CN206337277U - A kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes - Google Patents
A kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes Download PDFInfo
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- CN206337277U CN206337277U CN201621126526.5U CN201621126526U CN206337277U CN 206337277 U CN206337277 U CN 206337277U CN 201621126526 U CN201621126526 U CN 201621126526U CN 206337277 U CN206337277 U CN 206337277U
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Abstract
The utility model is related to a kind of magnetic bionanoparticles method sorting CD3+T cell reagent boxes, lid including box body and above box body, plate is provided with box body, plate is provided with multiple storage tanks for being contained with reagent bottle, the bottom of lid is provided with multigroup neck, every group of neck is made up of removably clamping finite place piece, the locating part clamp and the limited post being connected on clamp, and limited post is made up of the elastomeric material of hollow structure；Clamp is connected in neck just, and spacing column bottom has stopper slot, when covering lid, and the stopper slot of limited post inserts the top of correspondence reagent bottle just.The kit is simple to operate, carries out specific T cells magnetic separation specifically designed for complex clinical sample, can be supplied to the fields such as scientific research or the clinical detection of different demands and use.
Description
Technical field
The utility model belongs to biological technical field, more particularly to a kind of magnetic bionanoparticles method sorting CD3+T cell examinations
Agent box.
Background technology
Since magnetic separation technique based on micro-nano magnetic bead is born from the eighties in last century, life science and face
More and more applied in the fields such as bed detection.Beads enrichment technical operation is simple, and strong adaptability was both manually operable,
Automation equipment can be applied to very well to operate.Magnetic bionanoparticles be one by Microbe synthesis magnetic nanoparticle, be natural
Biomagnetism nano material, with the incomparable advantage of some artificial synthesized magnetic beads.Utilize technique for gene engineering or knot
Chemical modification technology is closed, special biologically functional molecule can be shown in magnetic bionanoparticles surface orientation, such as through antigen/antibody
The nanometer magnetic bead of molecular modification is also referred to as immunomagnetic beads, has important application value in biochemical analysis or immune detection.
Immunomagnetic beads application value in clinical detection is very big, because clinical sample and actual conditions are extremely complex, to exempting from
The quality requirement of epidemic disease magnetic bead is very high, and its DNA nucleic acid compositions of the existing sample extraction for separate sources need to use different places
Reason method, develops maturation, standard, easy to operate kit.Such as patent 201620303318.1,201620303202.8
Disclosed kit, detection reagent is vertical respectively to be contained in different cavitys, and classify storage, and access is convenient, so as to carry
High user's scientific research, the efficiency for detecting work.
When carrying out lyophilized processing to diagnostic reagent and storing, the glass serum vials with plug are that optimal packaging is held
Device, but available reagent box such as is likely to occur inversion, dropped at inappropriate operation or the accident during transport, use, easily
Break reagent bottle, cause the pollution and waste of whole kit；In addition, lyophilized medication is easily by moisture or other polluters
Erosion cause to go bad.For the situation, applicant is thought on the basis of available reagent box, and urgent need is improved, and improves examination
The shockproof drop resistant and moisture protection of agent box, still need to be developed maturation, standard, easy to operate kit.
Utility model content
In order to solve the above-mentioned technical problem, the utility model provides a kind of magnetic bionanoparticles method sorting CD3+T cell examinations
Agent box, the kit is simple to operate, carries out specific T cells magnetic separation specifically designed for complex clinical sample, can be supplied to different demands
Scientific research or the field such as clinical detection use.
The utility model concrete technical scheme is as follows：
The utility model provides a kind of magnetic bionanoparticles method sorting CD3+T cell reagent boxes, including box body and located at box
Plate is provided with lid above body, the box body, the plate is provided with multiple storage tanks for being contained with reagent bottle, the box
The bottom of lid is provided with multigroup neck, and neck described in every group is by removably clamping finite place piece, and the locating part is by clamp
Constituted with the limited post being connected on the clamp, the limited post is made up of the elastomeric material of hollow structure；The clamp is proper
It is connected to well in the neck, the spacing column bottom has stopper slot, when covering lid, and the stopper slot of the limited post is proper
The top of good insertion correspondence reagent bottle.
In the further scheme of the utility model, the height of limited post is 0.8-1.5cm, and the depth of groove of the stopper slot is
0.5-1cm。
In specific scheme, the outer side edges of the limited post are enclosed with the vapor barrier with cavity, the cavity of the vapor barrier
It is interior to be filled with moisture repellant matter.
Further, filling hole is offered in the vapor barrier, and is provided with filling hole closed cover.
Further, the stopper slot reinforcement of the inwall provided with annular, the further stable fixed reagent bottle.
In one of them preferred scheme, the neck is made up of a pair of axial cross sections for the right angle bar of L-type, described in a pair
The transverse bar body of right angle bar lower end is oppositely arranged.
In further technical scheme, the top of the box body side is provided with least two jacks, and the jack depth is
2-5cm；The bottom of the lid side is provided with least two inserted links, a length of 1.8-4.8cm of inserted link；When the box body closes
During lid, the inserted link and the jack coordinate, so that limit lid covers position, tester is made in lid more convenient
Quickly.
In further one technical scheme, the quantity of the jack is two, and the jack is arranged on the box body
The diagonal angle at top；The quantity for coordinating the inserted link of the jack is two, and the inserted link is arranged on the diagonal of the lid bottom
Place.
In another preferred scheme, the bottom of the box body is provided with the first caulking groove extended laterally, first caulking groove
Inside it is plugged with provided with the placement plate for placing magnetic means and/or operation instrument in drawer, the drawer, the placement plate is provided with
Multiple and magnetic means and/or operation instrument concrete form identical depressed part.
The magnetic bionanoparticles method of the present invention sorts CD3+T cell reagents box in a specific preferred scheme, described
The quantity of storage tank is 6, and the correspondence limited post quantity is 6；The reagent bottle includes the lyophilized Anti-CD3 of storage and exempted from
The reagent bottle of epidemic disease magnetic bead reagent, the reagent bottle for depositing freeze-dried reagent dilution buffer, the reagent for depositing T lymphocyte separation mediums
Bottle, the reagent bottle of storage lavation buffer solution, the reagent bottle for depositing elution buffer and the reagent bottle for depositing elution buffer B.
The utility model magnetic bionanoparticles method sorting CD3+T cell reagent boxes are simple in construction, modern design, practicality pole
It is good.The locating part of kit is configured for dismantled and assembled form, while the Design of length of locating part and its stopper slot is enough to length,
Its freely adjustable locating part is set to adapt to the reagent bottle that length differs；The setting of locating part makes reagent bottle be stably fixed on reagent
, will not be because being damaged colliding, extrude by external force etc. in box；The setting of vapor barrier can effectively stop that vapor oozes from bottleneck
Bottle is penetrated into, so as to protect lyophilized medication not corroded by moisture or other pollutants.In addition, this kit is also accompanied with magnetic force
Device and/or operation instrument, to detect the facility brought great convenience.
Brief description of the drawings
Fig. 1 is the structural representation for the first embodiment that magnetic bionanoparticles method sorts CD3+T cell reagent boxes；
Fig. 2 is the first the embodiment structural representation for the lid that magnetic bionanoparticles method sorts CD3+T cell reagent boxes
Figure；
Fig. 3 is that the part of the first embodiment of the lid that magnetic bionanoparticles method sorts CD3+T cell reagent boxes is put
Big figure；
Fig. 4 is that the part of second of embodiment of the lid that magnetic bionanoparticles method sorts CD3+T cell reagent boxes is put
Big figure；
Fig. 5 is the partial cutaway of second of embodiment of the lid that magnetic bionanoparticles method sorts CD3+T cell reagent boxes
Depending on enlarged drawing；
Fig. 6 is that the structure of the third embodiment of the box body that magnetic bionanoparticles method sorts CD3+T cell reagent boxes is shown
It is intended to；
Fig. 7 is that the structure of the third embodiment of the lid that magnetic bionanoparticles method sorts CD3+T cell reagent boxes is shown
It is intended to.
Embodiment
With reference to the accompanying drawings and examples, embodiment of the present utility model is further described.Implement below
Example is only used for clearly illustrating the technical solution of the utility model, and protection model of the present utility model can not be limited with this
Enclose.
Fig. 1-3 shows a kind of magnetic bionanoparticles method sorting CD3+T cell reagent boxes of the present utility model, including box body
1 and the lid 2 located at the top of box body 1, plate 3 is provided with the box body 1, and the plate 3 is contained with reagent bottle provided with multiple
Storage tank, the bottom of the lid 2 is provided with multigroup neck 20, and neck 20 described in every group passes through removably clamping limited location
Part 4, the locating part 4 is made up of clamp 40 and the limited post 41 being connected on the clamp 40, and the limited post 41 is hollow
The elastomeric material of construction is made；The clamp 40 is connected in the neck 20 just, and the bottom of limited post 41 has spacing
Groove 42, when covering lid 2, the stopper slot 42 of the limited post 41 inserts the top of correspondence reagent bottle just.Wherein described limit
The height of position post 41 is 0.8-1.5cm, and the depth of groove of the stopper slot 42 is 0.5-1cm.The neck 20 is by a pair of axial directions
Section is constituted for the right angle bar 21 of L-type, and the transverse bar body of the lower end of right angle bar 21 is oppositely arranged described in a pair.
Fig. 4-5 shows that the utility model magnetic bionanoparticles method sorts second of embodiment party of CD3+T cell reagent boxes
Formula, in the above-described embodiment, also including specific following technical characteristic：The outer side edges of the limited post 41 are enclosed with band cavity
Vapor barrier 43, be filled with moisture repellant matter 46, the vapor barrier 43 in the cavity of the vapor barrier 43 and offer filling hole, and
It is provided with filling hole closed cover 44.Reinforcement 45 of the inwall of the stopper slot 42 provided with annular.
The top of the side of box body 1 of the utility model kit is provided with least two jacks 10, and the depth of jack 10 is
2-5cm；The bottom of the side of lid 2 is provided with least two inserted links 5, a length of 1.8-4.8cm of the inserted link 5；When the box body 1
When closing lid 2, the inserted link 5 coordinates with the jack 10, so that limit lid 2 covers position.
Fig. 6-7 shows the preferred embodiment of a lid, and the quantity of the jack 10 is two, and the jack 10 is set
Diagonal angle at the top of box body 1；The quantity for coordinating the inserted link 5 of the jack 10 is two, and the inserted link 5 is arranged on described
The diagonal angle of the bottom of lid 2.
Fig. 6-7 shows that the utility model magnetic bionanoparticles method sorts the third embodiment of CD3+T cell reagent boxes,
The bottom of the box body 1 is provided with the first caulking groove 6 extended laterally, first caulking groove 6 and is plugged with drawer 7, the drawer 7
Provided with the placement plate 70 for placing magnetic means and/or operation instrument, the placement plate 70 provided with it is multiple with magnetic means and/or
Operation instrument concrete form identical depressed part 71.
The quantity of storage tank of the present utility model is 6, and the correspondence quantity of limited post 41 is 6；The reagent bottle bag
The reagent bottle for including the lyophilized Anti-CD3 immunomagnetic beads reagents of storage, the reagent bottle for depositing freeze-dried reagent dilution buffer, storage T
The reagent bottle of lymphocyte separation medium, the reagent bottle for depositing lavation buffer solution, the reagent bottle for depositing elution buffer and storage
Elution buffer B reagent bottle.
Claims (10)
1. a kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes, including box body (1) and the box above box body (1)
Cover (2), plate (3) is provided with the box body (1), the plate (3) is provided with multiple storage tanks for being contained with reagent bottle, and it is special
Levy and be, the height of multiple reagent bottles is differed；The bottom of the lid (2) is provided with multigroup neck (20), described in every group
Neck (20) is by removably clamping finite place piece (4), and the locating part (4) is by clamp (40) and is connected to the clamp
(40) limited post (41) on is constituted, and the limited post (41) is made up of the elastomeric material of hollow structure；The clamp (40) is just
It is connected to well in the neck (20), limited post (41) bottom has stopper slot (42), described when covering lid (2)
The stopper slot (42) of limited post (41) inserts the top of correspondence reagent bottle just.
2. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that described spacing
The height of post (41) is 0.8-1.5cm, and the depth of groove of the stopper slot (42) is 0.5-1cm.
3. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that described spacing
The outer side edges of post (41) are enclosed with the vapor barrier (43) with cavity, the cavity of the vapor barrier (43) and are filled with moisture repellant matter
(46)。
4. magnetic bionanoparticles method as claimed in claim 3 sorts CD3+T cell reagent boxes, it is characterised in that the protection against the tide
Filling hole is offered on part (43), and is provided with filling hole closed cover (44).
5. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that described spacing
Reinforcement (45) of the inwall of groove (42) provided with annular.
6. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that the neck
(20) be made up of a pair of axial cross sections for the right angle bar (21) of L-type, the transverse bar body phase of right angle bar (21) lower end described in a pair to
Set.
7. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that the box body
(1) top of side is provided with least two jacks (10), and jack (10) depth is 2-5cm；The bottom of lid (2) side
Portion is provided with least two inserted links (5), a length of 1.8-4.8cm of the inserted link (5)；When the box body (1) closes lid (2), institute
State inserted link (5) and the jack (10) to coordinate, so that limit lid (2) covers position.
8. magnetic bionanoparticles method as claimed in claim 7 sorts CD3+T cell reagent boxes, it is characterised in that the jack
(10) quantity is two, and the jack (10) is arranged on the diagonal angle at the top of the box body (1)；Coordinate the jack (10)
The quantity of inserted link (5) is two, and the inserted link (5) is arranged on the diagonal angle of the lid (2) bottom.
9. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that the box body
(1) bottom is provided with the first caulking groove (6) extended laterally, first caulking groove (6) and is plugged with drawer (7), the drawer (7)
The interior placement plate (70) provided with placement magnetic means and/or operation instrument, the placement plate (70) fills provided with multiple with magnetic force
Put and/or operation instrument concrete form identical depressed part (71).
10. magnetic bionanoparticles method as claimed in claim 1 sorts CD3+T cell reagent boxes, it is characterised in that described accommodating
The quantity of groove is 6, and correspondence limited post (41) quantity is 6；The reagent bottle includes the lyophilized Anti-CD3 of storage and exempted from
The reagent bottle of epidemic disease magnetic bead reagent, the reagent bottle for depositing freeze-dried reagent dilution buffer, the reagent for depositing T lymphocyte separation mediums
Bottle, the reagent bottle of storage lavation buffer solution, the reagent bottle for depositing elution buffer and the reagent bottle for depositing elution buffer B.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621126526.5U CN206337277U (en) | 2016-10-14 | 2016-10-14 | A kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621126526.5U CN206337277U (en) | 2016-10-14 | 2016-10-14 | A kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes |
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| Publication Number | Publication Date |
|---|---|
| CN206337277U true CN206337277U (en) | 2017-07-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621126526.5U Active CN206337277U (en) | 2016-10-14 | 2016-10-14 | A kind of magnetic bionanoparticles method sorts CD3+T cell reagent boxes |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270261A (en) * | 2018-09-19 | 2019-01-25 | 上海裕隆神光医学检验实验室有限公司 | A kind of magnetic bead chemiluminescence detection kit |
-
2016
- 2016-10-14 CN CN201621126526.5U patent/CN206337277U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270261A (en) * | 2018-09-19 | 2019-01-25 | 上海裕隆神光医学检验实验室有限公司 | A kind of magnetic bead chemiluminescence detection kit |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: 102200 Cage, Changping District science and Technology Park, Beijing, 6, No. 623, 2 building, No. 36, Zhenxing Road, science and technology park. Patentee after: BEIJING ZHONGKE YUANRONG BIOLOGICAL TECHNOLOGY DEVELOPMENT CO., LTD. Address before: 102208 6, 602, 2 building, 106 West Star Road, Changping District, Beijing. Patentee before: BEIJING ZHONGKE YUANRONG BIOLOGICAL TECHNOLOGY DEVELOPMENT CO., LTD. |
|
| CP02 | Change in the address of a patent holder | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210901 Address after: 102200 Beijing Changping District science and Technology Park, Zhenxing Road, 36, Cage 2, 6, 625, 627, 629, 631, 633, 635, 637, and 637, respectively. Patentee after: BEIJING GUOKE RONGZHI BIOTECHNOLOGY Co.,Ltd. Address before: 102200 Cage, Changping District science and Technology Park, Beijing, 6, No. 623, 2 building, No. 36, Zhenxing Road, science and technology park. Patentee before: BEIJING ZHONGKE YUANRONG BIOLOGICAL TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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| TR01 | Transfer of patent right |