CN103933671A - Precision photodynamic therapy system - Google Patents
Precision photodynamic therapy system Download PDFInfo
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- CN103933671A CN103933671A CN201410163212.1A CN201410163212A CN103933671A CN 103933671 A CN103933671 A CN 103933671A CN 201410163212 A CN201410163212 A CN 201410163212A CN 103933671 A CN103933671 A CN 103933671A
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- computer
- photosensitizer
- photodynamic therapy
- therapy system
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Abstract
The invention relates to a precision photodynamic therapy system which comprises an intravenous device use for injecting photosensitizer to the human body and a laser used for the illuminating nevus flammeus lesion portion of the human body. The photodynamic therapy system further comprises a digital micromirror device, a weak light detection system and a computer, wherein the weak light detection system is used for motivating and measuring the fluorescence-emission of the photosensitizer and organization spectrum through ultraviolet, and transmitting the detection information to the computer; the computer is used for calculating the concentration distribution of the photosensitizer in an organization according to the detection information, and generating a control signal for controlling the digital micromirror device; the digital micromirror device is used for adjusting the optical intensity distribution iradiated by the laser on the lesion portion under the control of the computer. By means of the precision photodynamic therapy system, the precision light dose delivery can be achieved, treatment effect is improved, and side effects are reduced.
Description
Technical field
Native system belongs to optical dynamic therapy equipment technical field, relates to digital micro-mirror device and is combined with optical dynamic therapy instrument.
Background technology
Nevus flammeus, claims again portwine stain, is that a kind of comparatively common high dermis congenital, low blood flow is main vascular malformation, during birth, exists, can not disappear voluntarily, Neonatal Morbidity up to.Histologic characteristics is blood capillary or the little vasodilation of papillary layer of corium or lamina reticularis, can invade and hypodermic shallow-layer, but without vascular endothelial proliferation.This disease often occurs in neck surface, and the most common with nervi trigeminus areal area, has a strong impact on patient's appearance, and patient is produced to serious mental pressure, may affect patient's personality development, and therefore, the hope that patient seeks treatment is very urgent.
At present look after home or domestic affairs beautiful jade etc. of state has successively been reported application photodynamic therapy treatment nevus flammeus.This novel therapies can optionally destroy this disease and be arranged in papillary layer of corium and expand lopsided capillary network, does not damage again the normal skin covering on it, without cicatrix, relatively very little to other skin injurys after treatment.
But, existing optical dynamic therapy equipment, in laser irradiation part, employing be even laser irradiation, as shown in Figure 1.Do not consider that focus different parts photosensitizer content is different, required intensity of illumination also should be different.Uniform irradiation makes the serious position of pathological changes not obtain enough illumination and cause treatment not thorough, and therapeutic effect is not good.Meanwhile, color is excessive compared with the illumination of superficial part position, and skin is caused to certain damage.
Summary of the invention
The object of the invention is to overcome the deficiency of existing optical dynamic therapy equipment, provide a kind of and can realize precision optical dynamic therapy, thereby can realize the therapeutic equipment of better healing effect.Technical scheme of the present invention is as follows:
A kind of photodynamic therapy system, comprise for the intravenous injection device to human injection's photosensitizer, for the laser instrument that the nevus flammeus lesions position of human body is irradiated, it is characterized in that, described photodynamic therapy system also comprises digital micro-mirror device, faint light detection system and computer, wherein
Described faint light detection system, for utilizing ultraviolet excitation and measuring fluorescent emission and the tissue spectrum of photosensitizer, and will detect the information transmission to computer;
Described computer is used for calculating according to detection information the CONCENTRATION DISTRIBUTION of photosensitizer in tissue, and generates the control signal of control figure micro mirror device;
Described digital micro-mirror device, for regulating laser illumination to arrive the light intensity distributions of lesions position under the control of computer.
Photodynamic therapy system of the present invention increases digital micro-mirror device (DMD), faint light detection system in existing photodynamic therapy system, after intravenous injection photosensitizer, and the demand by Algorithm Analysis focus different parts to light intensity.Regulate as required bright dark position, the light outgoing intensity of digital micro-mirror device, thereby realize the output intensity distribution of control figure micro mirror device.And then meet the required light intensity requirement of focus each several part, thereby can realize accurate optical dynamic therapy.
Accompanying drawing explanation
Fig. 1, treat general flow chart at present.
Treatment general flow chart after Fig. 2, improvement.
Therapy system after Fig. 3, improvement.
Description of reference numerals is as follows: 1, laser instrument; 2, DMD digital micro-mirror device; 3, computer; 4, faint light detection system; 5, focus; 6, holding wire
The specific embodiment
Photodynamic therapy system provided by the invention, the digital micro-mirror device (DMD) adopting, relies on micromirror rotation imaging.In each pixel, all have a rotary micro mirror, the position of micro mirror is different, and catoptrical shooting angle is just not identical, so each micro mirror is equivalent to a photoswitch.When photoswitch is when " ON state ", it is upper that reflected light just can be thrown into by projecting lens " screen ", and " screen " upper occurs bright state; Switch is when " OFF state ", and reflected light is thrown less than " screen " upper, and " screen " upper occurs dark state.By organism optical forward model carry out intralesional everywhere required light dosage calculate, and by computer control DMD, realize accordingly the accurate input of light dosage.
Utilize whole flow process that therapy system of the present invention treats as shown in Figure 2, therapy system structural representation as shown in Figure 3.
After intravenous injection photosensitizer, because it has fluorescent emission ability, utilize faint light detection system 4 burst of ultraviolel and measure fluorescent emission and the tissue spectrum of photosensitizer, by the information transmission to computer 3.Computer is by calculating the CONCENTRATION DISTRIBUTION of photosensitizer in tissue.Meanwhile, according to the conventional optical dynamic therapy specification of nevus flammeus, laser instrument 1 output largest light intensity.The laser of output is got on digital micro-mirror device 2.Computer, according to photosensitizer distributed density, utilizes organism optical forward model to calculate the focus 5 required light intensity distributions in each position.And control the bright dark position of micro mirror, light outgoing intensity, the output intensity of realizing control figure micro mirror device distributes, and then meets the required light intensity requirement of focus each several part.
Claims (1)
1. a photodynamic therapy system, comprise for the intravenous injection device to human injection's photosensitizer, for the laser instrument that the nevus flammeus lesions position of human body is irradiated, it is characterized in that, described photodynamic therapy system also comprises digital micro-mirror device, faint light detection system and computer, wherein
Described faint light detection system, for utilizing ultraviolet excitation and measuring fluorescent emission and the tissue spectrum of photosensitizer, and will detect the information transmission to computer;
Described computer, for calculate the CONCENTRATION DISTRIBUTION of photosensitizer in tissue according to detection information, and generates the control signal of control figure micro mirror device;
Described digital micro-mirror device, for regulating laser illumination to arrive the light intensity distributions of lesions position under the control of computer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410163212.1A CN103933671A (en) | 2014-04-22 | 2014-04-22 | Precision photodynamic therapy system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410163212.1A CN103933671A (en) | 2014-04-22 | 2014-04-22 | Precision photodynamic therapy system |
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| CN103933671A true CN103933671A (en) | 2014-07-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201410163212.1A Pending CN103933671A (en) | 2014-04-22 | 2014-04-22 | Precision photodynamic therapy system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224315A (en) * | 2018-09-13 | 2019-01-18 | 邵永红 | Visualize photodynamic therapy system |
| CN110681070A (en) * | 2019-10-31 | 2020-01-14 | 福建师范大学 | Photodynamic therapy light source capable of being regulated and controlled in personalized mode and regulation and control method |
| CN111991704A (en) * | 2020-08-28 | 2020-11-27 | 深圳大学 | Treatment method based on photodynamic treatment system and photodynamic treatment system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6146410A (en) * | 1995-11-24 | 2000-11-14 | Nagypal; Tibor | Apparatus for the photodynamic treatment of living beings or organs thereof |
| CN101301205A (en) * | 2008-06-30 | 2008-11-12 | 北京心润心激光医疗设备技术有限公司 | Light power medical instrument for nevus flammeus |
| CN101862510A (en) * | 2010-05-12 | 2010-10-20 | 中国科学院半导体研究所 | Two-photon excitation based tumor diagnosis and photodynamic tumor-treatment instrument |
| US20120314224A1 (en) * | 2010-02-26 | 2012-12-13 | Luellau Engineering Gmbh | Method and irradiating device for irradiating curved surfaces with non-ionizing radiation |
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2014
- 2014-04-22 CN CN201410163212.1A patent/CN103933671A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6146410A (en) * | 1995-11-24 | 2000-11-14 | Nagypal; Tibor | Apparatus for the photodynamic treatment of living beings or organs thereof |
| CN101301205A (en) * | 2008-06-30 | 2008-11-12 | 北京心润心激光医疗设备技术有限公司 | Light power medical instrument for nevus flammeus |
| US20120314224A1 (en) * | 2010-02-26 | 2012-12-13 | Luellau Engineering Gmbh | Method and irradiating device for irradiating curved surfaces with non-ionizing radiation |
| CN101862510A (en) * | 2010-05-12 | 2010-10-20 | 中国科学院半导体研究所 | Two-photon excitation based tumor diagnosis and photodynamic tumor-treatment instrument |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224315A (en) * | 2018-09-13 | 2019-01-18 | 邵永红 | Visualize photodynamic therapy system |
| CN110681070A (en) * | 2019-10-31 | 2020-01-14 | 福建师范大学 | Photodynamic therapy light source capable of being regulated and controlled in personalized mode and regulation and control method |
| CN110681070B (en) * | 2019-10-31 | 2021-02-26 | 福建师范大学 | Photodynamic therapy light source capable of being regulated and controlled in personalized mode and regulation and control method |
| CN111991704A (en) * | 2020-08-28 | 2020-11-27 | 深圳大学 | Treatment method based on photodynamic treatment system and photodynamic treatment system |
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Application publication date: 20140723 |