CN205749288U - A kind of protein detection Fibre Optical Sensor based on TFBG SPR - Google Patents
A kind of protein detection Fibre Optical Sensor based on TFBG SPR Download PDFInfo
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- CN205749288U CN205749288U CN201620394775.6U CN201620394775U CN205749288U CN 205749288 U CN205749288 U CN 205749288U CN 201620394775 U CN201620394775 U CN 201620394775U CN 205749288 U CN205749288 U CN 205749288U
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- tfbg
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- spr
- spectrogrph
- polarization controller
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Abstract
The utility model discloses a kind of protein detection Fibre Optical Sensor based on TFBG SPR, by wideband light source, Polarization Controller, Transmission Fibers, sensor, TFBG, surface biomolecules identification film, spectrogrph forms.Wideband light source is connected with Polarization Controller, and Polarization Controller is connected with sensor left end by Transmission Fibers, and sensor right-hand member is connected with spectrogrph by Transmission Fibers.The light beam that wideband light source is launched incides in sensor after adjusting polarization state by Polarization Controller, owing to being carved with TFBG in sensor, the incident illumination of forward conduction is effectively excited to cladding mode, can be with the molecule of the biomolecule identification membrane interaction on surface when testing sample has, gold film surface refractive index change can be caused, cause spr signal to change, changed by spectrogrph detection spr signal, thus detect protein.
Description
Technical field
This utility model belongs to technical field of optical fiber sensing, is specifically related to a kind of protein detection light based on TFBG-SPR
Fiber sensor.
Background technology
In many fields, the detection quick and sensitive to analytes in low concentration it is critical that, as medical domain,
The fields such as environmental monitoring field, food safety.The good scheme solving this problem is to use Fibre Optical Sensor, because
Fibre Optical Sensor has that highly sensitive, transmission information is big, safety high.Optical fiber based on inclined optical fiber grating (TFBG) passes
Sensor can well be avoided using tradition to delete the method for covering to the illumination measuring in fibre core.
SPR technique had, the past, the shape that significant progress, application include thin film, self assembled monolayer for 10 years
Become and character, the reciprocal action between protein, nucleoside, pharmaceuticals, surfactant equimolecular.SPR can be with real-time monitored to dividing
The superficial phenomena such as son combination, thin film formation, and the letter of high sensitivity, the high selectivity non-specific binding of minimum simultaneously can be given
Number.
FTBG-SPR sensor, can work so that Temperature cross-over is quick in a large-scale external agency refractive index
The integrity of optical fiber structure is not the most destroyed while perception minimum.There is low cost and portable feature, and it can
With the measurement data that real-time collecting is on-the-spot and long-range.
Summary of the invention
For the deficiencies in the prior art, the purpose of this utility model is to provide a kind of albumen quality inspection based on TFBG-SPR
Light-metering fiber sensor, by spr signal intensity reactive protein concentration in transmitted spectrum, this structure is easily achieved, highly sensitive.
This utility model is achieved through the following technical solutions: a kind of protein detection Fibre Optical Sensor based on TFBG-SPR
Device, by wideband light source (1), Polarization Controller (2), Transmission Fibers (3), sensor (4), TFBG (5), surface biomolecules identification
Film (6), spectrogrph (7) forms, it is characterised in that: light source (1) is connected with Polarization Controller (2), and Polarization Controller (2) is by passing
Losing fibre (3) to be connected with sensor (4) left end, sensor (4) right-hand member is connected with spectrogrph (7) by Transmission Fibers (3).
Described sensor (4) is carved with the single-mode fiber of the standard of TFBG (5) and constitutes with a fibre core, single-mode fiber model
For healthy and free from worry SMF-28, surface uniform plated with gold coating, coating layer thickness is 50nm, in gold plating extenal fixation layer of surface biomolecule
Identifying film (6), specifically used Thrombin aptamer, operation wavelength is at 1520nm-1570nm.
Described spectrogrph (7) model is Si720.
Operation principle of the present utility model is: wideband light source (1) launches the light beam of wavelength 1520nm～1570nm, by partially
The controller (2) that shakes adjusts the incident sensor (4) of polarization state tailing edge Transmission Fibers (3).Owing to being carved with TFBG (5) in sensor (4),
The incident illumination of forward conduction is effectively excited to cladding mode, can be with biomolecule identification film (6) on surface when having in determinand
The molecule interacted, can cause gold film surface refractive index change, cause spr signal to change, detect SPR by spectrogrph (7)
Signal intensity, thus detect protein.
The beneficial effects of the utility model are: (1) uses a common standard traffic single-mode fiber (healthy and free from worry SMF-28),
Within it it is carved with TFBG, eliminates the impact that Temperature cross-over is sensitive, effectively simplify apparatus structure, saved cost of manufacture；(2) single
Mode fiber loss is little, it is possible to achieve remotely measure；(3) inclination angle of fiber grating can adjust, and the scope of measurement is wide；Cause
This, this utility model has simple in construction, sensitivity advantages of higher, it is possible to realize the high precision test to protein, for albumen
Matter on-line monitoring provides a kind of realistic plan.
Accompanying drawing explanation
Fig. 1 is the systematic schematic diagram of a kind of protein detection Fibre Optical Sensor based on TFBG-SPR.
Fig. 2 is the cross sectional representation of sensing head in a kind of protein detection Fibre Optical Sensor based on TFBG-SPR.
Detailed description of the invention
With detailed description of the invention, this utility model is described in further detail below in conjunction with the accompanying drawings.
See accompanying drawing 1 and Fig. 2, a kind of protein detection Fibre Optical Sensor based on TFBG-SPR, by wideband light source (1),
Polarization Controller (2), Transmission Fibers (3), sensor (4), TFBG (5), surface biomolecules identification film (6), spectrogrph (7) group
Become, it is characterised in that: wideband light source (1) is connected with Polarization Controller (2), and Polarization Controller (2) is by Transmission Fibers (3) and biography
Sensor (4) left end is connected, and sensor (4) right-hand member is connected with spectrogrph (7) by Transmission Fibers (3)；Sensor (4) is with a fibre
Core is carved with the single-mode fiber of the standard of TFBG (5) and constitutes, and single-mode fiber model is healthy and free from worry SMF-28, and the uniform plated with gold in surface is coated with
Layer, coating layer thickness is 50nm, at gold plating extenal fixation layer of surface biomolecule identification film (6), specifically used thrombin nucleic acid
Fit, operation wavelength is at 1520nm-1570nm；Spectrogrph (7) model is Si720.
Operation principle of the present utility model is: wideband light source (1) launches the light beam of wavelength 1520nm～1570nm, by partially
The controller (2) that shakes adjusts the incident sensor (4) of polarization state tailing edge Transmission Fibers (3).Owing to being carved with TFBG (5) in sensor (4),
The incident illumination of forward conduction is effectively excited to cladding mode, when protein and the biomolecule identification film on surface in testing sample
(6) interact, gold film surface refractive index change can be caused, cause spr signal to change, detect spr signal by spectrogrph (7)
Change, thus detect protein.
Claims (3)
1. a protein detection Fibre Optical Sensor based on TFBG-SPR, by wideband light source (1), Polarization Controller (2), transmission
Optical fiber (3), sensor (4), TFBG (5), surface biomolecules identification film (6), spectrogrph (7) forms, it is characterised in that: light source
(1) being connected with Polarization Controller (2), Polarization Controller (2) is connected with sensor (4) left end by Transmission Fibers (3), sensor
(4) right-hand member is connected with spectrogrph (7) by Transmission Fibers (3).
A kind of protein detection Fibre Optical Sensor based on TFBG-SPR the most according to claim 1, it is characterised in that: institute
The sensor (4) stated is carved with the single-mode fiber of the standard of TFBG (5) and constitutes with a fibre core, and single-mode fiber model is healthy and free from worry SMF-
28, surface uniform plated with gold coating, coating layer thickness is 50nm, at gold plating extenal fixation layer of surface biomolecule identification film (6),
Specifically used Thrombin aptamer, operation wavelength is at 1520nm-1570nm.
A kind of protein detection Fibre Optical Sensor based on TFBG-SPR the most according to claim 1, it is characterised in that: institute
Spectrogrph (7) model stated is Si720.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620394775.6U CN205749288U (en) | 2016-05-04 | 2016-05-04 | A kind of protein detection Fibre Optical Sensor based on TFBG SPR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620394775.6U CN205749288U (en) | 2016-05-04 | 2016-05-04 | A kind of protein detection Fibre Optical Sensor based on TFBG SPR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205749288U true CN205749288U (en) | 2016-11-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620394775.6U Expired - Fee Related CN205749288U (en) | 2016-05-04 | 2016-05-04 | A kind of protein detection Fibre Optical Sensor based on TFBG SPR |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105758827A (en) * | 2016-05-04 | 2016-07-13 | 中国计量大学 | Protein detection fiber optic sensor based on TFBG-SPR |
| CN107014776A (en) * | 2017-03-22 | 2017-08-04 | 天津大学 | Measuring device for liquid refractive index and method based on super continuum source |
| CN107478891A (en) * | 2017-10-13 | 2017-12-15 | 中国计量大学 | A kind of Weak current signal detection fibre optical sensor based on TFBG SPR |
-
2016
- 2016-05-04 CN CN201620394775.6U patent/CN205749288U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105758827A (en) * | 2016-05-04 | 2016-07-13 | 中国计量大学 | Protein detection fiber optic sensor based on TFBG-SPR |
| CN107014776A (en) * | 2017-03-22 | 2017-08-04 | 天津大学 | Measuring device for liquid refractive index and method based on super continuum source |
| CN107478891A (en) * | 2017-10-13 | 2017-12-15 | 中国计量大学 | A kind of Weak current signal detection fibre optical sensor based on TFBG SPR |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161130 Termination date: 20200504 |