CN205288225U - A agitating unit and container for preparing colloid class plasma solubilizer - Google Patents
A agitating unit and container for preparing colloid class plasma solubilizer Download PDFInfo
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- CN205288225U CN205288225U CN201620074249.1U CN201620074249U CN205288225U CN 205288225 U CN205288225 U CN 205288225U CN 201620074249 U CN201620074249 U CN 201620074249U CN 205288225 U CN205288225 U CN 205288225U
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Abstract
The utility model provides an agitating unit of preparation colloid class plasma solubilizer, make up paddle with fixing at the epaxial bilayer of stirring including the (mixing) shaft, double -deck combination paddle includes bottom layer stirring paddle and upper -layer stirring paddle, the bottom layer stirring paddle is fixed the one end of (mixing) shaft, the upper -layer stirring paddle is fixed on the (mixing) shaft, the upper -layer stirring paddle is the oblique paddle of two leaves of variable cross section formula, the front and back edge of the main paddle of the oblique paddle of two leaves of variable cross section formula all is the cockscomb structure. The utility model provides an agitating unit can disperse macromolecule gelatin raw materials, cut and split effectual, has to keep even, stable and fast -speed stirring ability, reaches the best stirring flow pattern to effectual control molecular weight distribution improves the qualification rate of subsequent product, has saved the production time, can also guarantee when the stirring liquid medicine not wall built -up that does not splash, thereby reduce the raw materials loss, has practiced thrift manufacturing cost.
Description
Technical field
The utility model relates to whipping appts technical field, particularly relates to a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent and container.
Background technology
Stir the hybrid mode the most frequently used as industry; it is occur certain to circulate by agitator; the particle that gas in solution, liquid are even suspended mixes; and in order to reach this purpose; need to be realized by forced convection, mixed uniformly device; i.e. whipping appts, and the structure of whipping appts be stirred states of matter, volume, density, the viscosity of material, mix requirement or reaction mechanism etc. and have close relationship.
As, in the process preparing colloidal type blood plasma solubilizing agent, blood plasma solubilizing agent is also known as plasma extender, blood plasma dilatation agent or plasma substitute, and its application is a kind of effective means of blood conservation, it is possible to reach replenishment of blood content, increases perfused tissue, rescues patient; Hemodilution in art, reduces allosome blood transfusion; Reduce coagulation function, prevent thrombosis; Improve the objects such as oncotic pressure. Owing to China's year blood using amount is big, and unnecessary blood transfusion accounts for 50%. Again examining the Necessity and feasibility of Saving on oil closely, significant, thus domestic plasma substitute market scale is in rapid growth state all the time.
Blood plasma solubilizing agent comprises crystal class and colloidal type two kinds. Crystal class blood plasma solubilizing agent can enter circulation of blood very soon, but because of the relation of osmotic pressure again can be very fast from blood vessel " leakage " to surrounding tissue, it is very difficult to the blood circulation amount in guarantee blood vessel; And colloidal type blood plasma solubilizing agent (such as hydroxyethylamyle sodium solution and succinyl gelatin injection) can be added to rapidly in blood circulation, owing to its osmotic pressure is similar with blood, " can not leak " in surrounding tissue, thus ensure blood circulation amount.So colloidal type blood plasma solubilizing agent obtains huge development in recent years.
Produce colloidal type blood plasma solubilizing agent, such as succinyl gelatin injection, it is generally that gelatin material is carried out swelling with water for injection, heating for dissolving, then carry out degraded acidylate, manufacture colloidal type blood plasma solubilizing agent (succinyl gelatin injection). And the class protein that gelatin is collagen partial hydrolysis and obtains, gelatin and collagen have homology, and collagen has bar-shaped triple helix structure, when its partial hydrolysis is prepared in the process of gelatin, and this kind of triple-helix structure generating portion separation of collagen and fracture. The amino acid composition of gelatin is similar to collagen, but because of pretreated difference, moiety also may be different, and the gelatine molecular weight of different size is generally 15000��250000Da. Thus the variation on molecular weight result in the reaction efficiency of follow-up acylation reaction, and affects the qualification rate of subsequent product.
So, how to control the homogeneity of the preparation process middle-molecular-weihydroxyethyl of colloidal type blood plasma solubilizing agent, it is to increase the qualification rate of colloidal type blood plasma solubilizing agent, become industry Nei Ge production firm problem demanding prompt solution.
Practical novel content
In view of this, the technical problems to be solved in the utility model is to provide a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent and container, especially a kind of whipping appts preparing Gelatin step in colloidal type blood plasma solubilizing agent process, the whipping appts that the utility model provides, can be undertaken disperseing, shear and rupturing by macromole gelatin material, have and keep even, stable and stirring capacity at a high speed, thus ensure that homogeneity and the scope of molecular weight, and can ensure that liquid does not splash not wall built-up when stirring.
The utility model provides a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent, the bilayer combination blade comprising stir shaft He being fixed on stir shaft;
Described bilayer combination blade comprises bottom agitating vane and upper strata agitating vane, and described bottom agitating vane is fixed on one end of described stir shaft, and described upper strata agitating vane is fixed on described stir shaft;
Described upper strata agitating vane is the variable cross-section formula two oblique blade of leaf; The edge, front and back of the main blade of the described variable cross-section formula two oblique blade of leaf is all in spination.
Preferably, the sawtooth height of described main blade anterior border is 14��16mm, and the sawtooth height of described main blade posterior border is 14��16mm;
The described sawtooth height of main blade anterior border and the ratio of main blade width are 1:(7��9), the described sawtooth height of main blade posterior border and the ratio of main blade width are 1:(4��6).
Preferably, the described little blade of the variable cross-section formula two oblique blade of leaf and the angle of main blade are 44��46 ��.
Preferably, the posterior border of described bottom agitating vane is spination.
Preferably, the sawtooth height of the posterior border of described bottom agitating vane is 14��16mm;
The sawtooth height of the posterior border of described bottom agitating vane and the ratio of bottom agitating vane width are 1:(7��9).
Preferably, described bottom agitating vane is three leaf aerofoil profile blades.
Preferably, described three leaf aerofoil profile blades are three narrow leaf aerofoil profile blades.
The utility model provides a kind of container, comprises the whipping appts described in technique scheme any one;
Described container comprises still, tank, tank or pot.
Preferably, the stirring velocity of described whipping appts is for being less than or equal to 400r/min.
Preferably, the blade length of described whipping appts and the ratio of container internal diameter are (0.3��0.5): 1.
The utility model provides a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent, the bilayer combination blade comprising stir shaft He being fixed on stir shaft, described bilayer combination blade comprises bottom agitating vane and upper strata agitating vane, and described bottom agitating vane is fixed on one end of described stir shaft, and described upper strata agitating vane is fixed on described stir shaft, described upper strata agitating vane is the variable cross-section formula two oblique blade of leaf, the edge, front and back of the main blade of the described variable cross-section formula two oblique blade of leaf is all in spination. compared with prior art, the utility model adopts the combination blade of double-deck paddle, and bottom blade has good mixing of materials and shears dispersion function and avoid material wall built-up, upper strata adopts the two oblique oars of leaf, the material added can be drawn into fast among the circulation of blade formation, can also prevent gelatin from uniting on stir shaft caking, thus the whipping appts that the utility model provides, effectively macromole gelatin material can will be disperseed, shear and fracture, have and keep evenly, the stable stirring capacity with high speed, reach best stirring flow pattern, thus effectively control molecular weight distribution, improve the qualification rate of subsequent product, save the production time, can also ensure that liquid does not splash not wall built-up when stirring, thus decrease material loss, save production cost. experimental result shows, adopts whipping appts of the present utility model in the process preparing colloidal type blood plasma solubilizing agent, and the preparation time can save about 20 minutes, and product clarity qualification rate can improve 4.5%��6.5%.
Accompanying drawing explanation
The structural representation of the variable cross-section formula two oblique blade of leaf that Fig. 1 provides for the utility model;
The front view of the variable cross-section formula two oblique blade of leaf that Fig. 2 provides for the utility model and vertical view;
The structural representation of the three narrow leaf aerofoil profile blades that Fig. 3 provides for the utility model;
The front view of the three narrow leaf aerofoil profile blades that Fig. 4 provides for the utility model and vertical view;
The structural representation of gelatin preparing tank of Fig. 5 for providing in the utility model embodiment 1.
Embodiment
In order to understand the utility model further, below in conjunction with embodiment, the utility model preferred embodiment is described, it should be appreciated that these describe just for feature and advantage of the present utility model instead of the restriction to the utility model claim are described further.
The utility model material therefor and reaction raw materials, be not particularly limited its source, that commercially buy or prepare according to ordinary method well known to those skilled in the art.
The utility model material therefor, is not particularly limited its specification, adopts the conventional specification of this area, and the utility model preferably meets the related request of medical industry or the related request of food service industry.
The all reaction raw materials of the utility model, are not particularly limited its purity, and the utility model preferably adopts food pure or meet the related request of medical industry.
The utility model provides a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent, the bilayer combination blade comprising stir shaft He being fixed on stir shaft;
Described bilayer combination blade comprises bottom agitating vane and upper strata agitating vane, and described bottom agitating vane is fixed on one end of described stir shaft, and described upper strata agitating vane is fixed on described stir shaft;
Described upper strata agitating vane is the variable cross-section formula two oblique blade of leaf; The edge, front and back of the main blade of the described variable cross-section formula two oblique blade of leaf is all in spination.
Described colloidal type blood plasma solubilizing agent is not particularly limited by the utility model, and with colloidal type blood plasma solubilizing agent well known to those skilled in the art, the utility model is preferably succinyl gelatin; The preparation process of described colloidal type blood plasma solubilizing agent is not particularly limited by the utility model, with the preparation process of succinyl gelatin solution well known to those skilled in the art. Described stir shaft is not particularly limited by the utility model, with the stir shaft for whipping appts well known to those skilled in the art; The definition of described blade is not particularly limited by the utility model, with the definition of stirring rake blade well known to those skilled in the art; The model of described blade is not particularly limited by the utility model, with the model of stirring rake blade well known to those skilled in the art, oblique blade described in the utility model meets this area usual definition, the blade that namely blade lower edge (trailing edge) tilts along the opposite direction stirred; The direction of described stirring is also identical with this area usual definition, namely rotates clockwise.
In the present embodiment, whipping appts described in the utility model preferably includes bilayer combination blade; In other embodiments, described whipping appts can comprise multiple layer combination blade, and to keep evenly, to stablize and stirring capacity at a high speed, the not wall built-up that do not splash is preferred version.
In the present embodiment, described bottom agitating vane is fixed on one end of described stir shaft; In other embodiments, described bottom agitating vane can also be fixed on other positions of stir shaft, and to keep evenly, to stablize and stirring capacity at a high speed, the not wall built-up that do not splash is preferred version.
In the present embodiment, the position that described upper strata agitating vane is fixing is not particularly limited by the utility model, those skilled in the art can carry out selecting and adjusting according to the requirement of stirring state, material characteristic and quality and product, and the utility model is preferably lower than and closes on material liquid surface; In other embodiments, described upper strata agitating vane can also be fixed on other positions of stir shaft, and to keep evenly, to stablize and stirring capacity at a high speed, the not wall built-up that do not splash is preferred version.
In the present embodiment, described upper strata stirring rake is preferably the variable cross-section formula two oblique blade of leaf; In other embodiments, described upper strata agitating vane can also be other kind two oblique blades of leaf, and to keep evenly, to stablize and stirring capacity at a high speed, better formation radial flow and axis stream are combined as preferred version. Described variable cross-section is not particularly limited by the utility model, with the concept of variable cross-section well known to those skilled in the art, namely has main blade and little blade on blade, and main blade is different with the angle of inclination of little blade; Length and the width ratio of described main blade and little blade are not particularly limited by the utility model, those skilled in the art can carry out selecting and adjusting according to the requirement of stirring state, material characteristic and quality and product, the length of main blade described in the utility model and width ratio are preferably (3��5): 1, it is more preferably (3.25��4.75): 1, it is more preferably (3.5��4.5): 1, it is most preferred that be (3.75��4.25): 1; The length ratio of main blade described in the utility model and little blade is preferably (1.3��1.5): 1, it is more preferable to be (1.35��1.45): 1, it is more preferable to be (1.38��1.43): 1, it is most preferred that be 1.428:1.
In the present embodiment, the angle of inclination of the main blade of the described variable cross-section formula two oblique blade of leaf is preferably 44��46 ��, it is more preferable to be 44.5��45.5 ��, it is most preferred that be 45 ��.In other embodiments, the angle of inclination of the main blade of the oblique blade of variable cross-section formula two leaf can also be other angles, the angle of the common two oblique blades of leaf can be adopted, such as 24 ��, 45 �� or 60 �� of inclination angles, to keep evenly, to stablize and stirring capacity at a high speed, better formation radial flow and axis stream are combined as preferred version.
In the present embodiment, the little blade of the described variable cross-section formula two oblique blade of leaf and the angle of main blade are preferably 44��46 ��, it is more preferable to be 44.5��45.5 ��, it is more preferable to be 45 ��, it is most preferred that be horizontally disposed with for little blade is similar to. In other embodiments, the little blade of the oblique blade of variable cross-section formula two leaf and the angle of main blade can also be other angles, and to keep evenly, to stablize and stirring capacity at a high speed, better formation radial flow and axis stream are combined as preferred version.
In the present embodiment, the edge, front and back (front and rear edge) of the main blade of the described variable cross-section formula two oblique blade of leaf is preferably all in spination. In other embodiments, the edge, front and back of the main blade of the described variable cross-section formula two oblique blade of leaf can also be other shapes, and so that feed particles to be broken into thinner more small particle, playing dispersion shearing action further is preferred version.
In the present embodiment, the sawtooth height of described main blade anterior border is preferably 14��16mm, it is more preferable to be 14.5��15.5mm, it is most preferred that be 15mm. In other embodiments, the sawtooth height of described main blade anterior border can also be other height, and so that feed particles to be broken into thinner more small particle, playing dispersion shearing action further is preferred version.
In the present embodiment, the sawtooth height of described main blade anterior border and the ratio of main blade width are preferably 1:(7��9), it is more preferable to be 1:(7.2��8.8), it is most preferred that it is 1:(7.7��8.2). In other embodiments, the sawtooth height of described main blade anterior border and the ratio of main blade width can also be other ratios, and so that feed particles to be broken into thinner more small particle, playing dispersion shearing action further is preferred version.
In the present embodiment, the sawtooth height of described main blade posterior border is preferably 14��16mm, it is more preferable to be 14.5��15.5mm, it is most preferred that be 15mm. In other embodiments, the sawtooth height of described main blade posterior border can also be other height, and so that feed particles to be broken into thinner more small particle, playing dispersion shearing action further is preferred version.
In the present embodiment, the sawtooth height of described main blade posterior border and the ratio of main blade width are preferably 1:(7��9), it is more preferable to be 1:(7.2��8.8), it is most preferred that it is 1:(7.7��8.2). In other embodiments, the sawtooth height of described main blade posterior border and the ratio of main blade width can also be other ratios, and so that feed particles to be broken into thinner more small particle, playing dispersion shearing action further is preferred version
See the structural representation of the variable cross-section formula two oblique blade of leaf that Fig. 1, Fig. 1 provide for the utility model, wherein, 1 is main blade, and 2 is little blade, and 3 is main blade anterior border sawtooth, and 4 is main blade posterior border sawtooth. The front view of the variable cross-section formula two oblique blade of leaf provided for the utility model see Fig. 2, Fig. 2 and vertical view.
In the present embodiment, described bottom agitating vane is preferably three leaf aerofoil profile blades, it is more preferable to be three narrow leaf aerofoil profile blades. Described three leaf aerofoil profile blades are not particularly limited by the utility model, and with three leaf aerofoil profile blades well known to those skilled in the art, i.e. the airfoil type blade of three blade symmetries, blade has obliquity.The length of described three narrow leaf aerofoil profile blades and width ratio are not particularly limited by the utility model, those skilled in the art can carry out selecting and adjusting according to the requirement of stirring state, material characteristic and quality and product, the length of three narrow leaf aerofoil profile blades described in the utility model and width ratio are preferably (3��5): 1, it is more preferably (3.25��4.75): 1, it is more preferably (3.5��4.5): 1, it is most preferred that be (3.75��4.25): 1. The width of three narrow leaf aerofoil profile blades described in the utility model refers to the width of blade the widest part, i.e. maximum width. In other embodiments, described bottom agitating vane can also be the blade of other models, to form high-efficient axial stream, has good mixing of materials and shears dispersion function, and avoid material wall built-up to be preferred version.
In the present embodiment, the posterior border of described bottom agitating vane is preferably in spination. In other embodiments, the posterior border of described change bottom agitating vane can also be other shapes, to form high-efficient axial stream, has good mixing of materials and shears dispersion function, and avoid material wall built-up to be preferred version.
In the present embodiment, the sawtooth height of the posterior border of described bottom agitating vane is preferably 14��16mm, it is more preferable to be 14.5��15.5mm, it is most preferred that be 15mm. In other embodiments, the sawtooth height of described main blade posterior border can also be other height, to form high-efficient axial stream, has good mixing of materials and shears dispersion function, and avoid material wall built-up to be preferred version.
In the present embodiment, the sawtooth height of the posterior border of described bottom agitating vane and the ratio of described bottom agitating vane width are preferably 1:(7��9), it is more preferably 1:(7.2��8.8), it is most preferred that be 1:(7.7��8.2). The width of bottom agitating vane described in the utility model refers to the width of blade the widest part, i.e. maximum width. In other embodiments, the sawtooth height of the posterior border of described bottom agitating vane and the ratio of described bottom agitating vane width can also be other ratios, to form high-efficient axial stream, there is good mixing of materials and shear dispersion function, and avoid material wall built-up to be preferred version.
See the structural representation of the three narrow leaf aerofoil profile blades that Fig. 3, Fig. 3 provide for the utility model, wherein, 1 is narrow leaf aerofoil profile blade, and 2 is narrow leaf aerofoil profile blade posterior border sawtooth. The front view of the three narrow leaf aerofoil profile blades provided for the utility model see Fig. 4, Fig. 4 and vertical view.
The utility model provides a kind of whipping appts for the preparation of colloidal type blood plasma solubilizing agent, the utility model adopts the combination blade of double-deck paddle, bottom paddle employing trailing edge is the three narrow efficient Axial-flow stirrer of leaf aerofoil profile of spination, has good mixing of materials and shears dispersion function and avoid material wall built-up; Upper strata adopts the variable cross-section formula two oblique blade of leaf, certain radial flow can be formed, the material added is drawn into fast among the circulation of blade formation, and close to liquid level, be possible to prevent gelatin unite on stir shaft caking, and the fixed position of upper-layer paddle can move up and down along stir shaft, the concrete liquid level how many according to preparation material can regulate the installation position of blade. In addition, all with sawtooth on upper strata blade and bottom blade, it is possible to more effectively gelatin particle is broken into thinner more small particle, plays further dispersion shearing action.
Thus, the whipping appts that the utility model provides, can will effectively be undertaken disperseing, shear and rupturing by macromole gelatin material, have and keep even, stable and stirring capacity at a high speed, reach best stirring flow pattern, thus effectively control molecular weight distribution, improve the qualification rate of subsequent product, save the production time, moreover it is possible to ensure that liquid does not splash not wall built-up when stirring, thus decrease material loss, save production cost.
The utility model additionally provides a kind of container, comprises the whipping appts described in technique scheme any one;
Described container comprises still, tank, tank or pot.
Described container is not particularly limited by the utility model, the container stirred with the needs for mixing or react well known to those skilled in the art, the utility model preferably has the container of agitating function, it is more preferably still, tank, tank or the pot with agitating function, specifically can be preferably reactor, stirring tank, stirred pot, agitation vat, agitator tank or agitator kettle etc.
In the present embodiment, the stirring velocity of described whipping appts is preferably less than or equal to 400r/min, it is more preferable to be 50��400r/min, it is more preferable to be 100��300r/min, it is most preferred that be 150��250r/min. In other embodiments, the stirring velocity of described whipping appts can also be other revolutions, to keep evenly, to stablize and stirring capacity at a high speed, has good mixing of materials and shears dispersion function, and avoid material wall built-up to be preferred version.
The relative installation of described whipping appts and container is not particularly limited by the utility model, with the position of whipping appts well known to those skilled in the art and container. The ratio of the blade length of described whipping appts and container internal diameter is not particularly limited by the utility model, those skilled in the art can carry out selecting and adjusting according to practical condition, stirring material situation and product situation, the blade length of whipping appts described in the utility model and the ratio of container internal diameter are preferably (0.3��0.5): 1, it is more preferably (0.32��0.48): 1, it is more preferably (0.35��0.45): 1, it is most preferred that be (0.38��0.42): 1.
Other parts of described container are not particularly limited by the utility model, with the parts of conventional stirred vessel well known to those skilled in the art, the utility model preferably also comprises one or more in motor, step-down gear, step-down gear base, machine frame of speed reducing machine, shaft coupling and double mechanical seal. The cavity volume of described container is not particularly limited by the utility model, those skilled in the art can carry out selecting and adjusting according to practical condition, stirring material situation and product situation, the utility model is preferably 1000��5000L, it is more preferable to for the size of whipping appts carries out adaptations along with the size and shape of the cavity volume of container.
Described container is not particularly limited by the utility model in a particular application, those skilled in the art can select according to practical situation, the utility model is specifically preferably described container or whipping appts meets the gel-shaped semisolid that can be volume at 1000��5000L, automatically change when low whipping speed is within 0��400 turn/min, and require that tank inner liquid medicine can not splash wall built-up; The inside and outside layer temperature exchange of 1000��5000L liquid in tank is reached intensification (normal temperature rises to 80��90 DEG C), cooling (being down to 15��25 DEG C for 80��90 DEG C) rapidly, evenly by stirring rake; reach and macromole gelatin is disperseed, shear, fragment into micromolecule polypeptide; to ensure follow-up acylation reaction, the weight-average molecular weight meeting the succinyl gelatin generated is the micromolecule polypeptide of 5600��180000.
In the process preparing colloidal type blood plasma solubilizing agent, the whipping appts that the utility model provides can not only disperse, shear, fragment into micromolecule polypeptide by macromole gelatin, generate ensure product succinyl gelatin weight-average molecular weight be 5600��180000 micromolecule polypeptide (meeting the distributed area of specification of quality: the small molecules molecular weight being less than 10% is greater than 5600, the macromole molecular weight being less than 10% is less than 180000;Weight-average molecular weight is between 38000��56000; Number-average molecular weight is between 18000��26600), more require in whipping process that tank inner liquid medicine can not splash wall built-up, this is due in process of production, stirred pot inwall has heating function, if liquid splashing wall built-up, then the liquid of wall built-up can be too high because of temperature, and loses effectiveness. Therefore, the whipping appts that the utility model provides has the stirring capacity keeping even, stable and high speed so that different reactive material fully mixes rapidly, sufficient reacting, effectively control molecular weight distribution, it is to increase the qualification rate of subsequent product, saves the production time; Can also ensure that liquid does not splash not wall built-up when stirring, thus decrease material loss, save production cost. Experimental result shows, adopts whipping appts of the present utility model in the process preparing colloidal type blood plasma solubilizing agent, and the preparation time can save about 20 minutes, and product clarity qualification rate can improve 4.5%��6.5%.
In order to understand the utility model further, the whipping appts for the preparation of colloidal type blood plasma solubilizing agent and the container that are provided by the utility model below in conjunction with embodiment are described in detail, and protection domain of the present utility model is not limited by the following examples.
Embodiment 1
Bilayer combination blade is provided. Upper strata agitating vane is the variable cross-section formula two oblique blade of leaf, and the edge, front and back of main blade is all in spination, and sawtooth height is 15mm, and the angle of little blade and main blade is 45 ��; Bottom agitating vane is three narrow leaf aerofoil profile blades, and the sawtooth height of the posterior border of blade is 15mm. Bilayer combination blade and 1800L dense preparing tank being carried out assembly, is fixed on stir shaft, diameter of propeller blade and tank body internal diameter are than being 0.4:1. See Fig. 5, the structural representation of gelatin dense preparing tank of Fig. 5 for providing in the utility model embodiment 1, wherein, 1 is motor and speed reducer, and 2 is shaft coupling, 3 is machine frame of speed reducing machine, 4 is double mechanical seal, and 5 is step-down gear base, and 6 is stir shaft, 7 is the variable cross-section formula two oblique blade of leaf, and 8 is three narrow leaf aerofoil profile blades.
First the gelatin material that weight-average molecular weight is 15000��250000Da is put into above-mentioned dense preparing tank, then add water for injection, start stirring rake, from 0��100 turn/min stirring at low speed, slowly heat dense preparing tank, make gelatin swelling, finally make gelatin all dissolve, it is heated to 90 DEG C.
Then regulating stirring rake power, rise to 400 turns/min from 100 turns/min, carry out high-speed stirring, then add the NaOH aqueous solution and hydrochloric acid successively rapidly, detection pH value, adds Succinic anhydried, detection pH value;
Regulating stirring rake power again, be down to 100 turns/min stirring at low speed from 400 turns/min, be again slowly warming up to 120 DEG C after adding injection, insulation 20min, fixed appearance, stirs evenly, after being cooled to 60 DEG C, obtains product succinyl gelatin injection.
In whole preparation process, dispersion shear effect is good, and it is moderate that eddy current forms the whirlpool degree of depth respectively between stir shaft radial direction and inner tank wall, and radial flow is moderate, rotates steadily, and reaction mass is without splashing wall cling phenomenon.
With reference to above-mentioned experimentation, again choose gelatin material and carry out 2 parallel laboratory tests again, 3 groups of results are detected, detected result see table 1, the monitoring data contrast of the succinyl gelatin product that table 1 prepares succinyl gelatin product for the utility model embodiment and prepared by traditional way.
It is identical with above-mentioned steps that traditional way prepares succinyl gelatin product process, and difference is to use general stirring apparatus.
Embodiment 2
Bilayer combination blade is provided. Upper strata agitating vane is the variable cross-section formula two oblique blade of leaf, and the edge, front and back of main blade is all in spination, and sawtooth height is 14.5mm, and the angle of little blade and main blade is 44.5 ��; Bottom agitating vane is three narrow leaf aerofoil profile blades, and the sawtooth height of the posterior border of blade is 14.5mm. Bilayer combination blade and 1500L dense preparing tank being carried out assembly, is fixed on stir shaft, blade length and tank body internal diameter are than being 0.3:1. See Fig. 5, the structural representation of gelatin dense preparing tank of Fig. 5 for providing in the utility model embodiment 1, wherein, 1 is motor and speed reducer, and 2 is shaft coupling, 3 is machine frame of speed reducing machine, 4 is double mechanical seal, and 5 is step-down gear base, and 6 is stir shaft, 7 is the variable cross-section formula two oblique blade of leaf, and 8 is three narrow leaf aerofoil profile blades.
First the gelatin material that weight-average molecular weight is 17000��230000Da is put into above-mentioned dense preparing tank, then add water for injection, start stirring rake, from 0��100 turn/min stirring at low speed, slowly heat dense preparing tank, make gelatin swelling, finally make gelatin all dissolve, it is heated to 90 DEG C.
Then regulating stirring rake power, rise to 350 turns/min from 50 turns/min, carry out high-speed stirring, then add the NaOH aqueous solution and hydrochloric acid successively rapidly, detection pH value, adds Succinic anhydried, detection pH value;
Regulating stirring rake power again, be down to 50 turns/min stirring at low speed from 350 turns/min, be again slowly warming up to 120 DEG C after adding injection, insulation 20min, fixed appearance, stirs evenly, after being cooled to 60 DEG C, obtains product succinyl gelatin injection.
In whole preparation process, dispersion shear effect is good, and it is moderate that eddy current forms the whirlpool degree of depth respectively between stir shaft radial direction and inner tank wall, and radial flow is moderate, rotates steadily, and reaction mass is without splashing wall cling phenomenon.
With reference to above-mentioned experimentation, again choose gelatin material and carry out 2 parallel laboratory tests again, 3 groups of results are detected, detected result see table 1, the monitoring data contrast of the succinyl gelatin product that table 1 prepares succinyl gelatin product for the utility model embodiment and prepared by traditional way.
It is identical with above-mentioned steps that traditional way prepares succinyl gelatin product process, and difference is to use general stirring apparatus.
Embodiment 3
Bilayer combination blade is provided. Upper strata agitating vane is the variable cross-section formula two oblique blade of leaf, and the edge, front and back of main blade is all in spination, and sawtooth height is 15.5mm, and the angle of little blade and main blade is 45.5 ��; Bottom agitating vane is three narrow leaf aerofoil profile blades, and the sawtooth height of the posterior border of blade is 15.5mm. Bilayer combination blade and 2000L dense preparing tank being carried out assembly, is fixed on stir shaft, blade length and tank body internal diameter are than being 0.5:1. See Fig. 5, the structural representation of gelatin dense preparing tank of Fig. 5 for providing in the utility model embodiment 1, wherein, 1 is motor and speed reducer, and 2 is shaft coupling, 3 is machine frame of speed reducing machine, 4 is double mechanical seal, and 5 is step-down gear base, and 6 is stir shaft, 7 is the variable cross-section formula two oblique blade of leaf, and 8 is three narrow leaf aerofoil profile blades.
First the gelatin material that weight-average molecular weight is 18000��245000Da is put into above-mentioned dense preparing tank, then add water for injection, start stirring rake, from 0��100 turn/min stirring at low speed, slowly heat dense preparing tank, make gelatin swelling, finally make gelatin all dissolve, it is heated to 90 DEG C.
Then regulating stirring rake power, rise to 400 turns/min from 50 turns/min, carry out high-speed stirring, then add the NaOH aqueous solution and hydrochloric acid successively rapidly, detection pH value, adds Succinic anhydried, detection pH value;
Regulating stirring rake power again, be down to 50 turns/min stirring at low speed from 400 turns/min, be again slowly warming up to 120 DEG C after adding injection, insulation 20min, fixed appearance, stirs evenly, after being cooled to 60 DEG C, obtains product succinyl gelatin injection.
In whole preparation process, dispersion shear effect is good, and it is moderate that eddy current forms the whirlpool degree of depth respectively between stir shaft radial direction and inner tank wall, and radial flow is moderate, rotates steadily, and reaction mass is without splashing wall cling phenomenon.
With reference to above-mentioned experimentation, again choose gelatin material and carry out 2 parallel laboratory tests again, 3 groups of results are detected, detected result see table 1, the monitoring data contrast of the succinyl gelatin product that table 1 prepares succinyl gelatin product for the utility model embodiment and prepared by traditional way.
It is identical with above-mentioned steps that traditional way prepares succinyl gelatin product process, and difference is to use general stirring apparatus.
Embodiment 4
Bilayer combination blade is provided. Upper strata agitating vane is the variable cross-section formula two oblique blade of leaf, and the edge, front and back of main blade is all in spination, and sawtooth height is 14.8mm, and the angle of little blade and main blade is 44.8 ��; Bottom agitating vane is three narrow leaf aerofoil profile blades, and the sawtooth height of the posterior border of blade is 14.6mm. Bilayer combination blade and 2200L dense preparing tank being carried out assembly, is fixed on stir shaft, blade length and tank body internal diameter are than being 0.45:1. See Fig. 5, the structural representation of gelatin dense preparing tank of Fig. 5 for providing in the utility model embodiment 1, wherein, 1 is motor and speed reducer, and 2 is shaft coupling, 3 is machine frame of speed reducing machine, 4 is double mechanical seal, and 5 is step-down gear base, and 6 is stir shaft, 7 is the variable cross-section formula two oblique blade of leaf, and 8 is three narrow leaf aerofoil profile blades.
First the gelatin material that weight-average molecular weight is 15000��230000Da is put into above-mentioned dense preparing tank, then add water for injection, start stirring rake, from 0��100 turn/min stirring at low speed, slowly heat dense preparing tank, make gelatin swelling, finally make gelatin all dissolve, it is heated to 90 DEG C.
Then regulating stirring rake power, rise to 400 turns/min from 80 turns/min, carry out high-speed stirring, then add the NaOH aqueous solution and hydrochloric acid successively rapidly, detection pH value, adds Succinic anhydried, detection pH value;
Regulating stirring rake power again, be down to 80 turns/min stirring at low speed from 400 turns/min, be again slowly warming up to 120 DEG C after adding injection, insulation 20min, fixed appearance, stirs evenly, after being cooled to 60 DEG C, obtains product succinyl gelatin injection.
In whole preparation process, dispersion shear effect is good, and it is moderate that eddy current forms the whirlpool degree of depth respectively between stir shaft radial direction and inner tank wall, and radial flow is moderate, rotates steadily, and reaction mass is without splashing wall cling phenomenon.
With reference to above-mentioned experimentation, again choose gelatin material and carry out 2 parallel laboratory tests again, 3 groups of results are detected, detected result see table 1, the monitoring data contrast of the succinyl gelatin product that table 1 prepares succinyl gelatin product for the utility model embodiment and prepared by traditional way.
It is identical with above-mentioned steps that traditional way prepares succinyl gelatin product process, and difference is to use general stirring apparatus.
The monitoring data contrast of succinyl gelatin product prepared by the succinyl gelatin product of table 1 the utility model embodiment 1��4 preparation and traditional way
By the test of 12 batches of embodiment 1��4, in finished product succinyl gelatin injection weight-average molecular weight be 5600��180000 micromolecule polypeptide distribute very evenly, every Testing index meet or exceed quality criteria requirements.
The explanation of above embodiment just understands method of the present utility model and core concept thereof for helping. Should be understood that; for those skilled in the art; under the prerequisite not departing from the utility model principle, it is also possible to the utility model carries out some improvement and modification, these improve and modify in the protection domain also falling into the utility model claim.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are enable to realize or use the utility model. To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein when not departing from spirit or scope of the present utility model, can realize in other embodiments. Therefore, the utility model can not be limited in these embodiments shown in this article, but be met the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. the whipping appts for the preparation of colloidal type blood plasma solubilizing agent, it is characterised in that, the bilayer combination blade comprising stir shaft He being fixed on stir shaft;
Described bilayer combination blade comprises bottom agitating vane and upper strata agitating vane, and described bottom agitating vane is fixed on one end of described stir shaft, and described upper strata agitating vane is fixed on described stir shaft;
Described upper strata agitating vane is the variable cross-section formula two oblique blade of leaf; The edge, front and back of the main blade of the described variable cross-section formula two oblique blade of leaf is all in spination.
2. whipping appts according to claim 1, it is characterised in that, the sawtooth height of described main blade anterior border is 14��16mm, and the sawtooth height of described main blade posterior border is 14��16mm;
The described sawtooth height of main blade anterior border and the ratio of main blade width are 1:(7��9), the described sawtooth height of main blade posterior border and the ratio of main blade width are 1:(4��6).
3. whipping appts according to claim 1, it is characterised in that, the described little blade of the variable cross-section formula two oblique blade of leaf and the angle of main blade are 44��46 ��.
4. whipping appts according to claim 1, it is characterised in that, the posterior border of described bottom agitating vane is spination.
5. whipping appts according to claim 4, it is characterised in that, the sawtooth height of the posterior border of described bottom agitating vane is 14��16mm;
The sawtooth height of the posterior border of described bottom agitating vane and the ratio of bottom agitating vane width are 1:(7��9).
6. whipping appts according to claim 1, it is characterised in that, described bottom agitating vane is three leaf aerofoil profile blades.
7. whipping appts according to claim 6, it is characterised in that, described three leaf aerofoil profile blades are three narrow leaf aerofoil profile blades.
8. a container, it is characterised in that, comprise the whipping appts described in claim 1��7 any one;
Described container comprises still, tank, tank or pot.
9. container according to claim 8, it is characterised in that, the stirring velocity of described whipping appts is for being less than or equal to 400r/min.
10. container according to claim 8, it is characterised in that, the blade length of described whipping appts and the ratio of container internal diameter are (0.3��0.5): 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105478039A (en) * | 2016-01-25 | 2016-04-13 | 吉林省长源药业有限公司 | Stirring device and container for preparing colloid class plasma solubilizer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105478039A (en) * | 2016-01-25 | 2016-04-13 | 吉林省长源药业有限公司 | Stirring device and container for preparing colloid class plasma solubilizer |
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| TR01 | Transfer of patent right |
Effective date of registration: 20170918 Address after: Kumho high tech Industrial Development Zone, Jilin province Changchun road 130000 No. 1199 Patentee after: Changyuan Pharmaceutical Industry Co., Ltd., Jilin Prov. Address before: Kumho high tech Industrial Development Zone, Jilin province Changchun road 130000 No. 1199 Co-patentee before: Cao Fengjun Patentee before: Changyuan Pharmaceutical Industry Co., Ltd., Jilin Prov. Co-patentee before: Song Wenhui |
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| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Qin Kai Inventor after: Song Wenhui Inventor after: Sun Renchao Inventor after: Su Ziyang Inventor before: Song Wenhui |