CN205925998U - Control device of miniature magnetic bead - Google Patents
Control device of miniature magnetic bead Download PDFInfo
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- CN205925998U CN205925998U CN201620888559.7U CN201620888559U CN205925998U CN 205925998 U CN205925998 U CN 205925998U CN 201620888559 U CN201620888559 U CN 201620888559U CN 205925998 U CN205925998 U CN 205925998U
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- magnetic
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- magnetic field
- liquid medium
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Abstract
The utility model provides a control device of miniature magnetic bead, include: miniature permanent magnetism granule, stator, coil winding, operation container, liquid medium and drive control part, thereby coil winding winding produces magnetic field on the stator and by the the direction of current flow of drive control part control coil winding and current strength, the stator according to the circumference mode around the operation container, apply specific sequential magnetic force to operating the liquid medium and the permanent magnetism granule that contain in the container to realize the effect of stirring or separation. Device convenient operation realizes the separation and the stirring of different grade type granule improving the efficiency of separation or stirring through the size and orientation who controls chronogenesis and magnetic field intensity who changes the solenoid pole pair, reduces equipment cost and the work load that personnel operated, has extensive popularization meaning.
Description
Technical field
This utility model is related to field of medical device, in particular it relates to a kind of actuation means of miniature magnetic bead.
Background technology
The current manipulation for the minitype particle in solution does not have shirtsleeve operation method, especially dissimilar granule
Separation and stirring, manipulated more complicated by electromagnetic force, also do not have a kind of simplicity method realize.
Through retrieval, Publication No. CN1624447A, the Chinese invention of Application No. CN200310115558.6, this invention is public
Open magnetic microparticle operation controller, it is made up of the micro- point of the plane micro coil being integrated in same substrate positive and negative and magnetic, magnetic core.To flat
Face micro-coil passes to electric current, produces application electromagnetic field around plane micro coil, when magnetic particle is located near the micro- point of magnetic,
Under the action of a magnetic force, microgranule is adsorbed on the micro- point of magnetic, and after electric current disconnects, magnetic field force disappears, and microgranule will be released.
The operation object of this invention includes the microgranules such as magnetic bead, cell, biomolecule, can complete single microgranule manipulation, counting micro particles, screening
Or the function such as the separation of particle mixture, it is applied to the fields such as cytobiology, immunoassay, microfluid research, nanotechnology.
Publication No. CN102362183A, the Chinese invention of Application No. 201080013160.X, this invention is related to one kind
The microfluidic device being used together with the processing equipment including magnetic supply, described microfluidic device includes:It is set to accommodate life
Thing sample and comprise the chamber of at least one magnetic-particle, and for being stored in the form of being read by described processing equipment
Including the storage device of the information of magnetic agreement, wherein said magnetic supply can be according to the described magnetic reading from described storage device
Protocol information nucleus formation is in the magnetic force of one or more of magnetic-particles.
But：Above-mentioned patent can not realize separation and the agitating function of microgranule under identical platform.
Utility model content
For the deficiencies in the prior art, this utility model provides a kind of actuation means of miniature magnetic bead it is only necessary to pass through to change
Become solenoid extremely to manipulation sequential and magnetic field intensity size and Orientation, can quickly realize variable grain separation or
Stirring, reduces equipment cost and the workload of human users.
For realizing object above, this utility model provides a kind of actuation means of miniature magnetic bead, including：Miniature permanent magnet
Grain, stator, coil windings, process container, liquid medium and drive control part；Coil winding wound is on stator and by driving
, thus producing magnetic field, stator is centered around behaviour according to circular manner for the sense of current of control section control coil winding and current intensity
Making container surroundings, the liquid medium comprising and paramagnetic particles being applied with the magnetic force of specific time sequence, thus realizing in process container
Stirring or detached effect, wherein：
Produce electric current after described coil windings energising, produce the magnetic field of respective direction according to the sense of current, strong according to electric current
Degree produces corresponding magnetic field intensity；
Described process container is the container that can penetrate magnetic field, miniature in liquid medium and liquid medium for holding
Granule, described minitype particle includes Miniature permanent magnet granule and other miniature non-paramagnetic particles；
Described drive control part connects coil windings, the size of current for control coil winding and direction, thus controlling
Formulate the magnetic field intensity that in son, any one polar curve circle produces and direction.
Preferably, described Miniature permanent magnet granule is permanent magnet, or is the molecule being coated permanent magnet.
It is highly preferred that described Miniature permanent magnet granule is StreptAvidin magnetic bead, carboxyl biomagnetic beads, silicon substrate magnetic bead, blood
Slurry dissociative DNA extracts one or more of magnetic bead.
Preferably, the sheet metal that described stator has magnetic conductivity for multilamellar is formed by stacking, and sets some on lamination
Winding slot, laying coil windings in winding slot.
Preferably, described stator comprises some extremely right, and each magnetic pole is wound with a coil, and magnetic pole is evenly distributed on operation
Container surroundings.
It is highly preferred that described stator to comprise at least one extremely right.
It is highly preferred that described extremely to for two groups of magnetic poles in correspondence with each other, the magnetic direction of two groups of magnetic poles is contrary, physical location
Mutual deviation 180 degree, magnetic field intensity are consistent；When one of magnetic field is N level, another corresponding magnetic direction is S level；When wherein
One magnetic field is S level, and another corresponding magnetic direction is N level；And two groups of magnetic levels produce magnetic field, simultaneously turn off magnetic simultaneously
?.
Preferably, described drive control part includes：Driver part and control parts, wherein：
Described drive control part includes：Driver part and control parts, wherein：
Described driver part is made up of some power drive pipes, for the voltage signal of control is become current signal, from
And driving coil winding, coil windings produce magnetic field, and magnetic field intensity is corresponding with current signal, magnetic direction and the sense of current pair
Should；
Described control parts produce voltage signal to driver part, for controlling the electricity of the current signal of driver part generation
Stream size and current intensity.
It is highly preferred that described control parts control described magnetic pole of the stator, including：Control described process container circumference 0-180
Magnetic pole of the stator direction in the range of degree is all equidirectional, controls the magnetic pole of 0-180 degree inner stator to stop according to setting sequence starting,
Control the pole orientation of 180-360 degree scope inner stator in opposite direction with the magnetic pole of the stator in the range of 0-180 degree all the time, and and 0-
The magnetic pole conduction mode of 180 degree inner stator is synchronous；Then realize Miniature permanent magnet granule or small that has been coated Miniature permanent magnet granule
Other non-permanent magnetism molecules efficiently separate grain with liquid medium.
It is highly preferred that when described control parts control the magnetic pole in the range of described process container circumference 0-360 degree according to suitable
Clockwise controls stator according to fixing sense of current turn-on and turn-off, then realize the liquid in liquid medium and liquid is situated between
The different types of minitype particle that matter is comprised stirs according to clockwise.
It is highly preferred that the magnetic pole in the range of described control parts control operation container circumference 0-360 degree is according to counterclockwise
Direction controlling stator according to fixing sense of current turn-on and turn-off, then realizes the liquid in liquid medium and liquid medium institute
The different types of minitype particle comprising stirs according to counterclockwise.
Compared with prior art, this utility model has following beneficial effect：
Device described in the utility model is easy to operate, by change solenoid extremely to manipulation sequential and magnetic field intensity
Size and Orientation realize separation and the stirring of dissimilar granule, improve separate or stirring efficiency, reduce equipment cost and
The workload of human users.This utility model has good operability and versatility, has and is widely popularized meaning.
Brief description
By reading detailed description non-limiting example made with reference to the following drawings, of the present utility model other special
Levy, objects and advantages will become more apparent upon：
Fig. 1 is the structural representation of this utility model one preferred embodiment；
Fig. 2 is the assembling schematic diagram of this utility model one preferred embodiment；
Fig. 3 is the coil profile of this utility model one preferred embodiment；
Fig. 4 is the drive control part schematic diagram of this utility model one preferred embodiment；
Fig. 5 is the driver part circuit theory diagrams of this utility model one preferred embodiment；
Fig. 6 is the control parts circuit theory diagrams of this utility model one preferred embodiment；
In Fig. 7, (a), (b), (c) are the coil as variable grain separation function of this utility model one preferred embodiment
Sequential chart；
In Fig. 8, (a), (b), (c), (d), (e), (f) are this utility model one preferred embodiment as agitating function
Coil sequential chart；
In figure：1- Miniature permanent magnet granule, 2- stator, 3- coil windings, 4- process container, 5- liquid medium, 6- drives control
Part processed, 7- driver part, 8- control parts.
Specific embodiment
With reference to specific embodiment, this utility model is described in detail.Following examples will be helpful to this area
Technical staff further understands this utility model, but does not limit this utility model in any form.It should be pointed out that to ability
For the those of ordinary skill in domain, without departing from the concept of the premise utility, some deformation can also be made and improve.
These broadly fall into protection domain of the present utility model.
As shown in Figure 1 and Figure 2, a kind of actuation means of miniature magnetic bead, including：Miniature permanent magnet granule 1, stator 2, coil around
Group 3, process container 4, liquid medium 5 and drive control part 6；Coil windings 3 are wound around on the stator 2 and by drive control part
, thus producing magnetic field, stator 2 is centered around process container according to circular manner for the sense of current of 6 control coil windings and current intensity
Around 4, the liquid medium comprising in process container 4 and paramagnetic particles are applied with the magnetic force of specific time sequence, thus realizing stirring
Or detached effect.
Preferably, described Miniature permanent magnet granule 1 is the miniature granule with certain continuing magnetic force, Miniature permanent magnet
Grain 1 can be permanent magnet can also be the molecule being coated permanent magnet, have certain continuing magnetic force, and Miniature permanent magnet
The particle diameter of granule 1 is between 20nm-3um；
Described Miniature permanent magnet granule 1 includes but is not limited to StreptAvidin magnetic bead (biotin separating immune magnetic bead), carboxylic
Base biomagnetic beads, silicon substrate magnetic bead, plasma DNA extract one or more of magnetic bead.
Described stator 2 is lamination, has good magnetic conductivity, and lays coil windings 3 in groove；Described coil around
Group 3 is multiturn coil, or is single-turn circular coil；Coil number in each pole domain of described coil windings is equal.
Preferably, described stator 2 is a kind of stator core constitutes one by stator iron-core lamination and various securing member compression
Individual entirety, wherein：Stator iron-core lamination is by hot rolling, cold-reduced silicon sheet or nickel magnetically soft alloy thin plate punching；And institute
State stator 2 and comprise that at least one is extremely right, each magnetic pole is wound with a coil, and magnetic pole is evenly distributed on around process container 4；Described
Extremely to for two groups of magnetic poles in correspondence with each other, two groups of magnetic pole and magnetic fields are in opposite direction, physical location mutual deviation 180 degree, magnetic field intensity are consistent
(when one of magnetic field is N level, another corresponding magnetic direction is S level.When one of magnetic field is S level, corresponding
Another magnetic direction is N level), and two groups of magnetic levels produce magnetic field simultaneously, simultaneously turn off magnetic field.
As shown in figure 3, described coil windings 3 are wound around on the stator 2 according to certain way and the number of turn, coil windings 3 are led to
Electricity, can produce the magnetic field in corresponding direction according to the sense of current, can produce corresponding magnetic field intensity according to current intensity；
Described coil windings 3 can be multiturn coil or single-turn circular coil；Coil in each pole domain of described coil windings 3
Number is equal, and the shared slot number in each pole domain of each phase winding is equal.
Described process container 4 is to have the container of certain capacity, is used for holding and comprises liquid medium 5 and liquid medium 5
Interior dissimilar minitype particle；Described process container 4 is the container that can penetrate magnetic field, is uniformly dispersed with stator about
2 magnetic pole.
Described liquid medium 5 is presented with liquid form, contains different types of minitype particle, and described minitype particle includes
Miniature permanent magnet granule 1 and the miniature non-paramagnetic particles of other types.
Described drive control part 6 is used for size of current and the sense of current of control coil winding 3, thus controlling stator 2
In the magnetic field intensity that produces of any one polar curve circle and direction.
As shown in figure 4, described drive control part 6 includes：Driver part 7 and control parts 8, wherein：
Driver part 7 is made up of some power drive pipes, and the voltage signal of control is become with certain orientation and intensity
Current signal thus the magnetic direction of control coil winding 3 and magnetic field intensity.
Described control parts 8 produce voltage signal to driver part, for controlling the current signal that driver part 7 produces
Size of current and current intensity.
In one embodiment, as shown in figure 5, driver part 7 can adopt the IR2101 of IRF company as predrive, work(
The voltage signal of control parts 8 is converted into as bridge circuit by rate driving tube using the N-channel MOS pipe IRFR2407 of 6 IRF companies
Electric current drives.For guaranteeing effective turn-on and turn-off of IRFR2407, IR2101 receives the voltage break-make letter that control parts 8 send
Control the turn-on and turn-off of IRFR2407,6 IRFR2407 connect coil windings 3 as bridge circuit, produce electric current after number, thus
Produce magnetic field.
Control parts 8 produce voltage signal according to demand to driver part 7.In one embodiment, as shown in figure 5, controlling
Part 8 adopts the DSPIC30F4011 of microchip company, has 6 tunnel PWM controller, 6 tunnel PWM controller of control parts 8
Output voltage signal to IR2101 predrive chip thus controlling effective break-make of 6 IRFR2407 bridge circuits, 6 IRFR2407
Bridge circuit connects coil windings 3, produces current signal, the magnetic direction of control coil winding 3 and magnetic field intensity.
If as shown in fig. 7, the stator 2 magnetic pole side in the range of described control parts control operation container 4 circumference 0-180 degree
To being all equidirectional, the stator 2 magnetic pole break-make sequential in 0-180 degree arrives, according to (a) in Fig. 7, the reiteration control that (b) arrives (c)
System, stator 2 pole orientation in the range of 180-360 degree all the time in contrast, and with 0-180 degree in stator 2 magnetic pole conducting side
Formula is synchronous, then can realize Miniature permanent magnet body or be coated the molecule of permanent magnet and other molecules efficiently separate.
If as shown in figure 8, during stator 2 magnetic pole break-make in described control parts control operation container 4 circumference 0-360 degree
Sequence controls according to the reiteration that (a) in Fig. 8 arrives (b) to (c) to (d) to (e) to (f), then achieve the liquid in liquid medium 5
Body and different molecules stir according to clockwise；
If the stator 2 magnetic pole break-make sequential in described control parts control operation container 4 circumference 0-360 degree is according to Fig. 8
In (f) arrive (e) and arrive (d) and arrive (c) and arrive (b) and arrive the reiteration of (a) and control, then achieve liquid in liquid medium 5 and not
Same molecule stirs according to counterclockwise.
Apparatus structure described in the utility model is simple and convenient to operate, by change solenoid extremely to manipulation sequential with
And the size and Orientation of magnetic field intensity realizes separation and the stirring of dissimilar minitype particle, improve separate or stirring efficiency,
Reduce equipment cost and the workload of human users, have and be widely popularized meaning.
Above specific embodiment of the utility model is described.It is to be appreciated that this utility model not office
It is limited to above-mentioned particular implementation, those skilled in the art can make various modifications or modification within the scope of the claims,
This has no effect on flesh and blood of the present utility model.
Claims (10)
1. a kind of actuation means of miniature magnetic bead are it is characterised in that include：Miniature permanent magnet granule, stator, coil windings, operation
Container, liquid medium and drive control part；Coil winding wound is on stator and by drive control part control coil winding
The sense of current and current intensity thus producing magnetic field, stator is centered around around process container according to circular manner, to operation hold
The liquid medium comprising in device and the magnetic force of paramagnetic particles applying specific time sequence, thus realizing stirring or detached effect, its
In：
Produce electric current after described coil windings energising, produce the magnetic field of respective direction according to the sense of current, produced according to current intensity
Raw corresponding magnetic field intensity；
Described process container is the container that can penetrate magnetic field, for holding miniature in liquid medium and liquid medium
Grain, described minitype particle includes Miniature permanent magnet granule and other miniature non-paramagnetic particles；
Described drive control part connects coil windings, the size of current for control coil winding and direction, thus control determining
Magnetic field intensity and direction that in son, any one polar curve circle produces.
2. according to claim 1 a kind of actuation means of miniature magnetic bead it is characterised in that described Miniature permanent magnet granule be forever
Magnet, or be the molecule being coated permanent magnet.
3. according to claim 2 a kind of actuation means of miniature magnetic bead it is characterised in that described Miniature permanent magnet granule is
StreptAvidin magnetic bead, carboxyl biomagnetic beads, silicon substrate magnetic bead, plasma DNA extract one or more of magnetic bead.
4. according to claim 1 a kind of actuation means of miniature magnetic bead it is characterised in that described stator has for multilamellar leads
The sheet metal of magnetic is formed by stacking, and sets some winding slots on lamination, laying coil windings in winding slot.
5. according to claim 1 a kind of actuation means of miniature magnetic bead it is characterised in that described coil windings be multiturn line
Circle, or be single-turn circular coil；Coil number in each pole domain of described coil windings is equal.
6. according to claim 5 a kind of actuation means of miniature magnetic bead it is characterised in that described stator comprises some poles
Right, each magnetic pole is wound with a coil, and magnetic pole is evenly distributed on around process container；Wherein：
Described extremely to for two groups of magnetic poles in correspondence with each other, the magnetic direction of two groups of magnetic poles is contrary, physical location mutual deviation 180 degree, magnetic
Field intensity is consistent；When one of magnetic field is N level, another corresponding magnetic direction is S level；When one of magnetic field is S
Level, another corresponding magnetic direction is N level；And two groups of magnetic levels produce magnetic field, simultaneously turn off magnetic field simultaneously.
7. according to claim 1 a kind of actuation means of miniature magnetic bead it is characterised in that described drive control part subpackage
Include：Driver part and control parts, wherein：
Described driver part is made up of some power drive pipes, for the voltage signal of control is become current signal, thus driving
Moving winding winding, coil windings produce magnetic field, and magnetic field intensity is corresponding with current signal, and magnetic direction is corresponding with the sense of current；
Described control parts produce voltage signal to driver part, and the electric current for controlling the current signal of driver part generation is big
Little and current intensity.
8. according to any one of claim 1-7 a kind of actuation means of miniature magnetic bead it is characterised in that described control parts
Control described magnetic pole of the stator, including：The magnetic pole of the stator direction in the range of described process container circumference 0-180 degree is controlled to be all Tongfang
To the magnetic pole controlling 0-180 degree inner stator, according to setting sequence starting stopping, controlling the magnetic pole of 180-360 degree scope inner stator
Direction is in opposite direction with the magnetic pole of the stator in the range of 0-180 degree all the time, and same with the magnetic pole conduction mode of 0-180 degree inner stator
Step；Then realize Miniature permanent magnet granule or be coated small of other non-permanent magnetism of the molecule of Miniature permanent magnet granule and liquid medium
Grain efficiently separates.
9. according to any one of claim 1-7 a kind of actuation means of miniature magnetic bead it is characterised in that work as described control unit
Part controls the magnetic pole in the range of described process container circumference 0-360 degree to control stator according to fixing electric current according to clockwise direction
Direction turn-on and turn-off, then realize the liquid in liquid medium and different types of minitype particle that liquid medium is comprised by
Stir according to clockwise.
10. according to any one of claim 1-7 a kind of actuation means of miniature magnetic bead it is characterised in that work as described control
Magnetic pole in the range of component controls process container circumference 0-360 degree controls stator according to fixing electric current side according to counter clockwise direction
To turn-on and turn-off, then realize the liquid in liquid medium and different types of minitype particle that liquid medium is comprised according to
Stir counterclockwise.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620888559.7U CN205925998U (en) | 2016-08-16 | 2016-08-16 | Control device of miniature magnetic bead |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620888559.7U CN205925998U (en) | 2016-08-16 | 2016-08-16 | Control device of miniature magnetic bead |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205925998U true CN205925998U (en) | 2017-02-08 |
Family
ID=57917829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620888559.7U Withdrawn - After Issue CN205925998U (en) | 2016-08-16 | 2016-08-16 | Control device of miniature magnetic bead |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205925998U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106111329A (en) * | 2016-08-16 | 2016-11-16 | 闫维新 | A kind of actuation means of miniature magnetic bead |
| CN112444438A (en) * | 2019-08-27 | 2021-03-05 | 深圳市帝迈生物技术有限公司 | Sample detection equipment and mixing device thereof |
-
2016
- 2016-08-16 CN CN201620888559.7U patent/CN205925998U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106111329A (en) * | 2016-08-16 | 2016-11-16 | 闫维新 | A kind of actuation means of miniature magnetic bead |
| CN112444438A (en) * | 2019-08-27 | 2021-03-05 | 深圳市帝迈生物技术有限公司 | Sample detection equipment and mixing device thereof |
| CN112444438B (en) * | 2019-08-27 | 2023-12-05 | 深圳市帝迈生物技术有限公司 | Sample detection equipment and mixing device thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20170208 Effective date of abandoning: 20171013 |
|
| AV01 | Patent right actively abandoned |