CN204261563U - The aseptic micro-pore-film filtration device of a kind of veterinary drug injection - Google Patents

The aseptic micro-pore-film filtration device of a kind of veterinary drug injection Download PDF

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Publication number
CN204261563U
CN204261563U CN201420605279.1U CN201420605279U CN204261563U CN 204261563 U CN204261563 U CN 204261563U CN 201420605279 U CN201420605279 U CN 201420605279U CN 204261563 U CN204261563 U CN 204261563U
Authority
CN
China
Prior art keywords
chamber
lower chambers
filter course
microporous membrane
duct type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201420605279.1U
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Chinese (zh)
Inventor
罗建华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANGXI CHENGBIXIN BIOTECHNOLOGY Co Ltd
Original Assignee
JIANGXI CHENGBIXIN BIOTECHNOLOGY Co Ltd
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Priority to CN201420605279.1U priority Critical patent/CN204261563U/en
Application granted granted Critical
Publication of CN204261563U publication Critical patent/CN204261563U/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

The utility model discloses the aseptic micro-pore-film filtration device of a kind of veterinary drug injection, comprise overanxious chamber, be positioned at import above overanxious chamber, filter course and filtrate exit pipe, wherein, overanxious chamber is divided into upper chamber and lower chambers, and upper chamber is cylinder, lower chambers is inverted cone, and the position clamping be connected with lower chambers in upper chamber arranges filter course; Arrange heavy ion microporous membrane duct above described filter course, heavy ion microporous membrane duct is single cone straight hole duct type, bipyramid straight hole duct type, single cone inclined hole duct type or bipyramid inclined hole duct type; Filter core below described filter course superposes rear folding by liner, heavy ion microporous membrane and outer lining three and forms; Be provided with cylindrical inner case above filter core, below filter core, be positioned at filter course bottommost and be provided with cylindrical case; The coaxial filtrate exit pipe connecting taper bottom described lower chambers, this practical new rejection rate is high, flow large, and high temperature high voltage resistant, Stability Analysis of Structures, manufacturing cost is lower.

Description

The aseptic micro-pore-film filtration device of a kind of veterinary drug injection
Technical field
The utility model relates to micro-pore-film filtration device, specifically the aseptic micro-pore-film filtration device of a kind of veterinary drug injection.
Background technology
Membrane filtration is a kind of screening process relevant to membrane aperture size, and under differential pressure action, the particle being less than fenestra will all by filter membrane, and the particle being greater than fenestra is then trapped within filter membrane surface, thus achieves effective separation, reaches purifying object.
Utility model content
The purpose of this utility model is to provide a kind of good filtration effect, and efficiency is high, and use simple, the aseptic micro-pore-film filtration device of veterinary drug injection that cost is low, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the utility model provides following technical scheme:
The aseptic micro-pore-film filtration device of a kind of veterinary drug injection, comprise overanxious chamber, be positioned at import above overanxious chamber, filter course and filtrate exit pipe, wherein, overanxious chamber is divided into upper chamber and lower chambers, and upper chamber is cylinder, lower chambers is inverted cone, and the position clamping be connected with lower chambers in upper chamber arranges filter course; Arrange heavy ion microporous membrane duct above described filter course, heavy ion microporous membrane duct is single cone straight hole duct type, bipyramid straight hole duct type, single cone inclined hole duct type or bipyramid inclined hole duct type; Filter core below described filter course superposes rear folding by liner, heavy ion microporous membrane and outer lining three and forms; Be provided with cylindrical inner case above filter core, below filter core, be positioned at filter course bottommost and be provided with cylindrical case; The coaxial filtrate exit pipe connecting taper bottom described lower chambers, and filtrate exit pipe stretches in filtrate collection chamber below centre position, and the outer wall of the outer wall of lower chambers and filtrate collection chamber is tightly connected; Described filtrate collection chamber top is provided with vacuum interface, and vacuum interface connects vavuum pump.
Further, described overanxious chamber is formed in one manufacture.
Further, described upper chamber and lower chambers milled processed.
Compared with prior art, the installation of whole device of the present utility model, dismantle and change very quick, enhance productivity, filter course can be changed in time, ensure the quality of filtrate after filtering, improve the filter efficiency of filter, and in work, because heavy ion microporous membrane is because of the moulding process of its uniqueness, at present uniquely a kind ofly reach the filter membrane product sieving filtration completely, pore-size distribution is extremely narrow, it is the desirable film material of degerming end-filtration, so heavy ion microporous membrane is made foldable filter element, make full use of this film frivolous, the feature that filtering accuracy is high, the large discharge in complete degerming situation can be ensured, high life, namely rejection rate is high, flow is large, do not adsorb, do not come off, do not store breed bacteria, high temperature high voltage resistant, Stability Analysis of Structures, manufacturing cost is lower.
Accompanying drawing explanation
Fig. 1 is the structural representation of veterinary drug injection with aseptic micro-pore-film filtration device.
Fig. 2 is the structural representation of veterinary drug injection with heavy ion microporous membrane duct in aseptic micro-pore-film filtration device.
Fig. 3 is the part-structure schematic diagram of veterinary drug injection with filter course in aseptic micro-pore-film filtration device.
Fig. 4 is the part-structure cross-sectional schematic of veterinary drug injection with filter course in aseptic micro-pore-film filtration device.
In figure: the overanxious chamber of 1-filter course, 2-, 3-import, 4-lower chambers, 5-upper chamber, 6-filtrate exit pipe, 7-filtrate collection chamber, 8-vacuum interface, 11-heavy ion microporous membrane, 12-liner, 13-outer lining, 14-filter core, 15-cylindrical inner case, 16-cylindrical case, 17-heavy ion microporous membrane duct.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the utility model embodiment, be clearly and completely described the technical scheme in the utility model embodiment, obviously, described embodiment is only the utility model part embodiment, instead of whole embodiments.Based on the embodiment in the utility model, those of ordinary skill in the art are not making the every other embodiment obtained under creative work prerequisite, all belong to the scope of the utility model protection.
Refer to Fig. 1 ~ 4, in the utility model embodiment, the aseptic micro-pore-film filtration device of a kind of veterinary drug injection, comprise overanxious chamber 2, be positioned at import 3 above overanxious chamber, filter course 1 and filtrate exit pipe 6, wherein, overanxious chamber 2 is divided into upper chamber 5 and lower chambers 4, overanxious chamber 2 is formed in one manufacture, and upper chamber 5 is cylinder, lower chambers 4 is inverted cone, upper chamber 5 and lower chambers 4 milled processed, ensure sealing effectiveness, the position clamping be connected with lower chambers 4 in upper chamber 5 arranges filter course 1, above described filter course 1, heavy ion microporous membrane duct 17 is set, heavy ion microporous membrane duct 17 is single cone straight hole duct type, bipyramid straight hole duct type, single cone inclined hole duct type or bipyramid inclined hole duct type, wherein, the short liquid that is beneficial in single cone straight hole duct flows through, and have and not easily block, easy cleaned feature, the relatively short liquid that is beneficial in bipyramid straight hole duct flows through, difficulty of processing is relatively low, single cone inclined hole can effectively increase unit are the number of openings, increase liquid stream flux, and not easily block, be easy to cleaning, and bipyramid inclined hole effectively can increase unit are the number of openings, and difficulty of processing is relatively low, the heavy ion microporous membrane duct 17 of the utility model preferred bipyramid inclined hole type, filter core 14 below described filter course 1 superposes rear folding by liner 12, heavy ion microporous membrane 11 and outer lining 13 three and forms, be provided with cylindrical inner case 15 above filter core 14, below filter core 14, be positioned at filter course 1 bottommost and be provided with cylindrical case 16, in work, because heavy ion microporous membrane is because of the moulding process of its uniqueness, at present uniquely a kind ofly reach the filter membrane product sieving filtration completely, pore-size distribution is extremely narrow, it is the desirable film material of degerming end-filtration, so heavy ion microporous membrane is made foldable filter element, make full use of the feature that this film is frivolous, filtering accuracy is high, the large discharge in complete degerming situation, high life can be ensured, namely rejection rate is high, flow large, does not adsorb, does not come off, does not store breed bacteria, high temperature high voltage resistant, Stability Analysis of Structures, manufacturing cost is lower, the coaxial filtrate exit pipe 6 connecting taper bottom described lower chambers 4, and filtrate exit pipe 6 stretches in filtrate collection chamber 7 below centre position, and the outer wall of the outer wall of lower chambers 4 and filtrate collection chamber 7 is tightly connected, described filtrate collection chamber 7 top is provided with vacuum interface 8, and vacuum interface 8 connects vavuum pump, in work, vacuum interface 8 vacuumizes, and material enters filtrate collection chamber 7 after the filtration of filtering layer 4 under negative pressure, collects after terminating, stops vacuumizing.
To those skilled in the art, obvious the utility model is not limited to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present utility model or essential characteristic, can realize the utility model in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present utility model is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the utility model.Any Reference numeral in claim should be considered as the claim involved by limiting.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (1)

1. the aseptic micro-pore-film filtration device of veterinary drug injection, comprise overanxious chamber (2), be positioned at import (3) above overanxious chamber, filter course (1) and filtrate exit pipe (6), it is characterized in that, overanxious chamber (2) is divided into upper chamber (5) and lower chambers (4), and upper chamber (5) is cylinder, lower chambers (4) is inverted cone, and the position clamping be connected with lower chambers (4) in upper chamber (5) arranges filter course (1); Described filter course (1) top arranges heavy ion microporous membrane duct (17), and heavy ion microporous membrane duct (17) is single cone straight hole duct type, bipyramid straight hole duct type, single cone inclined hole duct type or bipyramid inclined hole duct type; The filter core (14) of described filter course (1) below superposes rear folding by liner (12), heavy ion microporous membrane (11) and outer lining (13) three and forms; Filter core (14) top is provided with cylindrical inner case (15), filter core (14) below, is positioned at filter course (1) bottommost and is provided with cylindrical case (16); The coaxial filtrate exit pipe (6) connecting taper in described lower chambers (4) bottom, and filtrate exit pipe (6) stretches into below filtrate collection chamber (7) interior centre position, and the outer wall of the outer wall of lower chambers (4) and filtrate collection chamber (7) is tightly connected; Described filtrate collection chamber (7) top is provided with vacuum interface (8), and vacuum interface (8) connects vavuum pump; Described overanxious chamber (2) is formed in one manufacture, upper chamber (5) and lower chambers (4) milled processed.
CN201420605279.1U 2014-10-20 2014-10-20 The aseptic micro-pore-film filtration device of a kind of veterinary drug injection Expired - Fee Related CN204261563U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201420605279.1U CN204261563U (en) 2014-10-20 2014-10-20 The aseptic micro-pore-film filtration device of a kind of veterinary drug injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201420605279.1U CN204261563U (en) 2014-10-20 2014-10-20 The aseptic micro-pore-film filtration device of a kind of veterinary drug injection

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CN204261563U true CN204261563U (en) 2015-04-15

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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108479418A (en) * 2018-04-27 2018-09-04 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 20
CN108554178A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 11
CN108554194A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 14
CN108554193A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 12
CN108554198A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 17
CN108554179A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 4
CN108554199A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 24
CN108554197A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 18
CN108554196A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 25
CN108554195A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 16
CN108579429A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 23
CN108579453A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 5
CN108579428A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 10
CN108579457A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 13
CN108579424A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 3
CN108579455A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 8
CN108579454A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 9
CN108579456A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 7
CN108579459A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 24
CN108579458A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 19
CN108579425A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 2
CN108579460A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 21
CN108619919A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 6
CN108619922A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 4
CN108619918A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 10
CN108619920A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 12
CN108654380A (en) * 2018-04-27 2018-10-16 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 14
CN108671763A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 16
CN108671768A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 15
CN108671762A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 22
CN108671761A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 17
CN108671766A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 2

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108479418A (en) * 2018-04-27 2018-09-04 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 20
CN108554178A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 11
CN108554194A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 14
CN108554193A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 12
CN108554198A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 17
CN108554179A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 4
CN108554199A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 24
CN108554197A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 18
CN108554196A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 25
CN108554195A (en) * 2018-04-27 2018-09-21 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 16
CN108579429A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 23
CN108579453A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 5
CN108579428A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 10
CN108579457A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 13
CN108579424A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 3
CN108579455A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 8
CN108579454A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 9
CN108579456A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 7
CN108579459A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 24
CN108579458A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 19
CN108579425A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 2
CN108579460A (en) * 2018-04-27 2018-09-28 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 21
CN108619919A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 6
CN108619922A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 4
CN108619918A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 10
CN108619920A (en) * 2018-04-27 2018-10-09 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 12
CN108654380A (en) * 2018-04-27 2018-10-16 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 14
CN108671763A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 16
CN108671768A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 15
CN108671762A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 22
CN108671761A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count is 17
CN108671766A (en) * 2018-04-27 2018-10-19 袁虹娣 The novel tree-shaped nanoscale cylindrical hole filter membrane that branch's hole count for Liquid-liquid separation is 2

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Address after: 331100 Jiangxi city of Fengcheng province Fengcheng Industrial Park, Longzhou Road, No. 11

Patentee after: JIANGXI CHENGBIXIN BIOTECHNOLOGY CO., LTD.

Address before: 331100 Jiangxi city of Shangrao province Fengcheng Fengyuan Industrial Park, Longzhou Road, No. 11

Patentee before: JIANGXI CHENGBIXIN BIOTECHNOLOGY CO., LTD.

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Granted publication date: 20150415

Termination date: 20171020

CF01 Termination of patent right due to non-payment of annual fee