CN106137746A

CN106137746A - Liquid preparation product is packed

Info

Publication number: CN106137746A
Application number: CN201610656663.8A
Authority: CN
Inventors: 吴敏玉
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-11
Filing date: 2016-08-11
Publication date: 2016-11-23

Abstract

The present invention is pharmaceutical liquid formulations, being placed in outer containter by inner packing, inner packing is used for filling liquid preparation, and forms the negative pressure less than atmospheric pressure between outer containter and inner packing, when small opening occurs in inner packing, the active force of negative pressure makes liquid preparation ooze out from small opening.Outer containter is for sealing structure and can keep original shape under suction function.Outer containter is made up of with lid 4 cavity 2；Cavity is used for loading inner packing, and forms negative pressure 3 in cavity；Cavity is provided with in cavity extraction negative pressure rear support cavity and keeps the cavity support section of shape, and obstruct outside air enters into the air barrier part in cavity；Lid seals in cavity, and lid seals structure with cavity composition.The present invention makes the technical feasibility utilizing negative pressure to check package in damaged condition.Outer containter structure is highly resistant to extract the deformation of products that negative pressure is brought, and protects inner packing admirably.The present invention improves product overall acceptability rate, reduces cost.

Description

Liquid preparation product is packed

Technical field

The present invention relates to the liquid preparation product packaging of a kind of pharmaceutical manufacturing enterprise.

Background technology

Safe medication is to concern the material particular that people's life is healthy and safe, is also hospital and the pharmacy enterprise being related to medication The material particular of industry existence.Therefore, drug safety is the most important thing of hospital and pharmacy corporation, is the life of hospital and pharmacy corporation Life.

Liquid preparation is the one in medicine, and conventional liquid preparation includes: oral formulations, irrigation and disinfection preparation, transfusion Preparation, injection etc..

Liquid preparation generally uses vial, plastic bottle and mantle bag packaging, and mantle bag packaging or quality are the softest Plastic bottle packing be referred to as flexible packaging, flexible packaging generally uses the packaging shape that charge segment and lid are welded as a whole Formula.

Above-mentioned preparation producing packaging, warehouse carry, transport, use during, the medicament in packaging will be prevented with outward Boundary contacts and is contaminated.But in the case of if packaging itself exists breakage, then need to reject the preparation being destroyed packaging, And the reason destroyed is multifarious with the position of destruction.

Search destroyed packaging, presently, there are a kind of method: a flexible glue outer bag on the outside of flexible packaging is overlapped again, Then in flexible glue outer bag, extract negative pressure and seal poly-bag, utilizing the negative pressure effect to flexible packaging, by the system in flexible packaging Agent extrudes and is formed macroscopic water spots at destruction, thus with the naked eye finds the packaging being destroyed, in order to picked by this product Remove.

But, through applicant, for a long time above-mentioned technology is carried out research and experiment, finds that said method is difficult to, especially Being cannot to apply to industrial automation produce, reason is as follows at all:

One, destroy product, make conforming product rate low.In the above-mentioned methods, enough negative pressure are had to make in needing flexible glue outer bag Firmly.But there is greatly negative effect in vacuum force: 1, flexible glue outer bag is shunk and produced greatly deformation；After deformation the most beautiful See；Easily it is torn after deformation.2, after taking out negative pressure, the bag mouth of flexible glue outer bag the most drastically shrinks extruding, produces substantial amounts of wrinkle, Make bag mouth be difficult to edge sealing welding, cause institute's failure welding, produce leakage hole, it is impossible to ensure the negative pressure value in flexible glue outer bag.3, soft After glue outer bag contraction distortion, built-in flexible packaging is produced extreme forces, oppress, distort, pull flexible packaging, soft interior The lid of bag then may be torn at mantle seam.The especially cervical region of lid is easily broken off.Therefore, go out improving product For the purpose of factory's qualification rate, manner of packing the most likely develops into the destruction of the active to product.

Two, cannot automatization.Owing to flexible packaging is inserted in flexible glue outer bag by needs, this step must use workman manual Tear flexible glue bag mouth, then flexible packaging is inserted in flexible glue outer bag, therefore, it is difficult to find suitable plant equipment automatization complete Become.Flexible glue bag is placed in the action on Negative pressure machine (vacuum machine) platform must by being accomplished manually because poly-bag profile is random and Softness, is currently and does not has the equipment of automatization can complete to put flexible glue bag.Finished product vanning to this product also cannot be certainly Dynamicization, because this deformation of products is very big, shape distortion, it is necessary to use man power encasement.Therefore, this technology realizes production automation difficulty Degree is big.And Drug packing must be able to realize automated production, otherwise this technology is the most nonsensical, and its reason is: metaplasia automatically Produce and reduce manual intervention, improve qualification rate, it is ensured that drug safety.And this amount of product throughput is very big, an even if middle-size and small-size enterprise Industry volume of production every day also reaches 30,000 (bags), produces 10000000 per year；The medium-and-large-sized enterprise daily output then up to 1,000,000 (bags) more than, Produce more than 1,000,000,000 per year, if this technology cannot realize automated production, no way intended justice.Therefore, if can not realize automatically Changing, then can not meet market consumption, and cause cost of labor high, workman's amount of labour is big, thus the overall cost of product is high.

Three, qualification rate is low, and cost is high.After extraction negative pressure, built-in flexible packaging is squeezed and distorts, and produces stronger Stress.If lid more crisp (lid must be designed to easily split off formula by some medicament), the later stage transport and carrying, pile up time Then it is easier to split off, produces a large amount of waste product, reduce conforming product rate, improve cost.

Four, use scene is bad piles up.The pharmacy of hospital, medical cupboard, nurse's platform need to put substantial amounts of medicament.Cause Very big for this deformation of products, shape distortion, so cannot be carried out effectively being neatly arranged, causes medical treatment on-the-spot chaotic, impact doctor Treat.

Five, after extracting negative pressure in flexible glue outer bag, negative pressure institute's holding time is inadequate.Because outer bag is flexible glue character material, plasticity becomes Shape amount is big, and after extraction negative pressure, through after a while, outer bag, under the inside stretching of negative pressure, makes outer bag produce plastic deformation, outward Space contraction in Dai, therefore the negative pressure in space diminishes or disappears.

Therefore, from prior art, package in damaged condition cannot realize to utilize negative pressure to check, more cannot volume production listing.

For solving above-mentioned topic, capable field technique personnel have redesigned the vacuum of negative pressure, or in flexible packaging Portion pours pressure, or the way of raising flexible packaging material, to scheme to improve flexible packaging deformation.But there is effect not The results such as good and production efficiency is the best.

The technology of package in damaged condition is for promoting medical level to utilize negative pressure to check, it is ensured that patient's drug safety has greatly Meaning, but cannot apply because of above-mentioned reason and promote, it is the very big obstruction to human health cause.

Summary of the invention

For solving the problems referred to above, the invention provides a kind of pharmaceutical liquid formulations, it is possible to interest concessions negative pressure checks breakage bag The technology of dress is promoted realization, it is possible to realizes industrial automation and produces.

A kind of liquid preparation product packaging of the present invention, including inner packing 1 and outer containter, inner packing is used for fill liquid Body preparation, inner packing is placed in outer containter, and forms bearing less than atmospheric pressure between outer containter and inner packing Pressure, when small opening occurs in inner packing, the active force of described negative pressure makes liquid preparation ooze out from described small opening.Described outer containter For sealing structure and original shape can be kept under suction function；Described inner packing 1 at least one.

A kind of liquid preparation product packaging as above, specifically, described outer containter is by cavity 2 and lid 4 groups Become；Cavity is used for loading inner packing, and forms negative pressure 3 in cavity；After described cavity is provided with in cavity extraction negative pressure Support cavity and keep the cavity support section of shape, and obstruct outside air enters into the air barrier part in cavity；Lid Sealing in cavity, lid seals structure with cavity composition.

A kind of liquid preparation product packaging as above, specifically, described cavity support section is to possess intensity Some supporting constructions, supporting construction is distributed in the wall of cavity, and described air barrier part is arranged between each supporting construction Gap；The heat seal plane sealed with described lid heat seal it is additionally provided with on cavity edge.

Liquid preparation product packaging as above a kind of, illustrate further into, be provided with protrusion in described cavity Limited block 2-3, limited block is for being fixed inner packing.

Liquid preparation product packaging as above a kind of, illustrate further into, described inner packing 1 with lid 4 is Transparent soft film material；Described cavity is made up of hard transparent plastic, and thickness is 0.3～3mm.

Liquid preparation product packaging as above a kind of, illustrate further into, described heat seal plane 2-2 width is More than 3mm.

Liquid preparation product packaging as above a kind of, illustrate further into, the degree of depth of described cavity is interior bag Filling the 50%～130% of 1 thickness, the degree of depth of described cavity is the face conduct that the area in several faces constituting cavity is maximum Bottom is to the height with the wall constituted around bottom；Described inner packing thickness is inner packing lower wall surface supreme wall when keeping flat Highly.

Liquid preparation product packaging as above a kind of, illustrate further into, the volume of described cavity is interior bag The 70%～300% of dress cumulative volume.Described inner packing outer surface is except the lower wall contacted with outer containter when inner packing keeps flat Remaining surface and outer containter interval minimum range outside face and upper wall surface are 1.5mm.

Liquid preparation product packaging as above a kind of, illustrate further into, described cavity is cassette shapes, institute The mouth rim that cavity edge is box body stated.Described air barrier part is Obstruct membrane；Supporting construction is a bracer.

Liquid preparation product packaging as above a kind of, illustrate further into, described lid and heat seal plane heat Closing, lid protrudes to outside with inner packing contact position, and remainder is recessed to cavity.

The invention have the benefit that

The present invention makes the technical feasibility utilizing negative pressure to check package in damaged condition.

1, the outer containter structure of the design of the present invention is highly resistant to extract the deformation of products that negative pressure is brought, fabulous Protect inner packing, the especially inner packing to some lid frangibility creates effectively protection, outer package after extraction negative pressure Structure of container is smooth intact, inner packing will not be produced new destruction, improve overall acceptability rate, reduces production waste, fall Low cost.

2, the outer containter regular shape of present invention design, shape is fixed, and on a production line inner packing is put into outsourcing In all processes such as the action that the action of packaging container, the extraction action of negative pressure, finished product are cased, the optional of automatization's action can be reached Equipment is the most, and therefore the present invention can realize full-automatic production enforcement, improves yield, reduces labor intensity.Automatically During metaplasia is produced, it is to avoid manual intervention, therefore further increase conforming product rate.

3, after product rolls off the production line, outer containter can provide more reliable protection for inner packing, prevents product carrying, transport During damage.

4, outer containter regular shape, shape is fixed, and is easy to pile in medical space, piles up neat, and stacking tier is high, Make medical space neat, improve medical efficiency.

5, the thickness of the inner packing of the present invention is total with inner packing with the cavity total measurement (volume) of the ratio of the degree of depth of cavity, the present invention Interval between the ratio of volume, inner packing and cavity, above-mentioned design parameter ensure that the total amount value of the negative pressure in cavity is setting In the range of effect, make the technical feasibility utilizing negative pressure to check package in damaged condition.

6, the outer containter of the present invention possesses the ability the most at utmost keeping shape under the effect of negative pressure, After negative pressure extracting, the deflection of outer containter is little, not because of vacuum force too much to contract, therefore in outer containter Volume space size keep, when space size keeps as far as possible, it is also possible to the negative pressure in holding space.

Accompanying drawing explanation

Fig. 1 is this product structure figure.

Fig. 2 is that the b-b of this product is to profile.

Fig. 3 is embodiment exemplary plot.

Fig. 4 is that the a-a of embodiment is to sectional view.

Detailed description of main elements in figure:

1, inner packing；1-1, inner packing welding edge sealing；1-2, inner packing lid；2, cavity；2-1, torn edges mouth；2-2, heat seal are put down Face；2-3, limited block；3, negative pressure；4, lid.

Detailed description of the invention

For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with the specific embodiment of the invention and Technical solution of the present invention is clearly and completely described by corresponding accompanying drawing 1, accompanying drawing 2, accompanying drawing 3, accompanying drawing 4.

A kind of liquid preparation product packaging of the present invention, including inner packing 1 and outer containter, liquid preparation fill is in interior In packaging, at least one inner packing is placed in outer containter.When outer containter is sufficiently large, can be in outer containter Load multiple inner packing；Multiple inner packings are arranged in outer package, can unify to place.

The inner packing that the present invention uses generally refers to packed in flexible pouchy, is made up of transparent mantle, then fills in inner packing Filling certain liquid preparation, be provided with the inner packing lid 1-2 that quality is relatively hard on the top of inner packing, inner packing periphery is interior Packaging welding edge sealing 1-1.

The outer containter of indication of the present invention is point two parts: cavity and lid；Cavity is necessary for the material of some strength Matter is made, and must have certain hardness, and material thickness is 0.3～3mm, can include PVC sheet film by material selection, or other is hard The transparent material of flap-type, such as transparent toughened glass material, transparent toughened plastic, hard transparent plastic, composite transparent material etc..Can It is processed into plate-like, bowl-shape, box body shape by methods such as blowing, punching press, hot-working, then welds with lid heat seal in edge indwelling Heat seal plane.Heat seal plane 2-2 width is more than 3mm, and selectable plane width is 3mm～40mm.

Such as cavity is box-like situation, and air barrier part of the present invention is Obstruct membrane, namely PVC sheet film； Supporting construction of the present invention is a bracer, namely for increasing the reinforcement of PVC sheet film-strength, certainly, supporting construction Shape does not limits, and can be lattice-like, strip, column, bulk, horizontal shape, longitudinal shape, concave shape, outer gibbosity；Position does not limits, can With at cavity wall, cavity bottom.If rapidoprint inherently high-strength material, then material self is then considered to support Block, for example with safety glass manufacture, safety glass itself possesses intensity, then use safety glass from as supporting block.This Bright outer containter is for sealing structure and can keep original shape under suction function；Wherein said energy under suction function Original shape is kept to refer to: after outer containter extraction negative pressure, negative pressure produces the work of inside for outer containter contraction distortion Firmly, and the outer containter of the present invention can resist described active force, makes outer containter keep indeformable, or deflection Control in certain scope；In certain scope, it requires described deformation amount controlling and principle is with reference to table 3 below, table 4.

In order to inner packing is effectively fixed in cavity, to prevent inner packing from turning round in outer containter further Bent deformation, suitably can be provided with the limited block 2-3 of protrusion, inner packing lid 1-2 or other parts and limit in outer containter Position block 2-3 coordinates, for being fixed inner packing.

Described lid is hard transparent material.The equal rounding of edge of outer containter.Do not affecting sealing effectiveness In the case of, heat seal plane is stayed a tile position do not carry out heat seal, it is simple to during use, to open lid.

In order to reach the optimum efficiency of the present invention, cavity preferred PVC sheet film production；And select PVC mantle to make lid, lid Body is welded on cavity by heat seal mode.To extract negative pressure in cavity, lid seals in cavity, and make in cavity is negative Pressure holding is applied in inner packing.

PVC sheet film is the material that material is harder, the easy-formation when making, and can be fabricated to ideal shape, can reach Produce required.After manufacturing, processed by certain material, after such as increasing the aluminum film of air barrier, the obstruct to air Ability increases, airtight, the vacuum effect in holding chamber body.It is of course also possible to use other way to increase the obstruct to air Ability.To the obstructing capacity of air according to the prescription of product depending on.PVC sheet film after shaping, fix by its shape, is removing Fortune, fetch during will not deform (deform the least, the most do not affect production, use).In order to increase the intensity of PVC, cavity Hardness, cavity devises reinforcement.

Example 1:

Inner packing 1 is the transparent soft film material of PP, and lid 4 is made for hard transparent material.Outer containter is hard transparent Plastic pvc is made, and thickness is 0.3mm, and its global shape is cassette shapes, and each Pedicellus et Pericarpium Trapae bending part of box body possesses enabling capabilities, Just as cavity wall supporting surface and cavity bottom supporting surface；In order to increase the enabling capabilities of cavity support section further, can To increase reinforcement everywhere at box body；Remainder is air barrier part.And at the edge designs heat seal plane 2-2 width of box body Degree is 3mm.In this example 1, the box body in description below represents outer containter.

The degree of depth of box body is the 50% of inner packing 1 thickness.The degree of depth of above-mentioned box body is the degree of depth in cavity, for constituting box The maximum face of area in several faces of body as bottom to the height with the wall constituted around bottom；Such as box body is common Drawer-like time, the degree of depth of box body is then for the height of base plate to limit wall top edge；When being cigarette case shape such as box body, the degree of depth of box body is then For the spacing between forward and backward two walls.Described inner packing thickness is inner packing height of lower wall surface supreme wall when keeping flat；Such as The inner packing that soft bag is made, its thickness then horizontal plane placed during horizontal positioned and table in inner packing after medicament by fill The vertical height in face；The diameter of the inner packing thickness in the present embodiment and inner packing lid is about etc..

The volume of box body is the 70% of inner packing cumulative volume.

Inner packing outer surface remaining surface in addition to lower wall surface is with upper wall surface when inner packing keeps flat with box body spacer is 1.5mm.The four fundamental rules limit of inner packing and cavity four side leave enough distances so that during suction function to cavity, box body has foot Enough space buffer, in order to avoid forming extruding to inner packing.

Lid and heat seal plane heat seal, lid protrudes to outside with inner packing contact position, and remainder is recessed to box body.

In this example, overall material cost is relatively low, but using effect does not reaches most preferably, and quality hold period is the shortest.

Example 2:

Inner packing 1 and the transparent soft film material of PP, lid 4 is made for hard transparent material；Cavity is hard transparent plastic PVC Making, material thickness is 0.8mm.Edge designs heat seal plane 2-2 width at cavity is 8mm.

The degree of depth of cavity is the 60% of inner packing 1 thickness.

The volume of cavity is the 90% of inner packing cumulative volume.

Inner packing outer surface remaining surface in addition to lower wall surface and upper wall surface when inner packing keeps flat is spaced with outer containter Away from for 3mm.

Lid and heat seal plane heat seal, lid protrudes to outside with inner packing contact position, and remainder is recessed to cavity.

In this example, overall material cost is relatively low, and using effect is not good enough, and quality hold period is the shortest.

Example 3:

Inner packing 1 and the transparent soft film material of PP, lid 4 is made for hard transparent material；Cavity is hard transparent plastic PVC Making, thickness is 1mm.Edge designs heat seal plane 2-2 width at cavity is 10mm.

The degree of depth of cavity is the 80% of inner packing 1 thickness.

The volume of cavity is the 180% of inner packing cumulative volume.

In this example, overall material cost is higher, and using effect is good, and quality hold period is the longest.

Example 4:

Inner packing 1 and the transparent soft film material of PP, lid 4 is made for hard transparent material；Cavity is hard transparent plastic PVC Making, thickness is 3mm.Edge designs heat seal plane 2-2 width at cavity is 20mm.

The degree of depth of cavity is the 80% of inner packing 1 thickness.

The volume of cavity is the 180% of inner packing cumulative volume.

In this example, overall material cost is too high, and using effect is good, and quality hold period is the longest.

From above-mentioned demonstration effect, outer containter is that hard transparent plastic is made；Its optional material thickness be 0.3～ 3mm；

Its effect such as table 1 below:

Vacuum	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa
										Thickness	0.3	0.6	1.0	1.3	1.6	2.0	2.3	2.6	3
Width	10	10	10	10	10	10	10	10	10
										The holding phase	March	May	August	October	14 months	18 months	22 months	24 months	24 months

Table 2: heat seal plane 2-2 width.

Vacuum	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa	-90KPa
										Thickness	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Width	0.3	0.6	1.0	1.3	1.6	2.0	2.3	2.6	3
										The holding phase	January	March	June	JIUYUE	13 months	18 months	23 months	24 months	On 24 months

In above table 1,2, when described vacuum is cavity interior formation negative pressure, the vacuum in cavity, its unit is: Relative vacuum degree.Described thickness is the former degree of material of cavity.Unit: mm.Described width is heat seal plane width, i.e. cavity Edge be heat sealing at lid together with area.The described holding phase refers to that vacuum degree declines in cavity after extraction negative pressure Subtract less than 20%.From above table, to there is the more preferable holding phase, need to use the higher material of thickness with more preferable Seals.

The ratio of the degree of depth of cavity and inner packing thickness, it is possible to controlling after extraction negative pressure, cavity is made by suction function Collapsed shape.That is: all submerge in cavity when inner packing, and during cavity internal upper part also one section of space of indwelling, negative pressure will be complete Portion is applied on cavity and lid, and lid presses down four walls tearing cavity will to be deformed to central reduction.When inner packing only Half by the cavity that submerges, and second half protrudes when containment portion completely, and negative pressure is applied on cavity and lid, is applied on lid Time, can be supported by inner packing projection, the degree of convergence that lid is pressed down is little, and four walls of cavity will not be deformed to central reduction Minimum.So because its projection is only mantle part when inner packing keeps flat, the described lid pressed down is only squeezed in mantle part, Inner packing will not be produced the impact of any destruction, will not distort and tearing inner packing.Therefore, the degree of depth of cavity is thick with inner packing The ratio reaction of degree is as follows in Wall deformation amount situation:

Such as, inner packing is built with 250ml liquid.Table 3:

Vacuum

-90KPa

Gross thickness

30mm

The degree of depth

10mm

14mm

18mm

22mm

26mm

30mm

34mm

37mm

39mm

Ratio

33%

47%

60%

73%

87%

100%

113%

123%

130%

Deflection

5mm

6mm

8mm

9mm

11mm

16mm

19mm

20mm

Gross thickness described in table 3 is the thickness of inner packing 1.Vacuum is relative vacuum degree, and the degree of depth is cavity depth.Ratio Ratio for cavity depth with inner packing thickness.Above-mentioned deflection refers to: in the case of outer containter is rectangular body, long The total distance producing displacement that long limit, square both sides is pulled to center by lid, the namely deflection of two side.Deflection Too big, can directly be expressed to the sidewall of inner packing, also can be expressed to inner packing lid, inner packing be produced quality impact, even may be used Can squeeze bad inner packing lid.And the extruding that inner packing can accept to have no effect on quality should be within deflection 10mm.But such as Really the degree of depth is too low, and after extraction negative pressure, lid again can be too high to the extruding force of inner packing, and cavity cannot be formed with effect to inner packing Protection, therefore cavity lowest depth takes 50% gross thickness.

The volume of cavity can determine negative pressure content with the ratio of inner packing cumulative volume.That is: it is 10 when the total measurement (volume) of cavity Individual volume unit, inner packing volume is 5 volume units, then ratio is 10:5, and then having half in cavity is air.Negative in extraction After pressure, air is pumped cavity and shrinks.Therefore the space in cavity is the biggest, and in order to meet vacuum, then what air was pumped gets over Many, air is pumped the most, and its Wall deformation is the biggest.Being reacted to table 4 as follows: such as, inner packing is built with 250ml liquid.

Vacuum

-90KPa

Inner packing

330cm³

Volume

300ml

330ml

400ml

500ml

600ml

700ml

800ml

900ml

990ml

Ratio

91%

100%

121%

152%

182%

212%

242%

273%

300%

Deflection

2mm

3mm

5mm

8mm

12mm

17mm

22mm

Described cavity volume is inner packing cumulative volume 91%, i.e. cavity volume less than the situation of inner packing volume is interior bag Dress a portion protrudes situation outside cavity, therefore, when cavity total measurement (volume) inner packing cumulative volume more than 70% All can implement the present invention.

Because can accept to have no effect within the deflection of quality is 10mm in view of inner packing.Therefore, total appearance of cavity Amass inner packing cumulative volume more than 70% be optional parameters.

In above-mentioned example, outer containter possesses the ability the most at utmost keeping shape under the effect of negative pressure, After negative pressure extracting, the deflection of outer containter is little, not because of vacuum force too much to contract, and therefore outer containter In volume space size keep, when space size keeps as far as possible, it is also possible to the negative pressure in holding space.From the formation of negative pressure Upper analysis, under Atmospheric Condition, after extracting a part of gas in the vessel space determined sealed, because of in container Gas reduces and less than air, then forms negative pressure.If but vessel space is uncertain, then same extraction one in vessel space Divide gas, and vessel space is followed to contract, then the gas content in vessel space and the vessel space ratio after contraction are put down Weighing apparatus, the gas in vessel space is still equal to air, is not negative pressure.

Therefore the present invention needs to remain in that under negative pressure the form of outer containter, makes the outsourcing dressing after extraction negative pressure The content space of device at atmospheric pressure environment requisite space more than gas, then forms negative pressure, and is maintained in outer containter.

The production process of the present invention approximately as:

1, inner packing is made, and filling liquid medicament in inner packing.

2, the inner packing welding inner packing lid of medicament by fill.

3, by inner packing with put into outer containter, the air in extraction outer containter reaches the vacuum of requirement.

4, after forming certain vacuum in outer package, if there being breakage in inner packing, regardless of badly broken degree such as What (no matter being bigger breakage or the sightless situation of the most tiny naked eyes), in the negative pressure formed in outer package can force In packaging, the medicament of fill is flowed between the outer containter in outer containter and inner packing, forms macroscopic water Speckle.If the breakage in inner packing is the most tiny situation, then product is after placing a period of time (1 to 20 day), in outer package Continuous negative pressure state the damaged of inner packing can be made equally to form water spots.

Therefore, reject the pharmaceutical liquid formulations having water spots, reduce it and be flowed into the probability that hospital is used, thus improve Dispatch from the factory conforming product rate.

The following is effect analysis of the present invention:

Following traditional group refers to: using in double casing, outer containter is soft-bag type, and inner container is soft bag Formula, and in inner container, extract the situation of negative pressure.Following qualification rate implication is: qualified products are (i.e. after extraction negative pressure, outward Effective sealing effectiveness of packing container, inner packing not because extraction negative pressure and damage, outer package not because extraction negative pressure and damage) ratio Example.As before extraction negative pressure, inner packing this disregard in table 5 below qualification rate in procedure of processing before is impaired.

Table 5, statistical effect of the present invention, calculate by medium-sized enterprise, annual production is that 100,000,000 (bag) product yields are calculated as follows:

Annual production 100000000	Output per day	Every day the amount of labour used	Recruitment every day cost	Qualification rate
					Traditional group	300000 (bag)	160 people	24000 yuan	97.16%
The present invention	300000 (bag)	6 people	799 yuan	99.95%

Based on producing 100000000 per year, the recruitment cost of the present invention reduces 8,000,000 yuan.

Based on producing 100000000 per year, calculating from qualification rate, traditional group produces substandard product about 2,840,000, the present invention every year Annual generation substandard product about 50,000, qualified products of the present invention relatively traditional group qualified products have more 2,790,000, by every one-tenth These 4 yuan of meters, then be equivalent to annual production cost about 11,160,000 yuan of saving more, and the material that deduction uses hard PVC sheet film to have more becomes This 5,000,000 (cavity must be made up of hard PVC sheet film, therefore has more 0.05 yuan/than the outer containter of flexible glue bag material), Still save production cost about 14,160,000 whole year.

Above-mentioned for exemplary illustration of the present invention, do not represent protection scope of the present invention.

Claims

1. liquid preparation product packaging, including inner packing (1) and outer containter, inner packing is used for filling liquid preparation, interior bag It is installed in outer containter, and between outer containter and inner packing, forms the negative pressure less than atmospheric pressure, work as inner packing When there is small opening, the active force of described negative pressure makes liquid preparation ooze out from described small opening, it is characterised in that described outer containter For sealing structure and original shape can be kept under suction function；Described inner packing (1) at least one.

2. liquid preparation product packaging as claimed in claim 1, it is characterised in that described outer containter by cavity (2) with Lid (4) forms；Cavity is used for loading inner packing, and forms negative pressure (3) in cavity；Described cavity is provided with in cavity Extraction negative pressure rear support cavity keeps the cavity support section of shape, and obstruct outside air enters into the air barrier in cavity Part；Lid seals in cavity, and lid seals structure with cavity composition.

3. liquid preparation product packaging as claimed in claim 2, it is characterised in that described cavity support section is strong for possessing Some supporting constructions of degree, supporting construction is distributed in the wall of cavity, and described air barrier part is arranged on each supporting construction Between gap；The heat seal plane sealed with described lid heat seal it is additionally provided with on cavity edge.

4. liquid preparation product packaging as claimed in claim 2, it is characterised in that be provided with the limit of protrusion in described cavity Position block (2-3), limited block is for being fixed inner packing.

5. liquid preparation product packaging as claimed in claim 2, it is characterised in that described inner packing (1) with lid (4) is Transparent soft film material；Described cavity is made up of hard transparent plastic, and thickness is 0.3～3mm.

6. liquid preparation product packaging as claimed in claim 3, it is characterised in that described heat seal plane (2-2) width is More than 3mm.

7. liquid preparation product packaging as claimed in claim 2, it is characterised in that the degree of depth of described cavity is inner packing (1) the 50%～130% of thickness, the degree of depth of described cavity is the face conduct that the area in several faces constituting cavity is maximum Bottom is to the height with the wall constituted around bottom；Described inner packing thickness is inner packing lower wall surface supreme wall when keeping flat Highly.

8. liquid preparation product packaging as claimed in claim 2, it is characterised in that the volume of described cavity is that inner packing is total The 70%～300% of volume；Described inner packing outer surface except when inner packing keeps flat the lower wall surface that contacts with outer containter and Remaining surface and outer containter interval minimum range outside upper wall surface are 1.5mm.

9. liquid preparation product packaging as claimed in claim 2, it is characterised in that described cavity is cassette shapes, described The mouth rim that cavity edge is box body；Described air barrier part is Obstruct membrane；Supporting construction is a bracer.

10. liquid preparation product packaging as claimed in claim 2, it is characterised in that described lid and heat seal plane heat seal After, protruding to outside with inner packing contact position in the middle part of lid, remainder is recessed to cavity.