CN204039419U - A kind of micro-capsule preparation facilities - Google Patents

Abstract

The utility model provides a kind of micro-capsule preparation facilities, and be made up of injecting unit and mixing power unit, described injecting unit comprises composite injection device, pallet, voltage generating unit, elevating lever and fixture; Vertical fixing elevating lever on pallet, elevating lever is provided with fixture moving up and down, described main body syringe is column shape container, and wall is provided with bipass, and the other end of bipass inserts input syringe; Voltage generating unit comprises positive electrode connective bar, negative potential incoming end, positive electrode incoming end; Described mixing power unit comprises Stirling power set and hand gear.The experiment condition that the microcapsules and microsphere that the utility model is produced provides in conjunction with the utility model, has volume little, and form is justified and uniform feature, good with the consistency of tissue.In order to control voltage and hydraulic piston movement, can additionally purchase high pressure static electricity field generator and microinfusion pump.Installation cost of the present utility model is low, easy to use.Whole device volume is little, can use in Bechtop.

Description

A kind of micro-capsule preparation facilities

Technical field

The utility model belongs to biochemical field, particularly, relates to a kind of device preparing the particle of wrapping biological macromole cell.

Background technology

Microencapsulation belongs to the one of immobilization technology, its essence is a kind of made semi-permeable membranes, enzyme, coenzyme, protein and other or animal and plant cells are wrapped in wherein.Microcapsule membrane allows the small-molecule substance by below 100ku, cell in capsule can carry out exchange of substance through microcapsule membrane and the external world, obtain nutrition and discharge metabolic waste, and the immunoglobulin (Ig) of macromolecule not by, thus improve cell density and product assay, and facilitate separation and purification treatment, avoid immunologic injury.

The method preparing micro-capsule mainly utilizes polyelectrolyte complex principle, and with polyanion and the polycation reaction of oppositely charged, around encrusting substance, form coating in physiological conditions, preparation method mainly comprises air-atomizing encystation method and high potentiometric dispersion technique.Islet cells is wrapped in sodium alginate by Lim in 1980 etc. first; in the poly-bad intoxicated polymine film of ammonia; be implanted into experimental diabetic rats intraperitoneal; maintain euglycemia and reach 3 weeks; experiment demonstrates the immune buffer action of micro-capsule; its protection graft from immunity of organism rejection, and extends the survival of external source pancreas islet and function is held time.This experiment brings initiative breakthrough to pancreatic islets transplantation research, thus makes pancreatic islets transplantation technology enter new epoch.

Current, the domestic personnel being engaged in microencapsulation research direction there is no a kind of specially, microencapsulation apparatus for preparation easily, mostly be homemade simple instrument, for patent CN 1566339A, this design mainly contains several shortcoming: be 1. difficult to accuracy controlling needle point to liquid level, controls the height condition of reaction.2. each use all needs lengthy and tedious number of assembling steps, as changed syringe etc.3. microinfusion pump is directly placed in more than response location, there is potential safety hazard.4. reaction vessel mixes function without solution, and the microcapsules and microsphere produced easily occurs pile up and cause sticking into group, the experiment material that waste is valuable.

Utility model content

For the weak point that this area exists, the purpose of this utility model proposes a kind of micro-capsule preparation facilities.

The technical scheme realizing the utility model object is:

A kind of micro-capsule preparation facilities, is made up of injecting unit and mixing power unit, and injecting unit and mixing power unit are all fixed in rectangular base;

Described injecting unit comprises composite injection device, pallet, voltage generating unit, elevating lever and fixture; Vertical fixing elevating lever on described pallet, elevating lever is provided with fixture moving up and down, described composite injection device is connected with fixing elevating lever by described fixture;

Described composite injection device comprises main body syringe, input syringe, needle assembly, bipass; Described needle assembly comprises the syringe needle that three are fixed on needle mount parallel connection, and described main body syringe is column shape container, and wall is provided with bipass, and the other end of bipass inserts input syringe;

Described voltage generating unit comprises positive electrode connective bar, negative potential incoming end, positive electrode incoming end; Described negative potential incoming end is connected by wire with positive electrode incoming end, and described positive electrode connective bar is connected with syringe needle by the wire of needle mount inside; The end of described negative potential incoming end is metal bar, is connected with pallet by switch assembly;

Described mixing power unit comprises Stirling power set and hand gear; Described Stirling power set comprises cylindrical glass outer cover, be placed in piston in glass outer and spirit lamp, and described piston is connected with the first driven rod; Described hand gear is can the handwheel of hand rotation, and described handwheel connects the second driven rod; Described first driven rod is all connected with pallet with the second driven rod.

Wherein, input syringe is conventional universal syringe, is responsible for interim accommodation microencapsulation object-enzyme, coenzyme, protein and other or animal and plant cells.Further, the bottom of needle assembly and composite injection device is designed for Detachable, agrees with by bottom outlet and ditch siphunculus the bottom being temporarily fixedly connected on composite injection device.

Wherein, described fixture is fixed with tubing, stationary jaw, for adjusting the upper and lower spiral micro actuator of fixture and pressing from both sides for pressing from both sides positive electrode connective bar electricity.

Described stationary jaw is provided with four variable folders, is fixed on by described composite injection device in the middle of four variable folders.

Wherein, described main body syringe is column shape container, and there is piston inside, and piston connects piston push rod and manual draw bar in turn; Described piston has the region moved up and down in column shape container;

Described main body syringe top has insertion sheath and the block that can open of tubing.

Preferably, the bottom of fixture is "T"-shaped height gauge, and the bottom syringe needle in parallel with three of ruler is high together; There is graduated scale the below of elevating lever, is subtracted each other by scale, conveniently can calculate the height of liquid level and needle point.Further, height gauge is located at the positive front lower place, bottom of fixture.

Wherein, the end of described negative potential incoming end is metal bar, exports pin be connected by switch assembly and negative potential, and described negative potential exports pin syringe needle and pallet spacing is 1-3mm.(syringe needle does not contact with pallet, because pallet will put culture dish, so there is the space of 1-3mm between syringe needle and pallet).

Preferably, described rectangular base is also provided with the safety switch for closing voltage of electric field.

Wherein, the cylindrical glass outer cover of described Stirling power set is provided with scatterer near one end of pallet; The second driven rod that described handwheel connects is outside equipped with heat radiation outer cover, is connected with nonrigid plastic open tube between cylindrical glass outer cover and heat radiation outer cover.Because the heat radiation outer cover of hand gear is the secondary heat abstractor of scatterer, in order to improving heat radiation efficiency and pneumatic efficiency, the scaled down version of Stirling power unit can be regarded as, just not add spirit lamp.So connecting two devices with open tube is the objects flowed between two to reach gas.So this open tube need be thinner pipe, and the material of open tube can be soft plastics or metal.

Wherein, described tray bottom is uniformly distributed four around bearing, is placed on basetray; Described threaded shaft is contracted and is drawn together disk, middle disk, lower disc, head bearing, lower bearing, upper disk, middle disk, and the edge of lower disc is fixedly connected with; Being positioned at four of tray bottom around bearing is one group every two of the same side around bearing, connects with belt.

Adopt device described in the utility model to prepare the method for micro-capsule, comprise step:

1) culture dish that calcium chloride solution is housed is placed on pallet, puts down negative potential and export pin end, confirm that needle point inserts liquid level and away from the center of culture dish, in case the microballoon of microencapsulation occurs sticky glutinous.

2) three syringe needles in parallel are adjusted between distance calcium chloride liquid level 9mm ~ 21mm;

3) drawing with input syringe the concentration mixed is the sodium alginate of 2% and the mixture of cell, then syringe is inserted the interface of bipass;

4) open the first bipass, push injection device afterbody makes sodium alginate mixture input main body syringe, and namely piston is pushed upwardly thereupon.

5) with spirit lamp Preheat glass outer cover.Before shaking table starts formal running, at least preheating 1min should be ensured.

6) open block, tubing injects liquid, as hydraulic power to the top of main body syringe.Until liquid by when filling up the top cavity volume of main body syringe, close block, stop bolus injection.

7) manual toggle pallet, under the effect of Stirling power set, pallet starts shaking table motion.

8) open the second bipass, safety switch, and control at 10-15ml/h by the transfusion speed of microinfusion pump, namely syringe needle starts to export sodium alginate mixture.

Preferably, described positive electrode connective bar and negative potential export the voltage between pin is 4000V ~ 11000V.

When lacking spirit lamp under experiment condition, can in step 7) in manually shake handwheel generation shaking table motion.

The rotating speed of coarse adjustment shaking table is carried out by the distance between debugging spirit lamp flame and glass outer.

The utility model method has the following advantages:

The experiment condition that the microcapsules and microsphere that the utility model is produced provides in conjunction with the utility model, has volume little, and form is justified and uniform feature, good with the consistency of tissue.In order to control voltage and hydraulic piston movement, can additionally purchase high pressure static electricity field generator and microinfusion pump.Installation cost of the present utility model is low, easy to use.Whole device volume is little, can use in Bechtop.

The fixture of the application can for the characteristic of the microballoon of different size or capsulating material, and accuracy controlling needle point is to liquid level; Change capsulating material or biomaterial, do not need to re-assembly, change syringe convenient; There is provided solution mixing function with Stirling power or dynamo power, the shake speed of pallet is controlled, more stable than the shaking apparatus of prior art, speed is adjustable.

Accompanying drawing explanation

Fig. 1 is the utility model micro-capsule preparation facilities stereographic map.

Fig. 2 is the micro-capsule preparation facilities stereographic map not placing injecting unit.

Fig. 3 is injecting unit stereographic map.

Fig. 4 is needle assembly stereographic map.

Fig. 5 is micro-capsule preparation facilities base partial view.

Fig. 6 is the front view of Stirling power set.

Fig. 7 be in Fig. 7 pallet remove after vertical view.

Fig. 8 is mixing power unit part sectioned view

In figure, component names and numbering corresponding relation are:

Composite injection device 1, base 2, pallet 3, mixing power unit 4, main body syringe 5, input syringe 6, needle assembly 7, fixture 8, elevating lever 9, base body 10, tray main body 11, negative potential exports pin 12, around bearing 13, syringe needle 14, needle mount 15, plastic safety cover 16, positive electrode connective bar 17, negative potential incoming end 18, positive electrode incoming end 19, safety switch 20, first bipass 21, second bipass 22, ditch siphunculus 23, block 24, manual draw bar 25, insert sheath 26, fixed leg 27, piston push rod 28, piston 29, tubing 30, microinfusion pump extension tube 31, bottom outlet 34, ditch siphunculus 35, stationary jaw 36, spiral micro actuator 37, electricity folder 38, variable folder 39, height gauge 40, graduated scale 41, plug 42, arc-shaped conductive film 44, metal bar 45, upper disk 46, middle disk 47, lower disc 48, head bearing 49, lower bearing 50, lower disc 51, belt 52, first driven rod 53, first driven rod connecting rod 54, scatterer 55, Stirling device piston 56, glass outer 57, Stirling device pillar stiffener 58, spirit lamp 59, seal cartridge 60, second driven rod 61, the piston 62 of hand gear, heat radiation outer cover 63, handwheel connecting rod 64, handwheel 65, hand gear pillar stiffener 66, hand gear seal cartridge 67, spill wheel shaft 68, nonrigid plastic open tube 69.

Embodiment

Following examples for illustration of the utility model, but are not used for limiting scope of the present utility model.

Unless stated otherwise, the technique means that the utility model adopts is the technique means of this area routine.

In description of the present utility model, it should be noted that, term " " center ", " longitudinal direction ", " transverse direction ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end " " interior ", orientation or the position relationship of the instruction such as " outward " are based on orientation shown in the drawings or position relationship, only the present invention for convenience of description and simplified characterization, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore limitation of the present invention can not be interpreted as.

Embodiment 1 micro-capsule preparation facilities

See Fig. 1 and Fig. 2, the present embodiment micro-capsule preparation facilities, is made up of injecting unit and mixing power unit 4, and injecting unit and mixing power unit are all fixed in rectangular base 2.Described injecting unit comprises composite injection device 1, pallet 3, voltage generating unit, elevating lever 9 and fixture 8; Vertical fixing elevating lever 9 on described pallet 3, elevating lever 9 is provided with fixture moving up and down, and described composite injection device 1 is connected with fixing elevating lever 9 by described fixture;

See Fig. 3.Described composite injection device 1 comprises main body syringe 5, input syringe 6, needle assembly 7, bipass 21; Described needle assembly 7 comprises the syringe needle 14 that three are fixed on needle mount 15 parallel connection, and described main body syringe 5 is column shape container, wall is provided with the first bipass 21 and the second bipass 21, and the other end of bipass inserts input syringe 6.The inside of bipass is a solid sphere, and spheroid has a hollow cylinder at the long axis direction at ditch siphunculus 23 place, has the function linking up input syringe 6 and main body syringe 5.When bipass rotates, hollow cylinder staggers the major axis of ditch siphunculus 23, and between input syringe 6 and main body syringe 5, pipeline was both closed.At the second bipass 22 of the bottom side of main body syringe, its structure is consistent with the first bipass 21, has the effect of the fluid passage opened or closed between main body syringe 5 and needle assembly 7.Black full-filling part on bipass shown in figure is finger contact and force sense of rotation.

Described voltage generating unit comprises positive electrode connective bar 17, negative potential incoming end 18 positive electrode incoming end 19; Described negative potential incoming end 18 is connected by wire with positive electrode incoming end 19, and described positive electrode connective bar 17 is connected with syringe needle 14 by the wire of needle mount 15 inside; The end of described negative potential incoming end 18 is metal bar 45, is connected with tray main body 11 (pallet 3 is positioned at tray main body 11 surface) by switch assembly;

This mixing power unit 4 comprises Stirling power set and hand gear; Described Stirling power set comprises cylindrical glass outer cover 57, be placed in piston 56 in glass outer 57 and spirit lamp 59, and described piston 56 is connected with the first driven rod connecting rod 54 and the first driven rod 53; Described hand gear be with pillar stiffener 66 support can the handwheel 65 of hand rotation, comprise transmission rod 64, handwheel 65, pillar stiffener 66, seal cartridge 67, spill wheel shaft 68.The outer rim of handwheel arranges handwheel connecting rod 64, and handwheel 65 connects the second driven rod 61 (being connected in the spill wheel shaft 68 of handwheel wheel shaft outer ring) by handwheel connecting rod 64; Second transmission rod 61 connects piston 62 (see Fig. 8), and have heat radiation outer cover 63 outside piston 62, described first driven rod 53 is all connected with pallet 3 with the second driven rod 61.The setting of hand gear seal cartridge 67 and effect are with Stirling device seal cartridge 60.

Fixture 8 is fixed with tubing 30, stationary jaw 36, for adjusting the spiral micro actuator 37 of fixture about 8 and pressing from both sides 38 for pressing from both sides positive electrode connective bar 17 electricity.Described stationary jaw 36 is provided with four variable folders 39, inserts fixed leg 27 and is fixed on by described composite injection device 1 in the middle of four variable folders 39.

Main body syringe 5 is column shape container, and there is piston 29 inside, piston connects in turn piston push rod 28 and manual draw bar 25; Piston 29 has the region moved up and down in column shape container;

Main body syringe 5 top has insertion sheath 26 and the block that can open 24 of tubing 30.The tubing 30 be fixedly linked with lifting device 8 can insert sheath 26.When microinfusion pump initiating switchup, first open block 24, then the liquid as impellent is made to enter tubing 30 from the back fluid inlet of combined lifting device 8 fast by supporting microinfusion pump extension tube 31, and then the top storage liquid space of main body syringe 5 is entered by feed liquor sheath 26, when liquid will fill up storage liquid space, stop microinfusion pump and close upper cap 24, for ensuing microcapsules and microsphere of formally preparing is prepared.See Fig. 4, the distributing position of three syringe needles is that three syringe needles 14 in parallel on the summit occupying an equilateral triangle are respectively connected with the metallic circuit of positive electrode connective bar 17 by needle mount 15 inside, and syringe needle 14 is communicated with bottom outlet 34 by inner path.Transparent plastic safety cover 16 is as insulation protection device annular around needle mount 15, and bottom level is a little more than syringe needle 14.Further, the bottom of needle assembly 7 and composite injection device 1 design for Detachable, agrees with by bottom outlet 34 and ditch siphunculus 35 bottom being temporarily fixedly connected on composite injection device 1.

In the present embodiment, the positive front lower place, bottom of fixture 8 is "T"-shaped height gauge 40, and the bottom of ruler is neat high with three syringe needles 14 fixed; There is graduated scale 41 below of elevating lever 9, is subtracted each other by scale, conveniently can calculate the height of liquid level and needle point.

The end of negative potential incoming end 18 is metal bar 45, exports pin 12 be connected by switch assembly and negative potential, and negative potential exports pin 12 syringe needle and pallet 3 spacing 2mm.Negative potential incoming end 18 and the positive electrode incoming end 19 of high pressure static electricity field generator connecting port is provided with on rear side of the upper left corner of base 10.Wherein, negative potential incoming end 18 is connected with plug 42 by internal wiring.Safety switch 20 controls generation or the stopping of high tension electrostatic field, and when switch is allocated to left side, has elastic arc-shaped conductive film 44 and be separated with metal bar 45, the high tension electrostatic field between needle point and liquid level disappears.Rectangular base 2 is also provided with the safety switch 20 for closing voltage of electric field.Base is positioned at the surface of base body 10.When switch 20 is allocated to right side, conducting strip engages with metal bar, and (see Fig. 5) is recovered in the high tension electrostatic field between needle point and liquid level.

See Fig. 6, Fig. 7.The cylindrical glass outer cover 57 of Stirling power set is provided with scatterer 55 near one end of pallet 3; Wherein, the first transmission rod 53, through namely can sealed gas, can make again the seal cartridge 60 that the first transmission rod 53 slides smoothly.Having between piston 56 and glass outer 57 can the slight void that flows of supplied gas, and scatterer 55 is the metal radiator element of annular superposition, has space for heat radiation, can be fixed on the outside of glass outer 57 between radiator element.

The motion ultimate principle of this single cylinder type simple and easy Stirling mixing power set: the inside of whole power set is closed space, but leave space between the inwall of piston 56 and glass outer 57 can supplied gas move, heated air available hydrogen, helium, nitrogen or air etc.First transmission rod 53 is fixedly linked through seal cartridge 60 and piston 56, and piston can be free to slide at the inwall of glass outer 57.When spirit lamp heating enclosure, as the heated air expanded by heating of working medium, after sufficiently long warm up time, Manual-pushing main body pallet rotates, if first piston shifts to fire end (i.e. spirit lamp place end), heated gas moves (i.e. scatterer place end) to colling end, gas cooling post shrinkage, and then driving the air of fire end to move to colling end, the hot gas simultaneously expanded also has the trend of promotion piston to fire end movement.When the first transmission rod 53 moves to distalmost end or most proximal end, under the inertia of wheel disc drives, turn over again end points farthest or nearest end points, piston shifts to colling end.Now because the air of colling end cools, the amount of the air of fire end occurs relatively to reduce, and continued to inhale to colling end at the effect lower piston of negative pressure, the freezing air flowing to fire end again expanded by heating occurs, and promotes piston further and shifts to colling end.Therefore, as long as the heating of spirit lamp does not stop, Stirling power set just can produce power endlessly, the contraction that piston and transmission rod just can move in circles.

The second driven rod 61 that described handwheel 65 connects is outside equipped with heat radiation outer cover 63, is connected with nonrigid plastic open tube 69, in order to improving heat radiation efficiency and pneumatic efficiency between cylindrical glass outer cover 57 and heat radiation outer cover 63.

Described tray main body 11 bottom even distributes four around bearing 13, is placed on basetray 10; Describedly comprise upper disk 46 around bearing 13, middle disk 47, lower disc 48, head bearing 49, lower bearing 50.Upper disk 46, middle disk 47, the edge of lower disc 48 (is specially: upper disk 46 is fixedly connected with middle disk 47 by bearing connection, middle disk is fixedly connected with head bearing 49, but head bearing 49 with upper disk 46 for on-fixed is connected, but can with the axle center of head bearing 49 for axle, mutual turn); Being positioned at bottom pallet 3 four around bearing is one group every two of the same side around bearing, connects with belt 52.

Adopt the device of the present embodiment to prepare the method for micro-capsule, comprise step:

1) culture dish that calcium chloride solution is housed is placed on pallet 3, puts down negative potential and export pin end 12, confirm that needle point inserts liquid level and away from the center of culture dish, in case the microballoon of microencapsulation occurs sticky glutinous.

2) three syringe needles 14 in parallel are adjusted between distance calcium chloride liquid level 9mm ~ 11mm;

3) drawing with input syringe 6 concentration mixed is the sodium alginate of 2% and the mixture of cell, then syringe is inserted the interface of bipass 21;

4) open the first bipass 21, push injection device afterbody makes sodium alginate mixture input main body syringe 5, and namely piston 29 is pushed upwardly thereupon.

5) with spirit lamp 59 Preheat glass outer cover 57.Before shaking table starts formal running, at least preheating 1min should be ensured.

6) open block 24, tubing 30 injects liquid, as hydraulic power to the top of main body syringe 5.Until liquid by when filling up the top cavity volume of main body syringe 5, close block 24, stop bolus injection.

7) manual toggle pallet 3, under the effect of Stirling power set, pallet 3 starts shaking table motion.

8) open the second bipass 22, safety switch 20, and control at 10-15ml/h by the transfusion speed of microinfusion pump, namely syringe needle 14 starts to export sodium alginate mixture.

Positive electrode connective bar 17 and the negative potential voltage exported between pin 12 is 5500V.

Although above done detailed description to the utility model with a general description of the specific embodiments, on the utility model basis, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements on the basis of not departing from the utility model spirit, all belong to the scope that the utility model is claimed.

Claims (8)

1. a micro-capsule preparation facilities, is characterized in that, is made up of injecting unit and mixing power unit (4), and injecting unit and mixing power unit are all fixed in rectangular base (2);

Described injecting unit comprises composite injection device (1), pallet (3), voltage generating unit, elevating lever (9) and fixture (8); The upper vertical fixing elevating lever (9) of described pallet (3), (9) are provided with fixture moving up and down with elevating lever, and described composite injection device (1) is connected with fixing elevating lever (9) by described fixture;

Described composite injection device (1) comprises main body syringe (5), input syringe (6), needle assembly (7), bipass (21); Described needle assembly (7) comprises three and is fixed on needle mount (15) syringe needle (14) in parallel, described main body syringe (5) is column shape container, wall is provided with the first bipass (21) and the second bipass (22), the other end of bipass inserts input syringe (6);

Described voltage generating unit comprises positive electrode connective bar (17), negative potential incoming end (18), positive electrode incoming end (19); Described negative potential incoming end (18) is connected by wire with positive electrode incoming end (19), and described positive electrode connective bar (17) is connected with syringe needle (14) by the wire that needle mount (15) is inner; The end of described negative potential incoming end (18) is metal bar (45), is connected with pallet (3) by switch assembly;

Described mixing power unit (4) comprises Stirling power set and hand gear; Described Stirling power set comprises cylindrical glass outer cover (57), be placed in piston (56) in glass outer (57) and spirit lamp (59), and described piston (56) is connected with the first driven rod (53); Described hand gear is can the handwheel (65) of hand rotation, and described handwheel (65) connects the second driven rod (61); Described first driven rod (53) is all connected with pallet (3) with the second driven rod (61).

2. micro-capsule preparation facilities according to claim 1, it is characterized in that, described fixture (8) is fixed with tubing (30), stationary jaw (36), for adjusting the upper and lower spiral micro actuator (37) of fixture (8) and pressing from both sides (38) for pressing from both sides positive electrode connective bar (17) electricity; Described stationary jaw (36) is provided with four variable folders (39), described composite injection device (1) is fixed in the middle of four variable folders (39).

3. micro-capsule preparation facilities according to claim 1, it is characterized in that, described main body syringe (5) is column shape container, and there is piston (29) inside, piston connects in turn piston push rod (28) and manual draw bar (25); Described piston (29) has the region moved up and down in column shape container;

Described main body syringe (5) top has insertion sheath (26) and the block that can open (24) of tubing (30).

4. micro-capsule preparation facilities according to claim 1, is characterized in that, the bottom of fixture (8) is "T"-shaped height gauge (40), the bottom of ruler and three syringe needles (14) high together; There is graduated scale (41) below of elevating lever (9).

5. micro-capsule preparation facilities according to claim 1, it is characterized in that, the end of described negative potential incoming end (18) is metal bar (45), export pin (12) by switch assembly and negative potential to be connected, described negative potential exports pin (12) syringe needle and pallet (3) spacing is 1-3mm.

6. micro-capsule preparation facilities according to claim 1, is characterized in that, described rectangular base (2) is also provided with the safety switch (20) for closing voltage of electric field.

7. according to the arbitrary described micro-capsule preparation facilities of claim 1-6, it is characterized in that, the cylindrical glass outer cover (57) of described Stirling power set is provided with scatterer (55) near one end of pallet (3); The second driven rod (61) that described handwheel (65) connects is outside equipped with heat radiation outer cover (63), is connected with nonrigid plastic open tube (69) between cylindrical glass outer cover (57) and heat radiation outer cover (63).

8., according to the arbitrary described micro-capsule preparation facilities of claim 1-6, it is characterized in that, described pallet (3) bottom even distributes four around bearing (13), is placed on basetray (10); Describedly comprise upper disk (46) around bearing (13), middle disk (47), lower disc (48), head bearing (49), lower bearing (50); Upper disk (46) is connected by bearing with middle disk (47), and middle disk (47) is connected by bearing with lower disc (48); Being positioned at four of pallet (3) bottom around bearing is one group every two of the same side around bearing, connects with belt (52).