CN206167385U - Liquid preparation product packaging - Google Patents

Abstract

The utility model discloses a medicinal liquid preparation product packaging arranges exterior container in by the inner packing, and the inner packing is used for the fill fluid preparation to form the negative pressure that is less than atmospheric pressure between exterior container and inner packing, when the small opening appeared in the inner packing, the effort of negative pressure made liquid preparation ooze from the small opening. Exterior container is for seal structure and can keep former tangible form under the negative pressure effect. Exterior container comprises cavity 2 and lid 4, the cavity is used for the inner packing of packing into to form negative pressure 3 in the cavity, the cavity is provided with the cavity support part that supporting cavity personally experienced sth. Part of the body and keeps the shape after the extraction negative pressure in the cavity, and the separation outside air enters into the air separation part in the cavity, the lid seals in to the cavity, and seal structure is constituteed with the cavity to the lid. The utility model discloses the messenger utilizes the technique of the damaged packing of negative pressure inspection feasible. The exterior container structure can extract the product deformation that the negative pressure was brought by effective resistance, has protected the inner packing fabulously. The utility model provides high overall product qualification rate, the cost is reduced.

Description

Liquid preparation product packaging

Technical field

The utility model is related to a kind of liquid preparation product packaging of pharmaceutical manufacturing enterprise.

Background technology

Safe medication is to concern the healthy and safe material particular of people's life, is also the hospital and pharmacy enterprise for being related to medication The material particular of industry existence.Therefore, drug safety is the most important thing of hospital and pharmacy corporation, is the life of hospital and pharmacy corporation Life.

Liquid preparation is the one kind in medicine, and conventional liquid preparation includes：Oral formulations, irrigation and disinfection preparation, transfusion Preparation, injection etc..

Liquid preparation is generally using vial, plastic bottle and mantle bag packaging, and mantle bag packaging or quality are very soft Plastic bottle packing be referred to as flexible packaging, the packaging shape that flexible packaging is generally welded as a whole using charge segment and lid Formula.

Above-mentioned preparation is carried in production packaging, warehouse, transport, during use, will prevent medicament in packaging with it is outer Boundary contacts and is contaminated.But if in the case that packaging has breakage in itself, then needing the preparation that will be destroyed packaging to reject, And position the reason for destroy with destruction is multifarious.

Lookup has been destroyed packaging, presently, there are a kind of method：A flexible glue outer bag on the outside of flexible packaging covers again, Then negative pressure is extracted in flexible glue outer bag and poly-bag is sealed, the effect using negative pressure to flexible packaging, by the system in flexible packaging Agent is extruded from destruction and forms macroscopic water spots, so that destroyed packaging is with the naked eye found, so that this product is picked Remove.

But, research and experiment is carried out to above-mentioned technology for a long time by applicant, it is found that the above method is difficult to, especially It is that cannot apply to industrial automation production at all, reason is as follows：

First, product is destroyed, makes product percent of pass low.In the above-mentioned methods, it is necessary to there is enough negative pressure to make in flexible glue outer bag Firmly.But there is greatly negative effect in vacuum force：1st, flexible glue outer bag is shunk and produces greatly deformation；It is extremely not beautiful after deformation See；Easily it is torn after deformation.2nd, the sack for taking out flexible glue outer bag after negative pressure inwardly drastically shrinks extruding, produces substantial amounts of wrinkle, Make sack be difficult to edge sealing to weld, cause institute's failure welding, produce leakage hole, it is impossible to ensure the negative pressure value in flexible glue outer bag.3rd, it is soft After glue outer bag contraction distortion, extreme forces are produced to built-in flexible packaging, oppress, distort, pullling flexible packaging, it is soft interior May be then torn at the lid of bag and mantle soldering.Especially the neck of lid is easily broken off.Therefore, gone out with improving product Factory's qualification rate is that purpose manner of packing is then possible to develop into the active destruction to product.

2nd, cannot automate.Due to needing that flexible packaging is inserted in flexible glue outer bag, the step must use workman's craft Flexible glue sack is torn, then flexible packaging is inserted in flexible glue outer bag, automated therefore, it is difficult to find suitable plant equipment Into.By flexible glue bag be placed in action on Negative pressure machine (vacuum machine) platform must by being accomplished manually because poly-bag profile it is random and Softness, is currently that the equipment not automated can complete putting to flexible glue bag.Finished product vanning to the product also cannot be certainly Dynamicization, because the deformation of products is greatly, shape distortion, it is necessary to use man power encasement.Therefore, the technology realizes that the production automation is difficult Degree is big.And Drug packing must be able to realize automated production, otherwise the technology is just nonsensical, and its reason is：Automatic metaplasia Produce and reduce manual intervention, improve qualification rate, it is ensured that drug safety.And the amount of product throughput is greatly, even if a middle-size and small-size enterprise The daily output of industry also reaches 30,000 (bags), produces 10000000 per year；Medium-and-large-sized enterprise's daily output then up to 1,000,000 (bags) more than, Produce more than 1,000,000,000 per year, the no way intended justice if the technology cannot realize automated production.Therefore, if can not realize automatic Change, then can not meet market consumption, and cause cost of labor high, workman's amount of labour is big, so that the overall high cost of product.

3rd, qualification rate is low, high cost.After extracting negative pressure, built-in flexible packaging is squeezed and distorts, and produces stronger Stress.If lid is more crisp (must be designed to for lid easily to split off formula by some medicaments), transport and carrying in the later stage, when piling up Then it is easier to split off, produces a large amount of waste products, reduce product percent of pass, improves cost.

4th, piled up using scene is bad.Need to put substantial amounts of medicament on the pharmacy of hospital, medical cupboard, nurse's platform.Cause For the deformation of products greatly, shape distortion, so cannot be effectively neatly arranged, causes medical scene chaotic, influence doctor Treat.

5th, negative pressure institute's holding time is inadequate after extracting negative pressure in flexible glue outer bag.Because outer bag is flexible glue property material, plasticity becomes Shape amount is big, after negative pressure is extracted, through after a while, outer bag makes outer bag produce plastic deformation, outward under the inside stretching of negative pressure Therefore space contraction in bag, the negative pressure in space diminishes or disappears.

Therefore, from prior art, check that package in damaged condition cannot be realized using negative pressure, more cannot volume production listing.

To solve above-mentioned topic, capable field technique personnel have redesigned the vacuum of negative pressure, or in flexible packaging Portion pours pressure, or improves the method for flexible packaging material, to scheme to improve flexible packaging deformation.But there is effect not The result such as good and production efficiency is not good.

Check the technology of package in damaged condition for lifting medical level using negative pressure, it is ensured that patient's drug safety has greatly Meaning, but cannot apply because of the above-mentioned reason with popularization, be the very big obstruction to human health cause.

Utility model content

To solve the above problems, the utility model provides a kind of pharmaceutical liquid formulations, can make concessions broken with negative pressure inspection The technology for damaging packaging is able to promote realization, can realize that industrial automation is produced.

A kind of liquid preparation product packaging of the present utility model, including inner packing 1 and outer containter, inner packing are used to fill Dress liquid preparation, inner packing is placed in outer containter, and is formed less than atmospheric pressure between outer containter and inner packing Negative pressure, when small opening occurs in inner packing, the active force of the negative pressure makes liquid preparation be oozed out from the small opening.The external packing Container is made up of cavity 2 with lid 4；Cavity is used to load inner packing, and negative pressure 3 is formed in cavity；Described cavity is set Have and the cavity support section that negative pressure rear support cavity keeps shape is extracted in cavity, and intercept outside air and enter into cavity Air barrier part；To being sealed in cavity, lid constitutes sealing structure to lid with cavity.

A kind of liquid preparation product packaging as described above, specifically, described cavity support section is possess intensity Some supporting constructions, supporting construction is distributed in the wall of cavity, and described air barrier part is arranged between each supporting construction Gap；The heat seal plane with the lid heat seal is additionally provided with cavity edge.

A kind of liquid preparation product packaging as described above, illustrates further to be provided with protrusion in described cavity Limited block 2-3, limited block be used for inner packing is fixed.

A kind of liquid preparation product packaging as described above, illustrates further as described inner packing 1 is with lid 4 Transparent soft film material；The cavity is made up of hard transparent plastic, and thickness is 0.3~3mm.

A kind of liquid preparation product packaging as described above, illustrates further as described heat seal plane 2-2 width is More than 3mm.

A kind of liquid preparation product packaging as described above, illustrates further as the depth of described cavity is interior bag The 50%~130% of 1 thickness is filled, the depth of described cavity is the face conduct of the area maximum in several faces for constitute cavity Height of the bottom extremely with the wall constituted around bottom；Described inner packing thickness is lower wall surface supreme wall when inner packing keeps flat Highly.

A kind of liquid preparation product packaging as described above, illustrates further as the volume of described cavity is interior bag The 70%~300% of dress cumulative volume.Described inner packing outer surface is except the lower wall contacted with outer containter when inner packing keeps flat Face is spaced minimum range for 1.5mm with the remaining surface outside upper wall surface with outer containter.

A kind of liquid preparation product packaging as described above, illustrates further as described cavity is cassette shapes, institute The cavity edge stated is the mouth rim of box body.Described air barrier part is Obstruct membrane；Supporting construction is support block.

A kind of liquid preparation product packaging as described above, illustrates further as described lid is warm with heat seal plane Close, lid protrudes with inner packing contact position to outside, remainder is recessed to cavity.

The beneficial effects of the utility model are：

The utility model makes to check the technical feasibility of package in damaged condition using negative pressure.

1st, the outer containter structure of design of the present utility model is highly resistant to and extracts the deformation of products that negative pressure is brought, Inner packing is admirably protected, especially the inner packing to some lid frangibilities generates effectively protection, extracts outside after negative pressure Packaging container structure is smooth intact, will not produce new destruction to inner packing, improves overall acceptability rate, reduces production wave Take, reduce cost.

2nd, the outer containter regular shape of the utility model design, shape is fixed, is on a production line put into inner packing In all processes such as the action of outer containter, the action for extracting negative pressure, the action of finished product vanning, automation action can be reached Optional equipment is very more, therefore the utility model can realize that full-automatic production is implemented, and improve yield, reduce work strong Degree.In full-automation production, it is to avoid manual intervention, therefore further increase product percent of pass.

3rd, after product is offline, outer containter can provide more reliable protection for inner packing, prevent product from carrying, transporting During damage.

4th, outer containter regular shape, shape is fixed, and pile is easy in medical space, is piled up neatly, and stacking tier is high, Make medical space neat, improve medical efficiency.

5th, the ratio of the depth of the thickness of inner packing of the present utility model and cavity, cavity total measurement (volume) of the present utility model with The ratio of inner packing cumulative volume, the interval between inner packing and cavity, above-mentioned design parameter ensure that the total of the negative pressure in cavity Value is being designed in effective scope, makes to check the technical feasibility of package in damaged condition using negative pressure.

6th, outer containter of the present utility model possesses the energy that shape is still at utmost kept in the presence of negative pressure Power, after negative pressure extracting, the deflection of outer containter is small, excessive to contract, therefore external packing not because of vacuum force Volume space size in container is tried one's best holding, when space size keeps, it is also possible to keep the negative pressure in space.

Brief description of the drawings

Fig. 1 is this product structure chart.

Fig. 2 is the b-b of this product to profile.

Fig. 3 is embodiment exemplary plot.

Fig. 4 is the a-a of embodiment to sectional view.

Detailed description of main elements in figure：

1st, inner packing；1-1, inner packing welding edge sealing；1-2, inner packing lid；2nd, cavity；2-1, torn edges mouthful；2-2, heat seal are put down Face；2-3, limited block；3rd, negative pressure；4th, lid.

Specific embodiment

It is specific below in conjunction with the utility model to make the purpose of this utility model, technical scheme and advantage clearer Embodiment and corresponding accompanying drawing 1, accompanying drawing 2, accompanying drawing 3, accompanying drawing 4 are clearly and completely described to technical solutions of the utility model.

A kind of liquid preparation product packaging of the present utility model, including inner packing 1 and outer containter, liquid preparation are filling In inner packing, inner packing is placed in outer containter.

The inner packing that the utility model is used generally refers to packed in flexible pouchy, is made up of transparent mantle, then in inner packing In filling certain liquid preparation, on the top of inner packing, textured relatively hard inner packing lid 1-2, inner packing periphery are set It is inner packing welding edge sealing 1-1.

The signified outer containter of the utility model is a point two parts：Cavity and lid；Cavity has been necessary for some strength Material make, and must have certain hardness, material thickness be 0.3~3mm, can material selection include PVC piece films, Huo Zheqi The transparent material of its stiff sheet type, such as transparent toughened glass material, transparent toughened plastic, hard transparent plastic, composite transparent material Deng.Discoid, bowl-shape, box body shape can be processed by methods such as blowing, punching press, hot-working, then in edge indwelling and lid heat Close the heat seal plane of welding.Heat seal plane 2-2 width is more than 3mm, and selectable plane width is 3mm~40mm.

Such as cavity is box-like situation, and air barrier part described in the utility model is Obstruct membrane, that is, PVC pieces Film；Supporting construction described in the utility model is support block, that is, to increase the reinforcement of PVC piece film-strengths, certainly, support The shape of structure is not limited, and can be lattice-like, strip, column, bulk, horizontal shape, longitudinal shape, concave shape, outer gibbosity；Position is not Limit, can be in cavity wall, cavity bottom.If rapidoprint inherently high-strength material, then material is then thought itself It is support block, for example with safety glass manufacture, safety glass possesses intensity in itself, then using safety glass from as support Block.Outer containter of the present utility model is sealing structure and original shape can be kept under suction function；It is wherein described Original shape can be kept to refer under suction function：After outer containter extracts negative pressure, negative pressure produces outer containter is inside The active force of contraction distortion, and outer containter of the present utility model can resist described active force, keep outer containter It is indeformable, or deformation amount controlling is in certain scope；In certain scope, it is required and principle ginseng described deformation amount controlling According to table 3 below, table 4.

In order to inner packing is effectively fixed in cavity, further to prevent inner packing from being turned round in outer containter Song deformation, can suitably be provided with the limited block 2-3 of protrusion, inner packing lid 1-2 or other parts and limit in outer containter Position block 2-3 coordinates, for being fixed to inner packing.

Described lid is hard transparent material.The equal rounding of edge of outer containter.Do not influenceing sealing effectiveness In the case of, stay a tile position not carry out heat seal in heat seal plane, lid is opened when easy to use.

In order to reach optimum efficiency of the present utility model, the preferred PVC pieces film production of cavity；And select PVC mantles to make lid Body, lid is welded on cavity by heat seal mode.Negative pressure will be extracted in cavity, lid makes cavity to being sealed in cavity Interior negative pressure keeps being applied in inner packing.

PVC pieces film is the harder material of material, and the easy-formation when making can be fabricated to ideal shape, can reach Required for production.After manufacturing, by certain material process, such as after increasing the aluminium film of air barrier, the obstruct to air Ability increases, airtight, the vacuum effect in holding chamber body.It is of course also possible to use other methods increase the obstruct to air Ability.Depending on quality requirement to the obstructing capacity of air according to product.PVC pieces film after shaping, fix by its shape, is removing Transport, fetch during will not deform (deformation very small, do not influence to produce completely, use).In order to increase the intensity of PVC, cavity Hardness, reinforcement is devised on cavity.

Example 1：

Inner packing 1 is the transparent soft film materials of PP, and lid 4 is made up of hard transparent material.Outer containter is hard transparent Plastic pvc is made, and thickness is 0.3mm, and its global shape is cassette shapes, and each water caltrop bending part of box body possesses enabling capabilities, Just as cavity wall supporting surface and cavity bottom supporting surface；In order to further increase the enabling capabilities of cavity support section, can Increase reinforcement everywhere with box body；Remainder is air barrier part.And it is wide in the edge designs heat seal plane 2-2 of box body It is 3mm to spend.Box body in this example 1 in description below represents outer containter.

The depth of box body is the 50% of the thickness of inner packing 1.The depth of above-mentioned box body is the depth in cavity, to constitute box The face of the area maximum in several faces of body is as bottom to the height with the wall constituted around bottom；Such as box body is common Drawer-like when, the depth of box body is then the height of base plate to side wall top edge；During such as box body for cigarette case shape, the depth of box body is then It is the spacing between forward and backward two wall.Described inner packing thickness is the height of lower wall surface supreme wall when inner packing keeps flat；For example The inner packing that soft bag is made, its thickness is then by the horizontal plane placed and inner packing upper table after filling medicament during horizontal positioned The vertical height in face；The diameter of inner packing thickness in the present embodiment and inner packing lid is about etc..

The volume of box body is the 70% of inner packing cumulative volume.

Remaining surface of inner packing outer surface when inner packing keeps flat in addition to lower wall surface and upper wall surface be with box body spacer 1.5mm.The four fundamental rules side of inner packing leaves enough distances with cavity four side so that when suction function is to cavity, box body has foot Enough space buffers, in order to avoid inner packing is formed extrude.

Lid and heat seal plane heat seal, lid protrude with inner packing contact position to outside, and remainder is recessed to box body.

In the example, overall material cost is relatively low, but using effect, not up to most preferably, quality hold period is very short.

Example 2：

Inner packing 1 and the transparent soft film materials of PP, lid 4 are made up of hard transparent material；Cavity is hard transparent plastic PVC It is made, material thickness is 0.8mm.It is 8mm in the edge designs heat seal plane 2-2 width of cavity.

The depth of cavity is the 60% of the thickness of inner packing 1.

The volume of cavity is the 90% of inner packing cumulative volume.

Remaining surface of inner packing outer surface when inner packing keeps flat in addition to lower wall surface and upper wall surface is spaced with outer containter Away from being 3mm.

Lid and heat seal plane heat seal, lid protrude with inner packing contact position to outside, and remainder is recessed to cavity.

In the example, overall material cost is relatively low, and using effect is not good enough, and quality hold period is very short.

Example 3：

Inner packing 1 and the transparent soft film materials of PP, lid 4 are made up of hard transparent material；Cavity is hard transparent plastic PVC It is made, thickness is 1mm.It is 10mm in the edge designs heat seal plane 2-2 width of cavity.

The depth of cavity is the 80% of the thickness of inner packing 1.

The volume of cavity is the 180% of inner packing cumulative volume.

Remaining surface of inner packing outer surface when inner packing keeps flat in addition to lower wall surface and upper wall surface is spaced with outer containter Away from being 3mm.

Lid and heat seal plane heat seal, lid protrude with inner packing contact position to outside, and remainder is recessed to cavity.

In the example, overall material cost is higher, and using effect is good, and quality hold period is very long.

Example 4：

Inner packing 1 and the transparent soft film materials of PP, lid 4 are made up of hard transparent material；Cavity is hard transparent plastic PVC It is made, thickness is 3mm.It is 20mm in the edge designs heat seal plane 2-2 width of cavity.

The depth of cavity is the 80% of the thickness of inner packing 1.

The volume of cavity is the 180% of inner packing cumulative volume.

Remaining surface of inner packing outer surface when inner packing keeps flat in addition to lower wall surface and upper wall surface is spaced with outer containter Away from being 3mm.

Lid and heat seal plane heat seal, lid protrude with inner packing contact position to outside, and remainder is recessed to cavity.

In the example, overall material cost is too high, and using effect is good, and quality hold period is very long.

From above-mentioned example effect, outer containter is made up of hard transparent plastic；Its optional material thickness be 0.3~ 3mm；Its effect such as table 1 below：

Vacuum	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa
										Thickness	0.3	0.6	1.0	1.3	1.6	2.0	2.3	2.6	3
Width	10	10	10	10	10	10	10	10	10
										The holding phase	March	May	August	October	14 months	18 months	22 months	24 months	24 months

Table 2：Heat seal plane 2-2 width.

Vacuum	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa
										Thickness	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Width	0.3	0.6	1.0	1.3	1.6	2.0	2.3	2.6	3
										The holding phase	January	March	June	September	13 months	18 months	23 months	24 months	On 24 months

In above table 1,2, described vacuum is the vacuum in cavity when forming negative pressure in cavity, and its unit is： Relative degree of vacuum.Described thickness is the material original degree of cavity.Unit：mm.Described width is heat seal plane width, i.e. cavity Area of the edge together with lid heat seal.The described holding phase refers to that vacuum degree declines in cavity after negative pressure is extracted Subtract no more than 20%.From above table, there is the more preferable holding phase, it is necessary to using to thickness material higher and preferably Seals.

The ratio between depth and inner packing thickness of cavity, can control after negative pressure is extracted, and cavity is made by suction function Collapsed shape.I.e.：When inner packing is all submerged in cavity, and cavity internal upper part also one section of space of indwelling when, negative pressure will be complete Portion is applied on cavity and lid, and lid is pushed to be torn four walls of cavity and will be deformed to central reduction.When inner packing only Half by the cavity that submerges, and second half protrudes in containment portion completely, and negative pressure is applied on cavity and lid, is applied on lid When, can be supported by inner packing projection, the degree of convergence that lid is pushed is small, and four walls of cavity will not be deformed to central reduction It is minimum.Its projection only mantle part when so being kept flat because of inner packing, the lid for pushing only is squeezed in mantle part, The influence of any destruction will not be produced to inner packing, will not be distorted and tearing inner packing.Therefore, the depth of cavity is thick with inner packing The reaction of the ratio between degree is as follows in Wall deformation amount situation：

For example, inner packing is built with 250ml liquid.Table 3：

Vacuum

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

Gross thickness

30mm

30mm

30mm

30mm

30mm

30mm

30mm

30mm

30mm

Depth

10mm

14mm

18mm

22mm

26mm

30mm

34mm

37mm

39mm

Ratio

33%

47%

60%

73%

87%

100%

113%

123%

130%

Deflection

5mm

6mm

8mm

9mm

11mm

16mm

19mm

20mm

20mm

Gross thickness described in table 3 is the thickness of inner packing 1.Vacuum is relative degree of vacuum, and depth is cavity depth.Ratio It is the ratio between cavity depth and inner packing thickness.Above-mentioned deflection refers to：It is long in the case where outer containter is rectangular body Square both sides side long by lid to center pull generation displacement total distance, that is, two side deflection.Deflection It is too big, the side wall of inner packing can be directly expressed to, inner packing lid can be also expressed to, quality influence is produced on inner packing, or even can Can squeeze bad inner packing lid.And the extruding that inner packing can receive to have no effect on quality should be within deflection 10mm.But such as Fruit depth is too low, and after negative pressure is extracted, lid again can be too high to the extruding force of inner packing, and cavity cannot be formed with effect to inner packing Protection, therefore cavity lowest depth takes 50% gross thickness.

The volume of cavity and the ratio of inner packing cumulative volume can determine negative pressure content.I.e.：When the total measurement (volume) of cavity is 10 Individual volume unit, inner packing volume is 5 volume units, then ratio is 10：5, it is air then to have half in cavity.It is negative extracting After pressure, air is pumped cavity contraction.Therefore the space in cavity is bigger, and in order to meet vacuum, then what air was pumped gets over Many, air is pumped more, and its Wall deformation is then bigger.It is reacted to table 4 as follows：For example, inner packing is built with 250ml liquid.

Vacuum

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

-90KPa

Inner packing

330cm3

330cm3

330cm3

330cm3

330cm3

330cm3

330cm3

330cm3

330cm3

Volume

300ml

330ml

400ml

500ml

600ml

700ml

800ml

900ml

990ml

Ratio

91%

100%

121%

152%

182%

212%

242%

273%

300%

Deflection

2mm

2mm

3mm

3mm

5mm

8mm

12mm

17mm

22mm

Described cavity volume is that inner packing cumulative volume 91%, i.e. cavity volume are interior bag less than the situation of inner packing volume Dress a portion situation of the protrusion outside cavity, therefore, when cavity total measurement (volume) inner packing cumulative volume more than 70% The utility model can be implemented.

Because considering that inner packing can receive to have no effect on the deflection of quality within 10mm.Therefore, total appearance of cavity More than the 70% of the long-pending cumulative volume in inner packing is optional parameters.

In above-mentioned example, outer containter possesses the ability that shape is still at utmost kept in the presence of negative pressure, After negative pressure extracting, the deflection of outer containter is small, excessive to contract, therefore outer containter not because of vacuum force In volume space size try one's best holding, when space size keeps, it is also possible to keep the negative pressure in space.From the formation of negative pressure Upper analysis, under Atmospheric Condition, after extracting a part of gas in a vessel space for determination of sealing, because in container Gas is reduced and is less than air, then form negative pressure.But if vessel space does not know, then one is extracted equally in vessel space Divide gas, and vessel space is followed to contract, then the gas content in vessel space and the vessel space ratio after contraction are put down Weighing apparatus, the gas in vessel space is still equal to air, is not negative pressure.

Therefore the utility model needs to remain in that the form of outer containter under negative pressure, make the outsourcing after extraction negative pressure The content space of packaging container is more than gas space needed for atmospheric pressure environment, negative pressure is then formed in outer containter, and protected Hold.

Production process of the present utility model approximately as：

1st, inner packing is made, and to filling liquid medicament in inner packing.

2nd, the inner packing of filling medicament is welded into inner packing lid.

3rd, inner packing is reached into the vacuum of requirement with outer containter, the air in extraction outer containter is put into.

4th, after forming certain vacuum in external packing, if there is breakage in inner packing, no matter badly broken degree is such as In the negative pressure formed in what (either larger breakage still the extremely tiny sightless situation of naked eyes), external packing can be forced Filling medicament is flowed between the outer containter in outer containter and inner packing in packaging, forms macroscopic water Spot.If breakage in inner packing is extremely tiny situation, then product after a period of time (1 to 20 day) is placed, in external packing Continuous negative pressure state the damaged of inner packing is formed water spots.

Therefore, the pharmaceutical liquid formulations for having water spots are rejected, it is reduced and is flowed into the possibility that hospital is used, so as to improve Dispatch from the factory product percent of pass.

The following is to the utility model effect analysis：

Following traditional group refers to：Using in double casing, outer containter is soft-bag type, and inner container is soft bag Formula, and the situation of negative pressure is extracted in inner container.Following qualification rate implication is：Qualified products are (after extracting negative pressure, outward Effective sealing effectiveness of packing container, inner packing not because extract negative pressure damage, external packing not because extract negative pressure damage) ratio Example.Such as before negative pressure is extracted, inner packing sheet is damaged in procedure of processing before to be disregarded in table 5 below qualification rate.

Table 5, the utility model effect statistics, is calculated by medium-sized enterprise, and annual production is that 100,000,000 (bag) product yields are calculated such as Under：

Annual production 100000000	Output per day	The daily amount of labour used	Daily recruitment cost	Qualification rate
					Traditional group	300000 (bag)	160 people	24000 yuan	97.16%
The utility model	300000 (bag)	6 people	799 yuan	99.95%

By producing per year based on 100,000,000, recruitment cost of the present utility model reduces 8,000,000 yuan.

By producing per year based on 100,000,000, calculated from qualification rate, traditional group produces substandard product about 2,840,000, this practicality every year New annual generation substandard product about 50,000, the utility model qualified products have more 2,790,000 compared with traditional group qualified products, Based on every 4 yuan of cost, then equivalent to annual many about 11,160,000 yuan of production costs of saving, deduction is had more using hard PVC piece film Material cost 5,000,000 (cavity must be made up of hard PVC piece film, thus than flexible glue bag material outer containter have more 0.05 yuan/only), whole year still saves production cost about 14,160,000.

Above-mentioned is the utility model exemplary illustration, and protection domain of the present utility model is not represented.

Claims (9)

1. liquid preparation product packaging, including inner packing (1) and outer containter, inner packing are used for filling liquid preparation, interior bag It is installed in outer containter, and the negative pressure less than atmospheric pressure is formed between outer containter and inner packing, its feature exists In the outer containter is made up of cavity (2) with lid (4)；Cavity is used to load inner packing, and negative pressure is formed in cavity (3)；Described cavity is provided with and the cavity support section that negative pressure rear support cavity keeps shape is extracted in cavity, and intercepts outer The air barrier part that boundary's air is entered into cavity；To being sealed in cavity, lid constitutes sealing structure to lid with cavity.

2. liquid preparation product packaging as claimed in claim 1, it is characterised in that described cavity support section is strong to possess Some supporting constructions of degree, supporting construction is distributed in the wall of cavity, and described air barrier part is arranged on each supporting construction Between gap；The heat seal plane with the lid heat seal is additionally provided with cavity edge.

3. liquid preparation product packaging as claimed in claim 1, it is characterised in that the limit of protrusion is provided with described cavity Position block (2-3), limited block is used to be fixed inner packing.

4. liquid preparation product packaging as claimed in claim 1, it is characterised in that described inner packing (1) is with lid (4) Transparent soft film material；The cavity is made up of hard transparent plastic, and thickness is 0.3~3mm.

5. liquid preparation product packaging as claimed in claim 2, it is characterised in that described heat seal plane (2-2) width is More than 3mm.

6. liquid preparation product packaging as claimed in claim 1, it is characterised in that the depth of described cavity is inner packing (1) the 50%~130% of thickness, the depth of described cavity is the face conduct of the area maximum in several faces for constitute cavity Height of the bottom extremely with the wall constituted around bottom；Described inner packing thickness is lower wall surface supreme wall when inner packing keeps flat Highly.

7. liquid preparation product packaging as claimed in claim 1, it is characterised in that the volume of described cavity is that inner packing is total The 70%~300% of volume；Described inner packing outer surface except the lower wall surface that is contacted with outer containter when inner packing keeps flat with Remaining surface and outer containter interval minimum range outside upper wall surface are 1.5mm.

8. liquid preparation product packaging as claimed in claim 2, it is characterised in that described cavity is cassette shapes, described Cavity edge for box body mouth rim；Described air barrier part is Obstruct membrane；Supporting construction is support block.

9. liquid preparation product packaging as claimed in claim 1, it is characterised in that described lid and heat seal plane heat seal Afterwards, lid middle part is protruded with inner packing contact position to outside, and remainder is recessed to cavity.