CN204120989U - Inner peeping type optical molecular image-guidance system - Google Patents
Inner peeping type optical molecular image-guidance system Download PDFInfo
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- CN204120989U CN204120989U CN201420406535.4U CN201420406535U CN204120989U CN 204120989 U CN204120989 U CN 204120989U CN 201420406535 U CN201420406535 U CN 201420406535U CN 204120989 U CN204120989 U CN 204120989U
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- 230000003287 optical effect Effects 0.000 title claims abstract description 154
- 208000008918 voyeurism Diseases 0.000 title claims abstract description 20
- 230000011664 signaling Effects 0.000 claims abstract description 54
- 238000012545 processing Methods 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 19
- 230000003595 spectral effect Effects 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 15
- 238000001228 spectrum Methods 0.000 claims abstract description 11
- 238000003384 imaging method Methods 0.000 claims description 20
- 239000013307 optical fiber Substances 0.000 claims description 16
- 230000005284 excitation Effects 0.000 claims description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000000701 chemical imaging Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
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Abstract
This utility model relates to a kind of inner peeping type optical molecular image-guidance system.System comprises: light source module, optical signalling acquisition module, computer control and processing module, system support module and optical filter handover module; The search coverage of light source module to tissue to be measured is irradiated, for search coverage provides exciting light and visible ray; Optical signalling acquisition module obtains fluorescence and visible images according to the reflected light of search coverage; Computer controls to control the first fluorescence camera in optical signalling acquisition module, the second fluorescence camera and color camera with processing module, and the fluorescence collect optical signalling acquisition module and visible images process and show; System support model calling and each parts of support; Optical filter handover module provides the optical filter of different spectrum for light source module and optical signalling acquisition module.The Image Mosaic of different spectral coverage to together, is realized the image co-registration of spectrum and shows by this utility model.
Description
Technical field
This utility model relates to optical image technology field, particularly relates to a kind of inner peeping type optical molecular image-guidance system.
Background technology
After radionuclide imaging, positron emission computerized tomography, single photon emission computed tomography and nuclear magnetic resonance, in recent years, molecular image learns a skill development, as one of the important mode of molecular image, optical molecular image technology becomes study hotspot gradually, and wherein near-infrared fluorescence imaging receives much attention.Even if but the application of optical molecular image is comparatively wide, penetration depth is still a large obstacle of its extensive use, and how can realize depth finding is current problem demanding prompt solution.
Utility model content
The purpose of this utility model is the defect for prior art, provides a kind of inner peeping type optical molecular image-guidance system, according to the feature of optical molecular image, adopts three cameras to realize the functions such as the acquisition of fluorescence, visible ray and split image.
For achieving the above object, this utility model provides a kind of inner peeping type optical molecular image-guidance system, and described system comprises: light source module (110), optical signalling acquisition module (120), computer control and processing module (130), system support module (140) and optical filter handover module (150);
Described system support module (140) is connected with optical signalling acquisition module (120) with described light source module (110) respectively, described light source module (110) is connected with described optical filter handover module (150), described optical filter handover module (150) is connected with described optical signalling acquisition module (120), and described optical signalling acquisition module (120) and described computer control to be connected with processing module (130);
The search coverage (100) of described light source module (110) to tissue to be measured is irradiated, and provides exciting light and visible ray; Described optical signalling acquisition module (120) obtains fluorescence and visible images according to the reflected light of described search coverage (100); Described computer controls to control the first fluorescence camera (129) in described optical signalling acquisition module (120), the second fluorescence camera (1210) and color camera (125) with processing module (130), and the fluorescence collect described optical signalling acquisition module (120) and visible images process and show; Described system support module (140) connects and supports each parts; Described optical filter handover module (150) provides the optical filter of different spectrum for described light source module (110) and described optical signalling acquisition module (120).
Further, described light source module (110) comprises exciting light optical fiber (111), visible ray optical fiber (112), the first optical filter (113), the second optical filter (114), exciting light sources (115) and visible light source (116) further;
Described exciting light optical fiber (111) is connected with described first optical filter (113), is guided out the exciting light that described exciting light sources (115) sends, and carries out excitation light irradiation to described search coverage (100);
Described visible ray optical fiber (112) is connected with described second optical filter (114), is guided out the visible ray that described visible light source (116) sends, and described search coverage (100) provides lighting source.
Further, described optical signalling acquisition module (120) comprises signals collecting optical fiber (121), endoscope head (122), the first Amici prism (123), the 3rd optical filter (124), the second Amici prism (126), the 4th optical filter (127), the 5th optical filter (128), the first fluorescence camera (129), the second fluorescence camera (1210) and color camera (125) further, wherein, described first Amici prism (123) and the second Amici prism (126) are made up of 55 Amici prisms;
Relative distance between each device in described optical signalling acquisition module (120) is fixed, optical signal enters described system by camera lens, be converted into directional light, by the first Amici prism (123) and the second Amici prism (126), light is divided into three beams, carries out imaging by three cameras respectively;
The camera lens of described optical signalling acquisition module (120) is endoscope, C interface camera lens or F interface camera lens.
Further, described computer controls to comprise control module (131), image processing module (132) and display module (133) further with processing module (130);
The imaging parameters of described control module (131) to described first fluorescence camera (129), the second fluorescence camera (1210) and color camera (125) controls;
Described image processing module (132) is taken to described first fluorescence camera (129), the second fluorescence camera (1210) and color camera (125) view data obtained and is processed;
Described display module (133) shows in real time for the image obtained after described image processing module (132) process.
Further, described system support module (140) comprises optical signalling collection support (141), computer support (142) and light source bracket (143) further;
Described optical signalling gathers support (141) support of optical signal acquisition module (120), and described optical signalling gathers support (141) multi-faceted imaging;
Described computer support (142) supports computer and controls and processing module (130);
Described light source bracket (143) supporting light sources module (110), described exciting light sources (115) and visible light source (116) are in described light source bracket (143).
Further, described optical filter handover module (150) is filter wheel device, according to the exciting characteristic of different fluorescence, adjusts the spectral coverage of each optical filter, carries out exciting and gathering of multispectral light.
This utility model is excited search coverage by light source module, optical signalling acquisition module carries out Real-time Collection light, the light of optical filter handover module to different spectral coverage filters, computer module carries out real-time process to the image information collected, by the Image Mosaic of different spectral coverage to together, realize the image co-registration of spectrum and show.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of this utility model inner peeping type optical molecular image-guidance system;
Fig. 2 is the light source module structure block diagram of this utility model inner peeping type optical molecular image-guidance system;
Fig. 3 is the optical signalling acquisition module structured flowchart of this utility model inner peeping type optical molecular image-guidance system;
The computer that Fig. 4 is this utility model inner peeping type optical molecular image-guidance system controls with shown in processing module structured flowchart;
Fig. 5 is the supporting module structural representation of this utility model inner peeping type optical molecular image-guidance system;
Fig. 6 is the flow chart of the multispectral imaging method of this utility model inner peeping type optical molecular image-guidance system.
Detailed description of the invention
Below by drawings and Examples, the technical solution of the utility model is described in further detail.
The detection mode of inner peeping type has the advantages such as investigation depth is controlled, effectively can solve the problem of penetration depth.By this utility model, interior of articles can be entered by endoscope head and carry out depth finding, can observe and localize fluorescent position, can be applied in industry detection and biomedical sector.
Fig. 1 is the schematic diagram of this utility model inner peeping type optical molecular image-guidance system, as shown in the figure, this utility model comprises light source module 110, optical signalling acquisition module 120, computer control and processing module 130, system support module 140 and optical filter handover module 150.
System support module 140 is connected with optical signalling acquisition module 120 with light source module 110 respectively, light source module 110 is connected with optical filter handover module 150, optical filter handover module 150 is connected with optical signalling acquisition module 120, and optical signalling acquisition module 120 and computer control to be connected with processing module 130.
The light source module structure block diagram of this utility model inner peeping type optical molecular image-guidance system shown in Figure 2 in the lump, the optical signalling acquisition module structured flowchart of this utility model inner peeping type optical molecular image-guidance system shown in Fig. 3, the computer of this utility model inner peeping type optical molecular image-guidance system shown in Fig. 4 controls with shown in processing module structured flowchart.
Light source module 110 for irradiating the search coverage 100 of tissue to be measured, for search coverage 100 provides exciting light and visible ray.
Optical signalling acquisition module 120 is for obtaining fluorescence and visible images according to the reflected light of search coverage 100.
Computer controls to be connected with optical signalling acquisition module 120 with processing module 130, for controlling the first fluorescence camera 129, second fluorescence camera 1210 in optical signalling acquisition module 120 and color camera 125, the fluorescence collect optical signalling acquisition module 120 and visible images process and show.
System support module 140, for connecting and supporting each parts.
Optical filter handover module 150, for providing the optical filter of different spectrum for light source module 110 and optical signalling acquisition module 120.
Light source module 110 comprises exciting light optical fiber 111, visible ray optical fiber 112, first optical filter 113, second optical filter 114, excitation source 115 and visible light source 116 further, wherein, exciting light optical fiber 111 is connected with the first optical filter 113, for being guided out the exciting light that exciting light sources 115 sends, to carry out excitation light irradiation to search coverage 100; Visible ray optical fiber 112 is connected with the second optical filter 114, for being guided out the visible ray that visible light source 116 sends, for search coverage 100 provides lighting source.
Optical signalling acquisition module 120 comprises signals collecting optical fiber 121, endoscope head 122, first Amici prism 123, the 3rd optical filter 124, second Amici prism 126, the 4th optical filter 127, the 5th optical filter 128, first fluorescence camera 129, second fluorescence camera 1210 and color camera 125 further, wherein, endoscope head 122 is connected with signals collecting optical fiber 121, for utilizing emitted light being guided to the first Amici prism 123 place and being adjusted to image sharpness; The incident light end of the first Amici prism 123 is connected with the end of endoscope head 122, two exit ends connect the 3rd optical filter 124 and the second Amici prism 126 respectively, 3rd optical filter 124 is connected with color camera 125, the incident light end of the second Amici prism 126 is connected with an exit end of the first Amici prism 123, two exit ends are connected with the second fluorescence camera 1210 with the first fluorescence camera 129 with the 5th optical filter 128 respectively by the 4th optical filter 127, are divided into three beams for Ray Of Light endoscope head 122 transmitted; First Amici prism 123 and the second Amici prism 126 are made up of 55 Amici prisms; First fluorescence camera 129, second fluorescence camera 1210 controls to be connected with processing module 130 with color camera 125 and computer, for carrying out imaging according to the emergent ray of the first Amici prism 123 and the second Amici prism 126, and the image transmitting with different spectrum or different-energy obtained respectively is controlled and processing module 130 to computer.
Relative distance between each device in optical signalling acquisition module 120 is fixing, namely optical signal enters in system by camera lens, first directional light is converted into, each optics distance is certain, namely light path is certain, optical signal propagation wherein does not affect the quality of imaging, by the first Amici prism 123 and the second Amici prism 126, light is divided into three beams, carries out imaging respectively by three cameras.So optical signalling acquisition module 120 is a general spectral module, and namely no matter camera lens is chosen as endoscope, C interface camera lens or F interface camera lens, as long as adjust to suitable flange distance, can blur-free imaging on computers.
Computer controls to comprise control module 131, image processing module 132 and display module 133 further with processing module 130, wherein, control module 131 is for controlling the imaging parameters such as time of exposure etc. of the first fluorescence camera 129, second fluorescence camera 1210 and color camera 125; Image processing module 132 processes for taking to the first fluorescence camera 129, second fluorescence camera 1210 and color camera 125 view data obtained, and process comprises the function such as image reconstruction and image co-registration; Wherein, image reconstruction algorithm comprises:
Step 1, tested discrete region is turned to tetrahedral grid, obtain sytem matrix A
Step 2, collection fluorescence data, obtain calculation matrix Φ
Step 3, calculating H=A
ta
Step 4, compute vector B=A
tΦ
The eigenvalue of maximum λ of step 5, compute matrix H
max
Step 6, make c=λ
max+ ε
Step 7, calculating D
(k)=c
-1b-c
-1hX
(k)+ X
(k)
Step 8, renewal x, X
(K+1)[i]=Shrink (D
(k)[i])
Step 9, repetition step 7,8, iteration 1000 times, exports x.
X is the concrete fluorescence information reconstructed, and comprises position and depth information, with Color Image Fusion, realizes observing fluorescent places in White-light image, realizes multispectral imaging.
Display module 133, for showing in real time for the image obtained after image processing module 132 process, is observed for operator.
Fig. 5 is the supporting module structural representation of this utility model inner peeping type optical molecular image-guidance system, and as shown in the figure, system support module 140 comprises optical signalling further and gathers support 141, computer support 142 and light source bracket 143.Wherein, optical signalling gathers support 141 for support of optical signal acquisition module 120, and optical signalling gathers support 141 can carry out 180 ° of rotations, for multi-faceted imaging; Computer support 142 controls and processing module 130 for supporting computer, and the control of system all completes with process on computer support 142; Light source bracket 143 is for supporting light sources module 110, and exciting light sources 115 and visible light source 116 are placed wherein.The arm of force of system support module 140 can carry out 360 ° of rotations, can realize the signals collecting in each orientation, greatly improve motility and the operability of system.
Optical filter handover module 140 is filter wheel device, for the exciting characteristic according to different fluorescence, adjusts the spectral coverage of each optical filter, to ensure exciting and gathering of multispectral light, avoids the mutual interference of different spectrum light.The spectral coverage of each optical filter, once after adjusting, will no longer switch in the process of whole realtime imaging.The quantity of optical filter can be installed as required, in this utility model one embodiment, the quantity of optical filter is the 5: first optical filter 113, second optical filter 114, the 3rd optical filter 124, the 4th optical filter 127 and the 5th optical filter 128, the spectral coverage of optical filter is near infrared range, is specially:
The spectral coverage of the first optical filter 113 is 710nm-770nm, and diameter is 25mm;
The spectral coverage of the second optical filter 114 is 400nm-650nm, and diameter is 25mm;
The spectral coverage of the 3rd optical filter 124 is 400nm-650nm, and diameter is 25mm;
The spectral coverage of the 4th optical filter 127 is 710nm-770nm, and diameter is 25mm;
The spectral coverage of the 5th optical filter 128 is 810nm-870nm, and diameter is 25mm.
In the actual use procedure of operator, the optical filter with suitable spectrum can be switched according to concrete demand.
Fig. 6 is the flow chart of the multispectral imaging method of this utility model inner peeping type optical molecular image-guidance system, and as shown in the figure, this method specifically comprises the steps:
Step S101, makes exciting light sources 115 and visible light source 116 pairs of search coverages 100 irradiate respectively;
Step S102, according to detection feature, optical filter modular converter 140 is arranged for the parameter of optical filter in light source module 110, optical signalling acquisition module 120;
Step S103, the imaging parameters of control module 131 to the first fluorescence camera 129, second fluorescence camera 1210 and color camera 125 adjusts, and the reflected light that the first fluorescence camera 129, second fluorescence camera 1210 and color camera 125 have different spectrum or energy according to search coverage 100 respectively collects image;
Step S104, image processing module 132 processes the image that the first fluorescence camera 129, second fluorescence camera 1210 and color camera 125 collect;
Step S105, image after the process that display module 133 obtains for step S104 shows in real time, if the image of display does not reach definition requirement, then regulated the parameter of endoscope head 122 by optical signalling acquisition module 120, until the image that display module 133 shows reaches definition requirement;
Step S106, mobile endoscope head 122, finds fluorescent object, finally obtains the picture rich in detail of fluorescent object in search coverage 100 to be measured.
This utility model is excited search coverage by light source module, optical signalling acquisition module carries out Real-time Collection light, the light of optical filter handover module to different spectral coverage filters, computer module carries out real-time process to the image information collected, by the Image Mosaic of different spectral coverage to together, realize the image co-registration of spectrum and show.Most fluorescent product all adopts single CCD camera to carry out imaging on the market at present, can only see fluoroscopic image or visible images, and cannot see multispectral image when its shortcoming is imaging; And surface image or shallow chart picture can only be seen during imaging, cannot detect its interior zone.And this utility model effectively solves this problem, reduce the threshold of optical molecular imaging research, expanded the scope of optical molecular imaging study and application.
Above-described detailed description of the invention; the purpose of this utility model, technical scheme and beneficial effect are further described; be understood that; the foregoing is only detailed description of the invention of the present utility model; and be not used in restriction protection domain of the present utility model; all within spirit of the present utility model and principle, any amendment made, equivalent replacement, improvement etc., all should be included within protection domain of the present utility model.
Claims (6)
1. an inner peeping type optical molecular image-guidance system, it is characterized in that, described system comprises: light source module (110), optical signalling acquisition module (120), computer control and processing module (130), system support module (140) and optical filter handover module (150);
Described system support module (140) is connected with optical signalling acquisition module (120) with described light source module (110) respectively, described light source module (110) is connected with described optical filter handover module (150), described optical filter handover module (150) is connected with described optical signalling acquisition module (120), and described optical signalling acquisition module (120) and described computer control to be connected with processing module (130);
The search coverage (100) of described light source module (110) to tissue to be measured is irradiated, and provides exciting light and visible ray; Described optical signalling acquisition module (120) obtains fluorescence and visible images according to the reflected light of described search coverage (100); Described computer controls to control the first fluorescence camera (129) in described optical signalling acquisition module (120), the second fluorescence camera (1210) and color camera (125) with processing module (130), and the fluorescence collect described optical signalling acquisition module (120) and visible images process and show; Described system support module (140) connects and supports each parts; Described optical filter handover module (150) provides the optical filter of different spectrum for described light source module (110) and described optical signalling acquisition module (120).
2. system according to claim 1, it is characterized in that, described light source module (110) comprises exciting light optical fiber (111), visible ray optical fiber (112), the first optical filter (113), the second optical filter (114), exciting light sources (115) and visible light source (116) further;
Described exciting light optical fiber (111) is connected with described first optical filter (113), is guided out the exciting light that described exciting light sources (115) sends, and carries out excitation light irradiation to described search coverage (100);
Described visible ray optical fiber (112) is connected with described second optical filter (114), is guided out the visible ray that described visible light source (116) sends, and described search coverage (100) provides lighting source.
3. system according to claim 1, it is characterized in that, described optical signalling acquisition module (120) comprises signals collecting optical fiber (121) further, endoscope head (122), first Amici prism (123), 3rd optical filter (124), second Amici prism (126), 4th optical filter (127), 5th optical filter (128), first fluorescence camera (129), second fluorescence camera (1210) and color camera (125), wherein, described first Amici prism (123) and the second Amici prism (126) are made up of 55 Amici prisms,
Relative distance between each device in described optical signalling acquisition module (120) is fixed, optical signal enters described system by camera lens, be converted into directional light, by the first Amici prism (123) and the second Amici prism (126), light is divided into three beams, carries out imaging by three cameras respectively;
The camera lens of described optical signalling acquisition module (120) is endoscope, C interface camera lens or F interface camera lens.
4. system according to claim 1, it is characterized in that, described computer controls to comprise control module (131), image processing module (132) and display module (133) further with processing module (130);
The imaging parameters of described control module (131) to described first fluorescence camera (129), the second fluorescence camera (1210) and color camera (125) controls;
Described image processing module (132) is taken to described first fluorescence camera (129), the second fluorescence camera (1210) and color camera (125) view data obtained and is processed;
Described display module (133) shows in real time for the image obtained after described image processing module (132) process.
5. system according to claim 1, is characterized in that, described system support module (140) comprises optical signalling further and gathers support (141), computer support (142) and light source bracket (143);
Described optical signalling gathers support (141) support of optical signal acquisition module (120), and described optical signalling gathers support (141) multi-faceted imaging;
Described computer support (142) supports computer and controls and processing module (130);
Described light source bracket (143) supporting light sources module (110), described exciting light sources (115) and visible light source (116) are in described light source bracket (143).
6. system according to claim 1, is characterized in that, described optical filter handover module (150) is filter wheel device, according to the exciting characteristic of different fluorescence, adjusts the spectral coverage of each optical filter, carries out exciting and gathering of multispectral light.
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| CN201420406535.4U CN204120989U (en) | 2014-07-22 | 2014-07-22 | Inner peeping type optical molecular image-guidance system |
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| CN201420406535.4U CN204120989U (en) | 2014-07-22 | 2014-07-22 | Inner peeping type optical molecular image-guidance system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106066981A (en) * | 2016-06-01 | 2016-11-02 | 上海慧银信息科技有限公司 | Scanning head |
| CN107811706A (en) * | 2017-11-27 | 2018-03-20 | 东北大学 | A kind of operation guiding system based on image transmission optical fibre |
| CN107822585A (en) * | 2017-11-27 | 2018-03-23 | 东北大学 | A kind of multi-functional endoscopic system |
| CN111426640A (en) * | 2020-05-18 | 2020-07-17 | 中国工程物理研究院流体物理研究所 | Switchable continuous working spectrum camera and detection method |
| CN114052908A (en) * | 2021-12-01 | 2022-02-18 | 辽宁北镜医疗科技有限公司 | Navigation system and method in near-infrared fluorescence operation based on illumination adjustment |
-
2014
- 2014-07-22 CN CN201420406535.4U patent/CN204120989U/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106066981A (en) * | 2016-06-01 | 2016-11-02 | 上海慧银信息科技有限公司 | Scanning head |
| CN106066981B (en) * | 2016-06-01 | 2018-08-24 | 上海慧银信息科技有限公司 | Scanning head |
| CN107811706A (en) * | 2017-11-27 | 2018-03-20 | 东北大学 | A kind of operation guiding system based on image transmission optical fibre |
| CN107822585A (en) * | 2017-11-27 | 2018-03-23 | 东北大学 | A kind of multi-functional endoscopic system |
| CN107822585B (en) * | 2017-11-27 | 2019-03-05 | 东北大学 | A kind of multi-functional endoscopic system |
| WO2019100450A1 (en) * | 2017-11-27 | 2019-05-31 | 东北大学 | Multi-functional endoscope system |
| WO2019100449A1 (en) * | 2017-11-27 | 2019-05-31 | 东北大学 | Imaging fiber based surgical navigation system |
| CN111426640A (en) * | 2020-05-18 | 2020-07-17 | 中国工程物理研究院流体物理研究所 | Switchable continuous working spectrum camera and detection method |
| CN114052908A (en) * | 2021-12-01 | 2022-02-18 | 辽宁北镜医疗科技有限公司 | Navigation system and method in near-infrared fluorescence operation based on illumination adjustment |
| CN114052908B (en) * | 2021-12-01 | 2024-02-13 | 辽宁北镜医疗科技有限公司 | Near infrared fluorescence intraoperative navigation system and method based on illumination adjustment |
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