CN105078441A - Human microcirculation blood perfusion detecting instrument and method - Google Patents
Human microcirculation blood perfusion detecting instrument and method Download PDFInfo
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- CN105078441A CN105078441A CN201510617832.2A CN201510617832A CN105078441A CN 105078441 A CN105078441 A CN 105078441A CN 201510617832 A CN201510617832 A CN 201510617832A CN 105078441 A CN105078441 A CN 105078441A
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Abstract
The invention relates to a human microcirculation blood perfusion detecting instrument and method. The detecting instrument comprises a laser module, a light probe, a detecting module, a signal processing module and a user interface module. The laser module emits laser signals of preset wavelength to the light probe. The light probe transmits the laser signals emitted by the laser module to human tissue and transmits light signals reflected by the human tissue to the detecting module. The detecting module converts the light signals transmitted by the light probe into corresponding electric signals and transmits the electric signals to the signal processing module. The signal processing module extracts Doppler shift signals from the electric signals and calculates blood perfusion according to the Doppler shift signals. The user interface module displays the blood perfusion visually. The detecting instrument can help doctors or related medical staff find the situation in time and take effective treatment measures when microcirculation disturbance happens to a patient, and therefore health of the patient is ensured.
Description
Technical field
The present invention relates to technical field of biomedical detection, be specifically related to a kind of microcirculation in human body blood perfusion detecting instrument, can the perfusion of Non-invasive detection tissue microcirculation blood flow, simultaneously also correspondingly relate to a kind of detection method.
Background technology
Microcirculation is the blood circulation between arteriole and venule in blood capillary, it is the 26S Proteasome Structure and Function unit of human recycle system Zhong basic unit, the approach of mass exchange is carried out as blood of human body and each tissue, cell, it is responsible for each organ, each histiocyte provides oxygen, nutriment, transferring energy, discharge carbon dioxide and metabolic waste etc., so the clinical measurement of microcirculation in human body is for judging that whether healthy and have important guidance and assosting effect for disease treatment human body respectively organized.
Especially in Intensive Care Unit (ICU) the inside, a lot of patient with severe symptoms is when accepting treatment, because blood circulation function declines to some extent, make patient's fingers and toes part microcirculation blood supply insufficiency, if doctor does not have Timeliness coverage and take effective remedy measures, the fingers and toes of patient finally can be caused to occur downright bad.
Summary of the invention
The object of the invention is to, a kind of detector organizing microcirculation blood flow to pour into can monitored ICU patient with severe symptoms and comprise fingers and toes is provided, help medical personnel's Timeliness coverage when microcirculation disturbance appears in patient and take effective remedy measures, to ensure the health of patient.
A kind of microcirculation in human body blood perfusion detector that the present invention proposes, comprises laser module, light probe, detecting module, signal processing module and subscriber interface module; Wherein,
Described laser module, for launching the laser signal of preset wavelength to light probe;
Described light probe, for contacting with human tissue surface, the laser signal transmission of being launched by laser module is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detecting module;
Described detecting module, changes into the corresponding signal of telecommunication for the optical signal with doppler shifted signal light probe transmission come, and transfers to signal processing module;
Described signal processing module, extracts doppler shifted signal for transmitting in the next signal of telecommunication from detecting module, and calculates blood perfusion according to this doppler shifted signal;
Described subscriber interface module, shows with visual pattern for the blood perfusion calculated by signal processing module.
In present invention further optimization scheme, described light probe is provided with an outgoing optical fiber and Duo Gen and is laid in incident optical around described outgoing optical fiber; Described outgoing optical fiber is connected with described laser module, and incident optical is connected with described detecting module.
In present invention further optimization scheme, the diameter of each optical fiber of described light probe is 50 μm to 250 μm, and the distance between adjacent fiber is 250 μm to 2000 μm.
In present invention further optimization scheme, described signal processing module comprises extraction unit and computing unit; Described extraction unit comprises the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter;
Described first filter circuit, carries out preliminary filtering, to remove the noise outside useful signal bandwidth by the signal of telecommunication transmitted with doppler shifted signal through detecting module;
Described ac amplifier circuit, will amplify through the filtered signal of telecommunication of the first filter circuit;
Described second filter circuit, carries out secondary filtering by the signal of telecommunication amplified through ac amplifier circuit, and to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining also transports to described A/D converter;
Described DC amplification circuit, amplifies the signal of telecommunication with doppler shifted signal that detecting module transmission comes for direct, obtains an exaggerated raw electrical signal and transport to A/D converter;
Described A/D converter, converts digital form for the signal of telecommunication signal of telecommunication next for the second filter circuit transmission and DC amplification circuit transmission come to from analog form, and transports to described computing unit;
Described computing unit, calculates blood perfusion for the doppler shifted signal come according to A/D converter transmission.
In present invention further optimization scheme, described subscriber interface module specifically shows with numeral, curve chart or oscillogram.
In present invention further optimization scheme, described subscriber interface module is provided with elemental user pattern and advanced level user's pattern; Blood perfusion is shown with the form of numeral and curve chart under elemental user pattern; Under advanced level user's pattern except display blood perfusion, the oscillogram of the power spectrum of time variant voltage signal, power spectrum and frequency weight when also showing.
In present invention further optimization scheme, also comprise wavelength and module is set, for arranging the wavelength of the laser signal that laser module is launched.
In present invention further optimization scheme, the centre wavelength that wavelength arranges module installation is 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm.
Accordingly, the invention allows for a kind of microcirculation in human body blood perfusion detection method, comprise the following steps:
The laser signal of the preset wavelength that A1, transmitting are poured into for human body tissue blood flow;
A2, the optical signal with doppler shifted signal reflected from multi-faceted reception;
A3, the optical signal with doppler shifted signal is changed into the corresponding signal of telecommunication;
A4, from the described signal of telecommunication, extract doppler shifted signal, and calculate blood perfusion according to this doppler shifted signal.
In present invention further optimization scheme, calculate blood perfusion in described steps A 4 and be specially:
A41, convert the described signal of telecommunication to digital signal, Fourier transformation is carried out to described digital signal and obtains its power spectrum;
A42, the power spectrum of band frequency weight is carried out integral and calculating, result of calculation divided by the meansigma methods of raw electrical signal square converting digital signal to, to be normalized blood perfusion.
Beneficial effect: a kind of microcirculation in human body blood perfusion detector that the present invention proposes can be used for monitoring the microcirculation blood flow of organizing that ICU patient with severe symptoms comprises fingers and toes and pour into, and shown by visual pattern, doctor or associated care personnel Timeliness coverage can be helped when microcirculation disturbance appears in patient and take effective remedy measures, thus having ensured the health of patient.
A kind of microcirculation in human body blood perfusion detection method of the corresponding proposition of the present invention possesses above beneficial effect equally.
Accompanying drawing explanation
Fig. 1 is the modular construction schematic diagram of a kind of microcirculation in human body blood perfusion detector that embodiment one proposes.
Fig. 2 is the cross-sectional structure schematic diagram of light probe in embodiment one.
Fig. 3 is the schematic flow sheet of the kind microcirculation in human body blood perfusion detection method that embodiment two proposes.
Fig. 4 is the integrated operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example.
Fig. 5 is the partial operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example.
Fig. 6 detects the finger fingertip microcirculation blood flow perfusion optical signal side of propagation schematic diagram in application example.
Detailed description of the invention
For the ease of it will be appreciated by those skilled in the art that the present invention is described further below in conjunction with accompanying drawing and embodiment.
The microcirculatory ultimate principle of laser-Doppler human body is, by optical fiber, laser is sent to light probe, when light probe is placed on human tissue surface, laser is except part is by except tissue surface reflection, some enters in blood capillary, the light that the erythrocyte scattering that passive movement is returned will produce Doppler frequency shift, and be there is no Doppler frequency shift by the light that static tissue scatter returns, this two parts light is all changed into the signal of telecommunication by photoelectric detector, then device extracts Doppler signal after filtering, the amplitude of this signal and frequency are directly proportional to the erythrocyte quantity of moving in tested tissue volume and their speed respectively.Because the blood cell quantity in tested volume is a random quantity changed with the activity of pulse, the microcirculation rhythm and pace of moving things and other organs of human body, erythrocytic movement velocity in tested volume neither a single numerical value, and the optical signal received also may be through, and multiple impacts scattering returns, so the frequency of doppler shifted signal is not a single value, but be distributed in certain frequency range, integration is carried out to the signal in this frequency range, the blood perfusion of tested volume can be reflected.
Embodiment one
Refer to Fig. 1, a kind of microcirculation in human body blood perfusion of the present embodiment detector, it comprises laser module 10, light probe 20, detecting module 30, signal processing module 40 and subscriber interface module 50; Wherein,
Described laser module 10, for launching the laser signal of preset wavelength to light probe 20;
Described light probe 20, for contacting with human tissue surface, the laser signal transmission of being launched by laser module 10 is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detecting module 30;
Described detecting module 30, changes into the corresponding signal of telecommunication for light probe 20 being transmitted the optical signal with doppler shifted signal come, and transfers to signal processing module 40;
Described signal processing module 40, extracts doppler shifted signal for transmitting in the next signal of telecommunication from detecting module 30, and calculates blood perfusion according to this doppler shifted signal;
Described subscriber interface module 50, shows with visual pattern for the blood perfusion calculated by signal processing module 40.
In the present embodiment, laser module 10 is for launching the laser signal of specific wavelength, concrete preferably 650nm, 780nm or 850nm, erythrocyte is different to the absorptivity of different wave length, therefore the laser of different wave length can affect fathoming to tissue, therefore the present embodiment can select the laser of specific wavelength according to specific needs.Laser module 10 structurally can comprise a semiconductor laser and a control circuit; For the ease of with coupling fiber, semiconductor laser can be installed a standard fiber optic adapter (routine FC); Control circuit mainly comprises a direct current drive circuit, and the size of drive current can regulate on circuit boards.
In specific implementation, the present embodiment also can be set up wavelength and arrange module 60, for arranging the wavelength of the laser signal that laser module 10 is launched.The centre wavelength that wavelength arranges module 60 setting is preferably 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm.
The present embodiment is structurally optimized described light probe 20, concrete, as shown in Figure 2, described light probe 20 is provided with an outgoing optical fiber 21 and Duo Gen and is laid in incident optical 22 (incident optical 22 can be specifically as shown in Figure 26, can certainly be other suitable quantity) around described outgoing optical fiber; Described outgoing optical fiber 21 is connected with described laser module 10, for transmitting the laser signal that laser module 10 is launched; Incident optical 22 is connected with described detecting module 30, for the optical signal that collector soma reflects.Owing to shining the optical signal of tissue inside after Multiple Scattering and reflection, can propagate to numerous different direction, therefore the present embodiment is provided with many incident opticals 22, to improve the probability capturing Doppler signal.
In addition, distance between optical fiber and optical fiber is also very important, in the present embodiment, the diameter of each optical fiber of light probe 20 (outgoing optical fiber 21, incident optical 22) is 50 μm to 250 μm, distance between adjacent fiber is 250 μm to 2000 μm, to improve the probability capturing Doppler signal further.In use the end face of the multifiber of light probe 20 steadily is fixed on human tissue surface's (such as finger fingertip), to reduce pseudo-motion to detecting the impact brought as far as possible.
Described detecting module 30 structurally can comprise a photodiode and a receiving circuit.For the ease of with coupling fiber, on detecting module 30 surface, one standard fiber optic adapter (such as FC) can be installed.Described receiving circuit can ensure photodiode work under suitable conditions, and as the first amplifier stage, can amplify the small-signal reflected from tissue.
Described signal processing module 40 structurally can comprise extraction unit 41 and computing unit 42, and described extraction unit 41 comprises the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter.
Described first filter circuit, carries out preliminary filtering, to remove the noise outside useful signal bandwidth by the signal of telecommunication transmitted with doppler shifted signal through detecting module; Described ac amplifier circuit, will amplify through the filtered signal of telecommunication of the first filter circuit; Described second filter circuit, the signal of telecommunication amplified through ac amplifier circuit is carried out secondary filtering, to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining one also transports to described A/D converter, this time time variant voltage signal can represent with Vac (t); Described DC amplification circuit, for direct, the signal of telecommunication with doppler shifted signal that detecting module transmission comes is amplified, obtain an exaggerated raw electrical signal and transport to A/D converter, the raw electrical signal after amplification can represent with Vdc (t); Described A/D converter, converts digital form for the signal of telecommunication signal of telecommunication next for the second filter circuit transmission and DC amplification circuit transmission come to from analog form, and transports to described computing unit 42; Described computing unit 42 calculates blood perfusion for the doppler shifted signal come according to A/D converter transmission.
In the present embodiment, the method that described computing unit 42 calculates blood perfusion is: by time time variant voltage signal V
act () converts digital signal to, carry out Fourier transformation obtain its power spectrum P (ω) to described digital signal; Then the power spectrum of band frequency weight is carried out integral and calculating, result of calculation is divided by the raw electrical signal V converting digital signal to
dcthe meansigma methods of (t) square, to be normalized blood perfusion, specifically can with reference to following formula:
Wherein, CMBC (i.e. concentrationofmovingredbloodcell) refers to the erythrocytic concentration of flowing, time variant voltage signal V when P (ω) is
act power spectrum that () obtains after Fourier transformation; n
cMBC(i
dc) be the CMBC noise of system; ω refers to frequency, and ω P (ω) is the power spectrum of band frequency weight; n
perf(i
dc) be the Perf noise of system, i
dcbe the electric current form of expression of raw electrical signal Vdc (t), Perf (i.e. perfusion) is blood perfusion.
In the present embodiment, described subscriber interface module 50 specifically can numeral, curve chart or oscillogram show, and when microcirculation disturbance appears in patient, helps doctor's Timeliness coverage and takes effective remedy measures, to ensure the health of patient.
Described subscriber interface module 50 also can be provided with elemental user pattern and advanced level user's pattern further; Form that is digital and curve chart blood perfusion can be shown under elemental user pattern; Under advanced level user's pattern except display blood perfusion, the oscillogram etc. of the power spectrum of time variant voltage signal, power spectrum and frequency weight when also can show.Meanwhile, related data also can be stored in hard disk by described subscriber interface module 50, to analyze further.
Embodiment two
Refer to Fig. 3, corresponding with embodiment one, embodiment two proposes a kind of microcirculation in human body blood perfusion detection method, and it mainly comprises the following steps S100 to step S500:
The laser signal of the preset wavelength that S100, transmitting are poured into for human body tissue blood flow;
S200, the optical signal with doppler shifted signal reflected from multi-faceted reception;
S300, the optical signal with doppler shifted signal is changed into the corresponding signal of telecommunication;
S400, from the described signal of telecommunication, extract doppler shifted signal, and calculate blood perfusion according to this doppler shifted signal;
S500, the blood perfusion calculated to be shown with visual pattern.
Calculating blood perfusion in step S400 can computational methods in reference example one, is specifically summarized as follows:
S410, convert the described signal of telecommunication to digital signal, Fourier transformation is carried out to described digital signal and obtains its power spectrum;
S420, the power spectrum of band frequency weight is carried out integral and calculating, result of calculation divided by the meansigma methods of raw electrical signal square converting digital signal to, to be normalized blood perfusion.
Be understandable that, embodiment two can help doctor's Timeliness coverage when microcirculation disturbance appears in patient and take effective remedy measures, ensure the health of patient equally.
Application example
In order to realize above-described embodiment one or embodiment two better, below introduce an embody rule example.
To detect the finger tip of patient, refer to Fig. 4 to Fig. 6 figure, 4 is the integrated operation schematic diagrams detecting the perfusion of finger fingertip microcirculation blood flow in application example, Fig. 5 is the partial operation schematic diagram detecting the perfusion of finger fingertip microcirculation blood flow in application example, and Fig. 6 detects the finger fingertip microcirculation blood flow perfusion optical signal side of propagation schematic diagram in application example; In Fig. 4: 101-hands, 102-light probe, 103-fibre bundle, 104-includes the instrument host of subscriber interface module, and 105-includes the display of subscriber interface module, 106-user interface; In Fig. 5: 201-points, 202-refers to folder, the soft cushion of 203-, 204-light probe end, 205-fibre bundle, 206-spring; In Fig. 6: 301-finger capillary, 302-finger skin, 303-light probe end, 304-refers to folder, 305-outgoing optical fiber, 306-incident optical, the soft cushion of 307-.Application example comprises following scheme:
1, light probe is placed on the finger fingertip surface of patient;
2, laser module is with the laser signal of 780nm wavelength emission 5mW, and is transferred to the finger fingertip surface of patient by the outgoing optical fiber of in light probe;
4, laser signal part is by the finger fingertip surface reflection of patient, and other parts enter finger fingertip inside, interacts with the erythrocyte of movement, and partial dispersion goes back to the finger fingertip surface of patient;
5, the optical signal being scattered back the finger fingertip surface of patient is collected by many incident opticals in light probe, and transfers to signal processing module;
6, signal processing module filtering noise, and by amplifier adjustment output signal to suitable amplitude, then by A/D converter, analogue signal is changed into digital signal;
7, digital signal is performed fast Fourier transform to obtain with the power spectrum of doppler information, and blood perfusion is completed to the power spectrum integration of Weight and normalization calculate;
8, by subscriber interface module be user (such as doctor) show blood perfusion, time time variant voltage signal and power spectrum etc., also related data is stored in hard disk, to analyze further simultaneously.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a microcirculation in human body blood perfusion detector, is characterized in that, comprises laser module, light probe, detecting module, signal processing module and subscriber interface module; Wherein,
Described laser module, for launching the laser signal of preset wavelength to light probe;
Described light probe, for contacting with human tissue surface, the laser signal transmission of being launched by laser module is to tissue, and the optical signal transmission with doppler shifted signal tissue reflected is to detecting module;
Described detecting module, changes into the corresponding signal of telecommunication for the optical signal with doppler shifted signal light probe transmission come, and transfers to signal processing module;
Described signal processing module, extracts doppler shifted signal for transmitting in the next signal of telecommunication from detecting module, and calculates blood perfusion according to this doppler shifted signal;
Described subscriber interface module, shows with visual pattern for the blood perfusion calculated by signal processing module.
2. microcirculation in human body blood perfusion detector according to claim 1, is characterized in that, described light probe is provided with an outgoing optical fiber and Duo Gen and is laid in incident optical around described outgoing optical fiber; Described outgoing optical fiber is connected with described laser module, and incident optical is connected with described detecting module.
3. microcirculation in human body blood perfusion detector according to claim 2, is characterized in that, the diameter of each optical fiber of described light probe is 50 μm to 250 μm, and the distance between adjacent fiber is 250 μm to 2000 μm.
4. microcirculation in human body blood perfusion detector according to claim 1, it is characterized in that, described signal processing module comprises extraction unit and computing unit; Described extraction unit comprises the first filter circuit, ac amplifier circuit, the second filter circuit, DC amplification circuit and A/D converter;
Described first filter circuit, carries out preliminary filtering, to remove the noise outside useful signal bandwidth by the signal of telecommunication transmitted with doppler shifted signal through detecting module;
Described ac amplifier circuit, will amplify through the filtered signal of telecommunication of the first filter circuit;
Described second filter circuit, carries out secondary filtering by the signal of telecommunication amplified through ac amplifier circuit, and to remove the noise within useful signal bandwidth that circuit itself is introduced, time variant voltage signal when obtaining also transports to described A/D converter;
Described DC amplification circuit, amplifies the signal of telecommunication with doppler shifted signal that detecting module transmission comes for direct, obtains an exaggerated raw electrical signal and transport to A/D converter;
Described A/D converter, converts digital form for the signal of telecommunication signal of telecommunication next for the second filter circuit transmission and DC amplification circuit transmission come to from analog form, and transports to described computing unit;
Described computing unit, calculates blood perfusion for the doppler shifted signal come according to A/D converter transmission.
5. microcirculation in human body blood perfusion detector according to claim 1, is characterized in that, described subscriber interface module specifically shows with numeral, curve chart or oscillogram.
6. microcirculation in human body blood perfusion detector according to claim 5, is characterized in that, described subscriber interface module is provided with elemental user pattern and advanced level user's pattern; Blood perfusion is shown with the form of numeral and curve chart under elemental user pattern; Under advanced level user's pattern except display blood perfusion, the oscillogram of the power spectrum of time variant voltage signal, power spectrum and frequency weight when also showing.
7. microcirculation in human body blood perfusion detector according to claim 1, is characterized in that, also comprise wavelength and arrange module, for arranging the wavelength of the laser signal that laser module is launched.
8. microcirculation in human body blood perfusion detector according to claim 7, is characterized in that, the centre wavelength that wavelength arranges module installation is 650nm ± 10nm or 780nm ± 10nm or 850nm ± 10nm.
9. a microcirculation in human body blood perfusion detection method, is characterized in that, comprises the following steps:
The laser signal of the preset wavelength that A1, transmitting are poured into for human body tissue blood flow;
A2, the optical signal with doppler shifted signal reflected from multi-faceted reception;
A3, the optical signal with doppler shifted signal is changed into the corresponding signal of telecommunication;
A4, from the described signal of telecommunication, extract doppler shifted signal, and calculate blood perfusion according to this doppler shifted signal;
A5, the blood perfusion calculated to be shown with visual pattern.
10. microcirculation in human body blood perfusion detector according to claim 9, is characterized in that, calculates blood perfusion and be specially in described steps A 4:
A41, convert the described signal of telecommunication to digital signal, Fourier transformation is carried out to described digital signal and obtains its power spectrum;
A42, the power spectrum of band frequency weight is carried out integral and calculating, result of calculation divided by the meansigma methods of raw electrical signal square converting digital signal to, to be normalized blood perfusion.
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| CN109615999A (en) * | 2018-12-04 | 2019-04-12 | 紫罗兰家纺科技股份有限公司 | A kind of demonstration and detection method of energy product |
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| CN109965877A (en) * | 2019-04-08 | 2019-07-05 | 中国人民解放军陆军军医大学第二附属医院 | Portable tissue blood perfusion patient monitor based on abdomen impedance spectrum parameter |
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| CN109924969A (en) * | 2019-04-19 | 2019-06-25 | 优谱激光科技(南京)有限公司 | A kind of laser imaging blood perfusion detection device with light probe |
| CN114403840A (en) * | 2022-01-20 | 2022-04-29 | 雅安市人民医院 | Deep tissue perfusion degree calculation method based on near infrared spectrum |
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