CN203752640U - Full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment - Google Patents
Full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment Download PDFInfo
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- CN203752640U CN203752640U CN201420076399.7U CN201420076399U CN203752640U CN 203752640 U CN203752640 U CN 203752640U CN 201420076399 U CN201420076399 U CN 201420076399U CN 203752640 U CN203752640 U CN 203752640U
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- gripper shoe
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- sensor
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 17
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 17
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 17
- 238000001514 detection method Methods 0.000 title abstract description 13
- 238000007789 sealing Methods 0.000 title abstract description 5
- 239000012528 membrane Substances 0.000 title abstract 4
- 230000007246 mechanism Effects 0.000 claims abstract description 36
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 238000007731 hot pressing Methods 0.000 claims description 15
- 238000003825 pressing Methods 0.000 claims description 15
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052782 aluminium Inorganic materials 0.000 abstract description 2
- 239000011888 foil Substances 0.000 abstract description 2
- 238000007906 compression Methods 0.000 abstract 4
- 238000003745 diagnosis Methods 0.000 description 5
- 238000011161 development Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000005030 aluminium foil Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000008054 signal transmission Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Landscapes
- Lining Or Joining Of Plastics Or The Like (AREA)
Abstract
The utility model relates to a full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment. The full-automatic hot-sealing membrane device comprises a shell, wherein an automatic conveying mechanism is arranged in the shell, a thermo-compression mechanism is arranged above the automatic conveying mechanism, and the automatic conveying mechanism conveys a reaction plate under the thermo-compression mechanism and the thermo-compression mechanism compresses and cuts the reaction plate. With the adoption of the technical scheme, the full-automatic hot-sealing membrane device adopts the automatic conveying mechanism to convey the reaction plate to a set position and the thermo-compression mechanism to compress an aluminum foil on the reaction plate and cut, the whole process is operated automatically, the operation is simple and the efficiency is high.
Description
Technical field
The utility model relates to a kind of nucleic acid detection assay instrument, is specifically related to a kind of full-automatic heat sealer device that detects automation equipment for high-throughput nucleic acid.
Background technology
High-throughput nucleic acid detection technique is to using nucleic acid as diagnosis target, detects the variation of nucleic acid, and using this foundation as medical diagnosis on disease by nucleic acid amplification technologies or nucleic acid hybridization technique.With respect to traditional detection method, as microscopy, microorganism, cultivate or enzyme linked immunosorbent detection technology, the superiority of nucleic acid detection technique is its high sensitivity and high specific.Meanwhile, nucleic acid detection technique not only has advantage aspect medical diagnosis on disease, and at the somatotype of neurological susceptibility disease, all tool is of great significance by stages and aspect prognosis judgement and examination of curative effect.Therefore, the field such as the molecular diagnosis that is applied as infectious diseases and genetic disease examination, tumour of high-throughput nucleic acid detection technique and pharmacogenomics provides new technology platform.
Since First clinical research automation sample processing apparatus in 1980 is put into use, increasing laboratory automation device is designed, produces and comes into operation.Quick owing to possessing, accurate and indefatigable ability to work, the use of automation equipment can improve laboratory work efficiency greatly, brings powerful high flux detectability, and researcher is freed from the high-intensity duplication of labour.The test item that can contain along with development and the check field in epoch abundant gradually, automation equipment has been given play to more and more important effect at aspects such as clinical research diagnosis, treatment, monitorings.The demand of this development makes domestic laboratory be faced with a unprecedented challenge just, that is: should increase work efficiency to greatest extent, improve again detection quality and integrate with international standard laboratory gradually to meet hospital and laboratory, meet the demand of clinical research.In recent years, automatic detection instrument, automatic moving liquid system and control system etc. has obtained alarming development, from the past, merely according to speed, has determined that the epoch of all change into quality, demand, convenient future development.
It is reaction vessel that nucleic acid detection assay instrument be take 96 hole reaction plates, and the various functional modules that coupled system comprises can complete the various biochemical reactions in detection of nucleic acids process in the coordination of system controlling software with under controlling.Current 96 hole reaction plates still adopt artificial manual mode in the loading and unloading of instrument.In order to guarantee that the reagent in 96 hole reaction plates does not outwards spill in next operation rocking equipment, must use the sticking aluminum foil sealing of tool on the surface of 96 hole reaction plates.Manually carry out sealer and be easy to film to paste askew, and hand is easy to encounter stickum, operates very inconvenient; Manually-operated viscosity shrouding film can not be realized the full-automation of equipment, and operating efficiency is low.
Utility model content
The purpose of this utility model is to provide a kind of full-automatic heat sealer device that detects automation equipment for high-throughput nucleic acid, and this heat seal die device can be realized full automatic working, and operating efficiency is high.
For achieving the above object, the utility model has adopted following technical scheme: comprise housing, in described housing, be provided with automatic delivering mechanism, the top of described automatic delivering mechanism is provided with hot pressing mechanism, and the below Bing You hot pressing mechanism that described automatic delivering mechanism is delivered to hot pressing mechanism by reaction plate carries out pressing cutting to reaction plate.
Described housing comprises and is first, second side plate that vertical is arranged and is parallel to each other, and the bottom of first, second side plate is provided with the base plate that connects both, and base plate top is parallel is provided with middle plate, and described base plate and middle plate be layout in horizontal direction all.
Described automatic delivering mechanism comprises the guide rail being arranged on base plate, guide rail is provided with the first gripper shoe being slidably matched with its formation, the first described gripper shoe drives it on guide rail, to move by the conveying motor being arranged on the first side plate, the first described gripper shoe is provided with the second gripper shoe for placing response plate, described the first gripper shoe, the second gripper shoe all parallel with base plate, on the second side plate, be fixed with conveying detecting sensor, the first gripper shoe is provided with and the sensor sensing sheet of carrying detecting sensor to match.
On the output shaft of described conveying motor, be coaxially provided with conveyance gear, the first described gripper shoe is provided with the tooth bar being meshed with conveyance gear.
Described conveying detecting sensor is connected with the second side plate by sensor fixed support.
Described hot pressing mechanism comprises the fixed head that is successively set on middle plate below, cope match-plate pattern and lower bolster, on described middle plate, be fixed with lift motor, the output shaft of lift motor is connected with fixed head and drives fixed head to move up and down, the lower face of described cope match-plate pattern is provided with pressing plate, pressing plate is provided with heater and temperature sensor, the lower face of fixed head is provided with blade, between described lower bolster and middle plate, be provided with the lower bolster guide rod that is connected both, described cope match-plate pattern, between fixed head and middle plate, be provided with the cope match-plate pattern guide rod that is connected three, between described cope match-plate pattern and pressing plate, be also provided with the guide rod that connects both, the other end of guide rod is connected with fixed head, on the shaft of guide rod, be arranged with outer spring and inner spring.
On described pressing plate, offer groove, in groove, place heater and temperature sensor.
On described middle plate, be also provided with sensor stand, described sensor stand is provided with sensor.
As shown from the above technical solution, the utility model is transported to desired location by automatic conveying device by reaction plate, then by hot pressing mechanism, aluminium foil is pressed on reaction plate and is cut, and whole process realizes automatic operation completely, simple to operate, and efficiency is high.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the structural representation of the utility model automatic delivering mechanism.
The specific embodiment
Below in conjunction with accompanying drawing, the utility model is described further:
A kind of full-automatic heat sealer device that detects automation equipment for high-throughput nucleic acid as shown in Figure 1 and Figure 2, comprise housing, in housing, be provided with automatic delivering mechanism, the top of automatic delivering mechanism is provided with hot pressing mechanism, and the below Bing You hot pressing mechanism that automatic delivering mechanism is delivered to hot pressing mechanism by reaction plate 1 carries out pressing cutting to reaction plate 1.
Further, housing comprises first, second side plate 21,22 that is vertical layout and is parallel to each other, the bottom of first, second side plate 21,22 is provided with the base plate 23 that connects both, and base plate 23 tops are parallel is provided with middle plate 24, and base plate 23 is all arranged in horizontal direction with middle plate 24.
Further, automatic delivering mechanism comprises the guide rail 31 being arranged on base plate 23, guide rail 31 is provided with the first gripper shoe 32 being slidably matched with its formation, the first gripper shoe 32 drives it on guide rail 31, to move by the conveying motor 33 being arranged on the first side plate 21, the first gripper shoe 32 is provided with the second gripper shoe 34 for placing response plate, the first gripper shoe 32, the second gripper shoe 34 all parallel with base plate 23, on the second side plate 22, be fixed with and carry detecting sensor 35, the first gripper shoes 32 to be provided with and the sensor sensing sheet 36 of carrying detecting sensor 35 to match.
Further, on the output shaft of conveying motor 33, be coaxially provided with conveyance gear 37, the first gripper shoes 32 and be provided with the tooth bar 38 being meshed with conveyance gear 37.
Further, carry detecting sensor 35 to be connected with the second side plate 22 by sensor fixed support 39.
Further, hot pressing mechanism comprises the fixed head 41 that is successively set on middle plate 24 belows, cope match-plate pattern 42 and lower bolster 43, on middle plate 24, be fixed with lift motor 5, the output shaft of lift motor 5 is connected with fixed head 41 and drives fixed head 41 to move up and down, the lower face of cope match-plate pattern 42 is provided with pressing plate 44, pressing plate 44 is provided with heater and temperature sensor, the lower face of fixed head 41 is provided with blade 45, between lower bolster 43 and middle plate 24, be provided with the lower bolster guide rod 46 that is connected both, cope match-plate pattern 42, between fixed head 41 and middle plate 24, be provided with the cope match-plate pattern guide rod 47 that is connected three, between cope match-plate pattern 42 and pressing plate 44, be also provided with the guide rod 48 that connects both, the other end of guide rod 48 is connected with fixed head 41, on the shaft of guide rod 48, be arranged with outer spring and inner spring.
Further, on pressing plate 44, offer groove, in groove, place heater and temperature sensor.
Further, on middle plate 24, be also provided with sensor stand 6, sensor stand 6 is provided with sensor 61.
The utility model concrete operation step is as follows:
1) carry motor to work when initial position, the first gripper shoe is transported to the position of sensor sensing sheet;
2) by manipulator, reaction plate is put in the second gripper shoe, carries motor to turn back to initial position, by carrying detecting sensor transmission of signal to hot pressing mechanism;
3) heating plate of hot pressing mechanism starts heating, to be heated when the design temperature, temperature sensor transmission of signal is to lift motor, lift motor starts to move downward, first lower bolster contacts with cope match-plate pattern, realization compresses aluminium foil, lift motor continues motion, output shaft by lift motor promotes blade movement indirectly with being connected of fixed head, film action is cut in realization, when the sensor on central plate detects signal, and lift motor stop motion, wait for after 2 seconds, lift motor starts to move upward and gets back to initial position.
4) take discarded aluminium foil away, carry motor reaction plate to be delivered to the initial position of sensor sensing sheet, manipulator takes off reaction plate.
Above-described embodiment is described preferred embodiment of the present utility model; not scope of the present utility model is limited; do not departing under the prerequisite of the utility model design spirit; various distortion and improvement that those of ordinary skills make the technical solution of the utility model, all should fall in the definite protection domain of the utility model claims.
Claims (8)
1. a full-automatic heat sealer device that detects automation equipment for high-throughput nucleic acid, it is characterized in that: comprise housing, in described housing, be provided with automatic delivering mechanism, the top of described automatic delivering mechanism is provided with hot pressing mechanism, and the below Bing You hot pressing mechanism that described automatic delivering mechanism is delivered to hot pressing mechanism by reaction plate (1) carries out pressing cutting to reaction plate (1).
2. full-automatic heat sealer device according to claim 1, it is characterized in that: described housing comprises first, second side plate (21,22) that is vertical layout and is parallel to each other, the bottom of first, second side plate (21,22) is provided with the base plate (23) that connects both, the parallel middle plate (24) that is provided with in base plate (23) top, described base plate (23) is all arranged in horizontal direction with middle plate (24).
3. full-automatic heat sealer device according to claim 2, it is characterized in that: described automatic delivering mechanism comprises the guide rail (31) being arranged on base plate (23), guide rail (31) is provided with the first gripper shoe (32) being slidably matched with its formation, described the first gripper shoe (32) drives it upper mobile at guide rail (31) by the conveying motor (33) being arranged on the first side plate (21), described the first gripper shoe (32) is provided with the second gripper shoe (34) for placing response plate, described the first gripper shoe (32), the second gripper shoe (34) all parallels with base plate (23), on the second side plate (22), be fixed with and carry detecting sensor (35), the first gripper shoe (32) is provided with and the sensor sensing sheet (36) of carrying detecting sensor (35) to match.
4. full-automatic heat sealer device according to claim 3, it is characterized in that: on the output shaft of described conveying motor (33), be coaxially provided with conveyance gear (37), described the first gripper shoe (32) is provided with the tooth bar (38) being meshed with conveyance gear (37).
5. full-automatic heat sealer device according to claim 3, is characterized in that: described conveying detecting sensor (35) is connected with the second side plate (22) by sensor fixed support (39).
6. full-automatic heat sealer device according to claim 3, it is characterized in that: described hot pressing mechanism comprises the fixed head (41) that is successively set on middle plate (24) below, cope match-plate pattern (42) and lower bolster (43), on described middle plate (24), be fixed with lift motor (5), the output shaft of lift motor (5) is connected with fixed head (41) and drives fixed head (41) to move up and down, the lower face of described cope match-plate pattern (42) is provided with pressing plate (44), pressing plate (44) is provided with heater and temperature sensor, the lower face of fixed head (41) is provided with blade (45), between described lower bolster (43) and middle plate (24), be provided with the lower bolster guide rod (46) that is connected both, described cope match-plate pattern (42), between fixed head (41) and middle plate (24), be provided with the cope match-plate pattern guide rod (47) that is connected three, between described cope match-plate pattern (42) and pressing plate (44), be also provided with the guide rod (48) that connects both, the other end of guide rod (48) is connected with fixed head (41), on the shaft of guide rod (48), be arranged with outer spring and inner spring.
7. full-automatic heat sealer device according to claim 6, is characterized in that: described pressing plate offers groove on (44), places heater and temperature sensor in groove.
8. full-automatic heat sealer device according to claim 6, is characterized in that: on described middle plate (24), be also provided with sensor stand (6), described sensor stand (6) is provided with sensor (61).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420076399.7U CN203752640U (en) | 2014-02-24 | 2014-02-24 | Full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420076399.7U CN203752640U (en) | 2014-02-24 | 2014-02-24 | Full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203752640U true CN203752640U (en) | 2014-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420076399.7U Expired - Lifetime CN203752640U (en) | 2014-02-24 | 2014-02-24 | Full-automatic hot-sealing membrane device for high-flux nucleic acid detection automation equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203752640U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105346198A (en) * | 2015-10-26 | 2016-02-24 | 南京双威生物医学科技有限公司 | Multi-film heat seal cutting machine |
| CN108674718A (en) * | 2018-07-09 | 2018-10-19 | 广州市安亦捷自动化设备有限公司 | Film feeding film cutting apparatus and film pressing system |
-
2014
- 2014-02-24 CN CN201420076399.7U patent/CN203752640U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105346198A (en) * | 2015-10-26 | 2016-02-24 | 南京双威生物医学科技有限公司 | Multi-film heat seal cutting machine |
| CN108674718A (en) * | 2018-07-09 | 2018-10-19 | 广州市安亦捷自动化设备有限公司 | Film feeding film cutting apparatus and film pressing system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140806 |