CN205374308U - Multi -functional tumor cells or other pathology cells detection device - Google Patents
Multi -functional tumor cells or other pathology cells detection device Download PDFInfo
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- CN205374308U CN205374308U CN201521020132.7U CN201521020132U CN205374308U CN 205374308 U CN205374308 U CN 205374308U CN 201521020132 U CN201521020132 U CN 201521020132U CN 205374308 U CN205374308 U CN 205374308U
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The utility model discloses a multi -functional tumor cells or other pathology cells detection device, catch micro -fluidic chip, glimmering light reflector, photomultiplier, data process system including laser lamp -house, sharp light reflector, post lens, unicellular liquid stream system, cell separation, photomultiplier links to each other with data process system, still includes pulsed laser source, ultrasonic probe, ultrasonic probe links to each other with data process system, laser lamp -house, sharp light reflector, post lens form and arrive the focus system in the unicellular liquid stream system with the laser focusing, glimmering light reflector and photomultiplier form the collecting system of collecting unicellular liquid stream system and sending fluorescence, pulsed laser source and post lens form and focus on another focus system in the unicellular liquid stream system with pulsed laser, ultrasonic probe establishes in unicellular liquid stream system, cell separation catch micro -fluidic chip and establish the port in unicellular liquid stream system. It is accurate to detect.
Description
Technical field
This utility model relates to Cell Measurement Technique field, especially relates to a kind of multifunctional tumor cell or the detection of other pathological cells, separation, acquisition equipment.
Background technology
Whole world cancer is born currently with swift and violent speed increment, on average just has 1 people to die from cancer in every 8 deaths, and within 2012, the whole world has 8,200,000 people to die from cancer, and newly-increased cases of cancer reaches 14,000,000.Address prediction, by 2025, the whole world is annual newly-increased suffered from carninomatosis example and will increase to 19,000,000, will increase to 22,000,000 to the year two thousand thirty, will increase to 24,000,000 by 2035, and namely 20 years will increase nearly fifty percent.
Human health has been caused great threat by cancer, and studies and show that most cancer patient dies from metastatic carcinoma, but not primary cancer, the transfer of tumor is to cause cancer patient main causes of death.As far back as 1869, Australia nationality doctor ThomasAshworth observed circulating tumor cell first in the blood sample of cancer patient.In transfer process, the tumor cell of original site comes off, and invasion and attack enter the blood circulation such as blood or lymph, and the tumor cell wherein with height metastatic potential is survived in blood circulation, becomes circulating tumor cell.Circulating tumor cell constantly flows in blood circulation, after being diffused into remote organ delay or going back to the nest, forms transfer and relapse.Circulating tumor cell be tumor generation metastasis through step, therefore must detect in peripheral blood that tumor cell imply that it may happen that neoplasm metastasis.Therefore, the detection of circulating tumor cell is for external early diagnosis, and the rapid evaluation of chemotherapeutics, the detection of tumor recurrence etc. has great importance.
Traditional tumor cell detection method is that the cell dyeed through specific fluorescence utilizes suitable light source that unicellular stream is irradiated, and the cell in liquid stream is measured analysis by the scattered light signal sent by collecting tumor cell.This method is an important method of Clinical detection circulating tumor cell at present；But to pass through fixing due to the cell of the method detection and dyeing processes, certain change can occur its character, there is certain error in its testing result.
Utility model content
Not enough for prior art, technical problem to be solved in the utility model is to provide a kind of multifunctional tumor cell or other pathological cells detecting device, can respectively to through dyeing and detecting without hyperchromatic cell, and tumor cell is easily separated, catches, substantially increase the use scope of equipment and the accuracy of detection.
In order to solve above-mentioned technical problem, the technical scheme that this utility model adopts is:
nullA kind of multifunctional tumor cell or other pathological cells detecting device，Including LASER Light Source、Laser mirror、Post lens、Unicellular liquid fluid system、Cell separation catches micro-fluidic chip、Fluorescent reflection mirror、Photomultiplier tube、Data handling system，Described photomultiplier tube is connected with data handling system，Also include pulsed laser source、Ultrasonic probe，Described ultrasonic probe is connected with data handling system，Described LASER Light Source、Laser mirror、Post lens forming is by the focusing system on laser focusing to unicellular liquid fluid system，Described fluorescent reflection mirror and photomultiplier tube form the unicellular liquid fluid system of collection and send the collection system of fluorescence，Described pulsed laser source and post lens forming are by another focusing system on pulse laser focusing to unicellular liquid fluid system，Described ultrasonic probe is located on unicellular liquid fluid system，Described cell separation is caught micro-fluidic chip and is located at the port of unicellular liquid fluid system.
Further, the type of described LASER Light Source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and the optical maser wavelength sent can be 488nm or 561nm or 632nm.
Described unicellular liquid fluid system includes unicellular fluid flow tube and storage ware, and storage ware is positioned at below unicellular fluid flow tube, and ultrasonic probe is located on unicellular fluid flow tube.
The type of described pulsed laser source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and sending optical maser wavelength can be 1064nm or 808nm.
Described ultrasonic probe can be monocrystalline compressional wave normal probe or twin crystal compressional wave normal probe or monocrystalline transverse wave double-bevel detector or twin crystal transverse wave double-bevel detector or circumferential curvature probe or radial buckling probe or point focusing probe or line focus surface wave probe.
The reception frequency range of described ultrasonic probe is 1Hz-100MHz.
Described LASER Light Source is one group of LASER Light Source of different wave length.
Described unicellular fluid flow tube can be transparent optical glass pipe or quartz ampoule or earthenware.
This utility model compared with prior art, has the advantage that
This device can realize the two kinds of functions detected through hyperchromatic cell and detect without hyperchromatic cell on a platform, can be used for markd target cell being detected and unmarked target cell being detected, and tumor cell is easily separated, catches, substantially increase the use scope of equipment and the accuracy of detection；Can be widely applied to clinical medicine and the basic medical research fields such as immunology, hematology, oncology, cytobiology, cytogenetics, biochemistry；And its simple in construction, convenient operation, Wicresoft's safety is high.
Accompanying drawing explanation
Below the content expressed by each width accompanying drawing of this specification and the labelling in figure are briefly described:
Fig. 1 is this utility model structure of the detecting device schematic diagram.
In figure: A, LASER Light Source
B, unicellular liquid fluid system
C, photomultiplier tube
D, high-frequency pulsed lasers source
E, ultrasonic probe
F, data handling system
A, laser mirror I
B, laser mirror II
C, laser mirror III
D, laser mirror IV
E, laser mirror V
F, laser mirror VI
G, laser mirror VII
H, laser mirror VIII
M, fluorescent reflection mirror I
N, fluorescent reflection mirror II
J, fluorescent reflection mirror III
P, fluorescent reflection mirror IV
Q, fluorescent reflection mirror V
I, post lens.
Detailed description of the invention
Below against accompanying drawing, by the description to embodiment, detailed description of the invention of the present utility model is described in further detail.
As shown in Figure 1, this multifunctional tumor cell or other pathological cells detecting device, catch micro-fluidic chip including LASER Light Source A, laser mirror, post lens I, unicellular liquid fluid system B, fluorescent reflection mirror, photomultiplier tube C, data handling system F, high-frequency pulsed lasers source D, ultrasonic probe E, cell separation；Wherein, photomultiplier tube C is connected with data handling system F, and ultrasonic probe E is connected with data handling system F；Laser mirror is one group, respectively laser mirror I a, laser mirror II b, laser mirror III c, laser mirror IV d, laser mirror V e, laser mirror VI f, laser mirror VII g, laser mirror VIII h；Fluorescent reflection mirror is also one group, respectively fluorescent reflection mirror I m, fluorescent reflection mirror II n, fluorescent reflection mirror III j, fluorescent reflection mirror IV p, fluorescent reflection mirror V q.
LASER Light Source A, laser mirror, post lens I are formed the focusing system on laser focusing to unicellular liquid fluid system B, the laser that LASER Light Source sends will focus on unicellular liquid fluid system by laser mirror, cylindrical mirror, unicellular liquid fluid system is formed focus point, on unicellular liquid fluid system, namely forms form.
Fluorescent reflection mirror and photomultiplier tube C form the unicellular liquid fluid system of collection and send the collection system of fluorescence, unicellular liquid fluid system B has the target cell of fluorescence molecule labelling, other cell in circulating tumor cell, hemocyte, lymphocyte and blood, during the form formed by laser focusing, its fluorescence sent is reflected by fluorescent reflection mirror, is collected by photomultiplier tube.
High-frequency pulsed lasers source D and post lens forming are by another focusing system on pulse laser focusing to unicellular liquid fluid system, and ultrasonic probe is located on unicellular liquid fluid system；By post lens, the high-frequency pulsed lasers D pulse laser sent also is focused on unicellular liquid fluid system, when the form that target cell is formed by laser focusing, irradiation due to high frequency lasers, tumor cell can because absorbing laser and fever expansion generation ultrasound wave, ultrasonic probe E on this ultrasound wave coverlet Cell sap streaming system detects, unit interval can be carried out quantitative analysis by the cell number of this focus point after being processed by data handling system F, such as analysis of accounts.
Cell separation catch micro-fluidic chip G be arranged on the port of unicellular liquid fluid system B go out when cell flow through cell separation catch on micro-fluidic chip time, microchannel on chip can stop being significantly greater than Normocellular tumor cell, thus reaching the separation of cell and catching.Cell separation, catch micro-fluidic chip etches micro structure or the integrated microcavity volume array with filtering function or arrange magnetic field on chip.
Data handling system includes controller and display, the computer data processing system of formation, photomultiplier tube and ultrasonic probe is received signal and processes, and data show over the display in real time.
The type of LASER Light Source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and the optical maser wavelength sent can be 488nm or 561nm or 632nm.The type in high-frequency pulsed lasers source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and sending optical maser wavelength can be 1064nm or 808nm.
Unicellular liquid fluid system includes unicellular fluid flow tube and storage ware and sample cell, and sample cell is positioned at above unicellular fluid flow tube, and storage ware is positioned at below unicellular fluid flow tube, and ultrasonic probe is located on unicellular fluid flow tube.Unicellular fluid flow tube can be the optical glass pipe of transparent and stable or quartz ampoule or earthenware.
Ultrasonic probe can be monocrystalline compressional wave normal probe or twin crystal compressional wave normal probe or monocrystalline transverse wave double-bevel detector or twin crystal transverse wave double-bevel detector or circumferential curvature probe or radial buckling probe or point focusing probe or line focus surface wave probe；The reception frequency range of ultrasonic probe is 1Hz-100MHz.
Below by specific embodiment, this utility model is illustrated:
LASER Light Source is one group of LASER Light Source of different wave length, model machine is mounted with the LASER Light Source of tri-kinds of different wave lengths of 488nm, 561nm, 632nm, laser power is 20mw, 20mw, 40mw respectively, laser instrument is solid state laser, by laser mirror by the laser-bounce of three kinds of different wave lengths to same straight line, what this laser mirror adopted is dichroic beam splitter；By post lens by laser focusing to the form of unicellular liquid fluid system, the fluorescence signal inspired on fluorescence labeled cell from unicellular liquid fluid system enters photomultiplier tube by fluorescent reflection mirror, by data handling system, fluorescence signal is processed, utilize said apparatus to achieve the real-time monitoring of fluorescence labeled cell in unicellular liquid stream.Quantitative counting is analyzed, and experiment obtains good effect, has reached target.
There are also installed high-frequency pulsed lasers in this model machine, what high-frequency pulsed lasers adopted is 1064nm pulse laser, its repetition rate simultaneously > 50kHz, maximum impulse energy: 50uJ；The non-focused ultrasound the being probe that ultrasonic probe 10MHz adopts；By post lens by laser focusing to the form of unicellular liquid fluid system, n cell (melanoma cell) in unicellular liquid fluid system is detected, the ultrasonic signal that ultrasonic probe detects is analyzed processing by data handling system, experiment obtains good effect, has reached target.
Utilize this device a kind of detection method to tumor cell, the laser that LASER Light Source sends is by focusing on the form of unicellular liquid fluid system after laser mirror and post lens, when the target cell having fluorescence molecule labelling in unicellular liquid fluid system forms form by laser focusing, its fluorescence sent is collected by photomultiplier tube by the reflection of fluorescent reflection mirror, photomultiplier tube converts the fluorescence signal collected to the signal of telecommunication, then by data handling system to detecting that signal processes and at the cell number of the form of unicellular liquid fluid system, are carried out quantitative analysis by laser the unit interval.
The port of unicellular fluid flow tube in a device goes out to be provided with cell separation and catches micro-fluidic new Rhizoma Nelumbinis slice, when cell flow through cell separation catch on micro-fluidic chip time, microchannel on chip can stop being significantly greater than Normocellular tumor cell, has reached separating and the purpose caught of cell.
Utilize this device another kind of detection method to tumor cell, the pulse laser that high-frequency pulsed lasers source sends passes through post lens focus on the form of unicellular liquid fluid system, when the target cell in unicellular liquid fluid system forms form by laser focusing, it is subject to the irradiation of the high-frequency pulsed lasers of different wave length, tumor cell can because absorbing laser and fever expansion generation ultrasound wave, ultrasonic probe on this ultrasound wave coverlet Cell sap streaming system detects, by data handling system, the unit interval is carried out quantitative analysis by laser at the cell number of the form of unicellular liquid fluid system.
Above in conjunction with accompanying drawing, this utility model is exemplarily described; obvious this utility model implements and is not subject to the restrictions described above; as long as have employed design of the present utility model and the improvement of various unsubstantialities that technical scheme carries out; or not improved design of the present utility model and technical scheme are directly applied to other occasion, all within protection domain of the present utility model.
Claims (8)
- null1. a multifunctional tumor cell or other pathological cells detecting device，Including LASER Light Source、Laser mirror、Post lens、Unicellular liquid fluid system、Cell separation catches micro-fluidic chip、Fluorescent reflection mirror、Photomultiplier tube、Data handling system，Described photomultiplier tube is connected with data handling system，It is characterized in that: also include pulsed laser source、Ultrasonic probe，Described ultrasonic probe is connected with data handling system，Described LASER Light Source、Laser mirror、Post lens forming is by the focusing system on laser focusing to unicellular liquid fluid system，Described fluorescent reflection mirror and photomultiplier tube form the unicellular liquid fluid system of collection and send the collection system of fluorescence，Described pulsed laser source and post lens forming are by another focusing system on pulse laser focusing to unicellular liquid fluid system，Described ultrasonic probe is located on unicellular liquid fluid system，Described cell separation is caught micro-fluidic chip and is located at the port of unicellular liquid fluid system.
- 2. multifunctional tumor cell as claimed in claim 1 or other pathological cells detecting device, it is characterized in that: the type of described LASER Light Source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and the optical maser wavelength sent can be 488nm or 561nm or 632nm.
- 3. multifunctional tumor cell as claimed in claim 1 or other pathological cells detecting device, it is characterized in that: described unicellular liquid fluid system includes unicellular fluid flow tube and storage ware, storage ware is positioned at below unicellular fluid flow tube, and ultrasonic probe is located on unicellular fluid flow tube.
- 4. multifunctional tumor cell as claimed in claim 1 or other pathological cells detecting device, it is characterized in that: the type of described pulsed laser source can be fixed laser or semiconductor laser or gas laser or optical fiber laser or dye laser, and sending optical maser wavelength can be 1064nm or 808nm.
- 5. as claimed in claim 1 multifunctional tumor cell or other pathological cells detecting device, it is characterised in that: described ultrasonic probe can be monocrystalline compressional wave normal probe or twin crystal compressional wave normal probe or monocrystalline transverse wave double-bevel detector or twin crystal transverse wave double-bevel detector or circumferential curvature probe or radial buckling is popped one's head in or point focusing probe or line focus surface wave probe.
- 6. multifunctional tumor cell as claimed in claim 1 or other pathological cells detecting device, it is characterised in that: the reception frequency range of described ultrasonic probe is 1Hz-100MHz.
- 7. multifunctional tumor cell as claimed in claim 1 or other pathological cells detecting device, it is characterised in that: described LASER Light Source is one group of LASER Light Source of different wave length.
- 8. as claimed in claim 3 multifunctional tumor cell or other pathological cells detecting device, it is characterised in that: described unicellular fluid flow tube can be transparent optical glass pipe or quartz ampoule or earthenware.
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| CN2015106293138 | 2015-09-28 | ||
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| CN205374308U true CN205374308U (en) | 2016-07-06 |
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| CN201510908410.0A Pending CN105352931A (en) | 2015-09-28 | 2015-12-07 | Multifunctional device and method for detecting tumor cells or other pathologic cells |
| CN201521020132.7U Active CN205374308U (en) | 2015-09-28 | 2015-12-07 | Multi -functional tumor cells or other pathology cells detection device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105352931A (en) * | 2015-09-28 | 2016-02-24 | 周辉 | Multifunctional device and method for detecting tumor cells or other pathologic cells |
| CN109374588A (en) * | 2018-11-14 | 2019-02-22 | 暨南大学 | The devices and methods therefor of cell capture and fluorescence enhancement based on biological lens |
Families Citing this family (5)
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| CN106085962B (en) * | 2016-06-20 | 2022-03-22 | 上海交通大学 | Device for detecting and separating circulating melanoma cells |
| CN106290279B (en) * | 2016-08-09 | 2019-10-18 | 中国科学院电子学研究所 | A kind of single cell protein detection system and its application |
| CN110196220A (en) * | 2019-05-10 | 2019-09-03 | 无锡瑞生医疗科技有限公司 | High-throughput unicellular on-line detecting system |
| CN112945918A (en) * | 2021-01-28 | 2021-06-11 | 中国科学院深圳先进技术研究院 | Cell ultrasonic nerve regulation and control system |
| CN116519656B (en) * | 2023-06-25 | 2023-09-12 | 广州盛安医学检验有限公司 | Fluorescent scanning device |
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| US20080123083A1 (en) * | 2006-11-29 | 2008-05-29 | The Regents Of The University Of Michigan | System and Method for Photoacoustic Guided Diffuse Optical Imaging |
| CN101785662A (en) * | 2010-03-09 | 2010-07-28 | 华南师范大学 | Bimodal system and method integrating photoacoustic imaging and fluorescence imaging |
| CN102621115B (en) * | 2012-02-27 | 2014-08-27 | 华南师范大学 | Confocal simultaneous opto-acoustic imaging and fluorescence imaging method and device |
| CN103033464B (en) * | 2012-12-26 | 2014-12-24 | 华南师范大学 | Photoacoustic-fluorescence flow cytometer |
| CN103099604B (en) * | 2013-01-15 | 2015-05-06 | 东南大学 | An imaging method of tumor targeting based on enhancement effect of zinc ion signals |
| CN103361265B (en) * | 2013-07-02 | 2015-04-22 | 周辉 | Cancer cell or other pathologic cell detection diagnostic device |
| CN105352931A (en) * | 2015-09-28 | 2016-02-24 | 周辉 | Multifunctional device and method for detecting tumor cells or other pathologic cells |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105352931A (en) * | 2015-09-28 | 2016-02-24 | 周辉 | Multifunctional device and method for detecting tumor cells or other pathologic cells |
| CN109374588A (en) * | 2018-11-14 | 2019-02-22 | 暨南大学 | The devices and methods therefor of cell capture and fluorescence enhancement based on biological lens |
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| CN105352931A (en) | 2016-02-24 |
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