CN205020102U - Filter paper guide micro -fluidic chip - Google Patents
Filter paper guide micro -fluidic chip Download PDFInfo
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- CN205020102U CN205020102U CN201520618832.XU CN201520618832U CN205020102U CN 205020102 U CN205020102 U CN 205020102U CN 201520618832 U CN201520618832 U CN 201520618832U CN 205020102 U CN205020102 U CN 205020102U
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- inner core
- cover plate
- filter paper
- substrate
- chip
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Abstract
The utility model discloses a filter paper guide micro -fluidic chip, including cover plate, substrate and inner core, cover plate and substrate are located the upper strata and the bottom of inner core respectively, and the middle inner core that is constitutes sandwich structure, it imports and exports to have inner core liquid on the cover plate. Cover plate and substrate are transparent material such as PVC, PET, and the inner core material is for having hydrophilic filter paper. The utility model discloses the chip utilizes hydrophilicity filter paper as the chip inner core, and its capillary fibre guiding function of full play need not to have realized under the external drive mix of liquid, in the use, compare with test paper strip commonly used, the reaction liquid is not volatile can preserve the use for a long time.
Description
Technical field
The utility model relates to a kind of filter paper and guides sandwich micro-fluidic chip, is specifically related to a kind of integrated sandwich micro-fluidic chip, belongs to analytical chemistry field.
Background technology
After the nineties in 20th century, micro-full analytical system (Miniaturizedtotalanalysissystems, μ TAS) concept proposed, microfluidic chip analysis technology achieves and develops rapidly.Micro-total analysis system is also called chip lab, and its core is micro-fluidic chip.Along with the development of microfluidic chip analysis technology, also present variation for the material making microchip, and processing technology is also more and more succinct.The material being generally used for making microfluidic analysis chip at present has silicon, glass, quartz, metal and organic polymer (as epoxy resin, polymethyl methacrylate, dimethyl silicone polymer) etc.The chip majority of these materials adopts chemical etching technology to process.
People (Martinez, the A.W. such as Martinez in 2007; Phillips, S.T.; Butte, M.J.; Whitesides, G.M.AngewandteChemie-InternationalEdition2007,46,1318-1320.) proposition paper substrate is micro-fluidic first.Paper substrate is micro-fluidic processes microchannel to be using filter paper as chip material on filter paper, makes full use of the hydrophilic interaction of filter paper fibre layer, makes the aqueous solution reach the object of hybrid reaction by fibrage.The micro-fluidic diagnosis of paper substrate of this low cost and analytical equipment due to have easy to carry, analysis speed is fast, the advantage such as with low cost, be applied to the fields such as chemistry, biology, medical science more and more, and had good development prospect.
Filter paper is processed microchannel method a lot, that reports at present is generally photoetching technique (Martinez, A.W.; Phillips, S.T.; Butte, M.J.; Whitesides, G.M.AngewandteChemie-InternationalEdition2007,46,1318-1320.), wax printing technique (Carrilho, E.; Martinez, A.W.; Whitesides, G.M.AnalyticalChemistry2009,81,7091-7095.), print PDMS (Bruzewicz, D.A.; Reches, M.; Whitesides, G.M.AnalyticalChemistry2008,80,3387-3392.), oil pen portrays (Nie, J.F.; Zhang, Y.; Lin, L.W.; Zhou, C.B.; Li, S.H.; Zhang, L.M.; Li, J.P.AnalyticalChemistry2011,84,6331-6335.) etc. technology etc.Its essence is that hydrophobic substance such as utilizing paraffin, organic solvent, PDMS forms the control that hydrophobic wall realizes flow direction on filter paper.These method manufacture crafts are simple, but occur seepage sometimes or the phenomenon such as interface is unintelligible.Paper substrate micro-fluidic chip, although define hydrophilic microchannel, because liquid easily evaporates, can not keep for a long time simultaneously.
Summary of the invention
Technical problem to be solved in the utility model is for the deficiencies in the prior art, and provides a kind of filter paper to guide sandwich micro-fluidic chip, and this chip can realize the clear control of liquid flow path, can preserve use for a long time again.
To achieve these goals, the utility model adopts following technical scheme:
A kind of filter paper guides sandwich micro-fluidic chip, and comprise cover plate, substrate and inner core, described cover plate and substrate lay respectively at upper strata and the bottom of inner core, and centre is inner core, thus forms sandwich structure; Described cover plate has inner core liquid entrance.
Further, described cover plate and substrate are envelope sheet, can cold seal also can seal; Described envelope sheet material is transparent material, the thickness such as PVC, PET is 50-100 μm.
Further, described cover plate is identical with the size of substrate, decides according to inner core size; The shape of inner core is various, can be " ten " font, also can be " S " type, various shape such as " rice " font, five-pointed star etc.
Further, described inner core material, for having hydrophilic filter paper, can drive liquid to introduce and mixing by the capillarity of hydrophily filter paper, drive the mixing that can realize liquid without the need to external force.
Further, described cover plate card punch beats circular hole as inner core liquid entrance, and described Circularhole diameter is 1-4mm, and circular hole number experimentally requires to determine.
The advantage of technical solutions of the utility model is: utilize hydrophily filter paper as chip inner core, gives full play to its capillary fiber guiding function, achieves the mixing of liquid without the need to external force under driving; In use procedure, compared with conventional test strips, reaction liquid is not volatile can preserve use for a long time.
Accompanying drawing explanation
Fig. 1: the utility model filter paper guides the overall structure schematic diagram of sandwich micro-fluidic chip;
Fig. 2: the utility model chip, exploded view when inner core is " ten " font;
Fig. 3: the utility model chip, exploded view when inner core is " S " font;
Fig. 4: the utility model chip, exploded view when inner core is " S " font;
Wherein, 1, cover plate, 2, substrate, 3, inner core, 4, inner core liquid entrance.
Detailed description of the invention
Below the detailed description of the invention of technical solutions of the utility model is described in detail, but the present invention is not limited to following description content:
A kind of filter paper guides sandwich micro-fluidic chip, and as shown in Figure 1, comprise cover plate 1, substrate 2 and inner core 3, centre is inner core, and cover plate and substrate lay respectively at upper strata and the bottom of inner core, forms sandwich structure.The shape of inner core is various, can be cross passage, and as shown in Figure 2, four tops of cross passage are rounded; The long 55mm of described passage, wide 5mm, the diameter on top is 8mm.Cover plate card punch bores four circular holes as inner core liquid entrance 4, and circular hole position is corresponding with cross passage top, and Circularhole diameter is 4mm; Also can be S type, as shown in Figure 3, center and the top of " S " type passage be rounded; The overall length 80mm of described " S " type passage, wide 5mm, the diameter on top is 8mm.Cover plate card punch bores three circular holes as inner core liquid entrance 4, and circular hole position is corresponding with S type channel center and top, and Circularhole diameter is 4mm; Can also be " rice " font, as shown in Figure 4, the top of " rice " font passage be rounded; The long 40mm of described every bar passage, wide 3mm, the diameter on top is 6mm.Cover plate card punch bores nine circular holes as inner core liquid entrance 4, and circular hole position is corresponding with " rice " font center and passage top difference, and Circularhole diameter is 3mm.
Above-mentioned cover plate 1 and substrate 2 are envelope sheet, and material is preferably the transparent materials such as PVC, PET, thickness is preferably 50-100 μm.Inner core 3 material preferably has hydrophilic filter paper.
Above-mentioned cover plate 1, substrate 2 and inner core 3 are undertaken by plastic sealing machine together with involution; Comprise the following steps:
(1), utilize mapping software to design the shape of the passage of inner core 3 and corresponding size, wherein passage is colourless, and edge is black; Then printer is utilized to print on filter paper by the pattern of design;
(2), under sanction, inner core 3 is obtained along the edge of the pattern of design from filter paper with paper knife; Cutting out in patterning process and accomplish one-shot forming as far as possible, being sure not repeatedly Cutting Edge along making chip inner core 3 form a large amount of burr;
(3), by the inner core 3 under cutting out be put into the centre of cover plate 1 and substrate 2, be cover plate above, beneath is substrate; According to position and the size of inner core 3, bore the circular hole of four size couplings at the relevant position card punch of cover plate 1;
(4), have openning hole on cover plate after, fix the position of cover plate, inner core, substrate three, especially by inner core liquid entrance 4 and heart 3 position alignment; Cover plate above, inner core, puts into plastic sealing machine together after three is smooth, between temperature 100-120 DEG C, carries out involution in sandwich structure, obtain described sandwich micro-fluidic chip at middle, substrate below.
Above-mentioned example just for technical conceive of the present utility model and technical characterstic are described, can not limit protection domain of the present utility model with this.All equivalent transformations of doing according to essence of the present utility model or modification, all should be encompassed within protection domain of the present utility model.
Claims (5)
1. filter paper guides a micro-fluidic chip, and comprise cover plate (1), substrate (2) and inner core (3), it is characterized in that, described cover plate and substrate lay respectively at upper strata and the bottom of inner core, and centre is inner core; Described cover plate has inner core liquid entrance (4).
2. chip according to claim 1, is characterized in that, described cover plate (1) and substrate (2) are envelope sheet, and envelope sheet material is transparent material PVC, PET, thickness is 50-100 μm.
3. chip according to claim 1, is characterized in that, described cover plate (1) is identical with the size of substrate (2).
4. chip according to claim 1, is characterized in that, described inner core (3) material is for having hydrophilic filter paper.
5. chip according to claim 1, is characterized in that, described cover plate (1) card punch makes a call to 4 circular holes as inner core liquid entrance (4), and described Circularhole diameter is 1-4mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520618832.XU CN205020102U (en) | 2015-08-17 | 2015-08-17 | Filter paper guide micro -fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520618832.XU CN205020102U (en) | 2015-08-17 | 2015-08-17 | Filter paper guide micro -fluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205020102U true CN205020102U (en) | 2016-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520618832.XU Expired - Fee Related CN205020102U (en) | 2015-08-17 | 2015-08-17 | Filter paper guide micro -fluidic chip |
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| CN (1) | CN205020102U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104998705A (en) * | 2015-08-17 | 2015-10-28 | 山东省科学院海洋仪器仪表研究所 | Filter paper guided sandwiched micro-fluidic chip and processing method thereof |
| CN105866404A (en) * | 2016-03-31 | 2016-08-17 | 苏州市博纳泰科生物技术有限公司 | Membrane material-based micro-fluidic chip |
| CN113426497A (en) * | 2021-06-02 | 2021-09-24 | 广州大学 | Method for manufacturing micro-fluidic chip |
-
2015
- 2015-08-17 CN CN201520618832.XU patent/CN205020102U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104998705A (en) * | 2015-08-17 | 2015-10-28 | 山东省科学院海洋仪器仪表研究所 | Filter paper guided sandwiched micro-fluidic chip and processing method thereof |
| CN105866404A (en) * | 2016-03-31 | 2016-08-17 | 苏州市博纳泰科生物技术有限公司 | Membrane material-based micro-fluidic chip |
| CN113426497A (en) * | 2021-06-02 | 2021-09-24 | 广州大学 | Method for manufacturing micro-fluidic chip |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160210 Termination date: 20170817 |