CN205182755U - A anchor clamps for sandwich structure micro -fluidic chip - Google Patents
A anchor clamps for sandwich structure micro -fluidic chip Download PDFInfo
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- CN205182755U CN205182755U CN201521003843.3U CN201521003843U CN205182755U CN 205182755 U CN205182755 U CN 205182755U CN 201521003843 U CN201521003843 U CN 201521003843U CN 205182755 U CN205182755 U CN 205182755U
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Abstract
The application discloses an anchor clamps for sandwich structure micro -fluidic chip, including relative upper cover plate that sets up and lower apron, form a centre gripping space between upper cover plate and the lower apron, sandwich structure micro -fluidic chip set up in in the centre gripping space, sandwich structure micro -fluidic chip includes two chips and lies in filtration membrane between two chips, on two chips respectively processing have the microchannel and formed at little passage end's exit, offered respectively on upper cover plate and the lower apron with import and export the through -hole of intercommunication on the chip, through -hole and business turn over liquid articulate. These anchor clamps pass through pressure and realize the reversible sealed of micro -fluidic chip and filtration membrane, micro -fluidic chip repeatedly usable, and filtration membrane changes simply, through PEEK joint connecting catheters and chip inlet, it is convenient to connect, and the dead volume is little, have the packing ring between PEEK joint and chip inlet, through rotary joint realization close -fitting, pressure resistance is good, the difficult leakage.
Description
Technical field
The application belongs to micro fluidic chip technical field, particularly relates to a kind of fixture for sandwich structure micro-fluidic chip.
Background technology
" micro-fluidic chip/filter membrane/micro-fluidic chip " sandwich structure refers in particular to and clamps a slice filter membrane by two panels micro-fluidic chip, this sandwich structure is the common structure of micro-fluidic chip research field, can realize a series of functions such as fluid exchange, sample filtering and micro-fluid control chip electrophoretic on micro-fluidic chip.Be limited by micro Process and relevant packaging technology, the sandwich structure processing difficulties based on micro-fluidic chip is comparatively large, mainly concentrates on above small-scale scientific research field.
(Wangetal., 2013) adopt heat pressing process, filter membrane and PMMA are packaged together, but also indicate simultaneously, and this technique can cause the surface irregularity of film, the problem that film thickness reduces, and affect aperture and the filtering feature of film further.
(Noblittetal., 2007) what adopt is that the mode of plasma treatment carries out involution, although this mode is simple, plasma can the hydrophobic/hydrophilic character of modified filter membrane, thus change the mode of fluid exchange, the experiment purpose preset can not be realized.
(JannigandNguyen, 2011) one is reported, polymer surfaces by micro Process means process one with the hole of filter membrane consistent size, then filter membrane is placed wherein, then adopt traditional handicraft, sandwich structure is encapsulated, but this method complex operation, long processing time, cost is very high.
What above-mentioned three kinds of methods were taked is all irreversible involution, depends on the life-span of filter membrane the service life of whole sandwich structure completely, and usual service life is shorter.Therefore, this patent proposes a kind of reversible " micro-fluidic chip/filter membrane/micro-fluidic chip " sandwich structure fixture, by pressure reversible involution micro-fluidic chip and filter membrane, solves the problem that the processing of traditional sandwich structure is loaded down with trivial details, the life-span is shorter.
Utility model content
The purpose of this utility model is to provide a kind of reversible fixture for sandwich structure micro-fluidic chip, may be used for filtering flow and fluid exchange.
For achieving the above object, the utility model provides following technical scheme:
The embodiment of the present application discloses a kind of fixture for sandwich structure micro-fluidic chip, comprise the upper cover plate and lower cover that are oppositely arranged, a grasping part is formed between described upper cover plate and lower cover, described sandwich structure micro-fluidic chip is arranged in described grasping part, described sandwich structure micro-fluidic chip comprises two panels chip and the filter membrane between described two panels chip, described two panels chip is processed with respectively microchannel and is formed at the import and export of microchannel end, described upper cover plate and lower cover offer the through hole with the enterprising outlet of described chip respectively, described through hole is connected with liquid in-out joint.
Preferably, in the above-mentioned fixture for sandwich structure micro-fluidic chip, detachably fixed between described upper cover plate and lower cover by connector, described connector comprises the screw and nut that match.
Preferably, in the above-mentioned fixture for sandwich structure micro-fluidic chip, described liquid in-out joint comprises the tapered peek joint of neck and the conduit with peek fittings.
Preferably, in the above-mentioned fixture for sandwich structure micro-fluidic chip, described chip is imported and exported and be provided with O type packing ring between peek joint.
Preferably, in the above-mentioned fixture for sandwich structure micro-fluidic chip, described grasping part communicates with at least one side of described upper cover plate or lower cover.
Preferably, in the above-mentioned fixture for sandwich structure micro-fluidic chip, described through hole is screwed hole, and described liquid in-out joint cooperation is formed with external threaded surface.
Compared with the filtering separation device of routine, sandwiched film-chip structure fixture uses advantage:
(1), volume is little, and quality is light, and portability is strong;
(2), chip material can be the hard material such as PMMA, PC and glass, and upper and lower cover plates material is aluminum, and chemical stability is strong, anticorrosive;
(3), small-size chips is coordinated to use, chip runner flexible design;
(4), can change filter membrane at any time, the fixture life-span is long
(5) the filtered filter membrane of different pore size and hydrophilic and hydrophobic, is chosen according to the feature of separating liquid;
(6), temperature and pressure tolerance range is wide;
(7), simple to operate, easy to use, cost is low.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present application or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, the accompanying drawing that the following describes is only some embodiments recorded in the application, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Figure 1 shows that the solid assembling schematic diagram of the fixture of sandwich structure micro-fluidic chip in the utility model specific embodiment.
Figure 2 shows that the perspective exploded view of the fixture of sandwich structure micro-fluidic chip in the utility model specific embodiment.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the utility model embodiment, be described in detail the technical scheme in the utility model embodiment, obviously, described embodiment is only the utility model part embodiment, instead of whole embodiments.Based on the embodiment in the utility model, the every other embodiment that those of ordinary skill in the art obtain under the prerequisite not making creative work, all belongs to the scope of the utility model protection.
Shown in ginseng Fig. 1 and Fig. 2, for the fixture of sandwich structure micro-fluidic chip, comprise the upper cover plate 1 and lower cover 2 that are oppositely arranged, a grasping part 3 is formed between upper cover plate 1 and lower cover 2, sandwich structure micro-fluidic chip is arranged in grasping part, sandwich structure micro-fluidic chip comprises two panels chip 401 and the filter membrane between two panels chip 402, two panels chip 41 is processed with respectively microchannel and is formed at the import and export of microchannel end, upper cover plate 1 and lower cover 2 offer respectively the through hole 101 of the enterprising outlet with chip, through hole 101 is connected with liquid in-out joint 5.
Chip 41 is two standard chips, and monolithic chip is of a size of 24.0*24.0mm, and thickness is 2.0mm, and two panels chip is processed with identical microchannel, and centre accompanies filter membrane 402, forms sandwich structure, so that fluid communication or filtration; According to exchanging or the requirement of filter liquide, shape and the length of microchannel can be changed; Every sheet micro-fluidic chip arranges a pair import and export, and upper and lower cover plates lead to the hole site is corresponding; Chip material can be the hard material such as PMMA, PC and glass.
Filter membrane, slightly larger than chip overall dimensions, so that cover the fluid channel on whole micro-fluidic chip surface, is fixed between two panels chip by pressure by filter membrane 402 size.By choosing the filter membrane of different hydrophobe character, the functions such as single-phase filtration, multi-phase separation can be realized; By choosing the filter membrane of different pore size, realize the isolated by filtration of the particulate matter to different-grain diameter.
Upper cover plate 1 and lower cover 2 material are aluminum, and upper cover plate 1 each side has two screwed holes 102, is used for fixing upper and lower cover plates.
Lower cover 2 upper surface processing chip groove (grasping part), chip groove is communicated with the side of lower cover, and chip groove size superposes measure-alike with two panels micro-fluidic chip; Lower cover 2 each side has two screwed holes 201, corresponding with screwed hole 102 position of upper cover plate, and is furnished with nut groove, fixes upper and lower cover plates by screw 5 and nut 6.
Through hole 101 and liquid in-out joint 5 inside dimension coupling, liquid in-out joint is PEEK joint, by being connected with PEEK joint, realizes the constrained input of fluid sample.
Packing ring 7 is positioned between the import and export of chip and the sample introduction screwed hole of upper and lower cover plates, after PEEK joint and sample introduction screwed hole being tightened, is realized the compact siro spinning technology of " PEEK joint-O type packing ring-micro-fluidic chip is imported and exported ", avoid leakage by pressure.
Commercially available conduit selected by PTFE conduit 8, external diameter 1.6mm, internal diameter 0.6mm, and catheter outer diameter slightly larger than PEEK joint internal diameter, thus realizes close-fitting, avoids leak of liquid;
Screw 5 is positioned over upper cover plate, and nut 6 is positioned over the nut groove of lower cover lower surface processing, is tightened, provides pressure to whole fixture, realize reversible involution by die nut.Have and do not reveal, the little advantage of dead volume.Fixed by screw 5 and nut 6 between upper cover plate and lower cover, the pressure of about 40 kilograms is provided, utilizes fixture to realize the reversible involution of sandwich structure, improve integrally-built service life.
The assemble method of above-mentioned fixture comprises:
1. filter membrane 402 is placed between two micro-fluidic chips 41 and forms sandwich structure, microfluidic channel respectively towards filter membrane, two panels chip liquid entrance aligned in position.
2. sandwich structure is placed on lower cover chip groove 3, and upper cover plate 1 is placed into correct position, chip is imported and exported position and align with upper and lower cover plates lead to the hole site.
3. screw is positioned over upper cover plate pressurized screw hole, nut is positioned over lower cover bottom nut groove, applies pressure by spanner, makes integral clamp compact siro spinning technology.
4. O type packing ring is positioned over bottom upper and lower cover plates sample introduction screwed hole, PTFE conduit is inserted into bottom PEEK joint, then PEEK joint is screwed into upper and lower cover plates liquid in-out screwed hole, realizes compact siro spinning technology, reach liquid input and output object.
It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
The above is only the detailed description of the invention of the application; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the application's principle; can also make some improvements and modifications, these improvements and modifications also should be considered as the protection domain of the application.
Claims (6)
1. the fixture for sandwich structure micro-fluidic chip, it is characterized in that, comprise the upper cover plate and lower cover that are oppositely arranged, a grasping part is formed between described upper cover plate and lower cover, described sandwich structure micro-fluidic chip is arranged in described grasping part, described sandwich structure micro-fluidic chip comprises two panels chip and the filter membrane between described two panels chip, described two panels chip is processed with respectively microchannel and is formed at the import and export of microchannel end, described upper cover plate and lower cover offer the through hole with the enterprising outlet of described chip respectively, described through hole is connected with liquid in-out joint.
2. the fixture for sandwich structure micro-fluidic chip according to claim 1, is characterized in that: detachably fixed by connector between described upper cover plate and lower cover, described connector comprises the screw and nut that match.
3. the fixture for sandwich structure micro-fluidic chip according to claim 1, is characterized in that: described liquid in-out joint comprises the tapered peek joint of neck and the conduit with peek fittings.
4. the fixture for sandwich structure micro-fluidic chip according to claim 1, is characterized in that: be provided with O type packing ring between described chip and grasping part contact surface.
5. the fixture for sandwich structure micro-fluidic chip according to claim 1, is characterized in that: described grasping part communicates with at least one side of described upper cover plate or lower cover.
6. the fixture for sandwich structure micro-fluidic chip according to claim 1, is characterized in that: described through hole is screwed hole, and described liquid in-out joint cooperation is formed with external threaded surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521003843.3U CN205182755U (en) | 2015-12-07 | 2015-12-07 | A anchor clamps for sandwich structure micro -fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521003843.3U CN205182755U (en) | 2015-12-07 | 2015-12-07 | A anchor clamps for sandwich structure micro -fluidic chip |
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| CN205182755U true CN205182755U (en) | 2016-04-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
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Address after: 215808 Suzhou Industrial Park, Jiangsu Road, No. 128 Patentee after: Suzhou Wen Hao microfluidic technology Limited by Share Ltd Address before: 215808 Suzhou Industrial Park, Jiangsu Road, No. 128 Patentee before: Suzhou Wenhao Chip Technology Co., Ltd. |