CN203816276U - Detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates - Google Patents
Detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates Download PDFInfo
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- CN203816276U CN203816276U CN201420232677.3U CN201420232677U CN203816276U CN 203816276 U CN203816276 U CN 203816276U CN 201420232677 U CN201420232677 U CN 201420232677U CN 203816276 U CN203816276 U CN 203816276U
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- detachable
- chromatographic column
- column
- purification
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- 238000000926 separation method Methods 0.000 title claims abstract description 18
- 238000000746 purification Methods 0.000 title claims abstract description 16
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001179 sorption measurement Methods 0.000 claims abstract description 18
- 239000003480 eluent Substances 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 16
- 239000000654 additive Substances 0.000 claims description 10
- 230000000996 additive effect Effects 0.000 claims description 10
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 229920005479 Lucite® Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 3
- 239000006004 Quartz sand Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000395 magnesium oxide Substances 0.000 claims description 3
- 239000000391 magnesium silicate Substances 0.000 claims description 3
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 3
- 235000019792 magnesium silicate Nutrition 0.000 claims description 3
- 229920002647 polyamide Polymers 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 238000006303 photolysis reaction Methods 0.000 abstract description 8
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 239000011521 glass Substances 0.000 abstract description 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000015843 photosynthesis, light reaction Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000012780 transparent material Substances 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Abstract
The utility model relates to a detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates. The chromatographic column structurally comprises a charging chamber, multiple detachable column bodies and a funnel type receiving device which are connected sequentially, wherein the different detachable column bodies are spaced through adsorption columns; column coreadditives in the different adsorption columns can be same or different; each detachable column body is provided with an observation window; an eluent inlet pipe and a pressurization device are arranged at the front end of the charging chamber; the charging chamber, the multiple detachable column bodies and the funnel type receiving device are fixed through connection flanges; the charging chamber is in an open type; a throttling valve is arranged at the lower end of the funnel type receiving device; the number of the detachable column bodies is larger than or equal to 1; the detachable column bodies are made of colored organic glass. Compared with the prior art, the chromatographic column has the advantages that degradation of compounds prone to photolysis can be avoided, and the number of the detachable column bodies and thecolumn coreadditives in the adsorption columns can be adjusted as required.
Description
Technical field
The utility model relates to medicine intermediate separation technology field, particularly a kind of detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification.
Background technology
Chromatography is to utilize the difference of the distribution coefficient of each composition in some solvent in system and the capacity variance being adsorbed on adsorbent, thereby carries out the separating-purifying of chemical substance.In medicine intermediate building-up process, often need to be to synthetic or extract the compound obtaining and carry out separating-purifying, obtain single compound or there is a compounds of same structure parent nucleus, chromatographic column separator is the equipment that separating mixture is conventional.
Existing chromatographic column mostly is glass chromatography column, the liquid storage bottle and the filled column that are designed by integral type form, feed compartment cannot separate with cylinder, material loading inconvenience, not quick detachable and replacement, filler filling effect is poor, and defective tightness is even, can not change length according to product performance, because cylinder is longer, discharging and cleaning are brought to a lot of inconvenience, be difficult to clean chromatographic column clean, thereby pollute compound to be separated, and the chromatographic column price that specification is larger is more expensive, after chromatographic column part is damaged, whole chromatographic column will be scrapped, and cost is higher.
In addition, existing chromatographic column cylinder mostly is transparent material preparation, when the labile compound of light is shown in separation, due to photodissociation effect, makes that productive rate is low, separating effect is poor; For solving photodissociation problem, also there is part chromatographic column to adopt non-transparent material to make, but can not observe the released state of chromatographic column the inside, in the time that chromatography system goes wrong, be difficult for investigation in time.
Summary of the invention
The purpose of this utility model is, is difficult to dismounting, cleaning, gradient adds the technical disadvantages such as filler and photodissociation for existing chromatographic column, and a kind of detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification is provided.
The utility model is achieved through the following technical solutions:
A kind of detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification, it is characterized in that, structure comprises feed compartment (1), detachable cylinder (2) and funneling material collecting device (7), feed compartment (1), detachable cylinder (2) and funneling material collecting device (7) join successively, detachable cylinder (2) is provided with multiple, between different detachable cylinders (2), pass through adsorption column (4) interval, post core additive in different adsorption columns (4) can be selected identical or different, detachable cylinder (2) is provided with observation window (5), feed compartment front end is provided with eluant, eluent feed tube (6) and pressue device (8), further, described detachable cylinder (2) material is coloured lucite, described feed compartment (1), multiple detachable cylinders (2) and funneling material collecting device (7) are fixing by adpting flange (3).
Further, described feed compartment (1) is set to open type.
Further, described funneling material collecting device (7) lower end is provided with choke valve (9).
Further, the quantity of described detachable cylinder (2) is more than or equal to 1.
Further, described adsorption column (4) post core additive can be selected any one or the mixture in aluminium oxide, silica gel, polyamide, magnesium silicate, talcum powder, magnesia, starch, cellulose, quartz sand, sucrose and active carbon.
The utility model relates to a kind of detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification, and beneficial effect is:
1. the coloured lucite of the detachable cylinder material selection of the utility model, compared with transparent material, can effectively prevent the photodissociation of easy photodissociation material, further detachable main body is improved, on detachable cylinder after improvement, be provided with observation window, can realize the chromatography situation in chromatographic column is observed.
2. the detachable multisection type chromatographic column of medicine intermediate separation and purification that what the utility model related to be applied to, can increase and decrease the number of detachable chromatographic column as required, between different chromatographic columns, be provided with adsorption column, in adsorption column, can add as required post core additive single or that mix, in different adsorption columns, identical or different post core additive can be added, the independence of different adsorbents and the planarization of interface can be ensured.
3. the feed compartment that the utility model relates to is set to open type, and material loading is simple and convenient, is particularly useful for the dry method material-uploading style of solid product and fluid product; Be provided with independent eluant, eluent feed tube, eluant, eluent adds from the independent mouth of pipe, can be intermittent, also can continuity add, and be convenient to manipulation.
4. the utility model is provided with pressue device, can also can pressurize by normal pressure as required, expands the range of application of this multisection type chromatographic column; Funneling material collecting device lower end is provided with choke valve, in purifying products process, can interrupt as required or continue at any time.
Brief description of the drawings
Fig. 1 is the detachable multisection type chromatographic column structural representation that is applied to medicine intermediate separation and purification that the utility model relates to.
Detailed description of the invention
Consulting accompanying drawing 1 is described further the utility model.
The utility model relates to a kind of detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification, it is characterized in that, structure comprises feed compartment (1), detachable cylinder (2) and funneling material collecting device (7), feed compartment (1), detachable cylinder (2) and funneling material collecting device (7) join successively, detachable cylinder (2) is provided with multiple, between different detachable cylinders (2), pass through adsorption column (4) interval, post core additive in different adsorption columns (4) can be selected identical or different, detachable cylinder (2) is provided with observation window (5), feed compartment front end is provided with eluant, eluent feed tube (6) and pressue device (8), described detachable cylinder (2) material is coloured lucite, described feed compartment (1), multiple detachable cylinders (2) and funneling material collecting device (7) are fixing by adpting flange (3).
Described feed compartment (1) is set to open type.
Described funneling material collecting device (7) lower end is provided with choke valve (9).
The quantity of described detachable cylinder (2) is more than or equal to 1.
Described adsorption column (4) post core additive can be selected any one or the mixture in aluminium oxide, silica gel, polyamide, magnesium silicate, talcum powder, magnesia, starch, cellulose, quartz sand, sucrose and active carbon.
The detachable multisection type chromatographic column of medicine intermediate separation and purification that what the utility model related to be applied to, can increase and decrease the number of detachable chromatographic column as required, between different chromatographic columns, be provided with adsorption column, in adsorption column, can add as required post core additive single or that mix, in different adsorption columns, identical or different post core additive can be added, the independence of different adsorbents and the planarization of interface can be ensured; The detachable coloured lucite of cylinder material selection, compared with transparent material, can effectively prevent the photodissociation of easy photodissociation material, further detachable main body is improved, on detachable cylinder after improvement, be provided with observation window, can realize the chromatography situation in chromatographic column is observed; Feed compartment is set to open type, and material loading is simple and convenient, is particularly useful for the dry method material-uploading style of solid product and fluid product; Be provided with independent eluant, eluent feed tube, eluant, eluent adds from the independent mouth of pipe, can be intermittent, also can continuity add, and be convenient to manipulation; Detachable multisection type chromatographic column is provided with pressue device, can also can pressurize by normal pressure as required, expands the range of application of this multisection type chromatographic column; Funneling material collecting device lower end is provided with choke valve, in purifying products process, can interrupt as required or continue at any time.
The above; it is only preferably detailed description of the invention of the utility model; but protection domain of the present utility model is not limited to this; any be familiar with those skilled in the art the utility model disclose technical scope in; be equal to replacement or changed according to the technical solution of the utility model and utility model design thereof, within all should being encompassed in protection domain of the present utility model.
Claims (5)
1. one kind is applied to the detachable multisection type chromatographic column of medicine intermediate separation and purification, it is characterized in that, structure comprises feed compartment (1), detachable cylinder (2) and funneling material collecting device (7), feed compartment (1), detachable cylinder (2) and funneling material collecting device (7) join successively, detachable cylinder (2) is provided with multiple, between different detachable cylinders (2), pass through adsorption column (4) interval, post core additive in different adsorption columns (4) can be selected identical or different, detachable cylinder (2) is provided with observation window (5), feed compartment front end is provided with eluant, eluent feed tube (6) and pressue device (8), described detachable cylinder (2) material is coloured lucite, described feed compartment (1), multiple detachable cylinders (2) and funneling material collecting device (7) are fixing by adpting flange (3).
2. the detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification according to claim 1, is characterized in that, described feed compartment (1) is set to open type.
3. the detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification according to claim 2, is characterized in that, described funneling material collecting device (7) lower end is provided with choke valve (9).
4. the detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification according to claim 3, is characterized in that, the quantity of described detachable cylinder (2) is more than or equal to 1.
5. the detachable multisection type chromatographic column that is applied to medicine intermediate separation and purification according to claim 1, it is characterized in that, described adsorption column (4) post core additive can be selected any one or the mixture in aluminium oxide, silica gel, polyamide, magnesium silicate, talcum powder, magnesia, starch, cellulose, quartz sand, sucrose and active carbon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420232677.3U CN203816276U (en) | 2014-05-08 | 2014-05-08 | Detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420232677.3U CN203816276U (en) | 2014-05-08 | 2014-05-08 | Detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203816276U true CN203816276U (en) | 2014-09-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420232677.3U Expired - Lifetime CN203816276U (en) | 2014-05-08 | 2014-05-08 | Detachable multi-stage type chromatographic column applied to separation and purification of medical intermediates |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203816276U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108165759A (en) * | 2018-01-30 | 2018-06-15 | 芒市海华开发有限公司 | A kind of combined type desorption column |
| CN108245933A (en) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | Portable normal pressure chromatographic column sampling device |
| CN106390520B (en) * | 2016-11-18 | 2019-01-25 | 中国石油大学(北京) | The separation method of Various Groups In Crude Oil analysis chromatographic column and Various Groups In Crude Oil |
-
2014
- 2014-05-08 CN CN201420232677.3U patent/CN203816276U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390520B (en) * | 2016-11-18 | 2019-01-25 | 中国石油大学(北京) | The separation method of Various Groups In Crude Oil analysis chromatographic column and Various Groups In Crude Oil |
| CN108245933A (en) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | Portable normal pressure chromatographic column sampling device |
| CN108165759A (en) * | 2018-01-30 | 2018-06-15 | 芒市海华开发有限公司 | A kind of combined type desorption column |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |