CN114191728A - Radiation device and method for researching flash discharge effect - Google Patents
Radiation device and method for researching flash discharge effect Download PDFInfo
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- 230000005855 radiation Effects 0.000 title claims abstract description 49
- 230000000694 effects Effects 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 51
- 238000003384 imaging method Methods 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 11
- 230000001678 irradiating effect Effects 0.000 claims description 7
- 238000009434 installation Methods 0.000 claims description 3
- 238000011160 research Methods 0.000 abstract description 6
- 238000001959 radiotherapy Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 238000013170 computed tomography imaging Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000005865 ionizing radiation Effects 0.000 description 2
- 239000005355 lead glass Substances 0.000 description 2
- 238000004846 x-ray emission Methods 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005250 beta ray Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 238000002661 proton therapy Methods 0.000 description 1
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- 210000004881 tumor cell Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
- A61N2005/1076—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus using a dummy object placed in the radiation field, e.g. phantom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1095—Elements inserted into the radiation path within the system, e.g. filters or wedges
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Abstract
The invention discloses a radiation device and a method for researching a flash effect, wherein the radiation device comprises a machine table provided with a table top, a clamp mounting table is arranged in the center of the table top, and the clamp mounting table and the table top can rotate mutually; a clamp for clamping the experimental object is detachably fixed on the clamp mounting table; the table board is also provided with a plurality of groups of irradiation units, and each group of irradiation units comprises an X-ray bulb tube used for emitting high-dose-rate X rays and a plurality of flat panel detectors arranged on the emergent path of the X rays and used for displaying and displaying the X rays to image the experimental object; and a collimation collimator used for adjusting the irradiation range and uniformity of the X-ray is arranged between the X-ray bulb tube and the clamp. The invention also discloses a method for researching the flash effect, and the radiation device for researching the flash effect and the experimental object are applied to research the irradiation effect of the flash effect.
Description
Technical Field
The invention relates to the field of radiation platforms, in particular to a radiation device and a method for researching a flash discharge effect.
Background
Radiotherapy is a method of treating tumors using ionizing radiation, the main function of a radiation radiotherapy apparatus (e.g., an electron linac, a gamma knife, a proton radiotherapy apparatus, etc.) is to concentrate ionizing radiation (including X-rays, electrons, protons, etc.) in a tumor region and kill DNA of cancer cells to achieve the effect of treating tumors, and in addition, another main function of the radiation radiotherapy apparatus is to minimize irradiation to healthy tissues, thereby protecting normal cells from side effects caused by radiation; in the prior art, the effect of the radiation therapy apparatus is generally studied by arranging the radiation therapy apparatus on a radiation platform.
An existing radiation platform, such as an animal experimental device for precise radiotherapy research disclosed in chinese patent publication No. CN105769235A, includes: c shape framework rotary platform and year thing motion platform, wherein: the rotating central axis of the C-shaped framework rotating platform is vertically intersected with the rotating central axis of the object carrying moving platform; the C-shaped framework rotating platform comprises: the X-ray CT imaging system comprises a C-shaped support with a translation device, an X-ray light source with a grating, a cone-beam CT imaging detector, a SPECT imaging detector and a rotation driving device. Also, as disclosed in chinese patent publication No. CN205163940U, a β -ray quantitative skin irradiation experimental apparatus includes a lead glass box having a plurality of radiation source holes, a lifting platform for holding experimental animals is provided in the lead glass box, an irradiation dosimeter for measuring radiation dose output from the radiation source holes is provided on the lifting platform, and the lifting platform is driven to lift by a driving mechanism; the irradiation dose control box comprises a shielding box body.
The experimental device provided by the patent can realize traditional small dose rate irradiation; in recent years, researches show that the radiation with large dose rate has better protection effect on healthy cells compared with the traditional small-dose radiation, and simultaneously has the lethality of the radiation with small dose rate on tumor cells, the effect is called flash-discharge effect, the dose rate of the traditional radiation X-ray is less than 0.1Gy/s, and the dose rate of the X-ray is required to be more than 40Gy/s to realize the flash-discharge effect; therefore, the conventional radiation platform cannot realize the flash effect.
In the prior art, a linear accelerator is usually used for realizing the flash effect, but the linear accelerator is expensive, has a complex structure and is difficult to arrange on a radiation platform, so that difficulty is brought to the research on the flash effect; in addition, although there is a radiation platform capable of realizing a flash discharge effect in the prior art, most of the X-ray bulbs used by the radiation platform can only generate X-rays with high dose rate at a position close to a ray window, so that the X-rays can only be concentrated on the skin surface of the experimental subject and cannot be irradiated onto the tumor in the experimental subject; meanwhile, the radiation platform in the prior art cannot control the irradiation range and uniformity of the X-rays, and the X-rays are difficult to be distributed in a concentrated manner, so that the accuracy of the X-rays in tumor irradiation is reduced, and the research on the flash effect is not facilitated.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a radiation device and a method for researching a flash discharge effect.
The radiation device for researching the flash effect comprises a machine table provided with a table top, wherein a clamp mounting table is arranged in the center of the table top, and the clamp mounting table and the table top can rotate mutually; a clamp for clamping the experimental object is detachably fixed on the clamp mounting table;
the table board is also provided with a plurality of groups of irradiation units, and each group of irradiation units comprises an X-ray bulb tube used for emitting high-dose-rate X rays and a plurality of flat panel detectors arranged on the emergent path of the X rays and used for displaying the X rays to image the experimental object;
and a collimation collimator used for adjusting the irradiation range and uniformity of the X-ray is arranged between the X-ray bulb tube and the clamp, and the collimation collimator is arranged on an emergent path of the X-ray.
Specifically, because the clamp is fixed on the clamp mounting table, and the clamp mounting table and the table top can rotate mutually, the relative position between the experimental object positioned on the clamp and the irradiation unit can be adjusted by rotating the clamp mounting table or the table top.
The X-ray bulb tube and the flat panel detector in each group of irradiation units are respectively arranged on the table boards on two opposite sides of the clamp, the X-ray bulb tube emits X rays, the imaging of the X rays to an experimental object is displayed on the flat panel detector, the size and the position of a tumor in the experimental object can be determined by imaging the experimental object, then the tumor is accurately irradiated, and the requirements on the irradiation range and the uniformity of the X rays on the space are different because the experimental objects are different and the position and the size of the tumor in the experimental object are different, so that the leveling collimator is required to be arranged to adjust the irradiation range and the uniformity of the X rays aiming at different experimental objects.
The X-ray bulb tube can be a rotary anode type X-ray bulb tube; the X-ray bulb tube can ensure that the dose rate of X-rays is larger than 30Gy/s to realize flash discharge or the dose rate of X-rays is lower than 30Gy/s to realize traditional irradiation in a certain range from an X-ray emission hole when a plurality of X-ray bulb tubes are irradiated simultaneously by controlling tube voltage and tube current. (ii) a After the position and the size of the tumor are determined by combining a flat panel detector, the irradiation range and the uniformity of the X-ray are adjusted by utilizing a collimation collimator, and the X-ray can be ensured to be accurately irradiated to the tumor in the experimental object body by arranging the experimental object at a proper position according to the range of the high dose rate X-ray.
Preferably, the flat collimator comprises a wheel disc made of a radiation-proof material, a plurality of collimation holes with different sizes are formed in the wheel disc, and the collimation holes are used for limiting the irradiation range of the X-ray; each collimating hole is detachably provided with a flat filter with a matched size and used for adjusting the distribution uniformity of the X-rays; and the wheel disc is also provided with a stepping motor for driving the wheel disc to rotate.
Specifically, the wheel disc is made of a radiation-proof material, so that X rays emitted from the X-ray bulb tube can only pass through the collimating holes, namely the collimating holes limit the irradiation range of the X rays; and each collimation hole is provided with a flat filter with adaptive size, X rays passing through the collimation holes enter the flat filter, and the flat filter enables the distribution of the X rays to be more uniform and better performs uniform irradiation on tumors in the experimental object.
When specifically irradiating the tumor, the size and the position of the tumor are determined through imaging of an experimental object, then the irradiation range and the uniformity of X rays are determined, and under the driving of a stepping motor, a wheel disc rotates, so that a proper collimating hole and a flat filter are matched with the position of an X ray emergent path, and then the X ray bulb tube is started.
Preferably, the X-ray bulb tube is movably fixed on the table top through a guide rail device; the guide rail device comprises an object carrying guide rail which is fixed on the table top and points to the clamp mounting table, and a guide rail bracket which is vertical to the object carrying guide rail and slides along the object carrying guide rail is arranged on the object carrying guide rail; the X-ray bulb tube is movably fixed on the guide rail bracket.
Specifically, the dose rate of the X-ray is gradually reduced along with the fact that the X-ray is farther away from the X-ray emitting hole, and the requirements for the dose rate of the X-ray are changed due to the fact that the sizes and the properties of tumors in different experimental objects are different, so that the irradiation range and the dose rate of the X-ray irradiated on the experimental objects can be further adjusted to a certain extent by adjusting the relative position between the clamp and the X-ray bulb tube, and the dose of the X-ray irradiated on the tumors is more accurate.
Preferably, the guide rail device further comprises a rotating member arranged between the X-ray bulb and the guide rail bracket and used for driving the X-ray bulb to rotate.
Specifically, the adjustment of the X-ray radiation range, direction and dose rate can be realized by adjusting the angle of the X-ray bulb tube.
Preferably, a mounting frame for mounting the collimation collimator is arranged on the table top between the object carrying guide rail and the clamp mounting table.
Specifically, the flat collimator is installed on the mounting frame so as to facilitate rotation of the wheel disc.
Preferably, the flat panel detector is fixed on the table top through a rotating device; the rotating device comprises a sliding guide rail which is fixed on the table top and points to the fixture mounting table, and a detector support which is arranged on the sliding guide rail and can slide along the sliding guide rail and is used for fixing the flat panel detector; the rotation of the rotary platform drives the detector bracket and the flat panel detector to rotate.
Specifically, before the irradiation of the experimental object, the position and size of the tumor need to be determined in advance, and the size and position of the tumor are usually determined by an X-ray imaging method, so a flat panel detector needs to be arranged for facilitating the imaging; in order to ensure the imaging accuracy, the plane of the flat panel detector needs to be perpendicular to the beam direction of the X-ray, so that the structure that the rotating device is arranged below the flat panel detector is suitable.
Preferably, the bottom of the detector support is fixed on the rotating platform, and the top of the detector support is provided with an opening for mounting the flat panel detector.
Particularly, under the structure, the detector support does not need to be disassembled when the flat panel detector is replaced, and the replacement of the flat panel detector is greatly simplified.
Preferably, the radiation device for researching the flash effect further comprises a shielding box made of a radiation-proof material, and the machine platform is arranged in the shielding box; the shielding box is provided with a shielding door, and the shielding door is made of transparent radiation-proof materials.
Specifically, locate the board and work in the shielded cell, can carry out radiation protection to the staff, set up transparent guard gate, make things convenient for staff's observation.
A method for studying the flash effect, which adopts the radiation device for studying the flash effect as described in any one of the above items, the method comprises the following specific steps,
clamping an experimental object by using a clamp, and then installing the clamp with the experimental object on a clamp installation table;
adjusting the positions of the flat panel detector and the X-ray bulb tube to ensure that the flat panel detector is vertical to the X-ray beam direction emitted by the X-ray bulb tube, and then imaging the experimental object by utilizing the flat panel detector and the X-ray bulb tube to confirm the size and the position of the tumor in the experimental moving object;
according to the size and the position of the tumor, the relative position between the experimental object and the irradiation device is adjusted by rotating the fixture mounting table or the table top, and the irradiation range and the uniformity of the X-ray are adjusted by utilizing the collimation collimator, so that the irradiation range of the X-ray is matched with the position and the size of the tumor;
opening at least 1X-ray bulb tube, setting exposure time, adjusting the dose rate and the total dose of X-rays, and irradiating the experimental object;
and (5) after the irradiation is finished, taking down the clamp with the experimental object.
Preferably, the flat collimator is provided with a plurality of collimating holes with different sizes and a flat filter which is arranged on the collimating holes and matched with the collimating holes, and when the position and the size of the tumor are determined, the collimating holes with the largest size and the flat filter are selected; when irradiating a tumor in a subject, a collimation aperture and a flat filter are selected that are adapted to the size and dimensions of the tumor.
Compared with the prior art, the beneficial effects of the invention at least comprise:
(1) an X-ray bulb tube capable of generating high dose rate X-rays in a large range is adopted, and a structure of combining the X-ray bulb tube and a flat panel detector is utilized to image an experimental object, so that the position and the size of a tumor in the experimental object are determined; after the position and the size of the tumor are determined, the irradiation range and the uniformity of the X-ray are adjusted by using the collimation collimator, and meanwhile, the position of the experimental object is adjusted by using the fixture mounting table, so that the X-ray with high dose rate can perform accurate, concentrated and uniform irradiation on the tumor with any position and any size in the experimental object body as long as the experimental object is arranged in the irradiation range with high dose rate of the X-ray.
(2) The X-ray bulb tube widely used in the market is adopted to realize the flash effect, and the device is easy to popularize and use on a large scale.
Drawings
FIG. 1 is a schematic view of an assembly of a radiation device for studying the flash effect according to the present invention;
FIG. 2 is a schematic view of a part of the assembly of the radiation device for studying the flash effect according to the present invention;
fig. 3 is a schematic diagram of a collimator of a radiation device for studying the flash effect according to the present invention.
Detailed Description
The invention is further described with reference to the following figures and specific embodiments.
Fig. 1 is an assembly schematic view of a radiation device for researching a flash effect according to this embodiment, as can be seen from fig. 1, the radiation device for researching a flash effect includes a machine table 10 having a table 11, a fixture mounting table 20 is disposed at the center of the table 11, and a fixture 30 for clamping an experimental object is detachably fixed on the fixture mounting table 20; the table top 11 is further provided with a plurality of groups of irradiation units, each group of irradiation units comprises an X-ray bulb tube 40 used for emitting high dose rate X-rays 92 and a plurality of flat panel detectors 50 arranged on the emergent path of the X-rays 92 and used for displaying the X-rays 92 to image the experimental object; a collimation collimator 60 for adjusting the irradiation range and uniformity of the X-ray 92 is arranged between the X-ray bulb 40 and the clamp 30, and the collimation collimator 60 is arranged on the exit path of the X-ray 92.
Since the jig 30 is fixed on the jig mount 20 and the stage 11 are rotatable with respect to each other, the relative position between the test object positioned on the jig 30 and the irradiation unit can be adjusted by rotating the jig mount 20 or the stage 11.
The X-ray bulb tube 40 is movably fixed on the table top 11 through a guide rail device; the guide rail device comprises an object carrying guide rail 71 which is fixed on the table top 11 and points to the clamp mounting table 20, and a guide rail bracket 72 which is perpendicular to the object carrying guide rail 71 and slides along the object carrying guide rail 71 is arranged on the object carrying guide rail 71; the X-ray bulb tube 40 is movably fixed on the guide rail bracket 72; and a mounting rack 91 for mounting the collimation collimator 60 is arranged on the table top 11 between the object guide rail 71 and the clamp mounting table 20.
The dose rate of the X-ray 92 is gradually reduced as the X-ray 92 is farther from the X-ray emitting hole, and the requirements for the dose rate of the X-ray 92 are changed due to the fact that the sizes and properties of tumors in different experimental objects are different, so that the irradiation range and the dose rate of the X-ray 92 irradiated on the experimental object can be further adjusted to a certain extent by adjusting the relative position between the clamp 30 and the X-ray bulb tube 40, and the dose of the X-ray 92 irradiated on the tumor is more accurate.
The guide rail device further comprises a rotating member 73 arranged between the X-ray bulb tube 40 and the guide rail bracket 72 and used for driving the X-ray bulb tube 40 to rotate.
The adjustment of the radiation range, direction and dose rate of the X-ray 92 can also be realized by adjusting the angle of the X-ray tube 40.
The flat panel detector 50 is fixed on the table top 11 through a rotating device; the rotating device comprises a sliding guide rail 81 which is fixed on the table top 11 and points to the clamp mounting table 20, and a rotating platform 82 which is arranged on the sliding guide rail 81 and can slide along the sliding guide rail 81, wherein a detector support 83 for fixing the flat panel detector 50 is arranged on the rotating platform 82; the rotation of the rotary platform 82 drives the rotation of the detector bracket 83 and the flat panel detector 50.
Before the experimental subject is irradiated, the position and the size of the tumor need to be determined in advance, the size and the position of the tumor are determined by adopting an X-ray 92 imaging mode, and therefore, the flat panel detector 50 needs to be arranged for imaging; in order to ensure the imaging accuracy, the plane of the flat panel detector 50 needs to be perpendicular to the beam direction of the X-ray 92, so that a structure of disposing a rotating device below the flat panel detector 50 is suitable.
The detector support 83 is fixed to the rotary platform 82 at the bottom and has an opening at the top for mounting the flat panel detector 50.
With the structure, the detector support 83 does not need to be disassembled when the flat panel detector 50 is replaced, and the replacement of the flat panel detector 50 is greatly simplified.
FIG. 2 is a schematic assembled view of parts of a radiation device for studying the flash discharge effect according to the present embodiment; as can be seen from fig. 2, the X-ray tube 40 and the flat panel detector 50 in each group of irradiation units are respectively disposed on the table 11 on two opposite sides of the fixture 30, the X-ray tube 40 emits X-rays 92, the X-rays 92 image the experimental object on the flat panel detector 50, the size and position of the tumor in the experimental object can be determined by imaging the experimental object, and then the tumor is accurately irradiated, in this embodiment, 3X-ray tubes 40 and 3 flat panel detectors 50 are provided, so that the experimental object can be imaged from multiple directions and multiple angles; since the experimental subjects are different, and the positions and sizes of the tumors in the experimental subjects are different, the requirements on the irradiation range and uniformity of the X-rays in space are different, and therefore, the irradiation range and uniformity of the X-rays 92 need to be adjusted by setting the collimator 60 according to different experimental subjects.
The X-ray tube 40 of the present embodiment is a rotary anode type X-ray tube 40; the X-ray bulb tube 40 of the type can ensure that when three X-ray bulb tubes 40 are irradiated simultaneously, the X-ray 92 is in a certain range from an X-ray emission hole, the flash discharge is realized by controlling the tube voltage and the tube current to enable the dose rate of the X-ray to be larger than 30Gy/s, or the traditional irradiation is realized by enabling the dose rate of the X-ray to be lower than 30 Gy/s. (ii) a After the position and the size of the tumor are determined by combining the flat panel detector 50, the irradiation range and the uniformity of the X-ray 92 are adjusted by using the collimation collimator 60, and the X-ray 92 can be accurately irradiated to the tumor in the experimental object by arranging the experimental object at a proper position according to the range of the high dose rate X-ray 92.
Fig. 3 is a schematic diagram of a collimator 60 of an irradiation device for studying a flash discharge effect according to the present embodiment, and as shown in fig. 3, the collimator 60 includes a wheel disc 61 made of a radiation-proof material, a plurality of collimating holes 62 with different sizes are provided on the wheel disc 61, and the collimating holes 62 are used for limiting an irradiation range of X-rays 92; each collimating hole 62 is detachably provided with a flat filter 63 with a size suitable for adjusting the distribution uniformity of the X-rays 92; the wheel disc 61 is further provided with a stepping motor 64 for driving the wheel disc 61 to rotate.
The wheel disc 61 is made of a radiation-proof material, so that the X-ray 92 emitted from the X-ray bulb 40 can only pass through the collimation hole 62, i.e. the collimation hole 62 limits the irradiation range of the X-ray 92; and each collimation hole 62 is provided with a flat filter 63, the X-ray 92 passing through the collimation hole 62 enters the flat filter 63, and the flat filter 63 ensures that the X-ray 92 is distributed more uniformly, so that the tumor in the experimental object is better uniformly irradiated.
When a tumor is irradiated specifically, the size and the position of the tumor are determined through imaging of an experimental object, the irradiation range and the uniformity of the X-ray 92 are further determined, under the driving of the stepping motor 64, the wheel disc 61 rotates, so that the appropriate collimating hole 62 and the flat filter 63 are matched with the direction of the emergent path of the X-ray 92, and then the X-ray ball tube 40 is started.
In addition, the machine platform further comprises a shielding box made of radiation-proof materials, and the machine platform 10 is arranged in the shielding box; the shielding box is provided with a shielding door, and the shielding door is made of transparent radiation-proof materials.
Locate the interior work of shielded cell with board 10, can carry out radiation protection to the staff, set up transparent guard gate, make things convenient for staff's observation.
A method for studying a flash effect, using a radiation device as defined in any of the above, the method comprising the steps of:
clamping the experimental object by using the clamp 30, and then installing the clamp 30 with the experimental object on the clamp installation table 20;
adjusting the positions of the flat panel detector 50 and the X-ray bulb tube 40 to ensure that the beam direction of the flat panel detector 50 is vertical to that of an X-ray 92 emitted by the X-ray bulb tube 40, and then imaging the experimental object by utilizing the flat panel detector 50 and the X-ray bulb tube 40 to confirm the size and the position of the tumor in the experimental object;
according to the size and the position of the tumor, the relative position between the experimental object and the irradiation device is adjusted by rotating the fixture mounting table 20 or the table top 11, and the irradiation range of the X-ray 92 is adjusted by using the collimation collimator 60 to be matched with the position and the size of the tumor;
opening 1X-ray bulb tube 40, setting exposure time, adjusting the dose rate and the total dose of the X-rays 92, and irradiating the experimental object; the control of the X-ray tube 40 may be intelligent,
after the irradiation is completed, the jig 30 with the test object is removed.
In addition, when the experimental subject selects a small animal such as a mouse, the irradiation device is horizontally arranged, and the jig mounting table 30 is rotated to adjust the relative position between the mouse and the irradiation device; when the experimental subject selects middle-sized or even large-sized animals such as cats and dogs, the experimental subject needs to be horizontally arranged, and the position of the experimental subject is difficult to adjust in the research process, at this time, the rotary table 11 can be selected to adjust the relative position between the experimental subject and the irradiation device.
The flat collimator 60 is provided with a plurality of collimating holes 62 with different sizes and a flat filter 63 which is arranged on the collimating holes 62 and matched with the collimating holes 62, and when the position and the size of the tumor are determined, the collimating holes 62 with the largest size and the flat filter 63 are selected; when irradiating a tumor in a subject, a collimation aperture 62 and a flat filter 63 are selected that are adapted to the size and dimensions of the tumor.
Claims (10)
1. A radiation device for researching a flash effect comprises a machine table with a table top, and is characterized in that a clamp mounting table is arranged in the center of the table top, and the clamp mounting table and the table top can rotate mutually; a clamp for clamping the experimental object is detachably fixed on the clamp mounting table;
the table board is also provided with a plurality of groups of irradiation units, and each group of irradiation units comprises an X-ray bulb tube used for emitting high-dose-rate X rays and a plurality of flat panel detectors arranged on the emergent path of the X rays and used for displaying the X rays to image the experimental object;
and a collimation collimator used for adjusting the irradiation range and uniformity of the X-ray is arranged between the X-ray bulb tube and the clamp.
2. Radiation device for studying the lightning effect according to claim 1, characterized in that: the flat collimator comprises a wheel disc made of radiation-proof materials, a plurality of collimation holes with different sizes are formed in the wheel disc, and the collimation holes are used for limiting the irradiation range of X rays;
each collimating hole is detachably provided with a flat filter with a matched size and used for adjusting the distribution uniformity of the X-rays;
and the wheel disc is also provided with a stepping motor for driving the wheel disc to rotate.
3. Radiation device for studying the lightning effect according to claim 1, characterized in that: the X-ray bulb tube is movably fixed on the table board through a guide rail device;
the guide rail device comprises an object carrying guide rail which is fixed on the table top and points to the clamp mounting table, and a guide rail bracket which is vertical to the object carrying guide rail and slides along the object carrying guide rail is arranged on the object carrying guide rail; the X-ray bulb tube is movably fixed on the guide rail bracket.
4. A radiation device for studying the flash effect according to claim 3, characterized in that: the guide rail device also comprises a rotating piece which is arranged between the X-ray bulb tube and the guide rail bracket and is used for driving the X-ray bulb tube to rotate.
5. A radiation device for studying the flash effect according to claim 3, characterized in that: and a mounting frame for mounting the collimator is arranged on the table top between the object carrying guide rail and the clamp mounting table.
6. Radiation device for studying the lightning effect according to claim 1, characterized in that: the flat panel detector is fixed on the table top through a rotating device;
the rotating device comprises a sliding guide rail which is fixed on the table top and points to the fixture mounting table and a rotating platform which is arranged on the sliding guide rail and can slide along the sliding guide rail, and a detector support for fixing the flat panel detector is arranged on the rotating platform;
the rotation of the rotary platform drives the detector bracket and the flat panel detector to rotate.
7. Radiation device for studying the lightning effect according to claim 6, characterized in that: the bottom of the detector support is fixed on the rotary platform, and the top of the detector support is provided with an opening for installing the flat panel detector.
8. Radiation device for studying the lightning effect according to claim 1, characterized in that: the radiation device for researching the flash discharge effect further comprises a shielding box made of a radiation-proof material, and the machine table is arranged in the shielding box;
the shielding box is provided with a shielding door, and the shielding door is made of transparent radiation-proof materials.
9. A method for studying the flash effect, which is characterized by using the radiation device for studying the flash effect as claimed in any one of claims 1 to 8, and the method comprises the following steps:
clamping an experimental object by using a clamp, and then installing the clamp with the experimental object on a clamp installation table;
adjusting the positions of the flat panel detector and the X-ray bulb tube to ensure that the flat panel detector is vertical to the X-ray beam direction emitted by the X-ray bulb tube, and then imaging the experimental object by utilizing the flat panel detector and the X-ray bulb tube to confirm the size and the position of the tumor in the experimental object;
according to the size and the position of the tumor, the relative position between the experimental object and the irradiation device is adjusted by rotating the fixture mounting table or the table top, and the irradiation range and the uniformity of the X-ray are adjusted by utilizing the collimation collimator, so that the irradiation range of the X-ray is matched with the position and the size of the tumor;
opening at least 1X-ray bulb tube, setting exposure time, adjusting the dose rate and the total dose of X-rays, and irradiating the experimental object;
and (5) after the irradiation is finished, taking down the clamp with the experimental object.
10. The method of claim 9, wherein the collimator is provided with a plurality of collimating holes with different sizes and a flat filter mounted on the collimating holes and matching with the collimating holes, and when determining the position and size of the tumor, the collimating hole with the largest size and the flat filter are selected; when irradiating a tumor in a subject, a collimation aperture and a flat filter are selected that are adapted to the size and dimensions of the tumor.
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|---|---|---|---|---|
| US20050089141A1 (en) * | 2003-10-23 | 2005-04-28 | Elekta Ab (Publ) | Method and apparatus for treatment by ionizing radiation |
| US20060067467A1 (en) * | 2004-09-28 | 2006-03-30 | Minnesota Medical Physics Llc | Apparatus and method for conformal radiation brachytherapy for breast and other tumors |
| US8173983B1 (en) * | 2010-01-07 | 2012-05-08 | Velayudhan Sahadevan | All field simultaneous radiation therapy |
| EP2708919A2 (en) * | 2012-09-18 | 2014-03-19 | ELEKTA AB (publ.) | Radiation Detector and Radiotherapy Apparatus |
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