CN206408139U - A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus - Google Patents
A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus Download PDFInfo
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- CN206408139U CN206408139U CN201621146683.2U CN201621146683U CN206408139U CN 206408139 U CN206408139 U CN 206408139U CN 201621146683 U CN201621146683 U CN 201621146683U CN 206408139 U CN206408139 U CN 206408139U
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- chipal compounds
- chiral
- integrated apparatus
- solvent
- waste liquid
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The utility model, which belongs to, isolates and purifies engineering device technique field, specifically a kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus.The solvent that the integrated apparatus includes setting gradually from the top down in collection device and reactor removes system, active clapboard, impurity removal unit, metal ion removal system and chiral separation film layer；The solvent, which removes system, includes distillation unit and temperature, pressure adjustment unit.Compared with prior art, the purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus can effectively remove all kinds of impurity, expeditiously isolate and purify and obtain chipal compounds, technique is simple, can heavy industrialization operation, applied to all kinds of chipal compounds liquid waste processings.
Description
Technical field
The utility model, which belongs to, isolates and purifies engineering device technique field, specifically a kind of purifying of chipal compounds waste liquid and
Chiral resolution integrated apparatus.
Background technology
Chirality is the phenomenon of nature generally existing, and natural and synthesis chipal compounds are a lot, such as amino acid, carbohydrate
Also all it is chiral molecules.Because optically active compound and its bioactivity and pharmaceutical activity are closely related, effective ways are studied
Optically active compound is separated and prepares to receive significant attention.Wherein, the chiral separation method of enantiomter is included, i.e., in hand
Property auxiliary agent in the presence of, by racemate resolution be pure enantiomer.The large-scale chiral resolution of industrialization of racemic modification is system
The key of standby chipal compounds.
UF membrane is a kind of novel energy-conserving technology developed in recent years, and enantiomter is split in continuity by chiral film
There is remarkable advantage with Energy Efficient aspect.It is easy to operate continuously because the fractionation of solid film has, is easy to amplification, device design with being
System applies the outstanding advantages such as flexible, energy consumption is low, capacity usage ratio is high, thus the emphasis direction as film chiral resolution.Chirality choosing
The Selective recognition affinity difference for selecting agent enantiomer is crucial, and conventional chiral selector includes：It is protein, antibiotic, many
Sugar, amino acid and super molecular compound (such as cyclodextrin, crown ether), this kind of material have the specificity that can be acted on enantiomer
Binding site (including enantiomer binding site, chiral ring or hole), enantiomer and binding site number and the difference of adhesion
It is different to cause the gap between raceme infiltration capacity and infiltration rate.
At present, the widely using in natural product extraction and pharmaceutical synthesis due to chipal compounds, it is also largely present
In the waste liquid of part chipal compounds preparing craft.Because the technique being related to is different, metal ion is there may be in waste liquid,
Foreign pigment, solid impurity etc..Directly the waste liquid is split by chiral film, impurity present in it will influence the choosing of UF membrane
Selecting property and flux, but combined by substep purification kinds of processes and add processing step and equipment again, Recycling of waste liquid separation is carried
Flat cost is higher, it is impossible to large-scale application.
The content of the invention
In order to solve the above technical problems, the utility model provides purifying and the chiral resolution of a kind of chipal compounds waste liquid
Integrated apparatus.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the one
Makeup puts the solvent including being set gradually from the top down in collection device 9 and reactor 4 and removes system, active clapboard, impurity
Except unit, metal ion remove system and chiral separation film layer 8；The solvent, which removes system, includes distillation unit 2 and temperature pressure
Power adjustment unit 3；Collection device 9 is connected with the bottom of reactor 4.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the solvent
Solvent in removal system is water or organic solvent.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the impurity
Removal unit includes filter layer 5 and adsorption layer 6 setting up and down, for removing foreign pigment and solid impurity.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the filtering
Layer 5 is diatomite filter layer, and the adsorption layer 6 is activated carbon adsorption layer.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the metal
Ion remaval system is amberlite lipid layer 7.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the chirality
Separation membrane layer 8 is loaded with chiral recognition agent, and the chiral recognition agent is amino acid derivativges, cyclodextrin or bovine serum albumin.
A kind of purifying of chipal compounds waste liquid described in the utility model and chiral resolution integrated apparatus, the reaction
The top left side of kettle 4 is provided with charging aperture 1.
Using when, for the waste liquid containing chipal compounds comprising a kind of chipal compounds, also comprising a small amount of moisture
Or the one or more in organic solvent, solid impurity, foreign pigment, metal ion.The waste liquid is passed through reactive tank, it is optional
Addition azeotropic solvent, temperature of reaction kettle and pressure are controlled by temperature and pressure adjustment unit, vacuum distillation or are azeotroped off
Moisture or solvent therein, it is to avoid itself and chipal compounds formation solvate, influence follow-up chiral separation effect, after processing
Reaction solution pass sequentially through foreign pigment and solid impurity removal unit and metal ion using Action of Gravity Field and remove system, according to
The content of impurity selects diatomite, activated carbon or amberlite in suitable filter layer, adsorption layer and amberlite lipid layer
The consumption of fat, also, the speed and separative efficiency that liquid passes through are controlled by the consumption, then, reaction solution is by being loaded with hand
Property identifier chiral separation film, suitable chiral Recognition reagent is selected according to the structure of separated chipal compounds, property, such as
Cyclodextrin, bovine serum albumin, amino acid derivativges etc., finally, enter collection device by the solution of chiral separation membranous system.
Compared with prior art, the purifying of chipal compounds waste liquid described in the utility model and chiral resolution are integrally disguised
All kinds of impurity can effectively be removed by putting, and expeditiously isolated and purified and obtained chipal compounds, and technique is simple, can heavy industrialization behaviour
Make, applied to all kinds of chipal compounds liquid waste processings.
Brief description of the drawings
Fig. 1：Integrated apparatus schematic diagram described in the utility model；Charging aperture 1, distilling apparatus 2, adjustment unit 3, reaction
Kettle 4, filter layer 5, adsorption layer 6, amberlite lipid layer 7, chiral separation film 8, collection device 9.
Embodiment
The purifying to chipal compounds waste liquid described in the utility model and chiral resolution with reference to specific embodiment
Integrated apparatus is described further, but protection domain of the present utility model is not limited to this.
Embodiment 1
A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus, the integrated apparatus, which includes collecting, to be filled
Put the solvent set gradually from the top down in 9 and reactor 4 and remove system, active clapboard, impurity removal unit, metal ion
Except system and chiral separation film layer 8；The solvent, which removes system, includes distillation unit 2 and temperature, pressure adjustment unit 3；It is described to receive
Acquisition means 9 are connected with the bottom of reactor 4.Solvent in the solvent removal system is water or organic solvent.The impurity is removed
Unit includes filter layer 5 and adsorption layer 6 setting up and down, for removing foreign pigment and solid impurity.The filter layer 5 is silicon
Diatomaceous earth filter layer, the adsorption layer 6 is activated carbon adsorption layer.It is amberlite lipid layer 7 that the metal ion, which removes system,.Institute
State chiral separation film layer 8 and be loaded with chiral recognition agent, the chiral recognition agent is cyclodextrin, bovine serum albumin or amino acid derived
Thing.The top left side of reactor 4 is provided with charging aperture 1.
During operation, the waste liquid comprising chipal compounds enters reactor 4 by charging aperture 1, is adjusted by temperature and pressure
Temperature and pressure in the regulation kettle of unit 3, the moisture in reaction solution is distilled out by distilling apparatus 2, the top of filter layer 5 is provided with work
Dynamic dividing plate, stops that reaction solution is directly entered filter layer 5, and question response liquid opens active clapboard, the reaction after above-mentioned processing
Liquid is first by filter layer 5, the effective filtering solid contaminants of diatomite therein, then by adsorption layer 6, wherein activated carbon is further
Foreign pigment therein is adsorbed, then by amberlite lipid layer 7, the metal ion in reaction solution is removed, then reaction solution
By chiral separation film 8, the chiral separation film by processing, is loaded with supermolecule cyclodextrin, its shape, volume thereon in advance
Chiral selectivity is presented with polarity, drug molecule, such as chlorthalidone can be effectively split, other can also be loaded as needed chiral
Identifier, or recognition group is introduced with chemical modification, finally, the solution after separation enters collection device 9, realizes chipal compounds
Efficiently separate.
Claims (1)
1. purifying and the chiral resolution integrated apparatus of a kind of chipal compounds waste liquid, the integrated apparatus include collection device
(9) solvent and in reactor (4) set gradually from the top down removes system, active clapboard, impurity removal unit, metal ion
Removal system and chiral separation film layer (8)；The solvent, which removes system, includes distillation unit (2) and temperature, pressure adjustment unit
(3)；The collection device (9) connects with reactor (4) bottom；Solvent in the solvent removal system is water or organic molten
Agent；The impurity removal unit includes filter layer (5) and adsorption layer (6) setting up and down, for removing foreign pigment and solid
Impurity；The filter layer (5) is diatomite filter layer, and the adsorption layer (6) is activated carbon adsorption layer；The metal ion is removed
System is amberlite lipid layer (7)；Reactor (4) top left side is provided with charging aperture (1)；Characterized in that, the hand
Property separation membrane layer (8) be loaded with chiral recognition agent, the chiral recognition agent be amino acid derivativges, cyclodextrin or bovine serum albumin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621146683.2U CN206408139U (en) | 2016-10-21 | 2016-10-21 | A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621146683.2U CN206408139U (en) | 2016-10-21 | 2016-10-21 | A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206408139U true CN206408139U (en) | 2017-08-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621146683.2U Expired - Fee Related CN206408139U (en) | 2016-10-21 | 2016-10-21 | A kind of purifying of chipal compounds waste liquid and chiral resolution integrated apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206408139U (en) |
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2016
- 2016-10-21 CN CN201621146683.2U patent/CN206408139U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170815 Termination date: 20181021 |
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| CF01 | Termination of patent right due to non-payment of annual fee |