, internal diameter 18-78mm, The cavity of high 5-50mm.

In above-mentioned intensity detecting device, substrate retainer ring is solid by screw thread, screw or fastener It is scheduled on substrate lock chamber, is preferably threadably secured.The effect of substrate retainer ring is by substrate Film is fixed on substrate chamber, and matrix membrane is the uncrosslinked albuminous membranaes such as casing, Corii Sus domestica or pericardium Material, is beneficial to the contact condition of simulated human tissue and surgical operating sealing agent material.By force Matrix membrane in use, is first covered on substrate lock chamber by degree detection device, solid by substrate Determining ring to be fixed by matrix membrane, matrix membrane center card punch punches, and pore diameter range is preferably 2-5mm.

In above-mentioned intensity detecting device, preferably connect an exhaust-valve in substrate lock chamber side, It is beneficial to regulate the pressure limit of substrate lock chamber.

In above-mentioned intensity detecting device, booster pump can be gas boosting pump or liquid booster pump. Booster pump pressure limit is preferably 0-50kPa.If during liquid booster pump, then substrate lock chamber Side must connect an exhaust-valve, is beneficial to the discharge toward substrate lock chamber perfusion liquid space-time gas.

In above-mentioned intensity detecting device, preferably by liquid crystal display monitor and a pressure transducer Connect, be beneficial to record Strength Changes.The preferred scope of pressure transducer is in 0-100kPa, essence Degree scope ± 0.1%-0.5%.

As a kind of preferred embodiment, this utility model provides a kind of intensity detecting device, Including substrate lock chamber (1), substrate retainer ring (2), booster pump (3), pressure transducer (4), Monitor (6) and exhaust-valve (7)；Wherein, substrate retainer ring (2) passes through screw thread and base Matter lock chamber (1) connects fixing；Substrate lock chamber (1) upper end open, side connects a row Empty valve (7), bottom by thribble road (5) respectively with booster pump (3) and pressure sensing Device (4) connects, and pressure transducer (4) is connected with monitor (6).

Material BURSTING STRENGTH described in the utility model detection device, simple in construction, easy to use. This utility model also demonstrates described detection device at surgical operation sealing agent BURSTING STRENGTH Application in detection.In use, first matrix membrane is covered on substrate lock chamber, pass through base Matrix membrane is fixed on substrate lock chamber by matter retainer ring.Matrix membrane is casing, Corii Sus domestica or pericardium The uncrosslinked albuminous membranae material such as film, is beneficial to simulated human tissue and surgical operating sealing agent The contact condition of material.After fixing, matrix membrane center card punch punches, and pore diameter range is excellent Elect 2-5mm as.Then material to be detected such as surgical operating sealing agent is sprayed to substrate table Face, until surgical operation with after sealing agent gel, closes exhaust-valve, opens booster pump, monitor Record Strength Changes.Surgical operation sealing agent gel breaks, or sealing agent and substrate peels off, Intensity reduces.The maximum that intensity reaches is surgical operation sealing agent BURSTING STRENGTH.It is suitable for The surgical operating sealing agent such as hydrogel material of detection, the Progel envelope of such as Bard company Mixture (albumin/polyethylene glycol gel), the Coseal sealing agent (double groups of Baxter company Part polyethylene glycol gel), Confluent Surgical company DuraSeal sealing agent, HyperBranch Medical Technology company's Adherus sealing agent and Ocuseal Sealing agent, CryoLife company BioGlue surgical adhesive etc..Additionally, this device It is also applied for tissue adhesive's (such as DERMABOND surgical appliance adhesive of Ethicon) and hemostasis The sealing strength detection of agent (such as lyophilizing condition of human blood fibrin glue).

Described material BURSTING STRENGTH detection device of the present utility model, preferably can be additionally used in detection The BURSTING STRENGTH of serum albumin gel, the concrete preparation technology of described gel is referred to China Patent application 201510960917.0, is hereby incorporated by reference.Described serum is white Protein gel can be prepared by following preferably method:

(1), preparation first liquid component: it is 6.0-10.0 that serum albumin is dissolved in pH scope In buffer solution, preparation obtains the serum albumin solution that concentration is 5%-45% (w/v)；Preferably , described serum albumin solution can process via radiation, and irradiation dose scope is Between 5kGy-45kGy；

(2), preparation second liquid component: by the hydrophilic polymer containing electrophilic functional group Solid constituent is dissolved in the buffer solution that pH scope is 6.0-10.0, and preparation obtains concentration and is The hydrophilic polymer components solution containing electrophilic functional group of 5%～45% (w/v), wherein said The hydrophilic polymer components containing electrophilic functional group and first liquid component in the white egg of serum White mass ratio is 0.3-2；

(3), first liquid component is mixed with second liquid component, be cross-linked to form serum white Protein gel.

Hydrophilic polymer containing electrophilic functional group can be selected from double amber imide propionic ester Base Polyethylene Glycol, double amber imide succinic acid ester group Polyethylene Glycol, double amber imide penta 2 Perester radical Polyethylene Glycol, double amber imide decanedioic acid ester group Polyethylene Glycol, the poly-second of tetramethylolmethane Glycol ethers four succinimidyl glutarate, pentaerythritol polyethylene glycol ether four butanimide fourth two One or more in acid, pentaerythritol polyethylene glycol ether four butanimide decanedioic acid, molecule Amount is 1000-100000, preferably 2000-50000, more preferably 3000-20000.Preferably Double amber imide succinic acid ester group Polyethylene Glycol, molecular weight is 1000-100000, is preferably 2000-50000, more preferably 3000-20000.

Described serum albumin gel can be used for the bonding of wound in the various surgical operation of human body, Application in hemostasis, antiseep or anti, the most medically can be used for cardiovascular, general outside Defect is sealed during section, department of plastic surgery, neurosurgery, ophthalmology, bone surgery or pulmonary surgery Tissue.

Outside BURSTING STRENGTH described in the utility model detection device is particularly suited for contact tissue The sealing strength detection of section's operation sealing agent or tissue adhesive.This device is economical and practical, side Just, high performance-price ratio, detect light and flexible, facilitate the operation of user of service, have safer, Reliably, the feature such as environmental protection, convenience.

Accompanying drawing explanation

Fig. 1 is that material BURSTING STRENGTH described in the utility model detects device schematic diagram.In figure 1 For substrate lock chamber, 2 is substrate retainer ring, and 3 is booster pump, and 4 is pressure transducer, and 5 are Thribble road, 6 is liquid crystal display monitor.

Fig. 2 is that material BURSTING STRENGTH described in the utility model detects device schematic diagram.In figure 1 For substrate lock chamber, 2 is substrate retainer ring, and 3 is booster pump, and 4 is pressure transducer, and 5 are Thribble road, 6 is liquid crystal display monitor, and 7 is exhaust-valve, and 8 is screw thread

Detailed description of the invention

Below in conjunction with the accompanying drawings preferred embodiment of the present utility model is described in detail, so that this The advantage of utility model and feature can be easier to be readily appreciated by one skilled in the art, thus to this reality Apparent clear and definite understanding is made with novel protection domain.

Embodiment 1

As it is shown in figure 1, a kind of surgical operation detects device with sealing agent BURSTING STRENGTH, wherein 1 For substrate lock chamber, 2 is substrate retainer ring, and 3 is booster pump, and 4 is pressure transducer, and 5 are Thribble road, 6 is liquid crystal display monitor.

Substrate lock chamber is external diameter 35mm, internal diameter 30mm, the cavity of high 50mm, by not Rust steel is made.Host material is casing film material, a diameter of 80mm, center card punch Punching, aperture 3mm.Host material is fixed on substrate lock chamber by substrate retainer ring On, substrate retainer ring and substrate lock chamber are fixed by fastener or screw.By surgical operation Stromal surface is sprayed to sealing agent Progel (albumin/polyethylene glycol gel) gel, Until surgical operation with after sealing agent gel, open booster pump, inflate in substrate lock chamber, Monitor record Strength Changes.Surgical operation sealing agent gel breaks, intensity reaches Maximum is surgical operation sealing agent BURSTING STRENGTH, surgical operation sealing agent Progel BURSTING STRENGTH is 15kPa.

Embodiment 2

As in figure 2 it is shown, 1 be substrate lock chamber in figure, 2 is substrate retainer ring, and 3 is supercharging Pump, 4 is pressure transducer, and 5 is thribble road, and 6 is liquid crystal display monitor, and 7 is emptying Valve, 8 is screw thread.

Substrate lock chamber is external diameter 35mm, internal diameter 30mm, the cavity of high 50mm, by not Rust steel is made.Host material is de-cell Cor Sus domestica coated fertilizer, a diameter of 80mm, in Heart card punch punches, aperture 3mm.Host material is fixed on by substrate retainer ring On substrate lock chamber, substrate retainer ring and substrate lock chamber are airtight by threaded engagement.Will Freeze-dried human fibrin gel precursors solution spraying, to stromal surface, treats Lyophilized Human fiber egg After white gel, close exhaust-valve, open booster pump, inflate in substrate lock chamber, note Record instrument record Strength Changes.Human fibrin gel is peeled off with substrate, and intensity reduces.By force The maximum that degree reaches is surgical operation sealing agent BURSTING STRENGTH, Lyophilized Human fiber egg White BURSTING STRENGTH is 1.2kPa.

Embodiment 3

As in figure 2 it is shown, 1 be substrate lock chamber in figure, 2 is substrate retainer ring, and 3 are Booster pump, 4 is pressure transducer, and 5 is thribble road, and 6 is liquid crystal display monitor, 7 is exhaust-valve, and 8 is screw thread.

Substrate lock chamber is external diameter 35mm, internal diameter 38mm, the cavity of high 25mm, by not Rust steel is made.Host material is used for de-cell Corii Sus domestica material, a diameter of 80mm, center Card punch punches, aperture 4mm.Host material is fixed on substrate by substrate retainer ring On lock chamber, substrate retainer ring and substrate lock chamber are airtight by threaded engagement.By α- Cyanoacrylate Rapid Medical Adhesive sprays to stromal surface, treats a-cyanoacrylate After Rapid Medical adhesive curing, open booster pump, in substrate lock chamber, fill normal saline, Close exhaust-valve, monitor record Strength Changes.A-cyanoacrylate Rapid Medical Glue is peeled off with de-cell Corii Sus domestica, and intensity reduces.The maximum that intensity reaches is α-cyanogen Base acrylate Rapid Medical Adhesive BURSTING STRENGTH, a-cyanoacrylate Rapid Medical Adhesive BURSTING STRENGTH is 26kPa.

Embodiment 4

As in figure 2 it is shown, 1 be substrate lock chamber in figure, 2 is substrate retainer ring, and 3 are Booster pump, 4 is pressure transducer, and 5 is thribble road, and 6 is liquid crystal display monitor, 7 is exhaust-valve, and 8 is screw thread.

Substrate lock chamber is external diameter 35mm, internal diameter 38mm, the cavity of high 25mm, by Rustless steel is made.Host material is de-cell Corii Sus domestica material, a diameter of 80mm, center Punch with card punch, aperture 4mm.Host material is fixed on base by substrate retainer ring On matter lock chamber, substrate retainer ring and substrate lock chamber are airtight by threaded engagement.

Take blood plasma source human serum albumin 0.4 gram (20%, w/v), be dissolved in by The 2mL phosphate buffer (10mM, pH 7.4) of deionized water preparation.370C is interrupted Stir 1 hour so that it is dissolve, after albumen thoroughly dissolves and becomes transparence liquid, use Vacuum pump is bled 30 minutes and bubble in solution is quickly eliminated.Predose human seralbumin Protein solution zero-shear viscosity is 33mPa s.The human serum albumin originated by blood plasma is molten Liquid is through electron beam irradiation, and irradiation dose is 25kGy.

Weigh the double amber imide succinic acid ester group Polyethylene Glycol that molecular weight is 5000 0.3g, is dissolved in 2ml phosphate buffer (10mM, the pH prepared by deionized water 8.4), vortex makes it dissolve becomes transparence liquid.

The human serum albumin solution that blood plasma is originated and double amber imide succinate After polyglycol solution equal-volume mix homogeneously, spray to stromal surface and be cross-linked to form serum Albumin gel.After solidification, close exhaust-valve, open booster pump, to substrate lock chamber Middle inflation, liquid crystal display monitor record Strength Changes.When serum albumin gel and base Matter is peeled off, and intensity reduces.The maximum that intensity reaches is serum albumin gel and bursts Intensity, BURSTING STRENGTH is 16kPa.

Claims (10)

1. surgical operation sealing agent BURSTING STRENGTH detects a device, including substrate lock chamber (1), substrate retainer ring (2), booster pump (3), pressure transducer (4) and monitor (6)；Wherein, substrate retainer ring (2) is fixed on substrate lock chamber (1)；Substrate lock chamber (1) upper end open, bottom is connected with booster pump (3) and pressure transducer (4) respectively by thribble road (5), and pressure transducer (4) is connected with monitor (6).

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterised in that: described device mesostroma lock chamber be shaped as cylinder or cube.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 2 detection device, it is characterised in that: described device mesostroma lock chamber is external diameter 20-80mm, internal diameter 18-78mm, the cylinder of high 5-50mm.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterised in that: described device mesostroma retainer ring is fixed on substrate lock chamber by screw thread, screw or fastener.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterized in that: described device comprises a matrix membrane, described matrix membrane covers on substrate lock chamber, is fixed by matrix membrane by substrate retainer ring, and matrix membrane center card punch punches；Described matrix membrane is casing, Corii Sus domestica or pericardium.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 5 detection device, it is characterised in that: described device mesostroma film punching back aperture scope is 2-5mm.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterised in that: substrate lock chamber side connects an exhaust-valve (7), is beneficial to regulate the pressure limit of substrate lock chamber.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterised in that: in described device, booster pump is gas boosting pump or liquid booster pump.

Surgical operation sealing agent BURSTING STRENGTH the most according to claim 1 detection device, it is characterised in that: a liquid crystal display monitor is connected with pressure transducer by described device, is beneficial to record Strength Changes.

10. surgical operation sealing agent BURSTING STRENGTH detects a device, including substrate lock chamber (1), substrate retainer ring (2), booster pump (3), pressure transducer (4), monitor (6) and exhaust-valve (7)；Wherein, substrate retainer ring (2) is connected fixing by screw thread with substrate lock chamber (1)；Substrate lock chamber (1) upper end open, side connects an exhaust-valve (7), bottom is connected with booster pump (3) and pressure transducer (4) respectively by thribble road (5), and pressure transducer (4) is connected with monitor (6).