CN206103954U - Biochip box that high flux jointly detected or filtered based on silica gel matrix - Google Patents
Biochip box that high flux jointly detected or filtered based on silica gel matrix Download PDFInfo
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- CN206103954U CN206103954U CN201621123825.3U CN201621123825U CN206103954U CN 206103954 U CN206103954 U CN 206103954U CN 201621123825 U CN201621123825 U CN 201621123825U CN 206103954 U CN206103954 U CN 206103954U
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- panel
- high flux
- detection
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Abstract
The utility model relates to a biological detection filters technical field, specifically is a biochip box that high flux jointly detected or filtered based on silica gel matrix, including a box cover and a box bod, the box body includes base, matrix piece and panel, the panel is through can the dismantlement mode installing on the base, the matrix piece sets up between base and the panel, the panel be equipped with run through in the through -hole of panel, be equipped with the base station on the base, the panel is close to one side of base is equipped with the cassette of joint at the base station edge, the matrix piece set up by in the joint district that the cassette encloses, be equipped with in the joint district and center on the space stop bar in the through -hole outside. The utility model discloses stable in structure is simple, equipment and convenient operation, high flux, low price, sensitivity are high, easily realize characteristics such as automatic, but wide application in the fields such as albumen detection, genetic test and drug screening of high flux.
Description
Technical field
This utility model is related to biological detection screening plant technical field, specially a kind of high flux based on silica matrix
Joint-detection or the biochip cartridge of screening.
Background technology
Biochip is the new and high technology developed rapidly in life science, is primarily referred to as by micro Process
Technology and microelectric technique solid chip surface construction miniature biochemical analysis system, with realize to cell, protein,
Accurate, quick, large information capacity the detection of DNA and other biological component.Originally need in very big laboratory, to need very
Many experimental apparatus, equipment and necessarily required environment are come the experiment that completes, it now is possible to be integrated on a slight chip just
Can complete.And, at present the Testing index great majority of various diseases are nonspecific indexs, not only multiple disease related proteins
Content is significantly raised and lowered simultaneously in same disease, also can raise in various diseases in same disease related protein content or
Reduce, therefore, the single index of detection is depended merely on, the difficulty of medical diagnosis on disease can be caused, so as to cause misdiagnosis rate to raise.In addition, with
The raising of quality of life, people's health consciousness gradually strengthens, and health examination is increasingly becoming a kind of fashion, and this causes hospital and the 3rd
The medical institutions such as side's detection need the examination experiment for carrying out large sample amount.In order to ensure the flux of reaction, and detected sample
Carry out under same reaction condition with standard substance and quality-control product, it is desirable to have a kind of reaction module, can simultaneously be equipped with tens
It is fixed with the biochip of identical biological raw material array.And this tens biochips for having identical biological raw material array exist
Each independent reaction system is all formed in whole course of reaction, is not influenced each other, not mutual seepage.
Under this technical background, joint-detection/screening was not only met but also had met high flux（It is i.e. extensive）, sample, calibration object
Arise at the historic moment with biochip of the quality-control product under same reaction condition.At present, have based on the upper of nitrocellulose filter on market
The C12A protein chips of Hai Mingyuan Shuo Kang biochips company limited, Huzhou Shuo Kang biochips company limited C12 albumen cores
Piece, Shanghai Yulong Biological Technology Co., Ltd and Beijing Jiuzhou Taikang Biological Technology Co., Ltd. produce many tumor-markers
Analyte detection test kit.But the carrier system of these products is that this substrate is that one kind is more based on the substrate of nitrocellulose filter
Void-rich material, mechanical strength is poor, occurs problems with often in test kit operating process：1st, sample-adding, concussion or washing
Easily occur film rupture in step, cause to be polluted between sample；2nd, albumen non-specific adsorption is strong, and background is high, needs loaded down with trivial details
The closing of avtive spot and washing process；3rd, sealing needs extra seal gasket to be aided between the Kong Yukong of chip, film
Positioning action it is comparatively laborious, easily damaged, operation difficulty is big.Meanwhile, based on the protein chip of this substrate, its detection process
Still needing manually to operate, it is impossible to realize full automation, and these limitation make it to adapt to the detection sieve of high flux, large sample
Choosing is required.
Utility model content
A purpose of the present utility model is to overcome the problems referred to above to provide a kind of high flux joint inspection based on silica matrix
The biochip cartridge surveyed or screen, has the advantages that simple structure, easy to assembly.
Above-mentioned technical purpose of the present utility model technical scheme is that：One kind is based on silica matrix
High flux joint-detection or screening biochip cartridge, including lid and box body, the box body includes pedestal, substrate tablet dough-making powder
Plate, by being removably mounted on the pedestal, the substrate tablet is arranged between the pedestal and panel the panel；
The panel is provided with the through hole through the panel, and the pedestal is provided with base station, the panel near the pedestal one
Side is provided with the deck for being connected to base station edge, and the substrate tablet is arranged in the clamping area surrounded by the deck, the clamping
The spacer bar being centered around on the outside of the through hole is provided with area.
Preferably, the deck is provided with the inserting column for being plugged on pedestal, the pedestal is provided with and the inserting column
The jack for matching.
Preferably, the deck is interval setting, between the two neighboring deck gap is provided with.
Preferably, the table top of the base station is rectangular configuration, in the angle of the table top of the base station chamfering is provided with.
Preferably, the cross section of the spacer bar is inverted triangular structure.
Preferably, the panel is provided with the boss for protruding from panel plate face, the through hole away from the side of the pedestal
It is arranged on the boss, the lid is located on the boss.
Preferably, the through hole with m*n array distributions on the boss, the through hole be rectangular opening or cylindrical hole or
Bellmouth.
Preferably, the panel is provided with the labelling number for showing lead to the hole site.
Preferably, the substrate tablet is with viscoelastic silicone rubber diaphragm.
This utility model has certain thickness and viscoelastic silicone rubber diaphragm by arranging between panel and pedestal, its
Surface has certain sense dough modification, it is ensured that the compactness between Kong Yukong, prevents space seepage, influences each other；
And accurate positioning, facilitate the Protein microdot arrays and porous plate and the positioning of plate well on film, prevent film from sliding, cause positioning not
It is accurate；Silica matrix surfacing, densification, with certain mechanical strength, no matter in chip point sample, assembling and transportation,
Or it is not easy film rupture occur in sample-adding, concussion or washing step, does not result in and polluted between sample；Silica matrix table
Face has certain chemical modification, therefore the non-specific adsorption of substrate is low, it is not necessary to the closing of loaded down with trivial details avtive spot and wash
Process is washed, therefore detection process easily realizes automatization.
The beneficial effects of the utility model：This utility model Stability Analysis of Structures is simple, assembling and easy to operate, high flux, valency
Lattice are cheap, sensitivity is high, it is easy to automate the features such as, can be widely applied to high-throughout Protein Detection, gene test and
The fields such as drug screening.
Description of the drawings
Fig. 1 is the structure decomposition figure of this utility model embodiment；
Fig. 2 is the structural representation of panel in this utility model embodiment；
Fig. 3 is the structural representation of pedestal in this utility model embodiment；
In figure：1- lids, 2- panels, 21- boss, 22- through holes, 23- spacer bars, 24- decks, 25- inserting columns, 3- substrate
Piece, 4- pedestals, 41- base stations, 42- chamferings, 43- jacks.
Specific embodiment
Specific examples below is only that, to explanation of the present utility model, it is not to restriction of the present utility model, sheet
Art personnel can make as needed the modification without creative contribution after this specification is read to the present embodiment,
But as long as all being protected by Patent Law in right of the present utility model.
Embodiment：As shown in Figure 1, Figure 2 and Figure 3, a kind of high flux joint-detection or the life of screening based on silica matrix
Thing chip cartridges, including lid 1 and box body, the box body includes pedestal 4, substrate tablet 3 and panel 2, and the panel 2 is by detachable
Mode is arranged on the pedestal 4, and the substrate tablet 3 is arranged between the pedestal 4 and panel 2；The panel 2 is provided with and runs through
In the through hole 22 of the panel 2, the pedestal 4 is provided with base station 41, and the table top of the base station 41 is rectangular configuration, in the base
The angle of the table top of platform 41 is provided with chamfering 42, is easy to peel off substrate tablet 3 from base station 41 when substrate tablet 3 is changed.It is described
Panel 2 is provided with the deck 24 for being connected to the edge of base station 41 near the side of the pedestal 4, and the deck 24 is provided with for being plugged on
Inserting column 25 on pedestal 4, the pedestal 4 is provided with the jack 43 matched with the inserting column 25.The deck 24 sets for interval
Put, between the two neighboring deck 24 gap is provided with.The substrate tablet 3 is with viscoelastic silicone rubber diaphragm, surface tool
There are certain sense dough modification, including hydroxyl, carboxyl, sulfonic group, sulfydryl, epoxy radicals, amino etc..The substrate tablet 3 is arranged
In the clamping area surrounded by the deck 24, the spacer bar 23 for being centered around the outside of the through hole 22 is provided with the clamping area,
The cross section of the spacer bar 23 is inverted triangular structure.
As shown in figure 1, the panel 2 is provided with the boss 21 for protruding from the plate face of panel 2, institute away from the side of the pedestal 4
State through hole 22 to be arranged on the boss 21, the lid 1 is located on the boss 21.The through hole 22 is with m*n arrays point
On the boss 21, the through hole 22 is rectangular opening or cylindrical hole or bellmouth to cloth, and in the present embodiment, through hole 22 is rectangle
Hole, and with 8*12 array distributions.The panel 2 is provided with the labelling number for showing the position of through hole 22.
Claims (9)
1. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix, including lid（1）And box body, its
It is characterised by：The box body includes pedestal（4）, substrate tablet（3）And panel（2）, the panel（2）Installed by removably
In the pedestal（4）On, the substrate tablet（3）It is arranged on the pedestal（4）With panel（2）Between；The panel（2）It is provided with and passes through
It is through at the panel（2）Through hole（22）, the pedestal（4）It is provided with base station（41）, the panel（2）Near the pedestal
（4）Side be provided with and be connected to base station（41）The deck at edge（24）, the substrate tablet（3）It is arranged on by the deck（24）Enclose
Into clamping area in, be provided with the clamping area and be centered around the through hole（22）The spacer bar in outside（23）.
2. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 1,
It is characterized in that：The deck（24）It is provided with for being plugged on pedestal（4）On inserting column（25）, the pedestal（4）Be provided with
The inserting column（25）The jack for matching（43）.
3. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 2,
It is characterized in that：The deck（24）For interval setting, the two neighboring deck（24）Between be provided with gap.
4. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 1,
It is characterized in that：The base station（41）Table top be rectangular configuration, in the base station（41）The angle of table top be provided with chamfering
（42）.
5. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 1,
It is characterized in that：The spacer bar（23）Cross section be inverted triangular structure.
6. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 1,
It is characterized in that：The panel（2）Away from the pedestal（4）Side be provided with and protrude from panel（2）The boss of plate face（21）, institute
State through hole（22）It is arranged on the boss（21）On, the lid（1）It is located at the boss（21）On.
7. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 6,
It is characterized in that：The through hole（22）With m*n array distributions in the boss（21）On, the through hole（22）For rectangular opening or circle
Post holes or bellmouth.
8. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 7,
It is characterized in that：The panel（2）It is provided with display through hole（22）The labelling number of position.
9. a kind of high flux joint-detection or the biochip cartridge of screening based on silica matrix according to claim 1,
It is characterized in that：The substrate tablet（3）It is with viscoelastic silicone rubber diaphragm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621123825.3U CN206103954U (en) | 2016-10-14 | 2016-10-14 | Biochip box that high flux jointly detected or filtered based on silica gel matrix |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621123825.3U CN206103954U (en) | 2016-10-14 | 2016-10-14 | Biochip box that high flux jointly detected or filtered based on silica gel matrix |
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| Publication Number | Publication Date |
|---|---|
| CN206103954U true CN206103954U (en) | 2017-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621123825.3U Expired - Fee Related CN206103954U (en) | 2016-10-14 | 2016-10-14 | Biochip box that high flux jointly detected or filtered based on silica gel matrix |
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| CN (1) | CN206103954U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107192815A (en) * | 2017-06-13 | 2017-09-22 | 厦门生命互联科技有限公司 | A kind of antibody incubation kit and its application method |
-
2016
- 2016-10-14 CN CN201621123825.3U patent/CN206103954U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107192815A (en) * | 2017-06-13 | 2017-09-22 | 厦门生命互联科技有限公司 | A kind of antibody incubation kit and its application method |
| CN107192815B (en) * | 2017-06-13 | 2019-06-11 | 厦门生命互联科技有限公司 | A kind of antibody incubation kit and its application method |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170419 Termination date: 20181014 |