CN204995462U - Microcirculation blood flow fills detector - Google Patents

Abstract

The utility model relates to a microcirculation blood flow fills detector includes laser instrument, light probe, detector, signal processor and user interface machine, wherein, light probe passes through the channel with laser instrument, detector respectively and is connected, detector, signal processor and user interface machine three electricity in proper order connect, the utility model discloses can be used for monitoring the organize microcirculation blood flow of ICU severe patients including the finger toe fills to show through visual form, can help doctor or relevant medical personnel in time to discover when microcirculation disorder appears in the patient and take effectual therapeutical measure, thereby ensure patient's health.

Description

Microcirculation in human body blood perfusion detector

Technical field

This utility model relates to technical field of biomedical detection, is specifically related to a kind of microcirculation in human body blood perfusion detecting instrument, can the perfusion of Non-invasive detection tissue microcirculation blood flow.

Background technology

Microcirculation is the blood circulation between arteriole and venule in blood capillary, it is the 26S Proteasome Structure and Function unit of human recycle system Zhong basic unit, the approach of mass exchange is carried out as blood of human body and each tissue, cell, it is responsible for each organ, each histiocyte provides oxygen, nutriment, transferring energy, discharge carbon dioxide and metabolic waste etc., so the clinical measurement of microcirculation in human body is for judging that whether healthy and have important guidance and assosting effect for disease treatment human body respectively organized.

Especially in Intensive Care Unit (ICU) the inside, a lot of patient with severe symptoms is when accepting long-term treatment, because blood circulation function declines to some extent, make patient's fingers and toes part microcirculation blood supply insufficiency, if doctor does not have Timeliness coverage and take effective remedy measures, the fingers and toes of patient finally can be caused to occur downright bad.

Utility model content

The purpose of this utility model is, a kind of detector organizing microcirculation blood flow to pour into can monitored ICU patient with severe symptoms and comprise fingers and toes is provided, help medical personnel's Timeliness coverage when microcirculation disturbance appears in patient and take effective remedy measures, to ensure the health of patient.

A kind of microcirculation in human body blood perfusion detector that the utility model proposes, comprises laser instrument, light probe, detector, signal processor and user interface machine; Wherein, light probe is connected by channel with laser instrument, detector respectively; Detector, signal processor and user interface machine three are electrically connected successively; Described laser instrument launches the laser signal of preset wavelength to light probe; The laser signal transmission that laser instrument is launched by light probe is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detector; The optical signal with doppler shifted signal that light probe transmission comes is changed into the corresponding signal of telecommunication by detector, and transfers to signal processor; Signal processor extracts doppler shifted signal from the signal of telecommunication that detector transmission comes, and calculates blood perfusion according to this doppler shifted signal; The blood perfusion that signal processor calculates by user interface machine shows with visual pattern.

In further preferred version of the present utility model, described laser instrument comprises semiconductor laser transmitter and laser control circuit, the two electrical connection; Wherein, described semiconductor laser transmitter is provided with fiber adapter, and described laser control circuit comprises DC drive circuit.

In further preferred version of the present utility model, the centre wavelength of the laser signal that described laser instrument is launched is 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm.

In further preferred version of the present utility model, described detector comprises photodiode and receiving circuit, the two electrical connection.

In further preferred version of the present utility model, described light probe is provided with an outgoing optical fiber and Duo Gen and is laid in incident optical around described outgoing optical fiber; Described outgoing optical fiber is connected with described laser instrument, and incident optical is connected with described detector.

In further preferred version of the present utility model, the diameter of each optical fiber of described light probe is 50 μm to 250 μm, and the distance between adjacent fiber is 250 μm to 2000 μm.

In further preferred version of the present utility model, described signal processor comprises extraction unit and computing unit, the two electrical connection; Extraction unit extracts doppler shifted signal from the signal of telecommunication that detector transmission comes; Computing unit calculates blood perfusion from according to general frequency shift signal of strangling.

In further preferred version of the present utility model, described extraction unit comprises the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter; Described first filter circuit, ac amplifier circuit are electrically connected successively with the second filter circuit three, and described second filter circuit is also electrically connected with described A/D converter; Described DC amplification circuit is electrically connected with described detector, A/D converter respectively; The signal of telecommunication transmitted with doppler shifted signal through detector is carried out preliminary filtering, to remove the noise outside useful signal bandwidth by the first filter circuit; Ac amplifier circuit will amplify through the filtered signal of telecommunication of the first filter circuit; The signal of telecommunication amplified through ac amplifier circuit is carried out secondary filtering by the second filter circuit, and to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining also transports to described A/D converter; The signal of telecommunication with doppler shifted signal that detector transmission comes directly amplifies by DC amplification circuit, obtains an exaggerated raw electrical signal and transports to A/D converter; The signal of telecommunication that second filter circuit transmission comes by described A/D converter and the signal of telecommunication that DC amplification circuit transmission comes convert digital form to from analog form, and transport to described computing unit.

Beneficial effect: a kind of microcirculation in human body blood perfusion detector that the utility model proposes can be used for monitoring the microcirculation blood flow of organizing that ICU patient with severe symptoms comprises fingers and toes and pour into, and shown by visual pattern, doctor or associated care personnel Timeliness coverage can be helped when microcirculation disturbance appears in patient and take effective remedy measures, thus having ensured the health of patient.

Accompanying drawing explanation

Fig. 1 is the Integral connection structure schematic diagram of a kind of microcirculation in human body blood perfusion detector that embodiment one proposes.

Fig. 2 is the detailed construction schematic diagram of Fig. 1.

Fig. 3 is the cross-sectional structure schematic diagram of light probe in embodiment one.

Fig. 4 is the integrated operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example.

Fig. 5 is the partial operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example.

Fig. 6 detects the finger fingertip microcirculation blood flow perfusion optical signal side of propagation schematic diagram in application example.

Detailed description of the invention

This utility model to be described further below in conjunction with accompanying drawing and embodiment for the ease of it will be appreciated by those skilled in the art that.

The microcirculatory ultimate principle of laser-Doppler human body is, by optical fiber, laser is sent to light probe, when light probe is placed on human tissue surface, laser is except part is by except tissue surface reflection, some enters in blood capillary, the light that the erythrocyte scattering that passive movement is returned will produce Doppler frequency shift, and be there is no Doppler frequency shift by the light that static tissue scatter returns, this two parts light is all changed into the signal of telecommunication by photoelectric detector, then device extracts Doppler signal after filtering, the amplitude of this signal and frequency are directly proportional to the erythrocyte quantity of moving in tested tissue volume and their speed respectively.Because the blood cell quantity in tested volume is a random quantity changed with the activity of pulse, the microcirculation rhythm and pace of moving things and other organs of human body, erythrocytic movement velocity in tested volume neither a single numerical value, and the optical signal received also may be through, and multiple impacts scattering returns, so the frequency of doppler shifted signal is not a single value, but be distributed in certain frequency range, integration is carried out to the signal in this frequency range, the blood perfusion of tested volume can be reflected.

Embodiment one

Refer to Fig. 1, a kind of microcirculation in human body blood perfusion of the present embodiment detector, it comprises laser instrument 10, light probe 20, detector 30, signal processor 40 and user interface machine 50; Wherein, light probe 20 is connected by channel with laser instrument 10, detector 30 respectively; Detector 30, signal processor 40 and user interface machine 50 three are electrically connected successively.

The laser signal of preset wavelength launched by described laser instrument 10 to light probe 20; The laser signal transmission that laser instrument 10 is launched by described light probe 20 is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detector 30; Light probe 20 is transmitted the optical signal with doppler shifted signal come and changes into the corresponding signal of telecommunication by described detector 30, and transfers to signal processor 40; Described signal processor 40 transmits the signal of telecommunication come from detector 30 and extracts doppler shifted signal, and calculates blood perfusion according to this doppler shifted signal; The blood perfusion that signal processor 40 calculates shows with visual pattern by described user interface machine 50.

In the present embodiment, laser instrument 10 is for launching the laser signal of specific wavelength, concrete preferably 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm, erythrocyte is different to the absorptivity of different wave length, therefore the laser of different wave length can affect fathoming to tissue, therefore the present embodiment can select the laser of specific wavelength according to specific needs.Refer to Fig. 2, laser instrument 10 structurally can comprise a semiconductor laser transmitter and a laser control circuit, the two electrical connection; For the ease of with coupling fiber, semiconductor laser can be installed a standard fiber optic adapter (routine FC); Laser control circuit mainly comprises a direct current drive circuit, and the size of drive current can regulate on circuit boards.

The present embodiment is structurally optimized described light probe 20, concrete, as shown in Figure 3, described light probe 20 is provided with an outgoing optical fiber 21 and Duo Gen and is laid in incident optical 22 (incident optical 22 can be specifically as shown in Figure 36, can certainly be other suitable quantity) around described outgoing optical fiber; Described outgoing optical fiber 21 is connected with described laser module 10, for transmitting the laser signal that laser module 10 is launched; Incident optical 22 is connected with described detecting module 30, for the optical signal that collector soma reflects.Owing to shining the optical signal of tissue inside after Multiple Scattering and reflection, can propagate to numerous different direction, therefore the present embodiment is provided with many incident opticals 22, to improve the probability capturing Doppler signal.

In addition, distance between optical fiber and optical fiber is also very important, in the present embodiment, the diameter of each optical fiber of light probe 20 (outgoing optical fiber 21, incident optical 22) is 50 μm to 250 μm, distance between adjacent fiber is 250 μm to 2000 μm, to improve the probability capturing Doppler signal further.In use the end face of the multifiber of light probe 20 steadily is fixed on human tissue surface's (such as finger fingertip), to reduce pseudo-motion to detecting the impact brought as far as possible.

Consult Fig. 2 equally, described detector 30 structurally can comprise a photodiode and a receiving circuit, the two electrical connection.For the ease of with coupling fiber, on detector 30 surface, one standard fiber optic adapter (such as FC) can be installed.Described receiving circuit can ensure photodiode work under suitable conditions, and as the first amplifier stage, can amplify the small-signal reflected from tissue.

Described signal processor 40 structurally can comprise extraction unit 41 and computing unit 42, the two electrical connection; Described extraction unit 41 transmits the signal of telecommunication come from detector 30 and extracts doppler shifted signal; Described computing unit 42 calculates blood perfusion according to doppler shifted signal.

In the present embodiment, described extraction unit 41 also can specifically comprise the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter further; Wherein, described first filter circuit by through detector 30, the signal of telecommunication transmitted with doppler shifted signal carries out preliminary filtering, to remove the noise outside useful signal bandwidth; Described ac amplifier circuit will amplify through the filtered signal of telecommunication of the first filter circuit; The signal of telecommunication amplified through ac amplifier circuit is carried out secondary filtering by described second filter circuit, to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining one also transports to described A/D converter, this time time variant voltage signal can use V _act () represents; Detector 30 is directly transmitted the signal of telecommunication with doppler shifted signal come and amplifies by described DC amplification circuit, and obtain an exaggerated raw electrical signal and transport to A/D converter, the raw electrical signal after amplification can represent with Vdc (t); The signal of telecommunication that second filter circuit transmission comes by described A/D converter and the signal of telecommunication that DC amplification circuit transmission comes convert digital form to from analog form, and transport to described computing unit 42.

In the present embodiment, the method that described computing unit 42 calculates blood perfusion is: by time time variant voltage signal V _act () converts digital signal to, carry out Fourier transformation obtain its power spectrum P (ω) to described digital signal; Then the power spectrum of band frequency weight is carried out integral and calculating, result of calculation is divided by the raw electrical signal V converting digital signal to _dcthe meansigma methods of (t) square, to be normalized blood perfusion, specifically can with reference to following formula:

$CMBC=\frac{{\∫}_0^{\mathrm{\∞}}P\left(\mathrm{\ω}\right)d\mathrm{\ω}}{{i_{dc}}^2}-n_{CMBC}\left(i_{dc}\right)---\left(1\right)$

$Perf=\frac{{\∫}_0^{\mathrm{\∞}}\mathrm{\ω}P\left(\mathrm{\ω}\right)d\mathrm{\ω}}{{i_{dc}}^2}-n_{perf}\left(i_{dc}\right)---\left(2\right)$

Wherein, CMBC (i.e. concentrationofmovingredbloodcell) refers to the erythrocytic concentration of flowing, time variant voltage signal V when P (ω) is _act power spectrum that () obtains after Fourier transformation; n _cMBC(i _dc) be the CMBC noise of system; ω refers to frequency, and ω P (ω) is the power spectrum of band frequency weight; n _perf(i _dc) be the Perf noise of system, i _dcthat the electric current form of expression of raw electrical signal Vdc (t) is (because Vdc (t)=i _dcr, resistance R is cancelled in the calculation, remaining current i _dc), Perf (i.e. perfusion) is blood perfusion.

In the present embodiment, described user interface machine 50 specifically can numeral, curve chart or oscillogram show, and when microcirculation disturbance appears in patient, helps doctor's Timeliness coverage and takes effective remedy measures, to ensure the health of patient.

Described user interface machine 50 also can be provided with elemental user pattern and advanced level user's pattern further; Form that is digital and curve chart blood perfusion can be shown under elemental user pattern; Under advanced level user's pattern except display blood perfusion, the oscillogram etc. of the power spectrum of time variant voltage signal, power spectrum and frequency weight when also can show.Meanwhile, related data also can be stored in hard disk by described user interface machine 50, to analyze further.

The method utilizing embodiment a pair microcirculation in human body blood perfusion to carry out detecting is with reference to as follows:

The laser signal of the preset wavelength that S100, transmitting are poured into for human body tissue blood flow;

S200, the optical signal with doppler shifted signal reflected from multi-faceted reception;

S300, the optical signal with doppler shifted signal is changed into the corresponding signal of telecommunication;

S500, convert the described signal of telecommunication to digital signal, Fourier transformation is carried out to described digital signal and obtains its power spectrum;

S600, the power spectrum of band frequency weight is carried out integral and calculating, result of calculation divided by the meansigma methods of raw electrical signal square converting digital signal to, to be normalized blood perfusion.

S700, the blood perfusion calculated to be shown with visual pattern.

Application example

In order to realize above-described embodiment one better, below introduce an embody rule example.

To detect the finger tip of patient, refer to Fig. 4 to Fig. 6 figure, 4 is the integrated operation schematic diagrams detecting the perfusion of finger fingertip microcirculation blood flow in application example, Fig. 5 is the partial operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example, and Fig. 6 detects the finger fingertip microcirculation blood flow perfusion optical signal side of propagation schematic diagram in application example; In Fig. 4: 101-hands, 102-light probe, 103-fibre bundle, 104-includes the instrument host of subscriber interface module, and 105-includes the display of subscriber interface module, 106-user interface; In Fig. 5: 201-points, 202-refers to folder, the soft cushion of 203-, 204-light probe end, 205-fibre bundle, 206-spring; In Fig. 6: 301-finger capillary, 302-finger skin, 303-light probe end, 304-refers to folder, 305-outgoing optical fiber, 306-incident optical, the soft cushion of 307-.Application example comprises following scheme:

1, light probe is placed on the finger fingertip surface of patient;

2, laser instrument is with the laser signal of 780nm wavelength emission 5mW, and is transferred to the finger fingertip surface of patient by the outgoing optical fiber of in light probe;

4, laser signal part is by the finger fingertip surface reflection of patient, and other parts enter finger fingertip inside, interacts with the erythrocyte of movement, and partial dispersion goes back to the finger fingertip surface of patient;

5, the optical signal being scattered back the finger fingertip surface of patient is collected by many incident opticals in light probe, and transfers to signal processor;

6, signal processor filtering noise, and by amplifier adjustment output signal to suitable amplitude, then by A/D converter, analogue signal is changed into digital signal;

7, digital signal is performed fast Fourier transform to obtain with the power spectrum of doppler information, and blood perfusion is completed to the power spectrum integration of Weight and normalization calculate;

8, by user interface machine be user (such as doctor) show blood perfusion, time time variant voltage signal and power spectrum etc., also related data is stored in hard disk, to analyze further simultaneously.

The above embodiment only have expressed several embodiment of the present utility model, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to this utility model the scope of the claims.It should be pointed out that for the person of ordinary skill of the art, without departing from the concept of the premise utility, can also make some distortion and improvement, these all belong to protection domain of the present utility model.Therefore, the protection domain of this utility model patent should be as the criterion with claims.

Claims (8)

1. a microcirculation in human body blood perfusion detector, is characterized in that, comprises laser instrument, light probe, detector, signal processor and user interface machine; Wherein, light probe is connected by channel with laser instrument, detector respectively; Detector, signal processor and user interface machine three are electrically connected successively; Described laser instrument launches the laser signal of preset wavelength to light probe; The laser signal transmission that laser instrument is launched by light probe is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detector; The optical signal with doppler shifted signal that light probe transmission comes is changed into the corresponding signal of telecommunication by detector, and transfers to signal processor; Signal processor extracts doppler shifted signal from the signal of telecommunication that detector transmission comes, and calculates blood perfusion according to this doppler shifted signal; The blood perfusion that signal processor calculates by user interface machine shows with visual pattern.

2. microcirculation in human body blood perfusion detector according to claim 1, it is characterized in that, described laser instrument comprises semiconductor laser transmitter and laser control circuit, the two electrical connection; Wherein, described semiconductor laser transmitter is provided with fiber adapter, and described laser control circuit comprises DC drive circuit.

3. microcirculation in human body blood perfusion detector according to claim 2, is characterized in that, the centre wavelength of the laser signal that described laser instrument is launched is 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm.

4. microcirculation in human body blood perfusion detector according to claim 1, it is characterized in that, described detector comprises photodiode and receiving circuit, the two electrical connection.

5. microcirculation in human body blood perfusion detector according to claim 1, is characterized in that, described light probe is provided with an outgoing optical fiber and Duo Gen and is laid in incident optical around described outgoing optical fiber; Described outgoing optical fiber is connected with described laser instrument, and incident optical is connected with described detector.

6. microcirculation in human body blood perfusion detector according to claim 5, is characterized in that, the diameter of each optical fiber of described light probe is 50 μm to 250 μm, and the distance between adjacent fiber is 250 μm to 2000 μm.

7. microcirculation in human body blood perfusion detector according to claim 1, it is characterized in that, described signal processor comprises extraction unit and computing unit, the two electrical connection; Extraction unit extracts doppler shifted signal from the signal of telecommunication that detector transmission comes; Computing unit calculates blood perfusion from according to general frequency shift signal of strangling.

8. microcirculation in human body blood perfusion detector according to claim 7, is characterized in that, described extraction unit comprises the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter; Described first filter circuit, ac amplifier circuit are electrically connected successively with the second filter circuit three, and described second filter circuit is also electrically connected with described A/D converter; Described DC amplification circuit is electrically connected with described detector, A/D converter respectively; The signal of telecommunication transmitted with doppler shifted signal through detector is carried out preliminary filtering, to remove the noise outside useful signal bandwidth by the first filter circuit; Ac amplifier circuit will amplify through the filtered signal of telecommunication of the first filter circuit; The signal of telecommunication amplified through ac amplifier circuit is carried out secondary filtering by the second filter circuit, and to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining also transports to described A/D converter; The signal of telecommunication with doppler shifted signal that detector transmission comes directly amplifies by DC amplification circuit, obtains an exaggerated raw electrical signal and transports to A/D converter; The signal of telecommunication that second filter circuit transmission comes by described A/D converter and the signal of telecommunication that DC amplification circuit transmission comes convert digital form to from analog form, and transport to described computing unit.