CN2052263U - Miniature physiological-parameter instrument for body fluid - Google Patents
Miniature physiological-parameter instrument for body fluid Download PDFInfo
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- CN2052263U CN2052263U CN 88216502 CN88216502U CN2052263U CN 2052263 U CN2052263 U CN 2052263U CN 88216502 CN88216502 CN 88216502 CN 88216502 U CN88216502 U CN 88216502U CN 2052263 U CN2052263 U CN 2052263U
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- pulse
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- body fluid
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- 210000001124 body fluid Anatomy 0.000 title claims abstract description 16
- 239000010839 body fluid Substances 0.000 title claims abstract description 16
- 238000012360 testing method Methods 0.000 claims abstract description 16
- 230000002457 bidirectional effect Effects 0.000 claims description 6
- 238000005070 sampling Methods 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 2
- 230000008034 disappearance Effects 0.000 claims description 2
- 230000010354 integration Effects 0.000 claims description 2
- 239000004973 liquid crystal related substance Substances 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 abstract description 12
- 238000005259 measurement Methods 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 208000017169 kidney disease Diseases 0.000 abstract description 3
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- 238000011160 research Methods 0.000 abstract description 3
- 238000013399 early diagnosis Methods 0.000 abstract description 2
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- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000002574 poison Substances 0.000 abstract 1
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- 210000002700 urine Anatomy 0.000 description 10
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- 238000002474 experimental method Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 1
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- 238000003306 harvesting Methods 0.000 description 1
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- 229910001410 inorganic ion Inorganic materials 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to a miniature measurer for human body fluid, which can check out various physiological parameters continuously and stably through the measurement of humoral conductivity, various mineral constituent and organic constituent in the excrement liquid, the saliva and the blood of a human can be checked out, and the measurer has the characteristics of no injuriousness, no poison and no illness. As a disease general investigation instrument, the measurer can carry out the early diagnosis of kidney disease, hepatic disease, cholecystopathy, etc. Meanwhile, the utility model can be used as a natural contraceptive effective tool for the women of childbearing age. The instrument is small, reliable and convenient in use in all kinds of medical units, medical colleges and research institutions. The utility model especially is suitable for portable testing apparatus for household healthy protection.
Description
The invention belongs to medical testing equipment.
At present existing technology and instrument to the human body fluid test are all tested with methods such as physics, chemistry, microscopes.Its method of testing complexity, the cycle is long.And the method for testing of some specific use is also very undesirable.For example: when on operating-table, will enrich blood to patient temporarily, still needing actually and continuing blood transfusion problems such as still blood transfusion has been enough and all can not finely solve.
The purpose of the invention is that a kind of electrical conductivity by the mensuration human body fluid of design is tested the instrument of various physiological parameters.Physiological parameter as various inorganic compositions, organic component in human urine, saliva, the blood etc. all can be tested, to satisfy the needs of growing medical diagnostic techniqu.
The application's scheme is as shown in Figure 1 by automatic signal generator, conductance cell, signal processing, store relatively, output shows, parts such as regulated power supply and decompression alarm are formed, tester produces the asymmetry pulse signal by asymmetric astable multibrator (also claiming multivibrator), be characterized in this signal pulse is handled, make its pulse back edge produce the identical undersuing of a width again, forming an amplitude that follows closely behind pulse signal after shaping and level transfer equates, the pulse signal that width is identical, again this two pulse is sent adder synthetic, former asymmetry pulse signal is synthesized the bidirectional pulse signal, again behind the conductance cell by electrode and human body fluid composition, produce a corresponding electric current, because the bidirectional pulse signal is a definite value, and the electric conductance of conductance cell is different because of the difference of body fluid parameter, make the electric current of generation that respective change take place thereupon, to carry out conversion by the electric current of conductance cell makes corresponding mutually with the body fluid physiological parameter, measure the value in a certain moment then, send display to show.For comparing with last test value, this tester is provided with the sub-value storage circuit, relatively the discerning by the demonstration of light emitting diode of test value next day.
Description of drawings:
Fig. 1 is the block diagram of this programme;
Fig. 2 is this programme circuit theory diagrams;
Fig. 3 represents the conductance cell model;
Fig. 4 represents the equivalent conductance pool model;
The change curve of saliva electric conductance in Fig. 5 menstrual cycle.
Further specify this programme architectural feature with reference to accompanying drawing:
As shown in Figure 2, this utility model utilizes NE555 intervalometer integrated package to constitute an asymmetric astable multibrator as pulse source, the impulse wave of output frequency and EDM Generator of Adjustable Duty Ratio: f
1.442695/(R
1+ R
2) C
1, t
1 
0.693R
1C
1t
2 
0.693R
2C
1, regulate R
1, R
2Can change output duty of ratio and frequency easily.From the tailing edge of the impulse wave of NE555 output through R
4C
2Parallel network postpones the back and imports the same wide reverse impulse ripple that the input of the phase inverter of being made up of NAND gate makes lag output (with respect to the pulse signal of pulse source output).Can be clear that from circuit and anyly to change to low level input signal from high level and all can make it produce a pulse signal, pulsewidth t=1/9R
4C
2, new pulse is carried out shaping through back secondary phase inverter, imports dual power supply amplifier A
1To realize that level shifts.Because the equivalent circuit of the conductance cell model that tested body fluid and electrode are formed, be illustrated in figure 4 as resistance and electric capacity also, series network, because of the existence of electric capacity, make that the generation polarization phenomena can cause test error in the charge and discharge process.Be adapted at bulk measurement and circuit is simple, inexpensive, eliminate capacitive effect under the miniaturization condition in order to reach, the test error that overcomes the undesirable element such as baseline drift of output level and produce, this programme has adopted the bidirectional pulse technology, it be easy to show that and work as the positive negative pulse stuffing pulse width difference in 1%, pulsewidth T is enough narrow, capacitive charge value is less than 1% of pulse voltage amplitude, then its error in 0.02%, capacitor C
XAnd C
PInterference just can get rid of, be not inaccessible in pulse technique to above-mentioned requirements.The synthetic method of dipulse signal is to involve hysteresis after the processing with wide pulse signal input summer A by the pulse that NE555 produces
2After carrying out superposition and shaping, promptly exportable positive and negative symmetric bidirectional pulse signal.A
2Be the dual power supply amplifier, it act as, 1. with two input pulse signal superpositions; 2. level transferance, A
2The signal of output is a symmetrical generating positive and negative voltage bidirectional pulse ripple.Constitute conductance cell by tested body fluid and electrode.Electrode structure adopts box structure, cassette holder is that the lucite that is used for dental materials is made, feed cassette holder by two stainless draw points, cassette holder has one side to have groove, make two stainless draw point ends in this groove, expose the formation bipolar electrode, make the electrode that is added with signal immerse the variation of experiencing its electric conductance behind the tested body fluid.For being used for the human test, electrode is made small-sized and is easy to and cleans.The mould shape of conductance cell as shown in Figure 3, symbol implication: C among the figure
CBe lead capacitance; C
dBe the electric double layer content; R
CBe conductor resistance; R
XBe solution resistance; Z
fBe induced impedance; C
iBe distribution capacity.C wherein
C, C
iWith the material of SOLUTION PROPERTIES, dielectric constant, electrode material, area, distance of wire, shielding situation etc. are relevant.Ignore small lead impedance, can be reduced to equivalent conductance pool model shown in Figure 4.C wherein
X, C
PBe respectively comprehensively also, series capacitance.From equivalent model as can be known, because the existence of electric capacity, make pulse add moment and can produce the current spike value, but its influence only limits to add moment, in the latter stage of reverse impulse, the influence of this peak current early can be ignored, and is not difficult to calculate that the electric current by conductance cell is directly proportional with the body fluid electric conductance in reverse impulse latter stage.This programme is correctly shown for the negative pulse current value corresponding with the conductance cell electric conductance in latter stage that will record, and needs this current value to be transformed into magnitude of voltage and must its value to remain unchanged in interpulse period, changes show value when measuring next time again.For this reason, circuit passes through A
2The dipulse signal of output passes through amplifier A through the current value that conductance cell obtains
3Be transformed to input sample keeper LF398 signal input part behind the magnitude of voltage, from the pulse signal of phase inverter through A
4Export R to
19, C
3Series circuit carries out inserting A behind the integration
5Work as U
C3Rise to A
5The open valve threshold voltage time, A
5Outfan is exported a positive pulse, and this pulse send sampling holder sampled signal input that the signal that signal input part is received is sampled, and sampled signal disappears synchronously with the disappearance of undersuing, enters the maintenance phase, produces until next sampling pulse.Here, sampled signal correctly occurs when needs are tested, and important effect is arranged, R in the circuit for the correctness of this instrument
31Be zero-regulator resistor, when no measuring current is imported, show null value.The display device of this tester is that digital lcd shows, delivers to the CC7106 integrated package by the signal of sampling holder output, can directly drive liquid crystal display.Regulate R by manual control
10Make U '=U
i, this moment D
3, D
4Two LED are all not luminous, so just can store test value on the same day, can judge difference with value yesterday intuitively according to the state of LED when measuring for the second time.Because electronic component has certain requirement to voltage in the circuit, circuit will produce distortion when being lower than setting, so the power supply setting has warning function.
Utilize this tester to do some practicality experimental studies, obtained positive effect, its result is as follows:
1. the experiment in the medical science:
JIUYUE in 1988 9 days was to JIUYUE 30 days, and we have carried out the test of electrical conductivity to more than 300 patients' urine in 117 hospitals of PLA of Nanjing Military Command.The urine that this experiment is got all is a urina sanguinis, and we have adopted following dilution method to each sample: urine: deionized water=1me:8me.Container and electrode are all rinsed well with deionized water after each the measurement.
In 300 all samples, there are 28 to be normal examinee, this is used for comparison as the standard urine.75 patients of section such as orthopaedics, department of eye are for example arranged among the inpatient in addition, and their urine composition generally is not subjected to the influence of disease yet, can regard as normal.Like this, one have two groups of normal urine conductivity values: i.e. normal value among health check-up normal value and the patient.Their urine conductivity measurements is as follows: the normal inspection person: 28 people.Conductivity range is:
0.710～2.346mv／cm， K＝1.574mv／cm，S＝0.4079mv／cm。Normal value among the patient: 75 examples.Conductivity range is: 0.783～2.029mv/cm, K=1.3238mv/cm, S=0.3227mv/cm.
According to normal urine electric conductivity value scope, we get the lower limit that 1.000mv/cm is a normal value, and 2.000mv/cm is the upper limit.Exceed this limit,, be undesired value just for too low or too high.Observe all cases, we find that higher sample has 7 examples, and are as shown in table 1.
The case that electrical conductivity is on the low side has 69 examples, and wherein apparent in view have 11 routine nephropathy, 6 routine hematurias, 7 routine hepatopathys, 5 routine cholecystopathys.Its result lists in table 2, table 3, table 4, table 5 respectively.
2. the experiment in the natural contraception:
We have looked for a collegegirl, carried out 1 wheat harvesting period saliva of buccal cavity in bulk measurement, the variation of saliva electrical conductivity is as shown in Figure 7 in women's menstrual cycle of measurement.
Above-mentioned curve is that the 3rd day of beginning from menstruation measured.Tangible peak appearred on the 9th day.Calculate that according to physiology ovulation rule carried out about the 14th day or 15 days this experimenter's the onset of ovulation.Again to curve chart like this, this young woman was at preovulatory the 5th day to the 6th day as can be known thus, and the electrical conductivity in its saliva has a tangible peak value to occur.
Can tentatively think thus: utilize test to educate the method that makes saliva electrical conductivity in the young woman oral cavity, may find out a method of natural contraception easily, replace making the women bring the medical contraception method of ailing and sequela to vast educating.For worldwide family planning hews out a brand-new road.
3. the experiment of research saliva of buccal cavity composition:
We have selected the average year order to measure the situation of change before and after on the feed of saliva composition in their oral cavity five Health College Students (male 2 people, women 3 people) of 22 years old, to measuring about 10 minutes of the ante cibum of early, middle and late breakfast, lunch and dinner, measured in then about after meal 10 minutes.Its 5 people's average data is as shown in table 6, and as can be seen, saliva resistivity after meal has significant increase than the ante cibum, and this shows significantly before and after the feed that the inorganic ions composition is by changeable few in the saliva, and organic component is by few variable condition how that becomes.
Can show this test instrunment from above-mentioned experimentation, needn't use reagent paper and microscope, do not cause injury, not intoxicating, not pathogenicly can draw test result rapidly, and have multi-functional effectiveness, can measure various physiological parameters in the body fluid such as human urine, saliva, blood.Can be in medical science as the generaI investigation means of disease, can carry out early diagnosis to some disease such as nephropathy, hepatopathy, cholecystopathy etc., can be as the effective tool of educating the natural contraception that makes the women, can study the various compositions in the human body fluid, the energy measurement blood flow, accurate simple and easy control foundation when transfusing blood as surgical patient, energy measurement content of hemoglobin, gaseous metabolism situation of monitoring patient or the like.It is all spendable light test instrunment of all kinds of medical departments, family, medical colleges and schools, research institution.
Table 6
Claims (3)
1, a kind of human body fluid parameter tester is characterized in that comparing, export parts such as demonstration, regulated power supply and decompression alarm by automatic signal generator, conductance cell, signal processing, storage forms, and from pulse source NE555 output impulse wave, its tailing edge is through R
4C
2Parallel network postpones the input that the phase inverter of being made up of NAND gate is imported in the back, with the same wide reverse impulse ripple of lag output, again pulse is involved reverse impulse ripple input summer A
2Output symmetrical generating positive and negative voltage bidirectional pulse ripple to conductance cell obtains current value after carrying out superposition and shaping, by amplifier A
3Be transformed to the signal input part of magnitude of voltage input sample keeper LF398, and from the pulse signal of phase inverter through A
4Export R to
19C
3Series circuit carries out inserting A behind the integration
9Work as U
C3Rise to A
9The open valve threshold voltage time, from A
3Exporting a positive pulse to sampling holder sampled signal input samples the signal that signal input part is received, sampled signal disappears synchronously with the disappearance of undersuing and enters the maintenance phase, until the generation of next sampling pulse, the signal of exporting from sampling holder send the CC7016 integrated package directly to drive liquid crystal display.
2, by the described tester of claim 1, it is characterized in that conductance cell is made of tested body fluid and electrode, electrode is a box structure, cassette holder is that the pmma material that is used for dentistry is made, two stainless draw points feed cassette holder, the one side of cassette holder has groove, and two stainless draw point ends are exposed in groove, forms bipolar electrode.
3, by the described tester of claim 1, it is characterized in that storage circuit is arranged, the same day test value with next day test value by the diode displaying comparison.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88216502 CN2052263U (en) | 1988-12-22 | 1988-12-22 | Miniature physiological-parameter instrument for body fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88216502 CN2052263U (en) | 1988-12-22 | 1988-12-22 | Miniature physiological-parameter instrument for body fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2052263U true CN2052263U (en) | 1990-02-07 |
Family
ID=4849120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88216502 Withdrawn CN2052263U (en) | 1988-12-22 | 1988-12-22 | Miniature physiological-parameter instrument for body fluid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2052263U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10299678B2 (en) | 2016-04-07 | 2019-05-28 | Chang Gung Memorial Hospital, Chiayi | Method and apparatus for detecting dehydration |
-
1988
- 1988-12-22 CN CN 88216502 patent/CN2052263U/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10299678B2 (en) | 2016-04-07 | 2019-05-28 | Chang Gung Memorial Hospital, Chiayi | Method and apparatus for detecting dehydration |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |