CN205133582U - Genetic chip that layering set up - Google Patents
Genetic chip that layering set up Download PDFInfo
- Publication number
- CN205133582U CN205133582U CN201520845554.1U CN201520845554U CN205133582U CN 205133582 U CN205133582 U CN 205133582U CN 201520845554 U CN201520845554 U CN 201520845554U CN 205133582 U CN205133582 U CN 205133582U
- Authority
- CN
- China
- Prior art keywords
- gene chip
- membrane layer
- base membrane
- layer
- probe array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The utility model discloses a genetic chip that layering set up, including bearer layer, base film layer and tectorial membrane layer, its characterized in that, base film layer set up in on the bearer layer, the tectorial membrane layer cover in base film layer is last, the last probe array that sets up of base film layer, set up on the tectorial membrane layer and go up the array aperture that probe array corresponds with base film layer. In addition set up the lid on the genetic chip, lid lid is on the tectorial membrane layer. This genetic chip still can set up a plurality of probe array subregions, carries out the detection of disparity items. The utility model discloses the genetic chip multilayer sets up, can effectively protect and detect the non -interference between the probe, and can carry out a plurality of target gene and detect.
Description
Technical field
The utility model belongs to biochip and diagnostic reagent technical field, is particularly related to the gene chip that a kind of layering is arranged.
Background technology
The prototype of gene chip (genechip) (also known as DNA chip, biochip) is that the mid-80 proposes.The order-checking principle of gene chip is sequencing by hybridization method, namely by carrying out the method for determining nucleic acid sequence with the nucleic acid probe hybridization of one group of known array, secures the probe of the known target nucleotide of sequence at one piece of substrate surface.In practical application, biochip technology can be widely used in medical diagnosis on disease and treatment, drug screening, farm crop good child-rearing preferably, judicial expertise, Food Hygiene Surveillance, environment measuring, national defence, many fields such as space flight.It opens up brand-new approach by for human knowledge's origin of life, heredity, growth and evolution, diagnosis for human diseases, treatment and control, for the rapid screening of lead compound in the macromolecular brand-new design of biology and drug development and pharmacogenomics research provide technical platform.
How many gene chips of current existence arranges base membrane layer on slide, and base membrane layer arranges detection probes, and in use procedure, base membrane layer is not subject to effective protection, is easy to be polluted, and affects the accuracy of detected result.Therefore need a kind of can the gene chip of available protecting base membrane layer conversion zone, to ensure the accuracy of the test item carried out.
In view of the deficiency that prior art exists, the utility model provides a kind of gene chip of available protecting base membrane layer conversion zone, is specially the gene chip that a kind of layering is arranged.
Utility model content
Can not the problem of available protecting base membrane layer conversion zone in order to overcome existing gene chip, the purpose of this utility model is to provide the gene chip that a kind of layering that can solve the problem is arranged.
The purpose of this utility model is achieved through the following technical solutions:
The gene chip that a kind of layering is arranged, comprise bearing bed, base membrane layer and coating layer, described base membrane layer is arranged on described bearing bed, described coating layer is covered on described base membrane layer, described base membrane layer arranges probe array, described coating layer arranges the hole array corresponding with probe array on base membrane layer.Layering arranges bearing bed in structure and effectively carries base membrane layer, and the coating layer of the hole array corresponding with probe array on base membrane layer effectively can prevent the mutual interference of base membrane layer respectively reacting between aperture.
Further, gene chip arranges lid, described lid is placed on coating layer; arranging of lid can effectively cover each conversion zone; prevent the pollution of each conversion zone of outer bound pair, each conversion zone of available protecting, make it be in a relative separation and closed environment.
Further, described lid one end is connected on described bearing bed by rotating shaft, rotating shaft arrange can be convenient folding cover.
Further, this gene chip also can arrange multiple probe array subregion, carries out the detection of disparity items, multiple different probe array partition the detection simultaneously can carrying out disparity items is set.
Further, described probe array subregion arranges 1-10.
Further, described probe array can arrange any type of array way, and be wherein preferably 3*5 array, this kind arranges the setting that can ensure multiple subregion, can ensure again the accuracy that each project detects.
Further, described base membrane layer is nylon membrane or nitrocellulose membrane.
Further, described probe array arranges positive control area, negative control area and detection zone.
Further, bearing bed and coating layer are all that transparent material is made, transparent material effective observation that can ensure detected result is set.
Further, other structures of relating to of gene chip are all identical with of the prior art.
The beneficial effects of the utility model are: the gene chip that layering is arranged effectively can ensure that each conversion zone is in a relative separation and closed environment, effectively ensure the accuracy of detected result; Many array partition the detection simultaneously can carrying out multiple project is set.
Accompanying drawing explanation
Fig. 1 the utility model one-piece construction schematic diagram;
Fig. 2 the utility model integral perspective structural representation;
Fig. 3 the utility model each layer isolating construction schematic diagram;
In figure 1, bearing bed; 2, base membrane layer; 21, probe array; 3, coating layer; 31, hole array; 4, lid; 41, rotating shaft;
Embodiment
The gene chip that embodiment 1 one kinds of layerings are arranged
The gene chip that a kind of layering is arranged, comprise bearing bed 1, base membrane layer 2 and coating layer 3, wherein base membrane layer 2 is arranged on bearing bed 1, and coating layer 3 is covered on base membrane layer 2, base membrane layer 2 is arranged probe array 21, coating layer 3 arranges the hole array 31 corresponding with probe array 21 on base membrane layer 2.Layering arranges bearing bed 1 effectively carrying base membrane layer 2 in structure, and the coating layer 3 of the hole array 31 corresponding with probe array 21 on base membrane layer 2 effectively can prevent the mutual interference of base membrane layer 2 respectively reacting between aperture.This gene chip arranges 1 probe array 21 subregion.Probe array 21 is 3*5 array.Base membrane layer 2 is nylon membrane or nitrocellulose membrane.Probe array 21 is arranged positive control area, negative control area and detection zone.Bearing bed 1 and coating layer 3 are all that transparent material is made, transparent material effective observation that can ensure detected result is set.
The gene chip that embodiment 2 one kinds of layerings are arranged
The gene chip that a kind of layering is arranged, comprise bearing bed 1, base membrane layer 2 and coating layer 3, wherein base membrane layer 2 is arranged on bearing bed 1, and coating layer 3 is covered on base membrane layer 2, base membrane layer 2 is arranged probe array 21, coating layer 3 arranges the hole array 31 corresponding with probe array 21 on base membrane layer 2.Layering arranges bearing bed 1 effectively carrying base membrane layer 2 in structure, and the coating layer 3 of the hole array 31 corresponding with probe array 21 on base membrane layer 2 effectively can prevent the mutual interference of base membrane layer 2 respectively reacting between aperture.Gene chip is arranged lid 4 in addition; lid 4 is placed on coating layer 3, and arranging of lid 4 can effectively cover each conversion zone, prevents the pollution of each conversion zone of outer bound pair; the each conversion zone of available protecting, makes it be in a relative separation and closed environment.This gene chip arranges 5 probe array 21 subregions, carries out the detection of disparity items, multiple different probe array 21 subregion the detection simultaneously can carrying out disparity items is set.Probe array 21 is 3*5 array.Base membrane layer 2 is nylon membrane or nitrocellulose membrane.Probe array 21 is arranged positive control area, negative control area and detection zone.Bearing bed 1 and coating layer 3 are all that transparent material is made, transparent material effective observation that can ensure detected result is set.
The gene chip that embodiment 3 one kinds of layerings are arranged
The gene chip that a kind of layering is arranged, comprise bearing bed 1, base membrane layer 2 and coating layer 3, wherein base membrane layer 2 is arranged on bearing bed 1, and coating layer 3 is covered on base membrane layer 2, base membrane layer 2 is arranged probe array 21, coating layer 3 arranges the hole array 31 corresponding with probe array 21 on base membrane layer 2.Layering arranges bearing bed 1 effectively carrying base membrane layer 2 in structure, and the coating layer 3 of the hole array 31 corresponding with probe array 21 on base membrane layer 2 effectively can prevent the mutual interference of base membrane layer 2 respectively reacting between aperture.Gene chip is arranged lid 4 in addition; lid 4 is placed on coating layer 3, and arranging of lid 4 can effectively cover each conversion zone, prevents the pollution of each conversion zone of outer bound pair; the each conversion zone of available protecting, makes it be in a relative separation and closed environment.Lid 4 one end is connected on bearing bed 1 by rotating shaft 41, rotating shaft 41 arrange can be convenient folding cover 4.This gene chip arranges 10 probe array 21 subregions, carries out the detection of disparity items, multiple different probe array 21 subregion the detection simultaneously can carrying out disparity items is set.Probe array 21 is 3*5 array.Base membrane layer 2 is nylon membrane or nitrocellulose membrane.Probe array 21 is arranged positive control area, negative control area and detection zone.Bearing bed 1 and coating layer 3 are all that transparent material is made, transparent material effective observation that can ensure detected result is set.
The explanation of above-described embodiment is just for understanding the utility model.It should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from the utility model principle, can also carry out some improvement to the utility model, these improvement also will fall in the protection domain of the utility model claim.
Claims (9)
1. the gene chip of a layering setting, comprise bearing bed (1), base membrane layer (2) and coating layer (3), it is characterized in that, described base membrane layer (2) is arranged on described bearing bed (1), described coating layer (3) is covered on described base membrane layer (2), described base membrane layer (2) is arranged probe array (21), described coating layer (3) is upper arranges hole array (31) corresponding to probe array (21) upper with base membrane layer (2).
2. the gene chip of layering setting according to claim 1, it is characterized in that, gene chip is arranged lid (4), lid (4) is placed on coating layer (3).
3. the gene chip of layering setting according to claim 2, it is characterized in that, described lid (4) one end is connected on described bearing bed (1) by rotating shaft (41).
4. the gene chip of layering setting according to claim 1, it is characterized in that, this gene chip also can arrange multiple probe array (21) subregion, carries out the detection of disparity items.
5. the gene chip of layering setting according to claim 3, it is characterized in that, described probe array (21) subregion arranges 1-10.
6. the gene chip of layering setting according to claim 1, it is characterized in that, described probe array (21) is 3*5 array.
7. the gene chip of layering setting according to claim 1, it is characterized in that, described base membrane layer (2) is nylon membrane or nitrocellulose membrane.
8. the gene chip of layering setting according to claim 1, it is characterized in that, (21) arrange positive control area, negative control area and detection zone to described probe array.
9. the gene chip that the layering according to claim 1-8 any one is arranged, is characterized in that, bearing bed (1) and coating layer (3) are all that transparent material is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520845554.1U CN205133582U (en) | 2015-10-28 | 2015-10-28 | Genetic chip that layering set up |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520845554.1U CN205133582U (en) | 2015-10-28 | 2015-10-28 | Genetic chip that layering set up |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205133582U true CN205133582U (en) | 2016-04-06 |
Family
ID=55619393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520845554.1U Active CN205133582U (en) | 2015-10-28 | 2015-10-28 | Genetic chip that layering set up |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205133582U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109853045A (en) * | 2018-12-03 | 2019-06-07 | 江苏苏博生物医学科技南京有限公司 | A kind of genetic chip of high-throughput detection |
| CN109971632A (en) * | 2019-04-16 | 2019-07-05 | 北京龙基高科生物科技有限公司 | The storing compartment of chip in a kind of gene sequencing |
-
2015
- 2015-10-28 CN CN201520845554.1U patent/CN205133582U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109853045A (en) * | 2018-12-03 | 2019-06-07 | 江苏苏博生物医学科技南京有限公司 | A kind of genetic chip of high-throughput detection |
| CN109853045B (en) * | 2018-12-03 | 2023-10-24 | 江苏苏博生物医学科技南京有限公司 | Gene chip for high-flux detection |
| CN109971632A (en) * | 2019-04-16 | 2019-07-05 | 北京龙基高科生物科技有限公司 | The storing compartment of chip in a kind of gene sequencing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Al-Hatmi et al. | Antifungal susceptibility testing of Fusarium: a practical approach | |
| López-Sandoval et al. | Photosynthesis and respiration in marine phytoplankton: Relationship with cell size, taxonomic affiliation, and growth phase | |
| Daza et al. | Monitoring living cell assays with bio-impedance sensors | |
| CN205844251U (en) | Detector electrode structure and detection orifice plate | |
| CN205133582U (en) | Genetic chip that layering set up | |
| EP2966447B1 (en) | Multi-diagnosis parallel-type linear biochip | |
| CN104297307B (en) | Electrochemical sensor based on stem-and-loop structured probe and preparation method of electrochemical sensor | |
| Almeida et al. | Genotoxicity in two bivalve species from a coastal lagoon in the south of Portugal | |
| Macdonald et al. | Recent advances in biomedical, biosensor and clinical measurement devices for use in humans and the potential application of these technologies for the study of physiology and disease in wild animals | |
| Carrasco-Pujante et al. | Associative conditioning is a robust systemic behavior in unicellular organisms: an interspecies comparison | |
| Pratlong et al. | Separate the wheat from the chaff: genomic scan for local adaptation in the red coral Corallium rubrum | |
| Ferentinos et al. | The use of artificial neural networks as a component of a cell-based biosensor device for the detection of pesticides | |
| CN106754244A (en) | A kind of genetic chip case | |
| CN205133588U (en) | Genetic chip placer | |
| CN208362321U (en) | It is a kind of for capturing the enrichment isolation mechanism of target cell or biomolecule | |
| CN205133610U (en) | Genetic chip of cancer susceptible genetic test | |
| Pescheck et al. | Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method | |
| CN201195724Y (en) | Tumour cell drug sensitive test compound checker board | |
| Shen-Orr | Challenges and promise for the development of human immune monitoring | |
| CN218666102U (en) | Culture apparatus for proliferation and transfer of organoid corpuscle | |
| CN113130000B (en) | Method for screening artemisinin antimalarial target gene | |
| Montgomery | High standards for high dimensional investigations | |
| Rohde | Conservation Genetics of a Declining Bumble Bee in Western North America: The Influence of Geography, Dispersal Limitation, and Anthopogenic Activity | |
| Li et al. | Enhanced metabolic potentials and functional gene interactions of microbial stress response towards high elevation in freshwater lakes | |
| Adetunji et al. | The Role of Biosensors in Inspection of Food and Agricultural Products: Current Advances |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160406 Address after: 065500, Hebei, Langfang, Guan Emerging Industries Demonstration Area Patentee after: GU'AN BOJIAN BIOTECHNOLOGY CO., LTD. Address before: 100080 Beijing city Haidian District Shanyuan Street No. 1 cubic court building room 3103 Patentee before: Beijing Yang Shen biology information technology company limited |
|
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 065500 Hebei Valley peptide biological medicine base of Guan Province Patentee after: GU'AN BOJIAN BIOTECHNOLOGY CO., LTD. Address before: 065500, Hebei, Langfang, Guan Emerging Industries Demonstration Area Patentee before: GU'AN BOJIAN BIOTECHNOLOGY CO., LTD. |