CN105769235A - Animal experimental device for precision radiotherapy research - Google Patents
Animal experimental device for precision radiotherapy research Download PDFInfo
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- CN105769235A CN105769235A CN201610209906.3A CN201610209906A CN105769235A CN 105769235 A CN105769235 A CN 105769235A CN 201610209906 A CN201610209906 A CN 201610209906A CN 105769235 A CN105769235 A CN 105769235A
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- 238000001959 radiotherapy Methods 0.000 title claims abstract description 34
- 241001465754 Metazoa Species 0.000 title claims abstract description 19
- 238000011160 research Methods 0.000 title claims abstract description 12
- 238000003384 imaging method Methods 0.000 claims abstract description 29
- 238000002603 single-photon emission computed tomography Methods 0.000 claims abstract description 18
- 238000013170 computed tomography imaging Methods 0.000 claims description 46
- 238000002474 experimental method Methods 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 abstract description 6
- 238000002591 computed tomography Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 230000005855 radiation Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000004088 simulation Methods 0.000 abstract description 3
- 238000013519 translation Methods 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000000693 radiobiological effect Effects 0.000 abstract description 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 230000005748 tumor development Effects 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
- A61B6/035—Mechanical aspects of CT
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/04—Positioning of patients; Tiltable beds or the like
- A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4064—Arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam
- A61B6/4085—Cone-beams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4266—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a plurality of detector units
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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Abstract
The invention belongs to the technical field of medical apparatus and instruments, and discloses an animal experimental device for precision radiotherapy research.The animal experimental device comprises a C-shaped structure rotation platform and a carrying movement platform.The rotation central axis of the C-shaped structure rotation platform perpendicularly intersects with the rotation central axis of the carrying movement platform.The C-shaped structure rotation platform comprises a C-shaped support with a translation device, an X-ray optical source with optical gratings, a cone-beam CT (computed tomography) imaging detector, a SPECT (single photon emission computed tomography) imaging detector and a rotation driving device.The animal experimental device has the advantages that human precision radiotherapy procedures can be accurately simulated by the aid of the animal experimental device, and the animal experimental device has structure and function precision imaging real-time guidance, objective target region precision irradiation functions and the like, is a novel radiotherapy scientific research simulation platform with integrated high-precision positioning, high-precision multi-modal structure and function image guidance and high-precision multi-mode inverse radiotherapy planning, and is applicable to radiation oncology preliminary clinical research in preliminary clinical research application places such as tumor formation and development mechanisms, radiotherapy response and tumor and normal tissue radiobiological effects.
Description
Technical field
The present invention relates to the device of a kind of technical field of medical instruments, specifically a kind of animal experiment device studied for accurate radiotherapy.
Background technology
Radiotherapy (radiotherapy), as all significant means of a kind of curative effect for the treatment of of cancer and cost benefit, is the most important and indivisible ingredient in combined therapy of tumour process.Accurate radiotherapy with its toxic and side effects and patient is damaged little advantage part instead of previously with operation be the oncotherapy of essential therapeutic arsenals.Pre-clinical research is a ring indispensable in Novel radiation treatment theoretical research, the ionizing radiation normal tissue damage that mainly high-energy ray produces is bigger, theoretical research needed fully to verify in pre-clinical setting before entering human clinical trial, and in vitro and biopsy sample, carry out simulation of radiotherapy treatment irradiation come proof theory reliability, such as zoopery.Existing animal radiotherapy apparatus limitation is bigger, limit its application in multiple scientific research environment, it is mainly reflected in several aspects such as frame for movement, image guidance mode and dosage put-on method: 1) the commonly used laboratory table framework of mechanical system, although frame for movement is relatively simple but being a lack of the environment true to nature of human body radiotherapy apparatus, Therapeutic Method is not directly applicable human body equipment；2) lack effective real time imaging and guide system, it is difficult to realize tumor target and be accurately positioned, cause that biological tissue's actual reception dosage is uncertain, hamper clinically relevant radiotherapy strategy and implement；3) the accurate radiotherapy planning system being applicable to toy is lacked, it is impossible to conformal accurate input radiation dose, to anatomical structure interested, causes that great quantities of spare dosage enters the normal structure closed on, produces toxicity so that the execution of experiment and result are explained highly difficult.
Summary of the invention
The present invention is directed to prior art above shortcomings, a kind of animal experiment device studied for accurate radiotherapy is provided, solve accurate radiotherapy zoopery not mate with clinical practice, lack the problems such as real time imaging guiding, there is the features such as the accurate Patients During Radiotherapy of accurate simulation human body, the accurate image guiding in real time of 26S Proteasome Structure and Function, the precisely irradiation of target target area, for the pre-clinical research of radiation oncology, for instance tumor produces and the clinical research in advance such as development mechanism, treatment response, tumor and normal structure radiobiological effect has important using value.
The present invention is achieved by the following technical solutions: a kind of animal experiment device studied for accurate radiotherapy, including: C-shaped frame structure rotation platform and loading motion platform, wherein: the center of rotation axis of C-shaped frame structure rotation platform and the center of rotation axis of loading motion platform intersect vertically.
Further, described C-shaped frame structure rotation platform includes: with the C shape support of translating device, X-ray source with grating, cone-beam CT imaging detector, SPECT imaging detector and rotating driving device, wherein: C shape support is with one end fixed cone beam CT imaging detector of translating device, the other end on the other side fixes X-ray source, X ray centred beam is vertical with cone-beam CT imaging detector plane, SPECT imaging detector is fixed on another orthogonal end of C shape support, place with cone-beam CT imaging main axis parallel, rotating driving device is fixing with C shape carriage rotational center to be connected.
Further, the described C shape support with translating device includes: central supported seat, X-ray source support arm, cone-beam CT imaging detector support arm, SPECT imaging detector support arm and translating device, wherein: X-ray source support arm and cone-beam CT imaging detector support arm are fixing with central supported seat respectively to be connected, and it is opposed in circumference 180 degree, SPECT imaging detector support arm is fixing with central supported seat to be connected, and with X-ray source support arm and cone-beam CT imaging detector support arm in 90 degree of layouts of circumference, translating device is arranged at the same one end of cone-beam CT imaging detector support arm.
Further, described central supported seat is fixing with rotating driving device to be connected.
Further, described translating device includes: guide rail, slide block and driver part, wherein: guide rail is fixed on central supported seat, guide rail is provided with slide block, slide block is fixed on cone-beam CT imaging detector support arm, the fixing end of driver part is connected with central supported seat, and driver part mobile terminal is connected with cone-beam CT imaging detector support arm.
Further, the described X-ray source with grating includes: grating aligner and X ray bulb, wherein: grating aligner is arranged at the light hole place of X ray bulb.
Further, described loading motion platform includes: object stage, x are to translating device, y to translating device, z to translating device and z-axis rotary apparatus, wherein: object stage is fixed on z on translating device, z is fixed on x on translating device to translating device, x is fixed on y on translating device to translating device, and y is fixed on z-axis rotary apparatus to translating device.
Further, described object stage table top is parallel to x y plane, and one end is unsettled, and the other end is connected to translating device is fixing with z.
Further, described loading motion platform center of rotation z-axis is coplanar with cone-beam CT imaging main shaft.
This device operation principle is as follows:
The highly integrated multimode images data acquisition equipment of C-shaped frame structure rotation platform and radiotherapy equipment, the X-ray source of imaging and treatment double duty is staggered relatively with cone-beam CT imaging detector, SPECT imaging detector is placed with cone-beam CT imaging main axis parallel, it is to avoid nuclear medicine is disturbed by the X ray of light source.C shape support can be driven freely rotatable around center of rotation axis by rotating driving device, the relative position of X-ray source, cone-beam CT imaging detector and SPECT imaging detector and C shape support is fixed, follow C shape support around the rotation of 360 degree of center of rotation axis, it is thus possible to realize the spinfunction around object stage, and carry out 360 degree of CT scan imagings and radiation therapy beam projection.By the translating device on C shape support, cone-beam CT imaging detector can be driven to be perpendicular to center of rotation axis direction relative to C shape support edge and to move in parallel, regulate the distance of detector and center of rotation such that it is able to realize the cone-beam CT imaging of multiple nanoscale object.
Loading motion platform possesses the translation freedoms along tri-directions of x y z and the rotational freedom around central axis.Object stage is driven to translating device by z, can move in parallel along the z-axis direction；Driven to translating device by x, can move in parallel along the x-axis direction；Driven to translating device by y, can move in parallel along the y-axis direction such that it is able to the real-time online realizing tested object space position dynamically adjusts.Object stage is driven by z-axis rotary apparatus, can be freely rotatable around z-axis such that it is able to realize CT scan imaging and the radiotherapy of non co axial ray mode.
Accompanying drawing explanation
Fig. 1 is the structural representation of embodiment 1.
Fig. 2 is the structural representation of C shape support.
Fig. 3 is the structural representation of loading motion platform.
In figure: 1C shape framework rotation platform, 2 loading motion platforms, 3 with the C shape support of translating device, 4 with the X-ray source of grating, 5 cone-beam CT imaging detectors, 6SPECT imaging detector, 7 rotating driving devices, 8 central supported seats, 9X ray source support arm, 10 cone-beam CT imaging detector support arms, 11SPECT imaging detector support arm, 12 translating devices, 13 guide rails, 14 slide blocks, 15 driver parts, 16 grating aligners, 17X ray tube, 18 object stages, 19x is to translating device, 20y is to translating device, 21z is to translating device, 22z shaft rotating device.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the invention being elaborated, the present embodiment is carried out under premised on technical solution of the present invention, gives detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
As it is shown in figure 1, this example includes: C-shaped frame structure rotation platform 1 and loading motion platform 2, wherein: the center of rotation axis of C-shaped frame structure rotation platform 1 and the center of rotation axis of loading motion platform 2 intersect vertically.
Described C-shaped frame structure rotation platform 1 includes: with the C shape support 3 of translating device, X-ray source 4 with grating, cone-beam CT imaging detector 5, SPECT imaging detector 6 and rotating driving device 7, wherein: C shape support 3 is with one end fixed cone beam CT imaging detector 5 of translating device, the other end on the other side fixes X-ray source 4, X ray centred beam is vertical with cone-beam CT imaging detector 5 plane, SPECT imaging detector 6 is fixed on another orthogonal end of C shape support 3, place with cone-beam CT imaging main axis parallel, rotating driving device 7 is fixing with C shape support 3 center of rotation to be connected.
The described C shape support 3 with translating device includes: central supported seat 8, X-ray source support arm 9, cone-beam CT imaging detector support arm 10, SPECT imaging detector support arm 11 and translating device 12, wherein: X-ray source support arm 9 and cone-beam CT imaging detector support arm 10 are fixing with central supported seat 8 respectively to be connected, and it is opposed in circumference 180 degree, SPECT imaging detector support arm 11 is fixing with central supported seat 8 to be connected, and with X-ray source support arm 9 and cone-beam CT imaging detector support arm 10 in 90 degree of layouts of circumference, translating device 12 is arranged at the same one end of cone-beam CT imaging detector support arm 10.
Described central supported seat 8 is fixing with rotating driving device 7 to be connected.
Described translating device 12 includes: guide rail 13, slide block 14 and driver part 15, wherein: guide rail 13 is fixed on central supported seat 8, guide rail 13 is provided with slide block 14, slide block 14 is fixed on cone-beam CT imaging detector support arm 10, the fixing end of driver part 15 is connected with central supported seat 8, and driver part 15 mobile terminal is connected with cone-beam CT imaging detector support arm 10.
The described X-ray source 4 with grating includes: grating aligner 16 and X ray bulb 17, wherein: grating aligner 16 is arranged at the light hole place of X ray bulb 17.
Described loading motion platform 2 includes: object stage 18, x are to translating device 19, y to translating device 20, z to translating device 21 and z-axis rotary apparatus 22, wherein: object stage 18 is fixed on z on translating device 21, z is fixed on x on translating device 19 to translating device 21, x is fixed on y on translating device 20 to translating device 19, and y is fixed on z-axis rotary apparatus 22 to translating device 20.
Described loading motion platform 2 center of rotation z-axis is coplanar with cone-beam CT imaging main shaft.
Described object stage 18 table top is parallel to x y plane, and one end is unsettled, and the other end is connected to translating device 21 is fixing with z.
This device work process is as follows:
The highly integrated multimode images data acquisition equipment of C-shaped frame structure rotation platform 1 and radiotherapy equipment, the X-ray source 4 of imaging and treatment double duty is staggered relatively with cone-beam CT imaging detector 5, SPECT imaging detector 6 is placed with cone-beam CT imaging main axis parallel, it is to avoid nuclear medicine is disturbed by the X ray of light source.C shape support 3 can be driven freely rotatable around center of rotation axis by rotating driving device 7, the relative position of X-ray source 4, cone-beam CT imaging detector 5 and SPECT imaging detector 6 and C shape support 3 is fixed, follow C shape support 3 around the rotation of 360 degree of center of rotation axis, it is thus possible to realize the spinfunction around object stage 18, and carry out 360 degree of CT scan imagings and radiation therapy beam projection.By the translating device 12 on C shape support 3, cone-beam CT imaging detector 5 can be driven to move in parallel along being perpendicular to center of rotation axis direction relative to C shape support 3, the distance of cone governor beam CT imaging detector 5 and center of rotation such that it is able to realize the cone-beam CT imaging of multiple nanoscale object.
Loading motion platform 2 possesses the translation freedoms along tri-directions of x y z and the rotational freedom around central axis.Object stage 18 is driven to translating device 21 by z, can move in parallel along the z-axis direction；Driven to translating device 19 by x, can move in parallel along the x-axis direction；Driven to translating device 20 by y, can move in parallel along the y-axis direction such that it is able to the real-time online realizing tested object space position dynamically adjusts.Object stage 18 is driven by z-axis rotary apparatus 22, can be freely rotatable around z-axis such that it is able to realize CT scan imaging and the radiotherapy of non co axial ray mode.
Claims (8)
1. the animal experiment device for the research of accurate radiotherapy, it is characterised in that including: C-shaped frame structure rotation platform and loading motion platform, wherein: the center of rotation axis of C-shaped frame structure rotation platform and the center of rotation axis of loading motion platform intersect vertically；Described C-shaped frame structure rotation platform includes: with the C shape support of translating device, with the X-ray source of grating, cone-beam CT imaging detector, SPECT imaging detector and rotating driving device, wherein: C shape support is with one end fixed cone beam CT imaging detector of translating device, the other end on the other side fixes X-ray source, X ray centred beam is vertical with cone-beam CT imaging detector plane, SPECT imaging detector is fixed on another orthogonal end of C shape support, placing with cone-beam CT imaging main axis parallel, rotating driving device is fixing with C shape carriage rotational center to be connected.
2. the animal experiment device studied for accurate radiotherapy according to claim 1, it is characterized in that, the described C shape support with translating device includes: central supported seat, X-ray source support arm, cone-beam CT imaging detector support arm, SPECT imaging detector support arm and translating device, wherein: X-ray source support arm and cone-beam CT imaging detector support arm are fixing with central supported seat respectively to be connected, and it is opposed in circumference 180 degree, SPECT imaging detector support arm is fixing with central supported seat to be connected, and with X-ray source support arm and cone-beam CT imaging detector support arm in 90 degree of layouts of circumference, translating device is arranged at the same one end of cone-beam CT imaging detector support arm.
3. the animal experiment device studied for accurate radiotherapy according to claim 2, is characterized in that, described central supported seat is fixing with rotating driving device to be connected.
4. the animal experiment device studied for accurate radiotherapy according to claim 2, it is characterized in that, described translating device includes: guide rail, slide block and driver part, wherein: guide rail is fixed on central supported seat, guide rail is provided with slide block, slide block is fixed on cone-beam CT imaging detector support arm, and the fixing end of driver part is connected with central supported seat, and driver part mobile terminal is connected with cone-beam CT imaging detector support arm.
5. the animal experiment device studied for accurate radiotherapy according to claim 1, is characterized in that, the described X-ray source with grating includes: grating aligner and X ray bulb, wherein: grating aligner is arranged at the light hole place of X ray bulb.
6. the animal experiment device studied for accurate radiotherapy according to claim 1, it is characterized in that, described loading motion platform includes: object stage, x are to translating device, y to translating device, z to translating device and z-axis rotary apparatus, wherein: object stage is fixed on z on translating device, z is fixed on x on translating device to translating device, x is fixed on y on translating device to translating device, and y is fixed on z-axis rotary apparatus to translating device.
7. the animal experiment device studied for accurate radiotherapy according to claim 6, is characterized in that, described object stage table top is parallel to x y plane, and one end is unsettled, and the other end is connected to translating device is fixing with z.
8. the animal experiment device studied for accurate radiotherapy according to claim 1, is characterized in that, described loading motion platform center of rotation z-axis is coplanar with cone-beam CT imaging main shaft.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610209906.3A CN105769235A (en) | 2016-04-05 | 2016-04-05 | Animal experimental device for precision radiotherapy research |
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Cited By (3)
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| CN107626048A (en) * | 2017-10-19 | 2018-01-26 | 大连理工大学 | A kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding |
| CN114191728A (en) * | 2021-12-31 | 2022-03-18 | 深圳湾实验室 | Radiation device and method for researching flash discharge effect |
| CN114515162A (en) * | 2022-01-29 | 2022-05-20 | 中国人民解放军空军军医大学 | X-ray multifunctional imaging and treating integrated machine and X-ray diagnosis and treatment equipment |
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