CN204709655U - A kind of precisely blood vessel photodynamic treatment device - Google Patents
A kind of precisely blood vessel photodynamic treatment device Download PDFInfo
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- CN204709655U CN204709655U CN201520076297.XU CN201520076297U CN204709655U CN 204709655 U CN204709655 U CN 204709655U CN 201520076297 U CN201520076297 U CN 201520076297U CN 204709655 U CN204709655 U CN 204709655U
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Abstract
This utility model relates to a kind of precisely blood vessel photodynamic treatment device, light dynamic method is utilized to treat vascular conditions, as nevus flammeus, choroidal artery disease etc., therapeutic equipment comprises treatment object lens, dichroscope, attenuating filters, monitoring lens, imageing sensor, spatial light modulator, treatment light source, wherein, imageing sensor is in the target vessel that is treated through treatment object lens, dichroscope, attenuating filters, monitoring lens after along the conjugate position on optical axis, spatial light modulator and the target vessel be treated are through treating object lens, conjugate position after dichroscope reflection, complete under external computer unit controls and treatment light source is penetrated through the accurate illumination of the selectivity of spatial light modulator to the target vessel be treated, thus control the irradiance for the treatment of light at target vessel, make photosensitizer, the blood oxygen concentration of light and target vessel reaches Optimum Matching, and avoid the photic damage to surrounding benign tissue.
Description
Technical field
The present invention relates to a kind of precisely blood vessel photodynamic treatment device, especially utilize light dynamic method to treat vascular conditions, as nevus flammeus, choroidal artery disease etc.
Background technology
Photodynamic therapy utilizes photosensitizer and light radiation generation photodynamic reaction to carry out a kind of new technique for the treatment of, compared to methods such as traditional chemotherapy, radiotherapies, photodynamic therapy have Wicresoft, toxicity humble, select the suitability good, can the advantage such as repetitive therapy and very little side effect.The curative effect of optical dynamic therapy relates to three kinds of key factors: photosensitizer, light dosage and tissue oxygen content, and its optimum curative effect depends on the best fit of three, and can reduce the damage to surrounding tissue.
Summary of the invention
The object of the invention is to provide accurate blood vessel photodynamic treatment device, use device of the present invention treatment light accurately can be projected target vessel, control the irradiance for the treatment of light at target vessel, make the blood oxygen concentration of photosensitizer, light and target vessel reach Optimum Matching, and avoid the photic damage to surrounding benign tissue.
The accurate blood vessel photodynamic treatment device of one according to the present invention, comprise treatment object lens, dichroscope, attenuating filters, monitoring lens, imageing sensor, spatial light modulator, treatment light source, wherein, imageing sensor is in the target vessel that is treated through treatment object lens, dichroscope, attenuating filters, monitoring lens after along the conjugate position on optical axis, spatial light modulator and the target vessel be treated are through treating object lens, conjugate position after dichroscope reflection, complete under external computer unit controls and treatment light source is penetrated through the accurate illumination of the selectivity of spatial light modulator to the target vessel be treated.
Monitor and Synchronization Control in demarcation before implementation process of the present invention mainly comprises treatment, treatment.Before treatment, calibration comprises the coordinate transformation relation etc. of the optical parametric of calibration treatment light source and projection lens thereof, treatment light source uniformity, the optical parametric of monitoring camera, treatment light source and monitoring camera; During treatment, according to the blood-vessel image that imageing sensor obtains, generate corresponding treatment modulation pattern in spatial light modulator, make treatment illumination cover blood vessel to be treated, and avoid irradiating normal structure.
According to therapy equipment of the present invention, because treatment light is accurately irradiated to target blood vessel thus decreases the damage to surrounding tissue, and can by the irradiation dose of modulation control, photosensitizer, light dosage and tissue oxygen content in light therapeutic process is made more easily to realize best fit, to obtain better therapeutic effect.
Accompanying drawing explanation
Fig. 1 is the system construction drawing of accurate blood vessel photodynamic treatment device of the present invention.
Fig. 2 is simulation target blood vessel digital picture schematic diagram formed by imageing sensor.
Fig. 3 is that spatial light modulator shines modulation image according to the transillumination of the digital image generation obtained, and wherein the transmitance of black region is minimum.
Fig. 4 is the lighting simulation design sketch at simulation target blood vessel, and dotted line inside is divided into effective illumination to illustrate, namely carries out for treatment area for treatment, and normal structure place is unglazed irradiation then.
Fig. 5 is by system construction drawing according to another embodiment of the present invention, and spatial light modulator becomes the system construction drawing of reflectance regulative mode.
In accompanying drawing, each label represents respectively: 1-target vessel, 2-treatment object lens, 3-dichroscope, 4-attenuating filters, 5-monitoring lens, 6-imageing sensor, 7-spatial light modulator, 8-treat light source.
Detailed description of the invention
Below in conjunction with accompanying drawing and example, the present invention is done and further describes in detail.At this, schematic description and description of the present invention is for explaining the present invention, but not as a limitation of the invention.
According to Fig. 1, imageing sensor (6) is in target vessel (1) optics through being arranged in order: the conjugate position after treatment object lens (2), dichroscope (3), attenuating filters (4), monitoring lens (5), spatial light modulator (7) then with target vessel (1) through treating object lens (2), dichroscope (3) reflect after conjugate position; Treatment light source (8) preferentially can adopt LASER Light Source, or the LED source etc. of collimation.
Before using, first system completes the demarcation of internal optics parameter.Target vessel (1) simulator or non-uniform reflection plate are positioned over operating position by operator, spatial light modulator (7) modulation therapy light source (8) forms correcting image under control of the computer, and synchronous this projected image that obtains is through dichroscope (3) and a series of images imaging in imageing sensor (6) after treating object lens (2), computer solving obtains the mapping relations of imageing sensor (6) and spatial light modulator (3) each pixel, i.e. calibration coefficient.
During treatment, the image of patient's target vessel (1) is obtained through servicing lighting, then this image is mapped to spatial light modulator (7) through calibration coefficient and form map image, also can expand to this map image by image processing algorithm under physician guidance, the operation such as corrosion, make treatment illumination cover target vessel (1) as requested.
According to the reflectance of dichroscope (3) and the relation of refractive index, spatial light modulator (7) and treatment light source (8) therapy component that forms can with imageing sensor (6), monitor the monitor component mirror image that lens (5) and attenuating filters (4) form and exchanges, the effect of attenuating filters (4) is the contrast improving imageing sensor (6), can install as required.The range size of pixel is regulated by image processing algorithm, and reflectance or transmitance pass through Timing.
Equally, spatial light modulator (3) can select the transmitance regulative mode as Fig. 1, also can select reflectance mode as shown in Figure 5.
According to said system of the present invention, the optical imagery of the target vessel (1) be treated is obtained by imageing sensor (6), reflectance or the transmitance that spatial light modulator (7) regulates respective pixel is controlled according to calibration coefficient, thus control the illuminance of target vessel (1) correspondence position, and then control this pixel and to overlap with the target vessel be treated (1) degree through treatment object lens (2) imaging.
The above is only embodiments of the invention, not does any pro forma restriction to structure of the present invention.Every above embodiment is done according to technical spirit of the present invention any simple modification, equivalent variations and modification, all still belong in the scope of technical scheme of the present invention.
Claims (4)
1. an accurate blood vessel photodynamic treatment device, accurately treat for carrying out blood vessel light power, comprise treatment object lens (2), dichroscope (3), attenuating filters (4), monitoring lens (5), imageing sensor (6), spatial light modulator (7), treatment light source (8), wherein, imageing sensor (6) is in the target vessel (1) that is treated through treatment object lens (2), dichroscope (3), attenuating filters (4), after monitoring lens (5) along the conjugate position on optical axis, spatial light modulator (7) and the target vessel (1) be treated are through treating object lens (2), conjugate position after dichroscope (3) reflection, complete under external computer unit controls and treatment light source (8) is penetrated through the accurate illumination of selectivity of spatial light modulator (7) to the target vessel be treated (1).
2. accurate blood vessel photodynamic treatment device according to claim 1, it is characterized in that light that described treatment light source (8) sends is through spatial light modulator (7) transmission or reflection directive dichroscope (3), carry out system calibrating by gathering scaling board and controlling spatial light modulator (7) projection uncalibrated image, obtain the corresponding relation of imageing sensor (6) each pixel and spatial light modulator (7) each pixel as calibration coefficient.
3. accurate blood vessel photodynamic treatment device according to claim 1, it is characterized in that the optical imagery being obtained the target vessel (1) be treated by imageing sensor (6), reflectance or the transmitance that spatial light modulator (7) regulates respective pixel is controlled according to calibration coefficient, thus control the illuminance of (1) target vessel correspondence position, and then control this pixel and to overlap with the target vessel be treated (1) degree through treatment object lens (2) imaging.
4. accurate blood vessel photodynamic treatment device according to claim 1, treatment light source (8) can adopt LASER Light Source, or the LED source of collimation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520076297.XU CN204709655U (en) | 2015-02-03 | 2015-02-03 | A kind of precisely blood vessel photodynamic treatment device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520076297.XU CN204709655U (en) | 2015-02-03 | 2015-02-03 | A kind of precisely blood vessel photodynamic treatment device |
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| CN204709655U true CN204709655U (en) | 2015-10-21 |
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| CN201520076297.XU Expired - Fee Related CN204709655U (en) | 2015-02-03 | 2015-02-03 | A kind of precisely blood vessel photodynamic treatment device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018040842A1 (en) * | 2016-08-29 | 2018-03-08 | 武汉亚格光电技术股份有限公司 | Intelligent nevus flammeus photodynamic therapeutic instrument system |
| CN108371756A (en) * | 2018-02-10 | 2018-08-07 | 中国医学科学院生物医学工程研究所 | A kind of diagnosis and treatment one cervical lesions photodynamic therapy system |
| CN109224315A (en) * | 2018-09-13 | 2019-01-18 | 邵永红 | Visualize photodynamic therapy system |
| CN110013610A (en) * | 2019-04-30 | 2019-07-16 | 东北大学 | A kind of optical heating device based on imaging |
-
2015
- 2015-02-03 CN CN201520076297.XU patent/CN204709655U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018040842A1 (en) * | 2016-08-29 | 2018-03-08 | 武汉亚格光电技术股份有限公司 | Intelligent nevus flammeus photodynamic therapeutic instrument system |
| CN108371756A (en) * | 2018-02-10 | 2018-08-07 | 中国医学科学院生物医学工程研究所 | A kind of diagnosis and treatment one cervical lesions photodynamic therapy system |
| CN108371756B (en) * | 2018-02-10 | 2024-01-30 | 中国医学科学院生物医学工程研究所 | Diagnosis and treatment integrated cervical lesion photodynamic therapy system |
| CN109224315A (en) * | 2018-09-13 | 2019-01-18 | 邵永红 | Visualize photodynamic therapy system |
| CN110013610A (en) * | 2019-04-30 | 2019-07-16 | 东北大学 | A kind of optical heating device based on imaging |
| WO2020220470A1 (en) * | 2019-04-30 | 2020-11-05 | 东北大学 | Imaging-based light heating apparatus |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151021 Termination date: 20180203 |
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| CF01 | Termination of patent right due to non-payment of annual fee |