CN204364476U - Ambroxol effervescent tablet - Google Patents
Ambroxol effervescent tablet Download PDFInfo
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- CN204364476U CN204364476U CN201420713324.5U CN201420713324U CN204364476U CN 204364476 U CN204364476 U CN 204364476U CN 201420713324 U CN201420713324 U CN 201420713324U CN 204364476 U CN204364476 U CN 204364476U
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- ambroxol
- acid source
- effervescent tablet
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- capsule skin
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Abstract
The utility model discloses a kind of ambroxol effervescent tablet, comprise acid source layer, ambroxol medicine layer and alkali source layer from inside to outside successively, described acid source layer comprises acid source utricule; Acid source utricule comprises the first capsule skin of acid source and parcel acid source; First capsule Intradermal is filled with alkali source granule.Ambroxol effervescent tablet of the present utility model, stable in properties, can not affect the stability of effervescent tablet because of the acid source moisture absorption; When needs effervescent, rate of effervescence is fast; Energy secondary effervescent, effervescent is abundant.
Description
Technical field
This utility model belongs to drug world, particularly a kind of ambroxol effervescent tablet.
Background technology
Ambroxol is mainly used in being applicable to acute and chronic respiratory tract disease, the thick sputum caused as acute and chronic bronchitis, bronchial asthma, bronchiectasis, pulmonary tuberculosis etc., the treatment of dys-expectoration disease, its preparation has ambroxol injection, Ambroxol Hydrochloride Oral Solution, ambroxol tablets, ambroxol capsule etc. at present.The oral formulations taste of injection use inconvenience, liquid preparation poor stability, other series is not good.Effervescent tablet can solve the problem of existing preparation well, onset is rapid, bioavailability is high, and mouthfeel is good, be particularly suitable for child, old people garment is used, but find no precedent ambroxol being made effervescent tablet in prior art, and most of effervescent tablet due to the acid source easy moisture absorption, quality is unstable.In order to solve the problem of the easy moisture absorption of acid source, be generally adopt soda acid to granulate respectively, remix tabletting after soda acid granule, object reduces the contact area of soda acid granule, improves the stability of sample; But the sample stability of preparation is still not high like this.
Utility model content
The purpose of this utility model is to provide and a kind ofly effectively can solves the easy moisture absorption of acid source and cause the ambroxol effervescent tablet of the problem of effervescent tablet instability.
Specific description is done to content of the present utility model below:
Ambroxol effervescent tablet of the present utility model, ambroxol effervescent tablet comprises acid source layer, ambroxol medicine layer and alkali source layer from inside to outside successively, and described acid source layer comprises acid source utricule; Acid source utricule comprises the first capsule skin of acid source and parcel acid source; First capsule Intradermal is filled with alkali source granule.
Acid source layer is arranged on innermost layer, prevents its moisture absorption; Be wrapped in by acid source in the first capsule skin, alkali source is particles filled in the first capsule Intradermal simultaneously, by soda acid source material separately, when needing effervescent, acid source is easy to mix with alkali source material and effervescent, can realize the effect of secondary effervescent, reach good effervescent effect.
Ambroxol effervescent tablet of the present utility model, is also provided with the second capsule skin between acid source layer and ambroxol medicine layer, the second capsule Intradermal is filled with moisture absorption granule.
The setting of moisture absorption granule in second capsule skin, can stop the moisture absorption of soda acid source material further, ensures the stability of ambroxol effervescent tablet.
Ambroxol effervescent tablet of the present utility model, is also provided with the 3rd capsule skin between ambroxol medicine layer and alkali source layer; Acid source granule is filled with in 3rd capsule skin.
The setting of acid source granule in 3rd capsule skin, can act on mutually with alkali source layer, and form an effervescent, rate of effervescence is fast.
Ambroxol effervescent tablet of the present utility model, ambroxol medicine layer is eight flap-type structures, and two adjacent lobes are filled with ambroxol utricule and ambroxol granule respectively, and ambroxol utricule is the utricule being filled with ambroxol liquid; Ambroxol granule is slow-release micro-pill or sustained-release micro-spheres.
Eight flap-type structures improve the contact area of acid source layer and alkali source layer, after effervescent, make it disperse evenly, be filled with ambroxol liquid in ambroxol utricule, can absorb fast, rapid-onset; Ambroxol granule plays the effect of slow release.
Ambroxol effervescent tablet of the present utility model, the 3rd capsule skin is provided with equally distributed groove.
The setting of groove, when needs effervescent, can accelerate rate of effervescence, makes effervescent tablet quick acting further.
Ambroxol effervescent tablet of the present utility model, alkali source layer comprises alkali source material and the 4th capsule skin, and alkali source material is filled in groove, and the 4th capsule suitcase is wrapped in the skin of the 3rd capsule skin and is fixed the alkali source material be filled in groove.
Alkali source layer be arranged on outermost layer serve in and the effect of gastric acid, can available protecting stomach; Also itself and acid source are separated simultaneously, improve ambroxol effervescent tablet stability; The alkali source material of alkali source layer can play the effect of first time effervescent with the acid source granule in the 3rd capsule skin.
The beneficial effect of ambroxol effervescent tablet of the present utility model is: ambroxol effervescent tablet of the present utility model, stable in properties, can not affect the stability of effervescent tablet because of the acid source moisture absorption; When needs effervescent, rate of effervescence is fast, can secondary effervescent, and effervescent is abundant.
Accompanying drawing explanation
Fig. 1 is the perspective view of ambroxol effervescent tablet of the present utility model;
Fig. 2 is the A-A profile of ambroxol effervescent tablet in embodiment 1;
Fig. 3 is the A-A profile of ambroxol effervescent tablet in embodiment 2;
Fig. 4 is the A-A profile of ambroxol effervescent tablet in embodiment 3;
Fig. 5 is the A-A profile of ambroxol effervescent tablet in embodiment 4;
Fig. 6 is the A-A profile of ambroxol effervescent tablet in embodiment 5.
Detailed description of the invention
Below in conjunction with embodiment, the utility model is described in further detail:
Embodiment 1
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1, 2,1 is acid source layer, and 11 is acid source utricule, and 111 is acid source, and 112 is the first capsule skin, and 113 is alkali source granule; 2 is ambroxol medicine layer; 3 is alkali source layer.
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1, 2, ambroxol effervescent tablet comprises acid source layer 1, ambroxol medicine layer 2 and alkali source layer 3 from inside to outside successively, and acid source layer 1 comprises acid source utricule 11; Acid source utricule 11 comprises the first capsule skin 112 of acid source 111 and parcel acid source; Alkali source granule 113 is filled with in first capsule skin 112.
Embodiment 2
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1,3,1 is acid source layer, and 11 is acid source utricule, and 111 is acid source, and 112 is the first capsule skin, and 113 is alkali source granule; 2 is ambroxol medicine layer; 3 is alkali source layer; 4 is the second capsule skin; 41 is moisture absorption granule.
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1,3, except from embodiment 1 exist following different except, all the other are all identical: be also provided with between acid source layer 1 and ambroxol medicine layer 2 in second capsule skin 4, second capsule skin 4 and be filled with moisture absorption granule 41.
Embodiment 3
Ambroxol effervescent tablet of the present utility model, as shown in Fig. 1,4,1 is acid source layer, and 11 is acid source utricule, and 111 is acid source, and 112 is the first capsule skin, and 113 is alkali source granule; 2 is ambroxol medicine layer; 3 is alkali source layer; 4 is the second capsule skin; 41 is moisture absorption granule; 5 is the 3rd capsule skin, and 51 is acid source granule.
Ambroxol effervescent tablet of the present utility model, as shown in Fig. 1,4, except from embodiment 2 exist following different except, all the other are all identical: be also provided with the 3rd capsule skin 5 between ambroxol medicine layer 2 and alkali source layer 3; Acid source granule 51 is filled with in 3rd capsule skin 5.
Embodiment 4
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1,5,1 is acid source layer, and 11 is acid source utricule, and 111 is acid source, and 112 is the first capsule skin, and 113 is alkali source granule; 2 is ambroxol medicine layer, and 21 is ambroxol utricule, and 22 is ambroxol granule; 3 is alkali source layer; 4 is the second capsule skin; 41 is moisture absorption granule; 5 is the 3rd capsule skin, and 51 is acid source granule.
Ambroxol effervescent tablet of the present utility model, as shown in Figure 1,5, except from embodiment 3 exist following different except, all the other are all identical: ambroxol medicine layer 2 is eight flap-type structures, two adjacent lobes are filled with ambroxol utricule 21 and ambroxol granule 22 respectively, and ambroxol utricule 21 is for being filled with the utricule of ambroxol liquid; Ambroxol granule 22 is slow-release micro-pill or sustained-release micro-spheres.
Embodiment 5
Ambroxol effervescent tablet of the present utility model, as a shown in Figure 6,1 is acid source layer, and 11 is acid source utricule, and 111 is acid source, and 112 is the first capsule skin, and 113 is alkali source granule; 2 is ambroxol medicine layer, and 21 is ambroxol utricule, and 22 is ambroxol granule; 3 is alkali source layer, and 31 is alkali source material, and 32 is the 4th capsule skin; 4 is the second capsule skin; 41 is moisture absorption granule; 5 is the 3rd capsule skin, and 51 is acid source granule.
Ambroxol effervescent tablet of the present utility model, as a shown in Figure 6, except from embodiment 4 exist following different except, all the other are all identical: the 3rd capsule skin 5 is provided with equally distributed groove; Alkali source layer 3 comprises alkali source material 31 and the 4th capsule skin 32, and alkali source material 31 is filled in groove, and the 4th capsule skin 32 is wrapped in the skin of the 3rd capsule skin 5 and is fixed the alkali source material 31 be filled in groove.
The beneficial effect of ambroxol effervescent tablet of the present utility model is: ambroxol effervescent tablet of the present utility model, stable in properties, can not affect the stability of effervescent tablet because of the acid source moisture absorption; When needs effervescent, rate of effervescence is fast; Energy secondary effervescent, effervescent is abundant.
Claims (6)
1. an ambroxol effervescent tablet, it is characterized in that, described ambroxol effervescent tablet comprises acid source layer (1), ambroxol medicine layer (2) and alkali source layer (3) from inside to outside successively, and described acid source layer (1) comprises acid source utricule (11); Described acid source utricule (11) comprises the first capsule skin (112) of acid source (111) and parcel acid source; Alkali source granule (113) is filled with in described first capsule skin (112).
2. ambroxol effervescent tablet according to claim 1, it is characterized in that, also be provided with the second capsule skin (4) between described acid source layer (1) and ambroxol medicine layer (2), in described second capsule skin (4), be filled with moisture absorption granule (41).
3. ambroxol effervescent tablet according to claim 2, is characterized in that, is also provided with the 3rd capsule skin (5) between described ambroxol medicine layer (2) and alkali source layer (3); Acid source granule (51) is filled with in described 3rd capsule skin (5).
4. ambroxol effervescent tablet according to claim 3, it is characterized in that, described ambroxol medicine layer (2) is eight flap-type structures, two adjacent lobes are filled with ambroxol utricule (21) and ambroxol granule (22) respectively, and described ambroxol utricule (21) is for being filled with the utricule of ambroxol liquid; Described ambroxol granule (22) is slow-release micro-pill or sustained-release micro-spheres.
5. ambroxol effervescent tablet according to claim 4, is characterized in that, described 3rd capsule skin (5) is provided with equally distributed groove.
6. ambroxol effervescent tablet according to claim 5, it is characterized in that, described alkali source layer (3) comprises alkali source material (31) and the 4th capsule skin (32), described alkali source material (31) is filled in described groove, and described 4th capsule skin (32) is wrapped in the skin of described 3rd capsule skin (5) and is fixed the alkali source material (31) be filled in described groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420713324.5U CN204364476U (en) | 2014-11-24 | 2014-11-24 | Ambroxol effervescent tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420713324.5U CN204364476U (en) | 2014-11-24 | 2014-11-24 | Ambroxol effervescent tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204364476U true CN204364476U (en) | 2015-06-03 |
Family
ID=53320734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420713324.5U Active CN204364476U (en) | 2014-11-24 | 2014-11-24 | Ambroxol effervescent tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204364476U (en) |
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2014
- 2014-11-24 CN CN201420713324.5U patent/CN204364476U/en active Active
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |