CN204945144U - A kind of biochip intelligent detecting instrument - Google Patents
A kind of biochip intelligent detecting instrument Download PDFInfo
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- CN204945144U CN204945144U CN201520724966.XU CN201520724966U CN204945144U CN 204945144 U CN204945144 U CN 204945144U CN 201520724966 U CN201520724966 U CN 201520724966U CN 204945144 U CN204945144 U CN 204945144U
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Abstract
The utility model discloses intelligent biological chip detector, comprise biochip signal generation apparatus (9), biological chip reading apparatus device (14) and signal conditioning package (16), biochip signal generation apparatus (9) is connected by communication with biological chip reading apparatus device, and biological chip reading apparatus device (14) is connected with signal conditioning package (16) communication, biological chip reading apparatus device comprises biochip sample feeding mechanism, the image capture module be connected with biochip sample feeding mechanism, the USB data transmission module be connected with image capture module, the computing machine be connected with USB data transmission module, the printer be connected with computing machine, the utility model creates the efficiency that improve detection, reduce detection time, reduce testing cost, network structure can catch the medical diagnostic information of each check point in real time, on-line checkingi data, patient information etc., form a large-scale specialized medical information bank for setting up large-scale medical information storehouse.
Description
Technical field
The utility model relates to a kind of Medical treatment device, particularly relates to a kind of biochip intelligent detecting instrument.
Background technology
Current existing biochip supplies analysis is generally simple biological detection, datumization information reporting can only be provided according to the biological sampling provided, the diagnosis of most of common clinical and frequently-occurring disease cannot be covered, detected object is more single, cannot realize detecting multiple sample simultaneously, another existing quantitative detection means all needs operator while detection sample, and configuration standard product detect and drawing standard curve separately.
Utility model content
The technical problems to be solved in the utility model is to provide a kind of intelligent chip detector, and this detector can detect multiple sample simultaneously, and draws the diagnostic message of concrete illness after datumization is analyzed.
In order to solve the problems of the technologies described above, the utility model provides a kind of intelligent biological chip detector, comprises biochip signal generation apparatus, biological chip reading apparatus device and signal conditioning package; Biochip signal generation apparatus is connected by communication with biological chip reading apparatus device, and biological chip reading apparatus device is connected with signal conditioning package communication.Communication connects for data line connection, remote bluetooth connects or mobile data transfer connects.
As further improvement of the utility model, described biological chip reading apparatus device comprises biochip sample feeding mechanism, the image capture module be connected with biochip sample feeding mechanism, the USB data transmission module be connected with image capture module, the computing machine be connected with USB data transmission module, the printer that is connected with computing machine.
As further improvement of the utility model, the Sheng sample dish plug that described biochip sample feeding mechanism comprises sample injection disc, the Sheng sample dish be located on sample injection disc, six detecting positions be located on Sheng sample dish are located at Sheng Yang disk center, also comprises for controlling to contain the rotating mechanism of sample disc spins and the feed mechanism for controlling sample injection disc turnover.
As further improvement of the utility model, described sample injection disc one end is provided with trim.Described rotating mechanism comprises synchronous motor, the synchronous driving wheel be connected with synchronous motor, the Timing Belt be connected with synchronous driving wheel, the synchronous engaged wheel be connected with Timing Belt and the Sheng sample dish gear that is meshed with synchronous engaged wheel, and described Sheng sample dish gear is connected with Sheng sample dish plug.
As further improvement of the utility model, described feed mechanism comprises sample introduction motor, the direct current generator gear be connected with sample introduction motor, to pass in and out gear with the pallet that direct current generator gear is meshed and passes in and out with pallet the feed mechanism base that gear is connected, and described feed mechanism base is connected with sample injection disc;
As further improvement of the utility model, described synchronous motor adopts USB interface Communication Control or 89S52 Single-chip Controlling.
As further improvement of the utility model, described sample introduction motor adopts USB interface Communication Control or 89S52 Single-chip Controlling.
Adopt said structure, its beneficial effect is by the signal produced on biochip by image acquisition, photoelectricity analog to digital conversion with form digitized image file after quantizing for: described biological chip reading apparatus device, thus realizes the analysis to bio signal quantitative and qualitative analysis.The described signal conditioning package for carrying out stored digital and management is that the signal analysis information obtained by biological reading apparatus is carried out storing, analyzes, reports, added up and daily management.Also comprise the network connection device that can be used for realizing the wireless or cable network of each check point and connect, can detect multiple object simultaneously, can realize simultaneously to process and the analysis of multiple sample, described biological chip reading apparatus when quantitatively detecting without the need to drawing standard curve voluntarily.Thus greatly improve the efficiency of detection, reduce the time of detection, reduce the cost of detection, network structure can catch the medical diagnostic information, on-line checkingi data, patient information etc. of each check point in real time, forms a large-scale specialized medical information bank for setting up large-scale medical information storehouse.
Whole pick-up unit, easy to operate, fast diagnosis: in conjunction with biochip distinctive reaction kinetics performance and simple and direct operating process, the whole detection time is compared existing method and greatly reduces.Complete whole detection and only need 25 minutes, survey report result immediate delivery.Simple to operate, not high to personnel qualifications.High flux, multiple project detects disposable completing, and systematization detects and improves detection efficiency.
Multi objective parallel detection: existing method often carries out one-time detection can only detect an index, and biochip can detect the content of multiple project simultaneously, and this design of more crucially biochip, when needing even if follow-up to use more biochemical indicator to detect to inborn defect, can be accomplished and realize on a chip equally.Thus greatly improve the efficiency of detection, reduce the time of detection, in addition, multiple chips, multi-sample parallel detect.The design of biological chip reading apparatus can operate 6 increments basis and 6 chips simultaneously, improves the efficiency of detection.
The property of biochip and design make operator without the need to drawing standard curve voluntarily, greatly improve detection efficiency and reduce testing cost.
Accompanying drawing explanation
Fig. 1 is the structural representation of the utility model intelligent biological chip detector.
Fig. 2 is the front view of the biochip sample feeding mechanism of the utility model intelligent biological chip detector.
Fig. 3 is that Fig. 2 A-A is to sectional view.
Fig. 4 is that Fig. 2 B-B is to sectional view.
Fig. 5 is the theory diagram of the utility model intelligent biological chip detector.
Embodiment
Below in conjunction with accompanying drawing, the utility model is described in more detail.
Refer to shown in accompanying drawing 1-5, a kind of intelligent biological chip detector, comprise biochip signal generation apparatus, biological chip reading apparatus device, for carrying out the signal conditioning package of stored digital and management.
Biochip signal generation apparatus is for carrying the carrier of test serum sample, and make the specific antibody in sample to be checked that specific immunity association reaction occur with it and form Ag-Ab immune complex on NC film, resist and these compound specific bindings by two of gold mark or enzyme labeling again, direct colour developing or the colour developing of catalysis related substrates, produce the signal that can catch and analyze for biological chip reading apparatus.
Biological chip reading apparatus device comprises biochip sample feeding mechanism, the image capture module be connected with biochip sample feeding mechanism, the USB data transmission module be connected with image capture module, the computing machine be connected with USB data transmission module, the printer that is connected with computing machine; The signal that biochip produces is formed digitized image file by image acquisition, photoelectricity analog to digital conversion and quantification are rear by described biological chip reading apparatus device, thus realizes the analysis to bio signal quantitative and qualitative analysis.
That the signal analysis information obtained by biological reading apparatus is carried out storing, analyzes, reports, added up and daily management for carrying out the signal conditioning package of stored digital and management.Also comprise the network connection device that can be used for realizing the wireless or cable network of each check point and connect.Also comprise the print-out device that can realize data-printing.Biochip signal generation apparatus can detect multiple object simultaneously, and biological chip reading apparatus device can realize simultaneously to process and the analysis of multiple sample; Biological chip reading apparatus when quantitatively detecting without the need to drawing standard curve voluntarily.
Select the specific antigen (or antibody) of tested microorganism (or target protein), be fixed on nitrocellulose membrane with microarray formats, specificity tuberculosis reaction in sample, and form antigen-antibody complex, resist and these compound specific bindings by two of gold mark or enzyme labeling again, after colour developing, these varying strengths colour developing spot is after camera shooting and sampling and image procossing, shows as different gray-scale values.Dot matrix color signal on chip is transformed into digitized gray-scale value by reading apparatus, analyzes based on gray-scale value to chip.On chip, the colour developing value of each test item dot matrix is less than or equal to Cutoff value for positive, is greater than Cutoff value for negative.Biological chip reading apparatus analysis software can store this numerical information, analyze, report, add up and the several functions such as daily management.
Implementation process is: 1. biochip process color.The sample of chip detection is serum or the plasma specimen of human body.Serum specimen is according to a conventional method by venous collection, and after blood sampling, room temperature leaves standstill 1 ~ 2 hour, after blood clotting, clot contraction, then in 3000 revs/min, centrifugal 15 minutes, draws serum stand-by.The serum specimen detected in 7 days can place 4 DEG C of Refrigerator stores.Sample is placed on-20 DEG C of refrigerators can preserve 3 months.Sample should avoid haemolysis or multigelation.Muddy or have the sample of precipitation answer 8000 revs/min centrifugal after get supernatant and detect.The serum that need preserve should note sterile working in collection, preservation process.Be added on by test serum on biochip is that specific antibody (antigen) in sample to be checked with it specific immunity association reaction occurs and form Ag-Ab immune complex on NC film, resist and these compound specific bindings by two of gold mark or enzyme labeling again, direct colour developing or the colour developing of catalysis related substrates, the final signal producing biological chip reading apparatus and can catch and analyze.
Chip reading instrument image acquisition and digitized process: the multidisciplinary technology such as light harvesting, electromechanics, biomedicine, computing machine, iconography are in one, be equipped with MARA analyzing biochips software, the signal produced by biochip is by image acquisition, photoelectricity analog to digital conversion and form digitized image file after quantizing, thus realizes the analysis to bio signal quantitative and qualitative analysis.Chip reading instrument adopts reflected light principle that the dot matrix color signal on protein chip is transformed into digitized gray-scale value by special CCD, nearly focus optical system, video adapter etc., automatically identifies, extracts, analyzes based on gray-scale value to the impact point on protein chip.
Claims (7)
1. an intelligent biological chip detector, is characterized in that: comprise biochip signal generation apparatus (9), biological chip reading apparatus device (14) and signal conditioning package (16); Biochip signal generation apparatus (9) is connected by communication with biological chip reading apparatus device (14), and biological chip reading apparatus device (14) is connected with signal conditioning package (16) communication;
Described biological chip reading apparatus device (14) comprises biochip sample feeding mechanism, the image capture module be connected with biochip sample feeding mechanism, the USB data transmission module be connected with image capture module, the computing machine (17) be connected with USB data transmission module, the printer (18) that is connected with computing machine.
2. a kind of intelligent biological chip detector according to claim 1, it is characterized in that: described biochip sample feeding mechanism comprises sample injection disc (3), the Sheng sample dish (7) be located on sample injection disc (3), be located at six detecting positions (2) of containing on sample dish (7) and be located at Sheng sample dish plug (22) containing sample dish (7) center, also comprising for controlling to contain rotating mechanism that sample dish (7) rotates and for controlling the feed mechanism that sample injection disc (3) passes in and out.
3. a kind of intelligent biological chip detector according to claim 2, is characterized in that: described sample injection disc (3) one end is provided with trim (1).
4. a kind of intelligent biological chip detector according to claim 2, it is characterized in that: described rotating mechanism comprises: synchronous motor (15), the synchronous driving wheel (12), the Timing Belt (11) be connected with synchronous driving wheel (12), the synchronous engaged wheel (10) be connected with Timing Belt (11) and Sheng sample dish gear (8) be meshed with synchronous engaged wheel (10) that are connected with synchronous motor (15), described Sheng sample dish gear (8) is connected with Sheng sample dish plug (22).
5. a kind of intelligent biological chip detector according to claim 2, it is characterized in that: described feed mechanism comprises: sample introduction motor (13), the direct current generator gear (6) be connected with sample introduction motor (13), to pass in and out gear (5) and pass in and out with pallet the feed mechanism base (4) that gear (5) is connected with the pallet that direct current generator gear (6) is meshed, described feed mechanism base (4) is connected with sample injection disc (3).
6. a kind of intelligent biological chip detector according to claim 4, is characterized in that: described synchronous motor (15) adopts USB interface Communication Control or 89S52 Single-chip Controlling.
7. a kind of intelligent biological chip detector according to claim 5, is characterized in that: described sample introduction motor (13) adopts USB interface Communication Control or 89S52 Single-chip Controlling.
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| CN201520724966.XU CN204945144U (en) | 2015-09-18 | 2015-09-18 | A kind of biochip intelligent detecting instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106370832A (en) * | 2016-11-09 | 2017-02-01 | 苏州呼医疗科技有限公司 | Intelligent breath molecule diagnostic system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106370832A (en) * | 2016-11-09 | 2017-02-01 | 苏州呼医疗科技有限公司 | Intelligent breath molecule diagnostic system |
| CN106370832B (en) * | 2016-11-09 | 2024-02-27 | 苏州一呼医疗科技有限公司 | Intelligent expiration molecular diagnosis system |
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