CN204865083U - Post chromatographic system - Google Patents
Post chromatographic system Download PDFInfo
- Publication number
- CN204865083U CN204865083U CN201520374099.1U CN201520374099U CN204865083U CN 204865083 U CN204865083 U CN 204865083U CN 201520374099 U CN201520374099 U CN 201520374099U CN 204865083 U CN204865083 U CN 204865083U
- Authority
- CN
- China
- Prior art keywords
- feed liquid
- eluent
- gravity tank
- tank
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a post chromatographic system, including the eluate storage tank that is equipped with the eluate, the drawing liquid pump, the material liquid storage tank who treats the former feed liquid of elution is equipped with, the chromatography column, 2 eluate gravity tank and a feed liquid gravity tank more than individual, eluate tank outlet connects the import of drawing liquid pump, the drawing liquid pumps the mouth and is connected to each eluate gravity tank through total pipeline reposition of redundant personnel, material liquid storage tank connects the feed liquid gravity tank, each eluate gravity tank bottom export and the export of feed liquid gravity tank bottom join the import of inflow chromatography column through the pipeline, the storage tank is deposited to the feed liquid that the chromatography column is connected behind the outside elution, the chromatography column advances to be equipped with on the export pipeline entry flow control valve, the inlet flow rate meter, export flow control valve and rate of discharge meter. The utility model provides a post chromatographic system, efficiency is prepared to the solvent when effectively improving gradient elution, satisfies industrialization scale's gradient elution requirement, realizes the operation of elution continuity and convenience, reduces sample contamination and pump and corrode, can the at utmost reduce energy consumption and personnel's work load.
Description
Technical field
The utility model relates to pharmaceutical technology sectors, relates generally to a kind of column chromatography system.
Background technology
Column chromatography technology is the difference utilizing the molecular shape of material, size, electriferous state, solubility, adsorption capacity, distribution coefficient, the physicochemical property such as molecular polarity and affinity, to make in mixture each component to be distributed in Stationary liquid and mobile phase in various degree, each component is progressively separated, its advantage is that separative efficiency is high, separation condition Selecting parameter is strong, operating condition is gentle, is widely used in the separation and purification of Effective Component of Chinese Medicine.
The column chromatography of industrially scalable, its applied sample amount and eluting solvent consumption are often very large, and column chromatography generally adopts gradient elution just can reach good separating effect.Directly add sample solution and eluent according to pump, following problem can be caused: 1) loading flow velocity, eluent add flow velocity and be difficult to control; 2) sample solution through pump add membership cause sample contamination and pump corrosion; 3) power consumption is large; 4) during gradient elution, solvent preparation can bring very large workload, possibly cannot realize continuous wash-out.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of column chromatography system, meets actual production requirement, and this system can realize continuity, convenience operation, and at utmost can reduce energy consumption and person works's amount.
For solving the problems of the technologies described above, the technical solution of a kind of column chromatography system of the utility model is:
Comprise eluent is housed eluent storage tank 1, drawing liquid pump 2, the feed liquid storage tank 3 and chromatographic column 10 for the treatment of wash-out material liquid are housed, it is characterized in that: also comprise more than 2 eluent gravity tanks 4 and a feed liquid gravity tank 5; Eluent storage tank 1 exports and connects drawing liquid pump 2 import by pipeline; Drawing liquid pump 2 exports and is connected to each eluent gravity tank 4 by total pipeline shunting; Feed liquid storage tank 3 connects feed liquid gravity tank 5 by pipeline;
Each eluent gravity tank 4 outlet at bottom and feed liquid gravity tank 5 outlet at bottom flow into chromatographic column 10 import by ducts converge, each eluent gravity tank 4 outlet at bottom pipeline is provided with eluent gravity tank bottom valve 6, and feed liquid gravity tank 5 outlet at bottom pipeline is provided with feed liquid gravity tank bottom valve 7; Chromatographic column 10 deposits storage tank by the feed liquid after pipeline connects outside wash-out.
Preferably, column chromatography system of the present utility model, described chromatographic column 10 inlet pipeline is provided with inflow control valve 11.
Further, column chromatography system of the present utility model, described chromatographic column 10 inlet pipeline is provided with inlet flow rate meter 12.
Preferably, column chromatography system of the present utility model, described chromatographic column 10 outlet conduit is provided with outlet flow control valves 11a.
Further, column chromatography system of the present utility model, described chromatographic column 10 outlet conduit is provided with outlet flow gauge 12a.
Preferably, column chromatography system of the present utility model, described feed liquid gravity tank 5 top is provided with vacuum valve 8 and exhaust-valve 9, and vacuum valve 8 is connected with outside vaccum-pumping equipment, and exhaust-valve 9 is communicated with ambient pressure.
Further, column chromatography system of the present utility model, described exhaust-valve 9 is closed, and vacuum valve 8 is opened.
Further, column chromatography system of the present utility model, described exhaust-valve 9 is opened, and vacuum valve 8 cuts out.
Preferably, column chromatography system of the present utility model, the magnitude setting of described eluent gravity tank 4 is 1 ~ 6.
The technique effect that the utility model can reach is:
The utility model provides a kind of column chromatography system, solvent confecting efficiency during effective raising gradient elution, meets the gradient elution requirement of industrially scalable, realizes wash-out continuity and convenience operation, reduce sample contamination and pump corrosion, at utmost can reduce energy consumption and person works's amount.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the utility model is described in further detail:
Fig. 1 is column chromatography system schematic of the present utility model.
Description of reference numerals in figure:
1 is eluent storage tank, and 2 is drawing liquid pump,
3 is feed liquid storage tank, and 4 is eluent gravity tank,
5 feed liquid gravity tanks, 6 is eluent gravity tank bottom valve,
7 is feed liquid gravity tank bottom valve, and 8 is vacuum valve,
9 is exhaust-valve, and 10 is chromatographic column,
11 is inflow control valve 11a outlet flow control valves
12 for inlet flow rate meter 12a be outlet flow gauge
Detailed description of the invention
As shown in Figure 1, a kind of column chromatography system of the utility model, comprise eluent is housed eluent storage tank 1, drawing liquid pump 2, the feed liquid storage tank 3 and chromatographic column 10 for the treatment of wash-out material liquid are housed, also comprise more than 2 eluent gravity tanks 4 and a feed liquid gravity tank 5;
Eluent storage tank 1 exports and connects drawing liquid pump 2 import by pipeline;
Drawing liquid pump 2 exports the import being connected to each eluent gravity tank 4 by total pipeline shunting, opens drawing liquid pump 2, pumps in eluent gravity tank 4 for subsequent use by the eluent prepared in eluent storage tank 1.
Feed liquid storage tank 3 connects feed liquid gravity tank 5 by pipeline;
Each eluent gravity tank 4 outlet at bottom and feed liquid gravity tank 5 outlet at bottom flow into chromatographic column 10 import by ducts converge, each eluent gravity tank 4 outlet at bottom pipeline is provided with eluent gravity tank bottom valve 6, feed liquid gravity tank 5 outlet at bottom pipeline is provided with feed liquid gravity tank bottom valve 7, open eluent gravity tank bottom valve 6 and feed liquid gravity tank 7, feed liquid in eluent in eluent gravity tank 4 and feed liquid gravity tank 5, by flowing into chromatographic column 10 after ducts converge;
Chromatographic column 10 deposits storage tank by the feed liquid after pipeline connects outside wash-out, and the feed liquid after feed liquid flows into wash-out after chromatographic column 10 wash-out deposits storage tank;
Chromatographic column 10 inlet pipeline is provided with inflow control valve 11, controls the flow of eluent and feed liquid mixed liquor;
Chromatographic column 10 inlet pipeline is provided with inlet flow rate meter 12, and by observing the flow velocity of inlet flow rate meter 12, regulate inflow control valve 11, what regulate chromatographic column 10 enters flow velocity;
Chromatographic column 10 outlet conduit is provided with outlet flow control valves 11a;
Chromatographic column 10 outlet conduit is provided with outlet flow gauge 12a, opens feed liquid gravity tank 5 bottom valve 7, regulates chromatography column inlet flow control valve 11 to make flowmeter 12 reading reach requirement flow velocity and carries out loading, close bottom valve 7 and flow control valve 11 after end of the sample;
Open eluent gravity tank 4 bottom valve 6, regulate chromatography column inlet flow control valve 11 to make flowmeter 12 reading reach requirement flow velocity and add eluent, when in chromatographic column, eluent is added to certain liquid, the flow control valve 11a opening chromatographic column outlet is adjusted to identical flow velocity and carries out wash-out;
Feed liquid gravity tank 5 top is provided with vacuum valve 8 and exhaust-valve 9, and vacuum valve 8 is connected with outside vaccum-pumping equipment, and exhaust-valve 9 is communicated with ambient pressure, and what control feed liquid gravity tank 5 by regulating vacuum valve 9 and exhaust-valve 9 vacuumizes state;
Exhaust-valve 9 is closed, vacuum valve 8 is opened, and feed liquid gravity tank 5 is in vacuum state, by the pipeline of binder liquid storage tank 3, extracts the feed liquid in feed liquid storage tank 3 to feed liquid gravity tank 5;
Exhaust-valve 9 is opened, and vacuum valve 8 cuts out, and destroys the vacuum state of feed liquid gravity tank 5, stops extracting the feed liquid in feed liquid storage tank 3;
The magnitude setting of eluent gravity tank 4 is 1 ~ 6, opens drawing liquid pump 2, is pumped into by the eluent prepared in 1 ~ 6 eluent gravity tank 4 for subsequent use in eluent storage tank 1.
Claims (9)
1. a column chromatography system, comprise eluent is housed eluent storage tank, drawing liquid pump, the feed liquid storage tank and chromatographic column for the treatment of wash-out material liquid are housed, it is characterized in that: also comprise more than 2 eluent gravity tanks and a feed liquid gravity tank;
Drawing liquid pump import described in described eluent outlet is connected by pipeline;
Described drawing liquid pump outlet is connected to described each eluent gravity tank by total pipeline shunting;
Feed liquid gravity tank described in described feed liquid storage tank is connected by pipeline;
Chromatographic column import described in described each eluent gravity tank outlet at bottom and described feed liquid gravity tank outlet at bottom are flowed into by ducts converge, described each eluent gravity tank outlet at bottom pipeline is provided with eluent gravity tank bottom valve, and described feed liquid gravity tank outlet at bottom pipeline is provided with feed liquid gravity tank bottom valve;
Described chromatographic column deposits storage tank by the feed liquid after pipeline connects outside wash-out.
2. column chromatography system according to claim 1, is characterized in that: described chromatographic column inlet pipeline is provided with inflow control valve.
3. column chromatography system according to claim 2, is characterized in that: described chromatographic column inlet pipeline is provided with inlet flow rate meter.
4. column chromatography system according to claim 1, is characterized in that: described chromatographic column outlet conduit is provided with outlet flow control valves.
5. column chromatography system according to claim 4, is characterized in that: described chromatographic column outlet conduit is provided with outlet flow gauge.
6. column chromatography system according to claim 1, is characterized in that: described feed liquid gravity tank top is provided with vacuum valve and exhaust-valve, and described vacuum valve is connected with outside vaccum-pumping equipment, and described exhaust-valve is communicated with ambient pressure.
7. column chromatography system according to claim 6, is characterized in that: described exhaust-valve is closed, and described vacuum valve is opened.
8. column chromatography system according to claim 6, is characterized in that: described exhaust-valve is opened, and described vacuum valve cuts out.
9. column chromatography system according to claim 1, is characterized in that: the magnitude setting of described eluent gravity tank is 1 ~ 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520374099.1U CN204865083U (en) | 2015-06-03 | 2015-06-03 | Post chromatographic system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520374099.1U CN204865083U (en) | 2015-06-03 | 2015-06-03 | Post chromatographic system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204865083U true CN204865083U (en) | 2015-12-16 |
Family
ID=54809520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520374099.1U Expired - Fee Related CN204865083U (en) | 2015-06-03 | 2015-06-03 | Post chromatographic system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204865083U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245931A (en) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | Mechanical column chromatography device |
| CN113171732A (en) * | 2021-03-22 | 2021-07-27 | 中船重工（邯郸）派瑞特种气体有限公司 | Dangerous liquid feeding system and method |
-
2015
- 2015-06-03 CN CN201520374099.1U patent/CN204865083U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245931A (en) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | Mechanical column chromatography device |
| CN113171732A (en) * | 2021-03-22 | 2021-07-27 | 中船重工（邯郸）派瑞特种气体有限公司 | Dangerous liquid feeding system and method |
| CN113171732B (en) * | 2021-03-22 | 2022-05-17 | 中船(邯郸)派瑞特种气体股份有限公司 | Dangerous liquid feeding system and method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202762142U (en) | Easy semi-automatic chromatography column | |
| CN204865083U (en) | Post chromatographic system | |
| CN107132299A (en) | A kind of multichannel pack tomographic system | |
| CN102580354A (en) | Multi-layer composite T-shaped pipe separator and separation method for separating two-phase flow or multiphase flow | |
| CN210356123U (en) | Series connection chromatography device | |
| CN205995080U (en) | One kind isolates and purifies device | |
| CN208295193U (en) | It is a kind of with point to diversion function valve for chemical industry | |
| CN206045481U (en) | A kind of washing device for preparing the employing of tissue stem cell extract | |
| CN206093066U (en) | Modular intelligent flow adjusts flushometer | |
| CN205258084U (en) | Energy -saving reverse osmosis water purification machine | |
| CN104291413B (en) | Automatic resin conveying device for nuclear power secondary circuit system | |
| CN209451413U (en) | Vinegar egg juice beverage conduit filter | |
| CN208937544U (en) | The inorganic and organic mercury blended liquid phase chromatographic separation device of isotope analysis | |
| CN203370322U (en) | Multi-grade extraction and separation device | |
| CN207608598U (en) | Recycle the device of noble metal in solution | |
| CN207445672U (en) | Adjustable solid-phase extraction column attachment device | |
| CN207067074U (en) | A kind of process-scale chromatography isolates and purifies device | |
| CN202267622U (en) | Filtration-solid-phase extraction combined device | |
| CN205999149U (en) | A kind of energy-saving extra-high pressure gas counter-infiltration system | |
| CN207672021U (en) | A kind of essential oil extraction device | |
| CN207609901U (en) | A kind of threeway of regulating flow quantity | |
| CN206424794U (en) | Internal circulating membrane system | |
| CN206257305U (en) | It is a kind of to organic phase and the valve of water phase Gravity Separation | |
| CN220603382U (en) | Device for separating sodium tripolyphosphate by chromatography | |
| CN214862550U (en) | Equipment for removing heavy metal and residual pesticide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151216 Termination date: 20170603 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |