CN204265664U - Be applicable to the integrating device of cobalami photochmeical reaction - Google Patents
Be applicable to the integrating device of cobalami photochmeical reaction Download PDFInfo
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- CN204265664U CN204265664U CN201420638453.2U CN201420638453U CN204265664U CN 204265664 U CN204265664 U CN 204265664U CN 201420638453 U CN201420638453 U CN 201420638453U CN 204265664 U CN204265664 U CN 204265664U
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Abstract
The utility model is the integrating device being applicable to cobalami photochmeical reaction, comprise head tank (1), fresh feed pump (2), photoreactor (3), resin column (4), sample introduction six-way valve (5) and holding tank (6), it is characterized in that: described head tank (1), liquid feed valve (7), strainer (8), fresh feed pump (2), photoreactor (3), resin column is linked in sequence by pipeline between (4), the outlet of described resin column (4) is connected by 1 end of pipeline with sample introduction six-way valve (5), 2 ends of described sample introduction six-way valve (5) are connected by 1 end of pipeline with T-valve (9), 2 ends of described T-valve (9) are connected with holding tank (6) by pipeline, 3 ends of T-valve (9) are connected with head tank (1) by pipeline.It is simple that the utility model has structure, and easy handling, the feature that speed of response is fast, transformation efficiency is high, belongs to field of chemical equipment.
Description
Technical field:
The utility model relates to a kind of chemical industry equipment, is specifically applicable to the integrating device of cobalami photochmeical reaction.
Background technology:
Cobalami, is commonly called as vitamins B
12, be one of very important water-soluble vitamins in humans and animals body, but it is unstable under illumination condition, easily generate other derivative, and hydroxocobalamine is exactly one of photolytic product of cobalami.Because hydroxocobalamine physiological action in human body is long-acting, so be the renewal substitute products of cobalami.
Hydroxocobalamine generally adopts chemical method to synthesize, and photoresist process also can be adopted to synthesize.Be widely used because photoresist process production cost is lower, and generally adopt the method separating active substances of resin absorption in the aftertreatment of product.
Summary of the invention:
The purpose of this utility model is to provide that a kind of structure is simple, speed of response is fast, transformation efficiency is high, convenient separation, can the integrating device that cobalami photochmeical reaction is applicable to of on-line quick detection.
The integrating device being applicable to cobalami photochmeical reaction described in the utility model, comprise head tank (1), fresh feed pump (2), photoreactor (3), resin column (4), sample introduction six-way valve (5) and holding tank (6), it is characterized in that: described head tank (1) is connected by pipeline one end with liquid feed valve (7), the other end of described liquid feed valve (7) is connected by pipeline one end with strainer (8), the other end of described strainer (8) is connected by the entrance of pipeline with fresh feed pump (2), the outlet of described fresh feed pump (2) is connected by the entrance of pipeline with photoreactor (3), the outlet of described photoreactor (3) is connected by the entrance of pipeline with resin column (4), the outlet of described resin column (4) is connected by 1 end of pipeline with sample introduction six-way valve (5), 2 ends of described sample introduction six-way valve (5) are connected by 1 end of pipeline with T-valve (9), 2 ends of described T-valve (9) are connected with holding tank (6) by pipeline, 3 ends of T-valve (9) are connected with head tank (1) by pipeline.
The bottom of described head tank (1) is provided with head tank tap valve (10), and top is provided with head tank blow-off valve (11).
The bottom of described holding tank (6) is provided with holding tank tap valve (12), and top is provided with holding tank blow-off valve (13).
4 ends of described sample introduction six-way valve (5) are connected with the moving phase of liquid chromatography with 5 ends, moving phase flows to from 4 ends of sample introduction six-way valve (5), from six-way valve (5) 5 ends flow out or moving phase flow to from 5 ends of sample introduction six-way valve (5), from six-way valve (5) 4 ends flow out.
Advantage of the present utility model and positively effect:
1, photochmeical reaction and resin isolation are organically combined, the feature of resins selective absorption hydroxocobalamine is utilized to realize the ON-LINE SEPARATION of raw material and product, thus the light transmission grow of stock liquid, be easy to reaction carry out to positive dirction, resin absorption lives hydroxocobalamine simultaneously, reduces the concentration of product, the angle analysis chemically balanced, also impel reaction to carry out to positive dirction, thus accelerate speed of response.
2, by fresh feed pump (2) charging, effectively control the time of raw material reaction in photoreactor (3) and the time of absorption in resin column (4), ensure that the carrying out of reaction.
3, by the online in-situ sampling of liquid chromatography realization response liquid, ensure that the accuracy of experimental result, also achieve the real-time monitoring to reaction process simultaneously, effectively reduce the generation of byproduct of reaction.
4, utilize resin column (4) on-line adsorption hydroxocobalamine, eliminate the process recycling resin absorption after obtaining cobalami photodissociation liquid, simplify operation.
Accompanying drawing illustrates:
Fig. 1 is the integrating device schematic diagram being applicable to cobalami photochmeical reaction.
Embodiment:
Below in conjunction with accompanying drawing, the utility model is described in further detail;
Be applicable to the integrating device of cobalami photochmeical reaction as shown in Figure 1, comprise head tank (1), fresh feed pump (2), photoreactor (3), resin column (4), sample introduction six-way valve (5) and holding tank (6), head tank (1), liquid feed valve (7), strainer (8) is connected successively by pipeline, the outlet of strainer (8) is connected by the entrance of pipeline with fresh feed pump (2), the outlet of fresh feed pump (2) is connected by the entrance of pipeline with photoreactor (3), the outlet of photoreactor (3) is connected by the entrance of pipeline with resin column (4), the outlet of resin column (4) is connected by 1 end of pipeline with sample introduction six-way valve (5), 2 ends of sample introduction six-way valve (5) are connected by 1 end of pipeline with T-valve (9), 2 ends of T-valve (9) are connected with holding tank (6) by pipeline, 3 ends of T-valve (9) are connected with head tank (1) by pipeline, the bottom of head tank (1) is provided with head tank tap valve (10), top is provided with head tank blow-off valve (11), the bottom of holding tank (6) is provided with holding tank tap valve (12), top is provided with holding tank blow-off valve (13), the moving phase of liquid chromatography flows to from 4 ends of sample introduction six-way valve (5), flow out from 5 ends of six-way valve (5).
During use, close head tank tap valve (10) and holding tank tap valve (12), open liquid feed valve (7), head tank blow-off valve (11) and holding tank blow-off valve (13), the position of T-valve (9) is switched to and is connected with 3 ends of T-valve (9), the certain density cobalami solution prepared is added in head tank (1), resin is loaded in chromatographic column (4), open photoreactor (3), after system stability, open fresh feed pump (2) charging.Sample introduction six-way valve (5) on-line period analysis can be passed through at any time in the process of reaction, when liquid chromatographic detection is less than cobalamin content, close photoreactor, the position of T-valve (9) is switched to and is connected with 2 ends of T-valve (9), utilize fresh feed pump (2) by the Liquid transfer in system in holding tank (6).
Here description of the present utility model and application is illustrative; not want by scope restriction of the present utility model in the above-described embodiments; therefore, the utility model is not by the restriction of the present embodiment, and the technical scheme that any employing equivalence replacement obtains is all in the scope of the utility model protection.
Claims (4)
1. be applicable to the integrating device of cobalami photochmeical reaction, comprise head tank (1), fresh feed pump (2), photoreactor (3), resin column (4), sample introduction six-way valve (5) and holding tank (6), it is characterized in that: described head tank (1) is connected by pipeline one end with liquid feed valve (7), the other end of described liquid feed valve (7) is connected by pipeline one end with strainer (8), the other end of described strainer (8) is connected by the entrance of pipeline with fresh feed pump (2), the outlet of described fresh feed pump (2) is connected by the entrance of pipeline with photoreactor (3), the outlet of described photoreactor (3) is connected by the entrance of pipeline with resin column (4), the outlet of described resin column (4) is connected by 1 end of pipeline with sample introduction six-way valve (5), 2 ends of described sample introduction six-way valve (5) are connected by 1 end of pipeline with T-valve (9), 2 ends of described T-valve (9) are connected with holding tank (6) by pipeline, 3 ends of T-valve (9) are connected with head tank (1) by pipeline.
2. the integrating device being applicable to cobalami photochmeical reaction according to claim 1, is characterized in that: the bottom of described head tank (1) is provided with head tank tap valve (10), and top is provided with head tank blow-off valve (11).
3. the integrating device being applicable to cobalami photochmeical reaction according to claim 1, is characterized in that: the bottom of described holding tank (6) is provided with holding tank tap valve (12), and top is provided with holding tank blow-off valve (13).
4. the integrating device being applicable to cobalami photochmeical reaction according to claim 1, it is characterized in that: 4 ends of described sample introduction six-way valve (5) are connected with the moving phase of liquid chromatography with 5 ends, moving phase flows to from 4 ends of sample introduction six-way valve (5), from six-way valve (5) 5 ends flow out or moving phase flow to from 5 ends of sample introduction six-way valve (5), from six-way valve (5) 4 ends flow out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420638453.2U CN204265664U (en) | 2014-10-29 | 2014-10-29 | Be applicable to the integrating device of cobalami photochmeical reaction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420638453.2U CN204265664U (en) | 2014-10-29 | 2014-10-29 | Be applicable to the integrating device of cobalami photochmeical reaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204265664U true CN204265664U (en) | 2015-04-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420638453.2U Expired - Fee Related CN204265664U (en) | 2014-10-29 | 2014-10-29 | Be applicable to the integrating device of cobalami photochmeical reaction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204265664U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110563786A (en) * | 2019-09-09 | 2019-12-13 | 天津理工大学 | Process and device for preparing high-concentration high-yield hydroxycobalamin |
-
2014
- 2014-10-29 CN CN201420638453.2U patent/CN204265664U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110563786A (en) * | 2019-09-09 | 2019-12-13 | 天津理工大学 | Process and device for preparing high-concentration high-yield hydroxycobalamin |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150415 Termination date: 20211029 |