CN204269592U - Multiparameter expiration nitric oxide measurement mechanism without a break - Google Patents
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Abstract
Disclose a kind of measurement mechanism of multiparameter expiration nitric oxide without a break, this device utilizes elongated tubular (ensureing that gas flowing is wherein piston flow when exhaling sampling and analysis to measure) with the expiration gas under the different expiratory duration (flow velocity) of fast speed synchronous collection in exhalation process, when analyzing to be passed through to carry out analysis to measure into sensor by the gas collected in elongated tubular compared with low flow velocity; Designed by gas circuit and make the NO concentration curve of sensor record corresponding with expiratory gas flow (time) curve to the control of gas flow ratio when sampling and measurement, thus realize utilizing the measurement of the electrochemical sensor of slow-response realization to fast-changing expiration NO concentration, and then calculate exhaled NO parameters according to expiration NO two compartment model.
Description
Technical field
The present invention relates to expiration nitric oxide measuring equipment.
Background technology
Expiration nitric oxide is analyzed as the detection that the mark of airway inflammation is used for the respiratory diseases such as asthma and has been obtained medical profession abundant affirmation.Thoracic cavity association of the U.S. and Europe are breathed association and were combined in 2005 and formulate and disclose the standardized method (" ATS/ERS ecommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Low Respiratory Nitric Oxide and Nasal Nitric Oxide; 2005 ") carrying out this measurement and propose its clinical practice guide (An Official ATS Clinical Practice Guideline:Interpretation of exhaled Nitric Oxide Level (FeNO) for Clinical Applications) in 2011, and these standards and guide are used for instructing diagnosis and therapeutic evaluation how to carry out detecting and testing result is used for the respiratory diseases such as asthma.
Because expiration NO is relevant with exhalation flow rate, and be easily subject to the interference of nasal cavity gas, thus the standardization expiration nitric oxide measuring method of ATS/ERS recommendation is for measuring the inflammation of lower respiratory tract, require under breath pressure is more than or equal to the condition of 5cm water column, single sustained exhalation is carried out 10 seconds (or children 6 seconds) under the fixing exhalation flow rate of 50ml/s, select the expiratory gas flow of 50ml/s main it is considered that under this flow, the contribution main source of expiration NO and air flue, and expiration control is easier to.
Nitrogen monoxide in expiration derives from alveolar and air flue, if can distinguish the NO concentration of zones of different, can evaluate the NO secretion raised or reduce occurs in which pathological regions, have clinical reference value widely.
About the meaning of steady state alveolar gas concentration at clinicing aspect, Hogman (J. Breath Res. 6 (2012) 047103) comments more than 100 section of document before 2012, it and some diseases relation can brief summary as follows:
1) asthma degree of depth diagnosis: bronchitis Ca
nOconstant and Jaw raises, bronchiolitis disease Ca
nOraise;
2) treating asthma therapeutic scheme is selected: corticosteroids inhaled is invalid and oral hormone should be taked to treat to bronchiolitis disease;
3) chronic obstructive pulmonary disease and smoking patient: chronic obstructive pulmonary disease patient Ca
nOcompared with normal group is high, and smoking is to the Ca of tester
nOindefinite;
4) systemic scleroderma: obtain interstitial lung disease (ILD) person Ca in systemic scleroderma patient
nO(do point of contact with 10.8ppb, specificity can reach 96%, Ca in obvious rising
nOcan be used as the mark of ILD;
5) pulmonary alveolitis: Ca
nOraise and Jaw is constant;
6) pulmonary fibrosis: Ca
nOraise;
7) hepatic and renal function syndrome: Ca
nOraise (8.3ppb vs 4.7ppb).
About the document of expiration nitric oxide detection method aspect is a lot, to existing various measuring method, Hogman(J. Breath Res. 7 (2013) 017104) do and introduced relatively comprehensively and objectively.Ca
nOcan not directly measure, must be deduced by certain physiological models and calculate, at present about the model of expiration NO mainly contains three, be respectively: two compartment model, three compartment model and loudspeaker model, can analyze three parameters had nothing to do with flow: steady state alveolar concentration, airway walls diffusing capacity (or maximum airway walls flux) and airway walls concentration, the loudspeaker model wherein with axial diffusion is believed to the NO output relevant to flow in lung provides good description.
Two Room models (2CM) are the simplest Exhaled nitric oxide physiological models, and it thinks expiration nitric oxide concentration (Ce
nO) be made up of two parts, come from alveolar region and air flue district (as shown in Figure 1) respectively, depend on three parameters according to fluctuations in discharge: NO total flow (the maximum airway walls flux Jaw deriving from airway walls
nO, pl/s), NO is at diffusivity (DawNO, the pl*s of air flue
-1*ppb
-1) the alveolar air concentration (Ca, and under stable state
nO, ppb).Maximum airway walls flux Jaw
nO(pl/s) and exhalation flow rate F be inversely proportional to; Caw
nOrefer to airway walls NO concentration.
The following relational expression of relation is met between each parameter:
(1)
When VE >5*DawNO ml/s or 50 ml/s(Healthy Peoples) time, this equation can be reduced to
(2)
In general, Ca
nO<2% Caw
nO, and J ' aw
nO=Daw
nO* Caw
nO, above equation can be reduced to
(3)
Thus, by the Ce under different expiratory gas flow (F)
nOthe mensuration of concentration, can in the hope of alveolar air concentration C a
nO, maximum airway walls flux Jaw.
Usually within the scope of 100 ~ 500ml/s expiratory gas flow, adopt (3) formula linear model to analyze, can Ca be calculated
nOand Jaw
nOtwo parameters, and to wider expiratory gas flow, as 10 ~ 500ml/s, adopt (1) formula nonlinear model to analyze, can calculate and obtain Ca
nO, Jaw
nO,caw
nOand Daw
nOfour parameters.
This model can explain the rule that expiration nitric oxide concentration changes with expiratory gas flow, and experimental data is also substantially identical with theoretical value, thus about Jaw
nOwith Ca
nOmeasurement, major part work all launches based on this model, and general method controls different expiratory gas flows repeatedly to exhale, and measure the expiration NO value under different in flow rate, then basis (1) or (3) formula calculates.
Analyze in document about Ca
nO, Jaw
nOand Ce
nOmeasurement result, the Ca that different data processing methods calculates
nO, Jaw
nOthere is not significant difference, various data processing method is equivalence substantially also.It is generally acknowledged adult normal's steady state alveolar gas concentration C a
nOgeneral between 1.0 ~ 5.6ppb, Jaw
nOwithin the scope of 420 ~ 1280pl/s (
j Appl Physiol91:2173 – 2181,2001).
Under the exhalation flow rate of 50ml/s, sustained exhalation 4 ~ 10s easily realizes comparatively speaking, under lower flow velocity (exhalation flow rate as 10ml/s at least needs constant flow rate to exhale 20 seconds) and higher expiration, (lower expiratory resistance is larger) sustained exhalation all can comparatively difficulty, for this reason, calendar year 2001 George team proposes a kind of variable-flow measuring technique without a break
[6], he, by regulating and controlling expiratory gas flow (from 300ml/s to 50ml/s) continuously, measures and the expiration NO concentration change relation recording expiratory gas flow and follow in time, calculates Jaw according to two Room models
nOand Ca
nO.But until the consistance of Bruno ability first time contrived experiments in 2006 to many implications variable-flow and one breath variable-flow method has carried out evaluating (Respiratory Physiology & Neurobiology 153 (2006) 148 – 156), by carrying out Bland Altman statistical study to experimental data, think that two kinds of methods are to Jaw
nOand Ca
nOmeasurement result be consistent, think that without a break variable-flow method is more simple and convenient simultaneously.
But because this technology is to sensor response time requirement higher (<200ms), only have Chemiluminescence Apparatus to meet this time-resolved requirement at present, utilize low cost but response slower electrochemical NO sensor cannot meet this requirement.
Summary of the invention
Realizing described one breath variable-flow measuring method requires higher to the response speed of sensor, only have Chemiluminescence Apparatus can meet this time-resolved requirement, but chemiluminescent analyzer cost is higher, difficult in maintenance, and NO value of exhaling under very fast flow velocity is lower, close to Chemiluminescence Apparatus Monitoring lower-cut, thus the quality of data can not be guaranteed, and measuring error is larger.
Thinking of the present invention be by gas circuit design will sample and measuring process separate, utilize elongated tubular (ensureing that gas flowing is wherein piston flow when exhaling sampling and analysis to measure) with the expiration gas under the different expiratory duration (flow velocity) of fast speed synchronous collection part in exhalation process, when analyzing to be passed through to carry out analysis to measure into sensor by the gas collected in elongated tubular compared with low flow velocity; Designed by gas circuit and make the NO concentration curve of sensor record corresponding with expiratory gas flow (time) curve to the control of gas flow ratio when sampling and measurement, thus realizing utilizing the measurement of the electrochemical sensor of slow-response realization to fast-changing expiration NO concentration.
Realize said method, measurement mechanism design and metering system need to consider and solves several key issue, being specially:
Does l expiratory gas flow control: how to ensure experimenter's sustained exhalation ensure the rule change that its expiratory gas flow is wished by us within the scope of certain hour?
About this point, solution of the present invention is that flow sensor and flow controller are combined into a flow automatic feedback control system, during experimenter's sustained exhalation, expiratory gas flow measured by flow sensor, and transfer data to flow controller, these data and the target flow preset compare by described flow controller, and latus rectum (is turned down when flow is excessive by the latus rectum of the pipeline of adjustment expiration in time, when flow is too small, latus rectum is tuned up), its feedback regulation speed is less than 100ms, substantially can ensure that expiratory gas flow is by the fluctuations in discharge rule change preset by the Quick Measurement to expiratory gas flow and the timely adjustment to pipeline latus rectum like this, as in 6 ~ 10 seconds, expiratory gas flow linearly drops to 20ml/s from 300ml/s.
Be make its linear attenuation to the control of expiratory gas flow variation pattern, as made it linearly drop to 20ml/s from 300ml/s within 6 ~ 10 second time, the bound of certain expiratory gas flow can adjust according to actual needs.The large advantage controlling expiratory gas flow linear change is that algorithm model is comparatively simple, and aforementioned theoretical formula draws under this condition.
Expiratory gas flow can certainly be controlled change with index or other any mode, different in algorithm process from expiratory gas flow linear change difference, algorithmically can solve by formulism with the flow of the mode rule changes such as linear or index, and when expiratory gas flow change does not have rule, solve comparatively complicated, numerical integration algorithm may be inevitable selection.
2 sample modes designs: breath is all collected and gets off to carry out analysis to measure, still an only collection analysis part wherein?
In order to reduce sample chamber volume, simplify synchronized algorithm simultaneously, the method that the present invention adopts be with the pump of a high flow capacity while exhaling by a part for expiratory air with in the elongated air chamber of constant flow rate suction.So just can ensure that the distribution of gas in elongated air chamber of different expiratory duration section is uniform.
3 sample storage:
Atmosphere storage to be analyzed is in air chamber, and the structure of described air chamber is an elongate conduit, and object is to ensure that the flowing of gas in air chamber meets the condition of piston flow in sampling and analytic process.
4 Measurement and analysis:
By flow rate that pump drives the gas in sample chamber constant during Measurement and analysis, and record the curve of whole measuring process, if known sampling and the ratio of gas flow and time synchronous point when analyzing, just the experiment curv of sensor can be associated with expiratory gas flow experiment curv, make the graph of a relation between sensor response and expiratory gas flow.
Sampling is larger with the throughput ratio of gas when analyzing, and lower to the requirement of sensor response time, the ratio as the two is 10:1, then the available response time is that the sensor measurement of 10 seconds is exhaled the situation of change of NO concentration in 1 second.Sampling and the size of Measurement and analysis gases used flow select to depend on the response time of sensor and the temporal resolution needed for measuring, analyze expiration NO, sample and analysis throughput ratio can be controlled in 5 ~ 20 times.
5 synchronous method:
Exhale and with high flow velocities, a part for expiratory air is stored in elongate conduit when sampling, and when analyzing, the gas in described pipeline is passed into sensor with comparatively low flow velocity and carry out analysis to measure, in order to these two relatively independent procedure correlations are got up, must have a synchronizing time point, choosing of described synchronous point realizes by gas circuit design.
One chooses synchronous point method for analysis pump is arranged in elongated air chamber leading portion, and first the gas at the end of sampling of exhaling like this be drawn into sensor analysis when Measurement and analysis, and what this start time point was corresponding is exactly the time point of sampling and terminating of exhaling.
The another kind of method choosing synchronous point is design one cycle analysis gas circuit, now analyze pump in the rear end of elongated air chamber, analyzing pump during analysis to measure drives the gas in air chamber to enter after sensor measures, get back in elongated air chamber after removing NO with NO filtrator, flowing due to gas in air chamber is piston flow, when this part gas is when getting back to sensor, because NO gas is fallen by NO metre filter, the response of NO sensor can rapidly drop to zero, and this time point corresponding be exactly exhale sampling at the end of time point.
Solve the problems referred to above, by designing suitable device, just can realize a bite multiparameter NO and measuring, although measurement mechanism analytic process can be different, the common ground of its Measurement and analysis process can be summarized as follows:
1) exhale: control to exhale with the flow program preset change, record expiratory gas flow change curve in time;
2) sample: the gas of breathe out expiration overall process or one portion collection are in an elongated tubular air chamber;
3) measure: the gas in elongated tubular is passed into sensor and carries out analysis to measure by the gas flow rate adapted with the sensor response time, record sensor responds change curve in time;
4) synchronous: synchronous expiration and analytic process, find the data corresponding relation between expiratory gas flow and expiration NO measured value;
5) calculate: calculate Jaw, Ca and FeNO according to corresponding relation between revised expiratory gas flow and expiration NO
50.
Fig. 2 is a kind of gas circuit structure schematic diagram realizing multiparameter expiration nitric oxide measurement mechanism without a break, described device gas circuit is made up of sampling module (100) and analysis module (200), it is characterized in that: described sampling module is by flow sensor (101), flow regulator (201), solenoid valve (301) is composed in series, and is connected between flow regulator (201) and solenoid valve (301) by threeway with the air chamber (401) in analysis module; Described analysis module forms circulation gas circuit by air chamber (401), threeway (501), analysis pump (602), gas humidity regulator (701), NO sensor (801), NO filtrator (901) and T-valve (302) successively; Pump (601) is connected with air chamber (401) by threeway (501), a T-valve (303) in parallel between NO filtrator (901) with NO sensor (801).
Fig. 3 is the another kind of gas circuit structure schematic diagram realizing multiparameter expiration nitric oxide measurement mechanism without a break, described device gas circuit is made up of sampling module (100) and analysis module (200), it is characterized in that: described sampling module is by flow sensor (101), flow regulator (201), solenoid valve (301) is composed in series, and is connected between flow regulator (201) and solenoid valve (301) by threeway with the solenoid valve (303) in analysis module; Described analysis module forms circulation gas circuit by solenoid valve (303), air chamber (401), threeway (501), analysis pump (602), gas humidity regulator (701), NO sensor (801), T-valve (302) successively; Pump (601) is connected with air chamber (401) by threeway (501), and NO filtrator (901) is by T-valve (303) connect into analysis gas circuit.
The electrochemical gas sensor utilizing above 2 kinds of gas circuit structures all can realize utilizing reaction velocity slower is followed and is measured fast-changing concentration of exhaled NO, and in fact the professional person of this area can design more implement device according to the principle of the invention.
Accompanying drawing explanation
Fig. 1. alveolar and air flue nitrogen monoxide produce and diffusion fixed double chamber bed.
Fig. 2. variable-flow expiration nitric oxide measuring equipment composition schematic diagram without a break.
Fig. 3 is variable-flow expiration nitric oxide measuring equipment composition schematic diagram without a break.
Embodiment
application Example one
Fig. 2 is the gas circuit structure schematic diagram of a kind of device realizing the inventive method, described device is made up of sampling module 100 and analysis module 200, its design feature is that described sampling module is by flow sensor 101, flow regulator 201, solenoid valve 301 is composed in series, and is connected between flow regulator 201 and solenoid valve 301 by threeway (not indicating) with the air chamber 401 in analysis module; Described analysis module successively by air chamber 401, threeway 501, analyze pump 602, gas humidity regulator 701(such as Nafion and manage), NO sensor 801, NO filtrator 901 and T-valve 302 form circulation gas circuit; Pump 601 is connected with air chamber 401 by threeway 501, a T-valve 303 in parallel between NO filtrator 901 with NO sensor 801.
When utilizing this device to carry out one breath variable-flow expiratory measurements, process is as follows:
1) exhale:
Open valve 301, after experimenter sucks cleaned air, continue expiration maintenance energetically 6 ~ 10 seconds, expiratory gas flow is controlled by the adjustment of programmed control flow regulator in exhalation process, make it with the flow velocity change of program (as linear decline) preset, real-time survey record expiratory gas flow change curve in time measured by flow sensor 101;
2) sample:
While expiration, open sampling pump 601, analyze pump 602, adjustment T-valve 302,303 position, a part for the gas of expiration overall process being breathed out is collected in elongated tubular air chamber 401, and now a part for sample gas is emptying through air chamber 401, threeway 501 and sampling pump 601; Another part through air chamber 401, threeway 501, analyze pump 602, gas humidity regulator 701, NO sensor 801, T-valve 303 and T-valve 302 emptying, now gas overall flow rate is about 10ml/s, 6 ~ 10 seconds sampling times;
3) measure:
To sample rear valve-off 301 and flow regulator 201, close sampling pump 601, open and analyze pump 602, the position of adjustment T-valve 302,303 makes gas flow direction become: air chamber 401, threeway 501, analysis pump 602, gas humidity regulator 701, NO sensor 801, NO filtrator 901, T-valve 302 and air chamber 401, now gas flow rate is about 1ml/s, the whole analytic process time is about 120 seconds, responds change curve in time at analysis overall process record sensor; The steady-state current that gas is recorded by sensor after NO filtrator 901 is zero current;
4) synchronous:
Expiration gas at the end of sampling of exhaling is collected in the least significant end of elongated air chamber 401, when analyzing, pump 602 driving gas flows (flowing of gas in pipeline is piston flow) in circulation gas circuit, after gas is filtered by NO filtrator 901 after sensor 801 is measured, NO concentration reduces to 0, this part gas can be got back in air chamber 401, after the expiration of collecting when air chamber 401 so has all been analyzed, the response current of sensor will be undergone mutation (zero current), and the concentration that this time point is corresponding is exactly the concentration of NO of exhaling at the end of sampling of exhaling;
Owing to demarcating sample gas flow (about 10ml/s) and analytical gas flow (about 1ml/s) in advance, be equivalent to breath per second and can measure 10 seconds on a sensor, Measuring Time has been exaggerated 10 times, there is the consistent of the flex point time of zero current with during analysis in the time that sampling of exhaling from the above mentioned terminates, can find the data corresponding relation between expiratory gas flow and expiration NO measured value thus;
5) calculate:
Jaw, Ca and FeNO50 is calculated according to corresponding relation between revised expiratory gas flow and expiration NO;
6) self-calibration:
Realize the self-calibration to transducer sensitivity, first the homogeneous NO gas of concentration (concrete concentration need not be known) to be collected in air chamber 401, this is by valve-off 301, adjustment T-valve 302, 303, open pump 601, 602 directly bleed sampling realize, now airflow direction is divided into two-way, one tunnel is: NO source of the gas, flow sensor 101, flow regulator 201, air chamber 401, threeway 501, pump 601 is then emptying, another road is: NO source of the gas, flow sensor 101, flow regulator 201, air chamber 401, threeway 501, pump 602, gas humidity adjusting device 701, NO sensor 801, T-valve 303, 302 is then emptying,
T-valve 302,303 position is adjusted during self-calibration, the gas in air chamber 401 is made to get back to air chamber 401 by threeway 501, pump 602, gas humidity regulator 701, NO sensor 801, T-valve 303,302 by pump 602, like this by 2 ~ 3 circulation Measurement and analysis, just NO gas concentration in air chamber 401 is directly calculated by method disclosed in patent ZL201210207872.6, and then calculate its sensitivity that NO is responded according to the response current of cyclic process NO sensor 801, realize self-calibration.
application Example two
Fig. 3 be realize the inventive method the gas circuit structure schematic diagram of a kind of another kind of device, described device is made up of sampling module 100 and analysis module 200, its design feature is that described sampling module is by flow sensor 101, flow regulator 201, solenoid valve 301 is composed in series, and is connected between flow regulator 201 and solenoid valve 301 by threeway (not showing) with the solenoid valve 303 in analysis module; Described analysis module successively by solenoid valve 303, air chamber 401, threeway 501, analyze pump 602, gas humidity regulator 701(such as Nafion and manage), NO sensor 801, T-valve 302 form circulation gas circuit; Pump 601 is connected with air chamber 401 by threeway 501, and NO filtrator 901 is by T-valve 303 connect into analysis gas circuit.
When utilizing this device to carry out one breath variable-flow expiratory measurements, process is as follows:
1) exhale:
Open valve 301, after experimenter sucks cleaned air, continue expiration maintenance energetically 6 ~ 10 seconds, expiratory gas flow is controlled by the adjustment of programmed control flow regulator in exhalation process, make it with the flow velocity change of program (as linear decline) preset, real-time survey record expiratory gas flow change curve in time measured by flow sensor 101;
2) sample:
While expiration, open sampling pump 601, analyze pump 602, adjustment T-valve 303,302 position, a part for the gas of expiration overall process being breathed out is collected in elongated tubular air chamber 401, and now a part for sample gas is emptying through air chamber 401, threeway 501 and sampling pump 601; Another part through air chamber 401, threeway 501, analyze pump 602, humidistat 701, NO sensor 801 and T-valve 302 emptying, now gas overall flow rate is about 10ml/s, 6 ~ 10 seconds sampling times;
3) measure:
To sample rear valve-off 301 and flow regulator 201, close sampling valve 601, open and analyze pump 602, the position of adjustment T-valve 302,303 makes gas flow direction become: air, NO filtrator 901, air chamber 401, threeway 501, analyze pump 602, humidistat 701, NO sensor 801, T-valve 302 are then emptying, now gas flow rate is about 1ml/s, the whole analytic process time is about 120 seconds, responds change curve in time at analysis overall process record sensor; The steady-state current that gas is recorded by sensor after NO filtrator 901 is zero current;
4) synchronous:
Expiration gas at the end of sampling of exhaling is collected in the least significant end of elongated air chamber 401, when analyzing, pump 602 driving gas flows (flowing of gas in pipeline is piston flow) in gas circuit, air is after filtering by NO filtrator 901, NO concentration reduces to 0, the gas that this part gas can promote air chamber 401 moves forward, after the expiration of collecting when air chamber 401 so has all been analyzed, the response current of sensor will be undergone mutation (zero current), and the concentration that this time point is corresponding is exactly the concentration of NO of exhaling at the end of sampling of exhaling;
Owing to demarcating sample gas flow (about 10ml/s) and analytical gas flow (about 1ml/s) in advance, be equivalent to breath per second and can measure 10 seconds on a sensor, Measuring Time has been exaggerated 10 times, there is the consistent of the flex point time of zero current with during analysis in the time that sampling of exhaling from the above mentioned terminates, can find the data corresponding relation between expiratory gas flow and expiration NO measured value thus;
5) calculate:
Jaw, Ca and FeNO50 is calculated according to corresponding relation between revised expiratory gas flow and expiration NO;
6) self-calibration:
Realize the self-calibration to transducer sensitivity, first the homogeneous NO gas of concentration (concrete concentration need not be known) to be collected in air chamber 401, this is by valve-off 301, adjustment T-valve 302, 303, open pump 601, 602 directly bleed sampling realize, now airflow direction is divided into two-way, one tunnel is: NO source of the gas, flow sensor 101, flow regulator 201, threeway 303, air chamber 401, threeway 501, pump 601 is then emptying, another road is: NO source of the gas, flow sensor 101, flow regulator 201, threeway 303, air chamber 401, threeway 501, pump 602, gas humidity adjusting device 701, NO sensor 901, T-valve 302, then emptying,
T-valve 302,303 position is adjusted during self-calibration, the gas in air chamber 401 is made to get back to air chamber 401 by threeway 501, pump 602, gas humidity regulator 701, NO sensor 801, T-valve 302,303 by pump 602, like this by 2 ~ 3 circulation Measurement and analysis, just NO gas concentration in air chamber 401 is directly calculated by method disclosed in patent ZL201210207872.6, and then calculate its sensitivity that NO is responded according to the response current of cyclic process NO sensor 801, realize self-calibration.
Claims (2)
1. one breath multiparameter expiration nitric oxide measurement mechanism, be made up of sampling module (100) and analysis module (200), it is characterized in that: described sampling module is by flow sensor (101), flow regulator (201), solenoid valve (301) is composed in series, and is connected between flow regulator (201) and solenoid valve (301) by threeway with the air chamber (401) in analysis module; Described analysis module forms circulation gas circuit by air chamber (401), threeway (501), analysis pump (602), gas humidity regulator (701), NO sensor (801), NO filtrator (901) and T-valve (302) successively; Pump (601) is connected with air chamber (401) by threeway (501), a T-valve (303) in parallel between NO filtrator (901) with NO sensor (801).
2. one breath multiparameter expiration nitric oxide measurement mechanism, be made up of sampling module (100) and analysis module (200), it is characterized in that: described sampling module is by flow sensor (101), flow regulator (201), solenoid valve (301) is composed in series, and is connected between flow regulator (201) and solenoid valve (301) by threeway with the solenoid valve (303) in analysis module; Described analysis module forms circulation gas circuit by solenoid valve (303), air chamber (401), threeway (501), analysis pump (602), gas humidity regulator (701), NO sensor (801), T-valve (302) successively; Pump (601) is connected with air chamber (401) by threeway (501), and NO filtrator (901) is by T-valve (303) connect into analysis gas circuit.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105445343A (en) * | 2014-11-28 | 2016-03-30 | 无锡市尚沃医疗电子股份有限公司 | Method and device for measuring nitric oxide of one-breath multi-parameter expiration |
| CN105388256B (en) * | 2015-12-04 | 2017-07-07 | 无锡市尚沃医疗电子股份有限公司 | The measuring method of breathing and circulatory system Gas Molecular Density in expiratory air |
| CN116660509A (en) * | 2023-06-01 | 2023-08-29 | 青岛瑞谱乐医疗科技有限公司 | Exhaled gas detection method |
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2014
- 2014-11-28 CN CN201420731042.8U patent/CN204269592U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105445343A (en) * | 2014-11-28 | 2016-03-30 | 无锡市尚沃医疗电子股份有限公司 | Method and device for measuring nitric oxide of one-breath multi-parameter expiration |
| CN105445343B (en) * | 2014-11-28 | 2019-01-11 | 无锡市尚沃医疗电子股份有限公司 | One breath multi-parameter expiration nitric oxide measurement method and device |
| CN105388256B (en) * | 2015-12-04 | 2017-07-07 | 无锡市尚沃医疗电子股份有限公司 | The measuring method of breathing and circulatory system Gas Molecular Density in expiratory air |
| CN116660509A (en) * | 2023-06-01 | 2023-08-29 | 青岛瑞谱乐医疗科技有限公司 | Exhaled gas detection method |
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