CN205758585U - The animal experiment device studied for accurate radiotherapy - Google Patents
The animal experiment device studied for accurate radiotherapy Download PDFInfo
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- CN205758585U CN205758585U CN201620278672.3U CN201620278672U CN205758585U CN 205758585 U CN205758585 U CN 205758585U CN 201620278672 U CN201620278672 U CN 201620278672U CN 205758585 U CN205758585 U CN 205758585U
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- 238000001959 radiotherapy Methods 0.000 title claims abstract description 32
- 241001465754 Metazoa Species 0.000 title claims abstract description 14
- 238000002474 experimental method Methods 0.000 title claims abstract description 14
- 238000013170 computed tomography imaging Methods 0.000 claims abstract description 43
- 238000003384 imaging method Methods 0.000 claims abstract description 28
- 238000002603 single-photon emission computed tomography Methods 0.000 claims abstract description 17
- 230000033001 locomotion Effects 0.000 claims abstract description 16
- 238000011160 research Methods 0.000 claims abstract description 10
- 238000013519 translation Methods 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 abstract description 8
- 108010022579 ATP dependent 26S protease Proteins 0.000 abstract description 3
- 230000005855 radiation Effects 0.000 abstract description 3
- 238000004088 simulation Methods 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 2
- 230000000693 radiobiological effect Effects 0.000 abstract description 2
- 238000002591 computed tomography Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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Abstract
The utility model discloses the animal experiment device studied for accurate radiotherapy of a kind of technical field of medical instruments, including: C-shaped frame structure rotation platform and loading motion platform, wherein: the center of rotation axis of C-shaped frame structure rotation platform and the center of rotation axis of loading motion platform intersect vertically.C-shaped frame structure rotation platform includes: the C-shaped support with translating device, the X-ray source with grating, cone-beam CT imaging detector, SPECT imaging detector and rotating driving device.The device accurate Patients During Radiotherapy of accurate simulation human body involved by this utility model, 26S Proteasome Structure and Function accurate image guiding in real time can be realized, and the function such as target target area precisely irradiation, it is to integrate hi-Fix, the guiding of the most multi-modal 26S Proteasome Structure and Function image and the Novel radiotherapy scientific research emulation platform of the reverse radiotherapy planning of high-precision multi-mode, it is applicable to the pre-clinical research application scenarios such as the pre-clinical research of radiation oncology, such as tumor generation and development mechanism, treatment response, tumor and normal structure radiobiological effect.
Description
Technical field
The utility model relates to the device of a kind of technical field of medical instruments, specifically a kind of for the research of accurate radiotherapy
Animal experiment device.
Background technology
Radiotherapy (radiotherapy), as a kind of curative effect for the treatment of of cancer and cost benefit all significantly means, is combined therapy of tumour
During most important and indivisible ingredient.Accurate radiotherapy has damaged little advantage with its toxic and side effects with to patient
Part instead of previously with the oncotherapy as essential therapeutic arsenals of performing the operation.Pre-clinical research is can not in Novel radiation treatment theoretical research
Or the ionizing radiation normal tissue damage that the ring lacked, mainly high-energy ray produce is relatively greatly, theoretical research is faced at entrance human body
Need fully to verify in pre-clinical setting before bed experiment, and in vitro and carrying out simulation of radiotherapy treatment photograph in biopsy sample
Penetrate proof theory reliability, such as zoopery.Existing animal radiotherapy apparatus limitation is relatively big, limits it in multiple section
Grind the application in environment, be mainly reflected in several aspects such as frame for movement, image guidance mode and dosage put-on method: 1) machinery
System commonly used laboratory table framework, although frame for movement is relatively simple but is a lack of the environment true to nature of human body radiotherapy apparatus, treatment
Method is not directly applicable human body equipment；2) lack effective real time imaging and guide system, it is difficult to realize tumor target accurately fixed
Position, causes biological tissue's actual reception dosage uncertain, hampers clinically relevant radiotherapy strategy and implement；3) shortage is applicable to little
The accurate radiotherapy planning system of animal, it is impossible to conformal accurate input radiation dose, to anatomical structure interested, causes great quantities of spare
Dosage enters the normal structure closed on, and produces toxicity so that the execution of experiment and result are explained highly difficult.
Summary of the invention
This utility model is for deficiencies of the prior art, it is provided that a kind of zoopery studied for accurate radiotherapy
Device, solves accurate radiotherapy zoopery and does not mates with clinical practice, lacks the problems such as real time imaging guiding, has accurately
The features such as the simulation accurate Patients During Radiotherapy of human body, 26S Proteasome Structure and Function accurate image guiding in real time, the precisely irradiation of target target area, for putting
Penetrate the pre-clinical research of tumor, such as tumor to produce and development mechanism, treatment response, tumor and normal structure radiobiological effect etc.
Pre-clinical research has important using value.
This utility model is achieved through the following technical solutions: a kind of animal experiment device studied for accurate radiotherapy,
Including: C-shaped frame structure rotation platform and loading motion platform, wherein: the center of rotation axis of C-shaped frame structure rotation platform and loading fortune
The center of rotation axis of moving platform intersects vertically.
Further, described C-shaped frame structure rotation platform includes: the C-shaped support with translating device, the X with grating penetrate
Line source, cone-beam CT imaging detector, SPECT imaging detector and rotating driving device, wherein: C-shaped support is with translation
One end fixed cone beam CT imaging detector of device, the other end on the other side fixes X-ray source, X-ray centred beam with
Cone-beam CT imaging detector plane is vertical, and SPECT imaging detector is fixed on another orthogonal end of C-shaped support, becomes with Cone-Beam CT
As detector is disposed vertically, rotating driving device is fixing with C-shaped carriage rotational center to be connected.
Further, the described C-shaped support with translating device includes: central supported seat, X-ray source support arm, cone
Beam CT imaging detector support arm, SPECT imaging detector support arm and translating device, wherein: X-ray source support arm and
Cone-beam CT imaging detector support arm is fixing with central supported seat respectively to be connected, and opposed in circumference 180 degree, and SPECT imaging is visited
Survey device support arm is fixing with central supported seat to be connected, and is week with X-ray source support arm and cone-beam CT imaging detector support arm
To 90 degree of layouts, translating device is arranged at the same one end of cone-beam CT imaging detector support arm.
Further, described central supported seat is fixing with rotating driving device to be connected.
Further, described translating device includes: guide rail, slide block and driver part, wherein: guide rail is fixed on central supported
On seat, guide rail is provided with slide block, and slide block is fixed on cone-beam CT imaging detector support arm, and driver part is fixed Duan Yu center and propped up
Support seat connects, and driver part mobile terminal is connected with cone-beam CT imaging detector support arm.
Further, the described X-ray source with grating includes: grating aligner and X-ray bulb, wherein: grating
Collimator is arranged at the light hole of X-ray bulb.
Further, described loading motion platform includes: object stage, x to translating device, y to translating device, z to translation
Device and z-axis rotary apparatus, wherein: object stage is fixed on z on translating device, z is fixed on x to translation dress to translating device
Putting, x is fixed on y on translating device to translating device, and y is fixed on z-axis rotary apparatus to translating device.
Further, described object stage table top is parallel to x y plane, and one end is unsettled, and the other end and z are fixing even to translating device
Connect.
This device operation principle is as follows:
C-shaped frame structure rotation platform highly integrated multimode images data acquisition equipment and radiotherapy equipment, imaging and the dual use for the treatment of
The X-ray source on way is staggered relatively with cone-beam CT imaging detector, SPECT imaging detector and cone-beam CT imaging main axis parallel
Place, it is to avoid nuclear medicine is disturbed by the X-ray of light source.C-shaped support can be driven around center of rotation by rotating driving device
Axis is freely rotatable, the relative position of X-ray source, cone-beam CT imaging detector and SPECT imaging detector with C-shaped support
Fixing, follow C-shaped support around the rotation of 360 degree of center of rotation axis such that it is able to realize the spinfunction around object stage, and
Carry out 360 degree of CT scan imagings and radiation therapy beam projection.By the translating device on C-shaped support, Cone-Beam CT can be driven
Imaging detector is perpendicular to center of rotation axis direction relative to C-shaped support edge and moves in parallel, regulation detector and center of rotation
Distance such that it is able to realize the cone-beam CT imaging of multiple nanoscale object.
Loading motion platform possesses the translation freedoms along tri-directions of x y z and the rotational freedom around central axis.Object stage leads to
Cross z to drive to translating device, can move in parallel along the z-axis direction；Driven to translating device by x, can be the most parallel
Mobile；Driven to translating device by y, can move in parallel along the y-axis direction such that it is able to realize tested object space position
Real-time online dynamically adjust.Object stage is driven by z-axis rotary apparatus, can be freely rotatable around z-axis such that it is able to realize non-
The CT scan imaging of coaxial line pattern and radiotherapy.
Accompanying drawing explanation
Fig. 1 is the structural representation of embodiment 1.
Fig. 2 is the structural representation of C-shaped support.
Fig. 3 is the structural representation of loading motion platform.
In figure: 1C shape framework rotation platform, 2 loading motion platforms, 3 with the C-shaped support of translating device, 4 with grating
X-ray source, 5 cone-beam CT imaging detectors, 6SPECT imaging detector, 7 rotating driving devices, 8 central supported
Seat, 9X ray source support arm, 10 cone-beam CT imaging detector support arms, 11SPECT imaging detector support arm, 12 flat
Moving device, 13 guide rails, 14 slide blocks, 15 driver parts, 16 grating aligners, 17X ray tube, 18 object stages, 19
X to translating device, 20y to translating device, 21z to translating device, 22z shaft rotating device.
Detailed description of the invention
Elaborating embodiment of the present utility model below in conjunction with accompanying drawing, the present embodiment with technical solutions of the utility model is being
Implement under premise, give detailed embodiment and concrete operating process, but protection domain of the present utility model does not limits
In following embodiment.
Embodiment 1
As it is shown in figure 1, this example includes: C-shaped frame structure rotation platform 1 and loading motion platform 2, wherein: C-shaped frame structure rotates
The center of rotation axis of platform 1 and the center of rotation axis of loading motion platform 2 intersect vertically.
Described C-shaped frame structure rotation platform 1 includes: the C-shaped support 3 with translating device, the X-ray source 4 with grating,
Cone-beam CT imaging detector 5, SPECT imaging detector 6 and rotating driving device 7, wherein: C-shaped support 3 is with translation dress
One end fixed cone beam CT imaging detector 5 put, the other end on the other side fixes X-ray source 4, X-ray centred beam
Vertical with cone-beam CT imaging detector 5 plane, SPECT imaging detector 6 is fixed on another orthogonal end of C-shaped support 3, with cone
Beam CT imaging main axis parallel is placed, and rotating driving device 7 is fixing with C-shaped support 3 center of rotation to be connected.
The described C-shaped support 3 with translating device includes: central supported seat 8, X-ray source support arm 9, Cone-Beam CT
Imaging detector support arm 10, SPECT imaging detector support arm 11 and translating device 12, wherein: X-ray source support arm
9 and cone-beam CT imaging detector support arm 10 is fixing with central supported seat 8 respectively is connected, and in circumferential 180 degree opposed, SPECT
Imaging detector support arm 11 is fixing with central supported seat 8 to be connected, and visits with X-ray source support arm 9 and cone-beam CT imaging
Survey device support arm 10 is in 90 degree of layouts of circumference, and translating device 12 is arranged at the same one end of cone-beam CT imaging detector support arm 10.
Described central supported seat 8 is fixing with rotating driving device 7 to be connected.
Described translating device 12 includes: guide rail 13, slide block 14 and driver part 15, wherein: guide rail 13 is fixed on center
Supporting on seat 8, guide rail 13 is provided with slide block 14, and slide block 14 is fixed on cone-beam CT imaging detector support arm 10, drives
The fixing end of parts 15 is connected with central supported seat 8, and driver part 15 mobile terminal is with cone-beam CT imaging detector support arm 10 even
Connect.
The described X-ray source 4 with grating includes: grating aligner 16 and X-ray bulb 17, wherein: grating is accurate
Straight device 16 is arranged at the light hole of X-ray bulb 17.
Described loading motion platform 2 includes: object stage 18, x to translating device 19, y to translating device 20, z to translation
Device 21 and z-axis rotary apparatus 22, wherein: object stage 18 is fixed on z on translating device 21, and z is to translating device 21
Being fixed on x on translating device 19, x is fixed on y on translating device 20 to translating device 19, and y is solid to translating device 20
On z-axis rotary apparatus 22.
Described loading motion platform 2 center of rotation z-axis is coplanar with cone-beam CT imaging main shaft.
Described object stage 18 table top is parallel to x y plane, and one end is unsettled, and the other end and z are connected to translating device 21 is fixing.
This device work process is as follows:
The highly integrated multimode images data acquisition equipment of C-shaped frame structure rotation platform 1 and radiotherapy equipment, imaging and treatment are dual
The X-ray source 4 of purposes is staggered relatively with cone-beam CT imaging detector 5, SPECT imaging detector 6 and cone-beam CT imaging
Main axis parallel is placed, it is to avoid nuclear medicine is disturbed by the X-ray of light source.C-shaped support can be driven by rotating driving device 7
3 is freely rotatable around center of rotation axis, X-ray source 4, cone-beam CT imaging detector 5 and SPECT imaging detector 6 and C
The relative position of shape support 3 is fixed, and follows C-shaped support 3 around the rotation of 360 degree of center of rotation axis such that it is able to realize around
The spinfunction of object stage 18, and carry out 360 degree of CT scan imagings and radiation therapy beam projection.By on C-shaped support 3
Translating device 12, cone-beam CT imaging detector 5 can be driven along being perpendicular to center of rotation axis direction relative to C-shaped support 3
Move in parallel, cone governor beam CT imaging detector 5 and the distance of center of rotation such that it is able to realize the cone-beam of multiple nanoscale object
CT imaging.
Loading motion platform 2 possesses the translation freedoms along tri-directions of x y z and the rotational freedom around central axis.Object stage
18 are driven to translating device 21 by z, can move in parallel along the z-axis direction；Driven to translating device 19 by x, can be along x
Direction of principal axis moves in parallel；Driven to translating device 20 by y, can move in parallel along the y-axis direction such that it is able to realize tested
The real-time online of object space position dynamically adjusts.Object stage 18 is driven by z-axis rotary apparatus 22, freely can turn around z-axis
Dynamic such that it is able to realize CT scan imaging and the radiotherapy of non co axial ray mode.
Claims (7)
1. the animal experiment device for the research of accurate radiotherapy, it is characterised in that including: C-shaped frame structure rotation platform and load
Thing motion platform, wherein: the center of rotation axis of C-shaped frame structure rotation platform is vertical with the center of rotation axis of loading motion platform
Intersect；Described C-shaped frame structure rotation platform includes: the C-shaped support with translating device, the X-ray source with grating,
Cone-beam CT imaging detector, SPECT imaging detector and rotating driving device, wherein: C-shaped support is with the one of translating device
End fixed cone beam CT imaging detector, the other end on the other side fixes X-ray source, X-ray centred beam and Cone-Beam CT
Imaging detector plane is vertical, and SPECT imaging detector is fixed on another orthogonal end of C-shaped support, with cone-beam CT imaging detector
Being disposed vertically, rotating driving device is fixing with C-shaped carriage rotational center to be connected.
The animal experiment device studied for accurate radiotherapy the most according to claim 1, is characterized in that, described with flat
The C-shaped support of moving device includes: central supported seat, X-ray source support arm, cone-beam CT imaging detector support arm, SPECT
Imaging detector support arm and translating device, wherein: X-ray source support arm and cone-beam CT imaging detector support arm respectively with
Central supported seat is fixing to be connected, and opposed in circumference 180 degree, and SPECT imaging detector support arm is fixing with central supported seat even
Connect, and with X-ray source support arm and cone-beam CT imaging detector support arm in 90 degree of layouts of circumference, translating device is arranged at
The same one end of cone-beam CT imaging detector support arm.
The animal experiment device studied for accurate radiotherapy the most according to claim 2, is characterized in that, described center is propped up
Support seat is fixing with rotating driving device to be connected.
The animal experiment device studied for accurate radiotherapy the most according to claim 2, is characterized in that, described translation dress
Put and include: guide rail, slide block and driver part, wherein: guide rail is fixed on central supported seat, and guide rail is provided with slide block, slide block
Being fixed on cone-beam CT imaging detector support arm, the fixing end of driver part is connected with central supported seat, driver part mobile terminal and
Cone-beam CT imaging detector support arm connects.
The animal experiment device studied for accurate radiotherapy the most according to claim 1, is characterized in that, described with light
The X-ray source of grid includes: grating aligner and X-ray bulb, wherein: grating aligner is arranged at going out of X-ray bulb
At unthreaded hole.
The animal experiment device studied for accurate radiotherapy the most according to claim 1, is characterized in that, described loading fortune
Moving platform includes: object stage, x to translating device, y to translating device, z to translating device and z-axis rotary apparatus, wherein:
Object stage is fixed on z on translating device, and z is fixed on x on translating device to translating device, and x is fixed on y to translating device
On translating device, y is fixed on z-axis rotary apparatus to translating device.
The animal experiment device studied for accurate radiotherapy the most according to claim 6, is characterized in that, described object stage
Table top is parallel to x y plane, and one end is unsettled, and the other end and z are connected to translating device is fixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620278672.3U CN205758585U (en) | 2016-04-05 | 2016-04-05 | The animal experiment device studied for accurate radiotherapy |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620278672.3U CN205758585U (en) | 2016-04-05 | 2016-04-05 | The animal experiment device studied for accurate radiotherapy |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769235A (en) * | 2016-04-05 | 2016-07-20 | 浙江大学 | Animal experimental device for precision radiotherapy research |
| CN112245814A (en) * | 2020-10-21 | 2021-01-22 | 浙江大学 | Animal sample conveying device for accurate radiotherapy research |
-
2016
- 2016-04-05 CN CN201620278672.3U patent/CN205758585U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769235A (en) * | 2016-04-05 | 2016-07-20 | 浙江大学 | Animal experimental device for precision radiotherapy research |
| CN112245814A (en) * | 2020-10-21 | 2021-01-22 | 浙江大学 | Animal sample conveying device for accurate radiotherapy research |
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