CN109507376A - Oral disintegrating tablet disintegration time mensuration instrument - Google Patents
Oral disintegrating tablet disintegration time mensuration instrument Download PDFInfo
- Publication number
- CN109507376A CN109507376A CN201811588285.XA CN201811588285A CN109507376A CN 109507376 A CN109507376 A CN 109507376A CN 201811588285 A CN201811588285 A CN 201811588285A CN 109507376 A CN109507376 A CN 109507376A
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- China
- Prior art keywords
- guide rail
- fixed
- casing
- crane
- disintegration time
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of mouths to collapse tablet disintegration time mensuration instrument, and structure is: guide rail bracket is fixed on the middle part of casing, and the both ends of guide rail bracket are equipped with guide rail, is equipped with upper and lower limit film and up and down limit optocoupler in the side of guide rail bracket.The two sides of crane are respectively fixed with guide rail slide block, eccentric wheel be fixed on motor shaft pop-up crane.Overhanging arm is fixed on crane front end.The centre of overhanging arm is equipped with shadoof, and the guide rail slide block and guide rail on crane form sliding pair.Electric cabinet is equipped on the top of casing；The lower part of casing is equipped with water bath；The lower part of water bath is equipped with chassis, and stripping rotor is placed in water bath, and motor is fixed on motor rack, and hanger is fixed on casing, is placed in behind guide rail bracket.Mouth collapses tablet disintegration time mensuration instrument under the premise of meeting pharmacopoeial requirements, and the measurement for being detected drug disintegration time limited is made to have unified standard.The start and stop and timing one-key operation of instrument, double light sources can be parked in high-low limit position convenient for observation, disintegration basket convenient for observation and operation.
Description
The invention belongs to drug measurement techniques, and in particular to survey in a kind of medicine inspection instrument to the disintegration time limited of oral disintegrating tablet
Fixed instrument.
Technical background
Oral disintegrating tablet is exactly the tablet in Orally disintegrating.Refer to and be not required to water or need to only use a small amount of water, meets saliva without chewing
Disintegration rapidly can enter stomach action by means of dynamical medicine is swallowed.The measurement of oral disintegrating tablet disintegration time limited has corresponding rule in pharmacopeia
It is fixed.
The disintegration tester applied at present is other than the prescribed requirement for being unsatisfactory for pharmacopeia.It is primarily present following deficiency: (1) stroke
It is too long.The stroke up and down of disintegration tester hanging basket is 55-57mm, so being not suitable for the measurement requirement of tablet disintegration time limited.(2) original to collapse
Mono- basket 6 of Xie Yiwei pipe, while 6 samples are surveyed, experimenter can not observe the disintegration time of 6 samples simultaneously, so also not
Meet the measurement requirement of drug disintegration time limited.(3) cup hypervolia is tested.Because oral disintegrating tablet belongs to the medicine in intraoral disintegration
Piece, so water used in every sample is seldom.Most waters where each sample of original disintegration tester in glass tube are
25.4ml, and 2.0ml is not to be exceeded in most waters where each sample in disintegration basket stainless steel tube.Therefore original disintegration tester
It is unable to satisfy the States Pharmacopoeia specifications of oral disintegrating tablet dosage form disintegration time mensuration.
The present invention be directed to the instrument that pharmacopoeial requirements are researched and developed, the measurement of oral disintegrating tablet disintegration time limited in pharmacopeia can satisfy
Requirement.
Summary of the invention
The object of the present invention is to provide a kind of instruments that the disintegration time limited for being exclusively used in oral disintegrating tablet dosage form is measured, and are meeting
On the basis of States Pharmacopoeia specifications, make the measurement of disintegration time limited that there is unified standard.
The principle of the present invention structure are as follows: it is sliding that oral disintegrating tablet disintegration time mensuration instrument includes guide rail bracket, casing, guide rail, guide rail
Block, upper and lower limit film, up and down limit optocoupler, crane, overhanging arm, motor, motor rack, resilient cushion, hanger, eccentric wheel, shadoof,
It is disintegrated basket, electric cabinet, water bath, chassis, stripping rotor, upper and lower light source, nut, jackscrew etc..It is characterized in that: guide rail bracket is fixed on machine
The both ends at the middle part of shell, guide rail bracket are equipped with guide rail, are equipped with upper and lower limit film and up and down limit optocoupler in the side of guide rail bracket.Lifting
The two sides of frame are respectively fixed with guide rail slide block, and motor is fixed on motor rack, and motor rack is connect with hanger, and hanger is fixed on casing
On be placed in behind guide rail bracket.Eccentric wheel be fixed on motor shaft pop-up crane.Overhanging arm is fixed on crane front end, outside
The centre of semi-girder is equipped with shadoof, and disintegration basket is mounted on the lower end of shadoof, and the guide rail slide block and guide rail on crane form sliding pair.
As the innovation in structure: disintegration basket is a piece of using a basket, it is ensured that experimenter, which observes, determines disintegration time.
As the innovation in structure: motor is fixed on motor rack, and motor rack is connect with hanger, and hanger is fixed on casing
It is placed in behind guide rail bracket.Electric cabinet is equipped on the top of casing；The lower part of casing is equipped with water bath, and stripping rotor is placed on water
In bath cabinet；The lower part of water bath is equipped with chassis.
As the innovation in structure: being equipped with upper light source in the upper side of guide rail bracket, be equipped with lower light source in the bottom end of water bath.
It is equipped with nut on shadoof top, jackscrew is equipped in the centre of crane, for locking shadoof and crane.
Upper light source is mounted on casing, and lamppost can move in a certain range, provides the illumination of shadoof from top to bottom.Lower light
Source is fixed light source, provides illumination from the bottom to top, to facilitate observation.
The working principle of oral disintegrating tablet disintegration time mensuration instrument is that disintegration basket is provided with sample to be detected and immerses in water bath
(drug) stripping rotor, the timing key for starting electric cabinet starts timing.According to the operational order of electric cabinet, it is driven by a motor bias
Wheel rotation, eccentric wheel drive the crane being fixed on guide rail slide block to move up and down along guide rail.Sample in observation disintegration basket
It is disintegrated situation, until sample is all disintegrated and by disintegration basket bottom screen, indicates that sample is all disintegrated, stops timing at this time.Institute
It is the disintegration time of this sample between clocking.It is disintegrated basket at the end of detection and is parked in upper limit position automatically.
The features of the present invention and the beneficial effect of generation are: the measurement of oral disintegrating tablet disintegration time limited requires in meeting pharmacopeia
Under the premise of, make the measurement for being detected drug disintegration time limited that there is unified standard.The start and stop and timing one-key operation of instrument, double light sources
Convenient for observation, disintegration basket can be parked in high-low limit position convenient for observation and operation.
Detailed description of the invention
Fig. 1 is the principle of the present invention and structural front view.
Fig. 2 is the left side view of structure of the invention.
Specific embodiment
Below in conjunction with attached drawing and by specific embodiment, the present invention is described further:
Oral disintegrating tablet disintegration time mensuration instrument, structure composition and principle are: guide rail bracket 3 is fixed on the middle part of casing 1, leads
The both ends of rail gantry are equipped with guide rail 2, the side of guide rail bracket be equipped with upper limit bit slice 4-1, lower limit bit slice 4-2 and upper limit optocoupler 5-1,
Lower limit optocoupler 5-2.The two sides of crane 6 are respectively fixed with guide rail slide block 7, and motor 8 is fixed on motor rack 18, motor rack 18
It is connect with hanger 20, hanger 20 is fixed on casing 11 and is placed in behind guide rail bracket 3.Eccentric wheel 22 is fixed on motor shaft pop-up
Crane.Overhanging arm 21 is fixed on crane front end.
The centre of overhanging arm is equipped with shadoof 9, and disintegration basket 10 is mounted on the lower end of shadoof, the guide rail slide block on crane with lead
Rail forms sliding pair.
Electric cabinet 11 is equipped on the top of casing；The lower part of casing is equipped with water bath 12；The lower part of water bath is equipped with chassis
13, stripping rotor 14 is placed in water bath.Cushion blocking 19 is equipped between motor rack and hanger.
It is equipped with upper light source 15-1 in the upper side of guide rail bracket, is equipped with lower light source 15-2 in the bottom end of water bath.Shadoof top
Equipped with nut 16, it is equipped with jackscrew 17 in the centre of overhanging arm, for locking shadoof and overhanging arm.
Electric cabinet, casing, water bath and chassis combination are fixed as one, and water bath is made of transparent material.
When oral disintegrating tablet disintegration time mensuration instrument is tested, disintegration basket is mounted on shadoof, shadoof is mounted on crane.Water
Bath cabinet is provided with the water that temperature is 37 ± 1 DEG C, and the water that stripping rotor is provided with about 900ml, temperature is 37 ± 1 DEG C is placed into water
In bath cabinet.
When sheltering from optocoupler due to upper and lower limit film, optocoupler generates potential change, and single-chip microcontroller reading potential becomes in electric cabinet
Change and controls motor stopping.Achieve the purpose that control disintegration basket is parked in high-low limit position.
Lower limit optocoupler is sheltered from by lower limit bit slice, control disintegration basket is parked in lower limit position.Specific practice is adjustment
Nut on shadoof guarantees that disintegration basket in lower limit position, is disintegrated basket bottom surface in 15 ± 1mm of underwater, is locked at this time with jackscrew
Tight shadoof.Upper limit optocoupler is sheltered from by upper limit bit slice, guarantees that disintegration basket is located at upper limit position.
The timing key for starting electric cabinet, is driven by a motor eccentric wheel rotation, and eccentric wheel drive is fixed on guide rail slide block
Crane does the up and down motion and self-clocking that stroke is 10 ± 1mm along guide rail.It is disintegrated basket at the end of measuring and is parked in pole
Extreme position is this sample disintegration time between clocking.
Claims (4)
1. mouthful collapsing tablet disintegration time mensuration instrument, there is guide rail bracket, casing, guide rail, guide rail slide block, upper and lower limit film, bound
Position optocoupler, crane, overhanging arm, motor, motor rack, resilient cushion, hanger, eccentric wheel, shadoof, disintegration basket, electric cabinet, water-bath
Case, chassis, stripping rotor, upper and lower light source, nut, jackscrew, it is characterized in that: guide rail bracket (3) is fixed on the middle part of casing (1), guide rail
The both ends of frame be equipped with guide rail (2), the side of guide rail bracket be equipped with upper and lower limit film (4-1,4-2) and up and down limit optocoupler (5-1,
5-2), the two sides of crane (6) are respectively fixed with guide rail slide block (7), and motor (8) is fixed on motor rack (18), motor rack with
Hanger (20) connection, hanger is fixed on casing and is placed in behind guide rail bracket, and eccentric wheel (22) is fixed on motor shaft pop-up
Crane, overhanging arm (21) are fixed on crane front end, and the centre of overhanging arm is equipped with shadoof (9), and disintegration basket (10), which is mounted on, to be mentioned
The lower end of bar, guide rail slide block and guide rail on crane form sliding pair.
2. mouth described in accordance with the claim 1 collapses tablet disintegration time mensuration instrument, it is characterized in that: being equipped on the top of the casing
Electric cabinet (11)；The lower part of casing is equipped with water bath (12)；The lower part of water bath is equipped with chassis (13), and stripping rotor (14) is placed on
In water bath, cushion blocking (19) are equipped between motor rack and hanger.
3. mouth described in accordance with the claim 1 collapses tablet disintegration time mensuration instrument, it is characterized in that: in the upper side of the guide rail bracket
Equipped with upper light source (15-1), it is equipped with lower light source (15-2) in the bottom end of the water bath, the shadoof top is equipped with nut (16),
Jackscrew (17) are equipped in the centre of the overhanging arm to be used to lock shadoof and overhanging arm.
4. mouth described in accordance with the claim 1 collapses tablet disintegration time mensuration instrument, it is characterized in that: the electric cabinet, casing, water-bath
Case and chassis combination are fixed as one, and water bath is made of transparent material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811588285.XA CN109507376A (en) | 2018-12-25 | 2018-12-25 | Oral disintegrating tablet disintegration time mensuration instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811588285.XA CN109507376A (en) | 2018-12-25 | 2018-12-25 | Oral disintegrating tablet disintegration time mensuration instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109507376A true CN109507376A (en) | 2019-03-22 |
Family
ID=65755206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811588285.XA Pending CN109507376A (en) | 2018-12-25 | 2018-12-25 | Oral disintegrating tablet disintegration time mensuration instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109507376A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113447664A (en) * | 2021-04-22 | 2021-09-28 | 山东大学第二医院 | Full-automatic sample processing system for blood coagulation detection |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2272432Y (en) * | 1996-08-30 | 1998-01-14 | 刘五星 | Portable automatic hydraulic jack |
| CN2898828Y (en) * | 2005-06-20 | 2007-05-09 | 天津市天大天发科技有限公司 | Transverse-arranged six-cup medicinal stripper with adjusting axiality |
| CN102398515A (en) * | 2010-09-07 | 2012-04-04 | 孟津县平乐小康机械加工厂 | Non-gear transmission device |
| CN102576119A (en) * | 2009-10-24 | 2012-07-11 | 3M创新有限公司 | Light source and display system incorporating same |
| CN203178221U (en) * | 2013-02-18 | 2013-09-04 | 成都神鹤药业有限责任公司 | Disintegrated time limiting instrument |
| CN205067476U (en) * | 2015-10-14 | 2016-03-02 | 华裕(无锡)制药有限公司 | Full -automatic oral cavity disintegrated tablet disintegration surveys device |
| CN208171923U (en) * | 2018-04-25 | 2018-11-30 | 苏州万纳生物科技有限公司 | Magnetosensitive immunity analysis instrument |
| CN209690287U (en) * | 2018-12-25 | 2019-11-26 | 天津市天大天发科技有限公司 | Oral disintegrating tablet disintegration time mensuration instrument |
-
2018
- 2018-12-25 CN CN201811588285.XA patent/CN109507376A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2272432Y (en) * | 1996-08-30 | 1998-01-14 | 刘五星 | Portable automatic hydraulic jack |
| CN2898828Y (en) * | 2005-06-20 | 2007-05-09 | 天津市天大天发科技有限公司 | Transverse-arranged six-cup medicinal stripper with adjusting axiality |
| CN102576119A (en) * | 2009-10-24 | 2012-07-11 | 3M创新有限公司 | Light source and display system incorporating same |
| CN102398515A (en) * | 2010-09-07 | 2012-04-04 | 孟津县平乐小康机械加工厂 | Non-gear transmission device |
| CN203178221U (en) * | 2013-02-18 | 2013-09-04 | 成都神鹤药业有限责任公司 | Disintegrated time limiting instrument |
| CN205067476U (en) * | 2015-10-14 | 2016-03-02 | 华裕(无锡)制药有限公司 | Full -automatic oral cavity disintegrated tablet disintegration surveys device |
| CN208171923U (en) * | 2018-04-25 | 2018-11-30 | 苏州万纳生物科技有限公司 | Magnetosensitive immunity analysis instrument |
| CN209690287U (en) * | 2018-12-25 | 2019-11-26 | 天津市天大天发科技有限公司 | Oral disintegrating tablet disintegration time mensuration instrument |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113447664A (en) * | 2021-04-22 | 2021-09-28 | 山东大学第二医院 | Full-automatic sample processing system for blood coagulation detection |
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