CN205286323U - There is not circulation of wound tumor cells detection diagnosis device - Google Patents
There is not circulation of wound tumor cells detection diagnosis device Download PDFInfo
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- CN205286323U CN205286323U CN201521015906.7U CN201521015906U CN205286323U CN 205286323 U CN205286323 U CN 205286323U CN 201521015906 U CN201521015906 U CN 201521015906U CN 205286323 U CN205286323 U CN 205286323U
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Abstract
The utility model discloses a there is not circulation of wound tumor cells detection diagnosis device is equipped with high frequency pulse laser (2), beam coupling ware (4) and ultrasonic probe (6), beam coupling ware (4) and ultrasonic probe (6) all paste on skin exposure ware (5). Adopt above -mentioned technical scheme, on live body fluorescence detection method's basis, combine biological tissue's optoacoustic effect, utilize biological tissue's the optoacoustic specificity and the deep penetration nature of supersound signal, overcome the inaccuracy that environmental change that external detection brought leads to, accomplish clinical test, non -invasive detection, need not draw blood, without the mark, provide new way for clinical tumor cells's early detection, have the advantage at the body, real -time supervision, can detect the patient for a long time, the device of the present invention has extensive application. Simple, the convenient operation of equipment structure, security height.
Description
Technical field
This utility model belongs to preclinical medicine scientific research and the technical field of clinical medicine detecting instrument equipment. More specifically, this utility model relates to a kind of noinvasive circulating tumor cell checkout and diagnosis device.
Background technology
Cancer is the disease of serious threat human health and life, cancer patient is if finding in early days and treating in time, it is possible not only to improve survival rate, the life quality of patient can also be improved, so wanting early discovery, early diagnosis for cancer and treating in time simultaneously.
In recent years, the early diagnosis of cancer includes imaging diagnosis such as: photoacoustic imaging, Photoacoustic tomography, optoacoustic spectroscopy microscope imaging etc., the middle and advanced stage of the result that iconography can detect often cancer patient, it is impossible to carry out detection and the diagnosis of early stage, the therapeutic potential of patient is little.
Medical research shows: cancer patient has part cancerous cell early stage and enters blood system, how to detect that the circulating tumor cell entered in blood becomes a key issue of cancer early discovery. The living body fluorescent labelling flow cytometer that development in recent years is got up overcomes iconography detection can not detect a difficult problem for circulating tumor cell in cancer patient's early stage entrance blood, find to provide a new detection method to the morning of cancer patient, but the method detects after needing vein sampling dyeing in vitro again, sampling dyeing course often affects cell physiological environment in vivo, and its testing result is often not accurate enough. Therefore, as how human body is object of study, carrying out at body, in real time detection tumor cell is an extremely urgent problem.
Experimentation shows: tumor cell is subject to can change into heat energy by luminous energy after the laser of specific band irradiates, sending the ultrasound wave of a kind of specific wavelength during tumor cell expanded by heating, hyperacoustic frequency that this hyperacoustic frequency sends with Normocellular expanded by heating is different.
Utility model content
This utility model provides a kind of noinvasive circulating tumor cell checkout and diagnosis device, its objective is to realize at body, detects tumor cell in real time, exactly.
To achieve these goals, the technical scheme that this utility model is taked is:
Noinvasive circulating tumor cell checkout and diagnosis device of the present utility model, is provided with high-frequency pulsed lasers device, beam coupler and ultrasonic probe;Described beam coupler and ultrasonic probe are all attached on contact skin device.
Described high-frequency pulsed lasers device is connected by signal line with signal generator.
The waveshape signal that described signal generator sends is rectangular wave; Or it is sinusoidal wave.
Described high-frequency pulsed lasers device is connected by Transmission Fibers with beam coupler.
Described ultrasonic probe is connected by signal line with signal processor.
Described signal processor is connected with display system by signal line.
The excitation wavelength of described high-frequency pulsed lasers device is: 1064nm; Or it is 808nm.
Described high-frequency pulsed lasers device is the one in solid state laser, semiconductor laser, gas laser, optical fiber laser and dye laser; The pattern of its laser output is pulse laser.
This described ultrasonic probe is the one in monocrystalline compressional wave normal probe, twin crystal compressional wave normal probe, monocrystalline transverse wave double-bevel detector, twin crystal transverse wave double-bevel detector, circumferential curvature probe, radial buckling probe, point focusing probe, line focus surface wave probe; The frequency range of described ultrasonic probe is 1-100MHz.
In order to realize the goal of the invention identical with technique scheme, this utility model additionally provides the checkout and diagnosis method being applied to above-described noinvasive circulating tumor cell checkout and diagnosis device, and its technical scheme is:
Described signal generator sends signal excitation high-frequency pulsed lasers device, and pulse laser sends laser, is transferred in beam coupler by Transmission Fibers, and laser enters in the laser form of contact skin device after light beam coupling, forms accumulation point;
When the target cell (in circulating tumor cell, hemocyte, lymphocyte and blood other cell) in blood circulation is by laser focus point (form) at this blood vessel, it is subject to the irradiation of the high-frequency pulsed lasers of different wave length, producing photoacoustic waves, the ultrasonic probe that its ultrasonic signal sent is placed on contact skin device detects;
Then the ultrasonic signal of the signal processing system circulation target cell to detecting processes, after filtering the ultrasonic signal of normal cell generation and the ultrasonic signal of human body skin generation, again the unit interval (such as per minute) is carried out quantitative analysis (counting) by laser at the cell number of the focus point (form) of this blood vessel, and show on the display system.
This utility model adopts technique scheme to provide the benefit that:
1, on the basis of living body fluorescent detection method, in conjunction with the optoacoustic effect of biological tissue, utilize the optoacoustic specificity of biological tissue and the deep penetration of ultrasonic signal, overcome the inaccuracy that the environmental change that vitro detection is brought causes;
2, Clinical detection, Non-invasive detection can be accomplished, need not draw blood, without labelling, detect for early stage of clinical tumor cell and provide new approach;
3, there is the advantage at body, monitoring in real time, can for a long time patient be detected;
4, this device is of many uses: can be widely applied to clinical medicine and the basic medical research fields such as immunology, hematology, oncology, cytobiology, cytogenetics, biochemistry.
5, this device structure operation simple, convenient, Wicresoft, safety height;
6, adopt liquid crystal display, there is the advantages such as display quality interface high, digital, volume are little, lightweight and low in energy consumption.
Accompanying drawing explanation
In accompanying drawing content and figure, labelling brief description is as follows:
Fig. 1 is the schematic diagram of noinvasive circulating tumor cell checkout and diagnosis device of the present utility model.
Description of reference numerals:
1, signal generator, 2, high-frequency pulsed lasers device, 3, Transmission Fibers, 4, beam coupler, 5, contact skin device, 6, ultrasonic probe, 7, signal processor, 8, display system.
Detailed description of the invention
Below against accompanying drawing, by the description to embodiment, detailed description of the invention of the present utility model is described in further detail, to help those skilled in the art that inventive concept of the present utility model, technical scheme are had more complete, accurate and deep understanding.
Structure of the present utility model as shown in Figure 1, for a kind of noinvasive circulating tumor cell checkout and diagnosis device. This utility model further relates to its tumor cell checkout and diagnosis method, especially a kind of noinvasive circulating tumor cell checkout and diagnosis method and apparatus, utilizes the metastatic cancer cell in the optoacoustic specificity of biological tissue and the deep penetration detection blood circulation of ultrasonic signal.
In order to solve prior art Problems existing and overcome its defect, it is achieved in body, the goal of the invention detecting tumor cell in real time, exactly, the technical scheme that this utility model is taked is:
As it is shown in figure 1, noinvasive circulating tumor cell checkout and diagnosis device of the present utility model, it is provided with high-frequency pulsed lasers device 2, beam coupler 4 and ultrasonic probe 6; Described beam coupler 4 and ultrasonic probe 6 are all attached on contact skin device 5.
For the defect that prior art exists, the utility model proposes the technical scheme of above-mentioned noinvasive circulating tumor cell checkout and diagnosis method and apparatus:
Focusing on a contact skin device 5 by a branch of high-frequency pulsed lasers by beam coupler 4, the laser focusing window of contact skin device 5 is placed on the suitable a certain blood vessel of human arm.
When the target cell (in circulating tumor cell, hemocyte, lymphocyte and blood other cell) in blood circulation is by laser focus point (form) at this blood vessel, it is subject to the irradiation of the high-frequency pulsed lasers of different wave length, producing photoacoustic waves, the ultrasonic probe 6 that its ultrasonic signal sent is placed on contact skin device 5 detects;
Then the ultrasonic signal of the signal processing system 7 circulation target cell to detecting processes, after filtering the ultrasonic signal of normal cell generation and the ultrasonic signal (denoising) of human body skin generation, and the unit interval (such as per minute) is carried out quantitative analysis (counting) by laser at the cell number of the focus point (form) of this blood vessel, and it is shown in display system 8. Early stage checkout and diagnosis for cancer patient provides a new method.
Described high-frequency pulsed lasers device 2 is connected by signal line with signal generator 1.
The waveshape signal that described signal generator 1 sends is rectangular wave; Or it is sinusoidal wave. Described signal generator 1 produces the signal of difformity and frequency, and laser instrument is triggered, and this signal generator can send the difform waveshape signal such as rectangular wave, sine wave, it is also possible to send the triggering signal of various frequency.
Described high-frequency pulsed lasers device 2 is connected by Transmission Fibers 3 with beam coupler 4. The exciting light of described high-frequency pulsed lasers device 2 is transmitted by Transmission Fibers 3, and the core diameter of this Transmission Fibers is determined according to different laser instrument.
Signal generator 1 sends signal excitation high-frequency pulsed lasers device 2, high-frequency pulsed lasers device 2 sends laser, being transmitted on beam coupler 4 by Transmission Fibers 3, laser enters in the laser form of contact skin device 5 after beam coupler 4 carries out light beam coupling.
Described ultrasonic probe 6 is connected by signal line with signal processor 7.
Described signal processor 7 is connected with display system 8 by signal line.
Described ultrasonic probe 6 is processed by signal processing system 7 after ultrasonic signal being detected,
The ultrasonic signal of the described signal processing system 7 circulation target cell to detecting processes and at the cell number of the focus point (form) of this blood vessel, is carried out quantitative analysis (counting) by laser the unit interval (such as per minute). Its result is shown in display system 8, and this display system 8 can be all kinds of display systems such as LD display, light-emitting diode display. This signal processing system 7 is all ultrasonic signal processing systems. Ultrasonic signal processing system will be effectively retained the frequency band signals that target cell produces, and filters the ultrasonic signal (denoising) of normal cell, human body skin and other wave band extraneous.
The excitation wavelength of described high-frequency pulsed lasers device 2 can be: the wavelength that 1064nm, 808nm etc. are different.
The type of described high-frequency pulsed lasers device 2 can be solid state laser, semiconductor laser, gas laser, optical fiber laser and dye laser; The pattern of its laser output is pulse laser.
This described ultrasonic probe 6 is the model such as monocrystalline compressional wave normal probe, twin crystal compressional wave normal probe, monocrystalline transverse wave double-bevel detector, twin crystal transverse wave double-bevel detector, circumferential curvature probe, radial buckling probe, point focusing probe, line focus surface wave probe probe, and the frequency range of described ultrasonic probe 6 is 1-100MHz.
This contact skin device 5 is furnished with optical fiber receiving port, Laser emission window and ultrasonic probe, the material of contact skin device 5 can be the flexible nontoxic material such as plastics, rubber, big I is adjusted, and this contact skin device 5 can be the various forms such as bracelet, paster.
In order to realize the goal of the invention identical with technique scheme, this utility model additionally provides the checkout and diagnosis method being applied to above-described noinvasive circulating tumor cell checkout and diagnosis device, and its technical scheme is:
Described signal generator 1 sends signal excitation high-frequency pulsed lasers device 2, and pulse laser sends laser, is transferred in beam coupler 4 by Transmission Fibers 3, and laser enters in the laser form of contact skin device 5 after light beam coupling, forms accumulation point;
When the target cell (in circulating tumor cell, hemocyte, lymphocyte and blood other cell) in blood circulation is by laser focus point (form) at this blood vessel, it is subject to the irradiation of the high-frequency pulsed lasers of different wave length, producing photoacoustic waves, the ultrasonic probe 6 that its ultrasonic signal sent is placed on contact skin device 5 detects;
Then the ultrasonic signal of the signal processing system 7 circulation target cell to detecting processes, after filtering the ultrasonic signal of normal cell generation and the ultrasonic signal of human body skin generation, again the unit interval (such as per minute) is carried out quantitative analysis (counting) by laser at the cell number of the focus point (form) of this blood vessel, and be shown in display system 8.
Application example of the present utility model:
The waveform that the signal generator 1 of described noinvasive circulating tumor cell checkout and diagnosis device sends is rectangular wave, the 50kHz of frequency;
What high-frequency pulsed lasers device 2 adopted is 1064nm pulse laser, its repetition rate > 50kHz, maximum impulse energy: 50uJ;
The core diameter of Transmission Fibers 3 is 50 microns, and what beam coupling system adopted is can the high power laser light bonder of life-time service;
The polythene material that contact skin device 5 adopts is made, size scalable;
The non-focused ultrasound the being probe that ultrasonic probe 6 adopts;
The maximum sample rate of signal processor 7 can reach the data collecting card of 200MS/s;
The common computer LED display that display system 8 adopts.
Utilizing said system that the skin carcinoma circulating tumor cell in human body is detected, experiment obtains good effect, has reached target.
Above in conjunction with accompanying drawing, this utility model is exemplarily described; obvious this utility model implements and is not subject to the restrictions described above; as long as have employed the improvement of the various unsubstantialities that method of the present utility model design carries out with technical scheme; or not improved design of the present utility model and technical scheme are directly applied to other occasion, all within protection domain of the present utility model.
Claims (9)
1. a noinvasive circulating tumor cell checkout and diagnosis device, it is characterised in that: described checkout and diagnosis device is provided with high-frequency pulsed lasers device (2), beam coupler (4) and ultrasonic probe (6); Described beam coupler (4) and ultrasonic probe (6) are all attached on contact skin device (5).
2. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: described high-frequency pulsed lasers device (2) is connected by signal line with signal generator (1).
3. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 2, it is characterised in that: the waveshape signal that described signal generator (1) sends is rectangular wave; Or it is sinusoidal wave.
4. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: described high-frequency pulsed lasers device (2) is connected by Transmission Fibers (3) with beam coupler (4).
5. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: described ultrasonic probe (6) is connected by signal line with signal processor (7).
6. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 5, it is characterised in that: described signal processor (7) is connected with display system (8) by signal line.
7. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: the excitation wavelength of described high-frequency pulsed lasers device (2) is: 1064nm; Or it is 808nm.
8. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: described high-frequency pulsed lasers device (2) is the one in solid state laser, semiconductor laser, gas laser, optical fiber laser and dye laser; The pattern of its laser output is pulse laser.
9. the noinvasive circulating tumor cell checkout and diagnosis device described in claim 1, it is characterised in that: described this ultrasonic probe (6) is monocrystalline compressional wave normal probe, twin crystal compressional wave normal probe, monocrystalline transverse wave double-bevel detector, twin crystal transverse wave double-bevel detector, circumferential curvature probe, one in radial buckling probe, point focusing probe, line focus surface wave probe; The frequency range of described ultrasonic probe (6) is 1-100MHz.
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| CN2015106277563 | 2015-09-28 | ||
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| CN201510903631.9A Pending CN105286805A (en) | 2015-09-28 | 2015-12-07 | Noninvasive circulating tumor cell detection and diagnosis device and detection and diagnosis method thereof |
| CN201521015906.7U Active CN205286323U (en) | 2015-09-28 | 2015-12-07 | There is not circulation of wound tumor cells detection diagnosis device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106725324A (en) * | 2016-12-27 | 2017-05-31 | 上海交通大学 | A kind of unmarked self-positioning circulation MC real-time detection apparatus of binary channels |
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| WO2021147023A1 (en) * | 2020-01-22 | 2021-07-29 | 深圳市汇顶科技股份有限公司 | Living organism photoacoustic detection system, biological information detection apparatus, electronic device, and living organism detection method |
| CN112315430A (en) * | 2020-11-25 | 2021-02-05 | 广东普洛宇飞生物科技有限公司 | Cell detection apparatus and cell detection method |
| CN115299994A (en) * | 2022-08-15 | 2022-11-08 | 马隆波 | In-vitro tumor positioning device based on photoacoustic effect |
| CN117731239B (en) * | 2023-12-19 | 2024-08-30 | 北京信息科技大学 | Device and method for noninvasive dynamic monitoring and killing of living circulating tumor cells |
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| US20130184544A1 (en) * | 2012-01-13 | 2013-07-18 | Nellcor Puritan Bennett Llc | Body-mounted photoacoustic sensor unit for subject monitoring |
| US20140275826A1 (en) * | 2013-03-15 | 2014-09-18 | Covidien Lp | Photoacoustic sensors for patient monitoring |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106725324A (en) * | 2016-12-27 | 2017-05-31 | 上海交通大学 | A kind of unmarked self-positioning circulation MC real-time detection apparatus of binary channels |
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Effective date of registration: 20171023 Address after: 510700, Guangzhou City, Guangdong province Whampoa District hi tech Industrial Development Zone Science City open source Avenue No. 11 B10 building 3 floor 306 room Patentee after: Guangzhou Rui Rui Biological Technology Co., Ltd. Address before: 241000 Software Park in Anhui province Wuhu City Economic and Technological Development Zone Branch Center Room 0123 Patentee before: Zhou Hui |