CN205067476U - Full -automatic oral cavity disintegrated tablet disintegration surveys device - Google Patents
Full -automatic oral cavity disintegrated tablet disintegration surveys device Download PDFInfo
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- CN205067476U CN205067476U CN201520792591.0U CN201520792591U CN205067476U CN 205067476 U CN205067476 U CN 205067476U CN 201520792591 U CN201520792591 U CN 201520792591U CN 205067476 U CN205067476 U CN 205067476U
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Abstract
The utility model relates to a full -automatic oral cavity disintegrated tablet disintegration surveys device. It includes the water bath, and the upper surface of water bath has and has the basin on opening and its. There is the support one side of water bath, has elevating gear on the support, and elevating gear is last to have the cantilever, and the cantilever below has hung the basket that disintegrates. Have heating the water tank on the support, having heaters in the heating the water tank, heating the water tank with be connected with circulation pipeline between the water bath. Its characteristics are there is the controller on the support, has storage device in the controller. The downside of cantilever has the camera, and the camera of camera is located the plane projection area of the basket that disintegrates. Elevating gear, heater and camera all link to each other with the controller through the wire. Adopt the disintegration of the device survey oral cavity disintegrated tablet, can carry out image display with the process of disintegrating of oral cavity disintegrated tablet, can have data record and image hold function simultaneously to can realize the function of full -automatic survey.
Description
Technical field
The utility model relates to a kind of pharmacy pick-up unit, is the full-automatic determinator of the disintegration time limited for detecting oral disnitegration tablet specifically.
Background technology
Oral disnitegration tablet (Orallydisintegratingtablets, hereinafter referred to as oral disintegrating tablet) preparation need not take water in oral cavity, without the need to chewing, meeting saliva and dissolving rapidly or disintegration.This formulation to children, old age, be unable to leave the bed, the patient such as dysphagia is suitable for.One of Key Quality attribute of this preparation is exactly disintegration time limited, and whether it investigates to there is oral disintegrating tablet in situation can disintegration within the time limit of regulation at a small amount of water.Before 2015 editions Chinese Pharmacopoeias are promulgated, there is no the unified method and apparatus for oral disintegrating tablet detection disintegration time limited.
June in 2015,2015 editions Chinese Pharmacopoeias promulgated the inspection method of oral disintegrating tablet:
1) apparatus: primary structure is the stainless-steel tube that a support that can be elevated and lower end stud with screen cloth.The support of lifting moves up and down distance for 10mm ± 1mm, and roundtrip frequency is 30 times per minute.
2) disintegration is blue: stainless-steel tube, pipe range 30mm, internal diameter 13.0mm, stainless steel mesh (being set in bottom stainless-steel tube) sieve aperture internal diameter 710 μm.
3) inspection technique: be fixed on by stainless-steel tube on support, immerses in 1000ml cup, and filling temperature in cup is that the water of 37 DEG C ± 1 DEG C is about 900ml, and when regulating height of water level to make stainless-steel tube lowest order, screen cloth is at underwater 15mm ± 1mm.Startup instrument, gets this product 1, is set up to state in stainless-steel tube to check, whole disintegration also should pass through screen cloth within 60 seconds, and if any a small amount of lightweight being floated or attaching to stainless steel inwall or screen cloth, but without hard-core person, can conform with the regulations opinion.Replication 6, all should conform with the regulations.
At present, the device listing of existing mensuration disintegration time limited according to pharmacopoeial requirements development.This equipment is made up of the unit such as tank (cup), water bath of disintegration basket, support, placement solution, can monitor water bath temperature and show, simultaneously displaying time.In addition, bottom water bath, is furnished with LED, convenient observation.
Along with Yao Jian department improving constantly for medicament research and development quality control level, for ensureing authenticity and the science of drug development process, the self registering requirement for various test also proposes gradually.Above equipment still lacks data recording function and Image preservation function, and the part of the manual operation of whole mensuration process need and intervention is more, cannot realize the demand of automatic assay.LED is placed in bottom water bath, and the light path from LED to screen cloth is longer, and refraction and scattering can occur, and affects result and observes.In addition, this equipment only detects water bath temperature, does not detect tank (cup) interior temperature, and pharmacopoeial requirements tank (cup) interior temperature is 37 DEG C ± 1 DEG C, although serviceability temperature flume (cup) interior temperature can be measured before the test, be not real time temperature, test findings may be made accurate not.
Utility model content
Problem to be solved in the utility model is to provide a kind of full-automatic disintegration time of orally disintegrating tablets determinator, this device is adopted to measure the disintegration time limited of oral disnitegration tablet, the disintegrating procedue of oral disnitegration tablet can be carried out image display, data record and Image preservation function can be had simultaneously, and the full-automatic function measured can be realized.
For solving the problem, take following technical scheme:
Full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model comprises water bath, and the upper surface of water bath has opening and it has tank, the bottom of tank to stretch in water bath and the opening of the lateral wall of tank and water bath in being sealed and matched.There is support the side of described water bath, and support has jacking gear, and jacking gear has cantilever, and cantilever underhung has disintegration basket, and the bottom of disintegration basket is mesh-like.Described support there is heating water tank, having heaters in heating water tank, between heating water tank and described water bath, be connected with circulation line.Be characterized in that described support has controller, in controller, have memory storage.There is video camera the downside of described cantilever, and the camera of video camera is positioned at the plane projection scope of disintegration basket.Described jacking gear, well heater are all connected with controller by wire with video camera.
Further improvement of the utility model scheme is that described jacking gear has display, and this display is connected with controller, video camera respectively by wire.The image utilizing display can record video camera carries out playing in real time and any playback, advantageously in the observation to disintegrating procedue.
Further improvement of the utility model scheme is that the downside of described cantilever has illuminating lamp, and illuminating lamp is positioned at the drop shadow spread of described disintegration basket.Described illuminating lamp is LED.Illuminating lamp is set below cantilever and illuminates scattering and the refraction that tank can reduce light from top, be conducive to observing more accurately, recording disintegrating procedue.
Further improvement of the utility model scheme has the first temperature sensor in described tank, and the first temperature sensor is connected with described controller by wire.Adopt the first temperature sensor to monitor in real time temperature in tank, guarantee the accuracy of experimental result.
Further improvement of the utility model scheme is that the upper surface of described cantilever is fluted, has magnet steel in groove; Described disintegration basket has hook, and this hook is ferrous material; The hook upper end of described disintegration basket is positioned at the groove of cantilever.Utilize the sidewall of groove can limit the transverse shifting of hook, utilize the adhesive of magnet steel to hook can limit the vertical movement of hook, when can guarantee that cantilever moves up and down, disintegration basket there will not be and rocks or meet water and rise and fall.
Further improvement of the utility model scheme has water pump in described heating water tank, water bath has two circulation mouths of a river, the water delivering orifice of heating water tank and water inlet by two circulation mouths of a river of pipeline and water bath in connecting one to one; The second temperature sensor is had in described heating water tank; Described water pump is all connected with described controller by wire with the second temperature sensor.Utilize water pump, and heating water tank water delivering orifice, water inlet and water bath the circulation mouth of a river between pipeline be connected, the water circulation between heating water tank and water bath can be realized.Meanwhile, adopt the second temperature sensor can to control the water temperature in heating water tank, avoid superheated or underheat.
In such scheme, described jacking gear comprises in the vertical guide rail arranged, has screw mandrel and stepper motor in guide rail, and the controlled throwing bar of stepper motor rotates; Described guide rail has slide block, and slide block and described screw mandrel are threaded engagement, and slide block and described cantilever are in being fixedly connected with.
Take such scheme, have the following advantages:
Because full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model is provided with controller on support, memory storage is had in controller, there is video camera the downside of cantilever, the camera of video camera is positioned at the drop shadow spread of disintegration basket, jacking gear there is display, having heaters in heating water tank, jacking gear, video camera, display are all connected with controller by wire with well heater, and video camera is connected with display by wire.During use, first in tank, add purification of aqueous solutions; The work of recycling controller control heater, makes the coolant-temperature gage in heating water tank raise; Then, the water pump utilizing heating water tank to carry supplies water to water bath Inner eycle, makes the water temperature in tank reach probe temperature requirement by water-bath heat transfer; Afterwards, oral disnitegration tablet tablet to be tested is put into disintegration basket, utilize controller to control jacking gear and cantilever is declined, the tablet in disintegration basket is immersed in the solution in tank, and starts timing; Finally, after minute arrives, utilize controller to control jacking gear and make cantilever increase, disintegration basket leaves the liquid level of solution in tank.Whole mensuration process, testing crew not only can pass through the situation of visual inspection disintegration, and the process of oral disnitegration tablet disintegration of tablet can also carry out complete recording by video camera.The data that mensuration process produces and image can be preserved in the storage device by controller record, are convenient to check at any time.And the whole mensuration process of this device is all used controller to control, and without the need to too much manual intervention, can realize the function of entire roboticized work.
Accompanying drawing explanation
Fig. 1 is the structural representation of full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model;
Fig. 2 is the structural representation of cantilever in Fig. 1;
Fig. 3 is the Facad structure schematic diagram of heating water tank in Fig. 1;
Fig. 4 is the electrical schematic of full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model.
Embodiment
Below in conjunction with accompanying drawing, the utility model is described in further detail.
As shown in Figure 1, full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model comprises water bath 8, the upper surface of water bath 8 has opening and it has tank 9, the bottom of tank 9 to stretch in water bath 8 and the opening of the lateral wall of tank 9 and water bath 8 in being sealed and matched.There is support 4 side of described water bath 8, support 4 has jacking gear 3, jacking gear 3 has cantilever 13, and cantilever 13 underhung has disintegration basket 10, and the bottom of disintegration basket 10 is mesh-like.Described jacking gear 3 comprises in the vertical guide rail arranged, has screw mandrel and stepper motor in guide rail, and the controlled throwing bar of stepper motor rotates; Described guide rail has slide block 2, slide block 2 and described screw mandrel are threaded engagement, and slide block 2 and described cantilever 13 are in being fixedly connected with.Described support 4 has heating water tank 7, and having heaters 703 in heating water tank 7, is connected with circulation line between heating water tank 7 and described water bath 8.Described support 4 there is controller 6, controller 6 internal storage system.There is video camera 11 downside of described cantilever 13, and the camera of video camera 11 is positioned at the plane projection scope of disintegration basket 10.Described jacking gear 3, well heater 703 are all connected with controller 6 by wire with video camera 11.
In the present embodiment, described jacking gear 3 is provided with display 1, this display 1 is connected with controller 6, video camera 11 respectively by wire.The disintegrating procedue of the oral disnitegration tablet that video camera 11 can be recorded by this display 1 carries out real-time displaying the play, and can also carry out playback to the mensuration image carried out in the past simultaneously.
In order to monitor in real time the temperature in tank 9, guarantee the accuracy of experimental result, in described tank 9, also be provided with the first temperature sensor 5, first temperature sensor 5 be connected with described controller 6 by wire.
Longer to the light path of disintegration basket 10 bottom screen in order to overcome illuminating lamp 12 in prior art, the problem that light refraction, scattering phenomenon are serious, the present embodiment arranges illuminating lamp 12 in the downside of described cantilever 13, illuminating lamp 12 is positioned at the plane projection scope of described disintegration basket 10, and this illuminating lamp 12 is LED.Like this, be conducive to observing more accurately, recording disintegrating procedue.
As shown in Figure 2, the upper surface fluted 14 of described cantilever 13, has magnet steel in groove 14.In the mounted state, described disintegration basket 10 has hook 15, this hook 15 is ferrous material; Hook 15 upper end of described disintegration basket 10 is positioned at the groove 14 of cantilever 13.The sidewall of groove 14 can limit the transverse shifting of hook 15, and the adhesive effect between magnet steel and hook 15 can limit the vertical movement of hook 15.Like this, cantilever 13 is when controlled device 6 controls to move up and down, and namely disintegration basket 10 there will not be and rock, and also there will not be the phenomenon of meeting water and rising and falling.
As shown in Figure 3, water pump 705 is had in described heating water tank 7, water bath 8 has two circulation mouths of a river, the water delivering orifice 704 of heating water tank 7 and water inlet 702 are by two circulation mouths of a river of pipeline and water bath 8 in connecting one to one, and water pump 705 is connected with controller 6 by wire.During heating, controller 6 is utilized to start well heater 703 in heating water tank 7, after water temperature arrival predetermined temperature, controller 6 controls water pump 705 and opens, hot water flows out the cocycle mouth of a river entering water bath 8 from water delivering orifice 704, then flow out at the lower circulation mouth of a river of water bath 8, flow into the water inlet 702 of heating water tank 7, thus realize the hot water circulation between heating water tank 7 and water bath 8.The second temperature sensor 701, second temperature sensor 701 is had to be connected with described controller 6 by wire in described heating water tank 7.Second temperature sensor 701 can control the water temperature in heating water tank 7, avoids superheated or underheat.
As shown in Figure 4, the electrical equipment annexation of full-automatic disintegration time of orally disintegrating tablets determinator of the present utility model is as follows:
Tank 9 temperature element (i.e. the first temperature sensor 5), heating water tank 7 temperature element (i.e. the second temperature sensor 701) are connected with the common input/output port of central processing unit (i.e. controller 6);
The display screen of display 1 is connected by spi bus with central processing unit, and has AV signal input port, is connected with video camera 11 control circuit;
On display 1, the button of control panel is connected with the common input/output port of central processing unit;
Clock circuit is connected with central processing unit by iic bus;
SD card (i.e. memory storage) is connected with central processing unit by spi bus;
Disintegration basket 10 moves control circuit (i.e. cantilever 13 control circuit) and is connected with the common input/output port of central processing unit;
Heating water tank 7 well heater 703 control circuit is connected with the common input/output port of central processing unit;
Heating cabinet water pump 705 control circuit is connected with the common input/output port of central processing unit;
Illuminating lamp 12 control circuit is connected with the common input/output port of central processing unit;
Video camera 11 control circuit is connected with central processing unit by spi bus, and Bing You mono-road AV signal exports the display screen AV input channel receiving display 1.
During use, testing crew is put into medicine and is added purified water at tank 9 in disintegration basket 10, sets in tank 9 after purified water temperature, starts test by the start button of display 1 control panel.After on-test, central processing unit utilizes tank 9 temperature element first to detect purified water temperature whether Pass Test temperature in tank 9, well heater 703 as then opened heating water tank 7 lower than test temperature heats, utilize water pump 705 to enter in water bath 8 by the heat-exchanger pump 705 in heating water tank 7 simultaneously, the purified water in tank 9 is heated.By the time after purified water temperature arrives design temperature, the stepper motor that central processing unit controls jacking gear 3 rotates, and control slide block 2 down moves and drives disintegration basket 10 to be down immersed in purified water, starts timing.After arriving the time of setting, the stepper motor that central processing unit controls jacking gear 3 rotates backward, and controls slide block 2 and up moves, and drives disintegration basket 10 up to leave purified water liquid level.In the process, the situation of medicine disintegration is observed by naked eyes or video camera 11.
Claims (8)
1. a full-automatic disintegration time of orally disintegrating tablets determinator, comprise water bath (8), the upper surface of water bath (8) has opening and it has tank (9), the bottom of tank (9) to stretch in water bath (8) and the opening of the lateral wall of tank (9) and water bath (8) in being sealed and matched; There is support (4) side of described water bath (8), support (4) has jacking gear (3), jacking gear (3) has cantilever (13), and cantilever (13) underhung has disintegration basket (10), and the bottom of disintegration basket (10) is mesh-like; Described support (4) there is heating water tank (7), heating water tank (7) interior having heaters (703), between heating water tank (7) and described water bath (8), be connected with circulation line; It is characterized in that described support (4) has controller (6), controller has memory storage in (6); There is video camera (11) downside of described cantilever (13), and the camera of video camera (11) is positioned at the plane projection scope of disintegration basket (10); Described jacking gear (3), well heater (703) are all connected with controller (6) by wire with video camera (11).
2. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 1, it is characterized in that described jacking gear (3) has display (1), this display (1) is connected with controller (6), video camera (11) respectively by wire.
3. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 1, it is characterized in that there is illuminating lamp (12) downside of described cantilever (13), illuminating lamp (12) is positioned at the drop shadow spread of described disintegration basket (10).
4. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 3, is characterized in that described illuminating lamp (12) is LED.
5. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 1, it is characterized in that there is the first temperature sensor (5) in described tank (9), the first temperature sensor (5) is connected with described controller (6) by wire.
6. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 1, it is characterized in that the upper surface of described cantilever (13) fluted (14), groove has magnet steel in (14); Described disintegration basket (10) has hook (15), and this hook (15) is ferrous material; Hook (15) upper end of described disintegration basket (10) is positioned at the groove (14) of cantilever (13).
7. full-automatic disintegration time of orally disintegrating tablets determinator as claimed in claim 1, it is characterized in that there is water pump (705) in described heating water tank (7), water bath (8) has two circulation mouths of a river, the water delivering orifice (704) of heating water tank (7) and water inlet (702) by two circulation mouths of a river of pipeline and water bath (8) in connecting one to one; The second temperature sensor (701) is had in described heating water tank (7); Described water pump (705) is all connected with described controller (6) by wire with the second temperature sensor (701).
8. the full-automatic disintegration time of orally disintegrating tablets determinator according to any one of claim 1 to 7, it is characterized in that described jacking gear (3) comprises in the vertical guide rail arranged, have screw mandrel and stepper motor in guide rail, the controlled throwing bar of stepper motor rotates; Described guide rail has slide block (2), slide block (2) and described screw mandrel are threaded engagement, and slide block (2) and described cantilever (13) are in being fixedly connected with.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520792591.0U CN205067476U (en) | 2015-10-14 | 2015-10-14 | Full -automatic oral cavity disintegrated tablet disintegration surveys device |
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| CN201520792591.0U CN205067476U (en) | 2015-10-14 | 2015-10-14 | Full -automatic oral cavity disintegrated tablet disintegration surveys device |
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| CN205067476U true CN205067476U (en) | 2016-03-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109507376A (en) * | 2018-12-25 | 2019-03-22 | 天津市天大天发科技有限公司 | Oral disintegrating tablet disintegration time mensuration instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109507376A (en) * | 2018-12-25 | 2019-03-22 | 天津市天大天发科技有限公司 | Oral disintegrating tablet disintegration time mensuration instrument |
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