CN203750207U - Novel ultrasonic device for extracting botanical drug active ingredients efficiently - Google Patents
Novel ultrasonic device for extracting botanical drug active ingredients efficiently Download PDFInfo
- Publication number
- CN203750207U CN203750207U CN201320260431.2U CN201320260431U CN203750207U CN 203750207 U CN203750207 U CN 203750207U CN 201320260431 U CN201320260431 U CN 201320260431U CN 203750207 U CN203750207 U CN 203750207U
- Authority
- CN
- China
- Prior art keywords
- ultrasonic
- stainless steel
- steel casing
- drug active
- power density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Extraction Or Liquid Replacement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses a novel ultrasonic device for extracting botanical drug active ingredients efficiently. The novel ultrasonic device for extracting botanical drug active ingredients efficiently has one of the characteristics that a high-energy transducer (1) consisting of a plurality of piezoelectric ceramics, and is fixed firmly with an ultrasonic wave emitter (5) by a screw rod (2), a rear cover plate (4) and a sound wave conduction component (3); the ultrasonic wave emitter is positioned at the center of the interior of a stainless steel outer shell (6) so as to form an ultrasonic field with the space acoustical power density adaptive to the efficient botanical drug active ingredient extraction: the ultrasonic frequency is 25+/-5kHz, the surface ultrasonic power density of the front end of the ultrasonic wave emitter is 5-18.6W/cm<2>; the space ultrasonic power density is 0.4-1.5W/cm<3>; a charge pipeline (7) of a drug-liquid mixture is arranged above the upper right part of the stainless steel outer shell, and a discharge pipeline (8) is arranged at the lower right part of the stainless steel outer shell; and botanical drugs are subjected to drastic ultrasonic biological effect process in the device so as to extract drug active ingredients efficiently.
Description
Technical field
The utility model belongs to pharmaceutical technology field, relates to a kind of autonomic drug extraction element, is specifically related to a kind of Novel ultrasonic device of autonomic drug active component high efficiency extraction.
Background technology
So far, utilize large power supersonic technology to carry out the technology and equipment of traditional Chinese medicine extraction both at home and abroad of common occurrence.Yet, because correlation technique and equipment relate to different majors knowledge and industry background, often there is such-and-such defect and deficiency.In fact, the technical bottleneck that causes its technical merit to be difficult to improve is mainly: (1) theoretical and academic understanding mistaken ideas: some technical staff simply think that the power of ultrasonic device is larger, its extractability is just stronger, and not exclusively understands " space ultrasonic energy " and the interactional real mechanism of biomaterial and control technology; (2) difference of experimental study and engineering application: many scholars hanker after the research that ultrasonic autonomic drug extracts.Yet the great many of experiments that they carry out, is but to use the experimental study that routine " supersonic wave cleaning machine " completes.Therefore,, for Industry Promotion, be just difficult to design and manufacture the special purpose device of performance brilliance; (3) process parameters design science not to the utmost: owing to having defect in science understanding and equipment design aspect, with regard to being difficult to, the technological parameter of ultrasonic extraction is scientifically rationally arranged.Therefore, be difficult to effectively utilize ultrasonic energy, give full play to the mechanism of action such as ultrasonic cavitation effect, cause the technical merit of its commercial application not high, small.
The device design problem that the utility model patent only reflects for bottleneck (1), (2).The relevant issues that relate to for bottleneck (3) will be reflected in another patent of invention " the ultrasonic high efficiency extraction technique of a kind of autonomic drug active component energy collecting type ".
Extracting technique of Chinese medicine is the primary link of Chinese medicine preparation work flow.The current pharmaceutical industry of China is in traditional Chinese medicine extraction is produced, still at the backward device of continuing to use consistent poach extractor one class decades.Decocting time is long, various active composition is subject to high temperature and lose, the drawback such as recovery rate is not enough, efficiency is low, energy consumption is high, greatly wasted resource, reduced drug effect.
China is since having formulated the modernization of Chinese medicine 12 development plans, and the research of the non-traditional extractive techniques such as ultrasonic, means of supercritical extraction application more and more comes into one's own.Wherein, the high efficiency of ultrasonic extraction, security and broad spectrum activity, be progressively applied to autonomic drug and extract research.Existing more than the 100 kind of medicinal material of < < Pharmacopoeia of People's Republic of China > > version in 2008 and preparation have been used ultrasonic extraction.Obviously, ultrasonic extraction process replaces traditional extraction technique, will include modernization of Chinese medicine process in.
Abroad, particularly Japan and the Southeast Asia higher country of Chinese herbal medicine occupation rate of market, the advantage of and environmental protection energy-conservation due to it, the research of ultrasound-enhanced purification Chinese herbal medicine and apply very general.Many tools of ultrasound assisted extraction technique achievement in research region feature of foreign scholar's issue, also has reference value.
Domestic, still there is some technical bottleneck in relevant ultrasonic extraction device design aspect, and its application of scale in pharmaceutical industries is still restricted.The Chinese medicine ultrasonic extraction device of current practical application, substantially belong to following a few class: (1) ultrasonic extractor class: traditional vertical decoction extractor is transformed, and distributing installation is organized ultrasonic transducer (place column transducer, surrounding placement transducer in the middle of comprising or disperse to install transducer etc.) more in tank., there is the problems such as ultrasonic energy deficiency, skewness in the ultrasonic extractor of this class reworked, affects ultrasonic extraction efficiency in various degree, is difficult to guarantee that medicinal active ingredient is fully extracted; (2) ultrasonic extraction tubing: this class level or tilted-putted extraction tube, its diameter is much smaller than vertical extractor, and internal diameter is 35 ~ 40cm left and right approximately, and transducer is distributed in the wall of pipeline, and ultrasonic wave is to pipeline center's direction transmitting.Solution and medicinal material inject from the different entrances of pipeline respectively, and along certain direction, flow continuously, also can mix inflow.The major advantage of this extraction process is to have realized continuity extraction, and efficiency is a little more than extractor class.But the major defect that pipeline extracts is, pipe interior needs screw impeller, complex structure, and cost is high, and fault rate is high.
The utility model that applicant obtains the authorization for 2010 " beam concentration type ultrasonic quick biological component extractor ", its technical characteristics is that tens ultrasonic transducers are assembled on the outer wall of extraction tube, so that in the inner high strength supersonic field that produces of extractor.This new technique can be combined closely with counter-flow extraction technology, to improve the extraction efficiency of biotic component.The advantage of this extractor is that operating efficiency is high, but the quantity of required ten thousand bright type ultrasonic transducers is large, high expensive.
The utility model of this application, is some defects for above-mentioned a few class ultrasonic extraction device electromechanical structures, and the high energy transducer that has adopted latest domestic to release, develops a kind of new design scheme.
Summary of the invention
the goal of the invention of this patent: in order to overcome current Chinese medicine ultrasonic extraction device in the technical bottleneck aspect structural design, a kind of method for designing of autonomic drug active component Novel ultrasonic high-efficiency device for extracting is proposed; Utilize this new design, can realize high efficiency and practicality that autonomic drug active component extracts, for through engineering approaches application provides technical support.
the inventive principle of this patent: different ultrasonic energies act on biological tissue, can produce different biological effect of ultrasounds, comprise enzyme activation, breaking-wall cell, organize apoptosis, carbonization etc.Different biological effects is for different bioengineering, as being applied to respectively ultrasonic transdermal, sound catalysis, cancer cell excision, external stone crushing etc.Theoretical research and experiment show, the Materialization mechanism of different biological effect of ultrasounds (comprising calorifics, dynamics and acoustic cavitation mechanism), is limited by sound field physical condition.In the time of in ultrasonic energy is controlled in zone of reasonableness, its biological effect only limits to breaking-wall cell, the harmless solvent of transferring to of active component in born of the same parents, and this is the ideal mechanism of the high efficiency extraction of autonomic drug active component.Yet existing ultrasonic extraction device often fails to meet ideal conditions, is difficult to realize high efficiency extraction.This patent basic principle: by the optimal design to ultrasonic extraction device electromechanical structure, set up rational spatial sound field energy in device inside and distribute, extract to realize active components of plants efficient lossless.
the summary of the invention of this patent:according to foregoing invention object and principle, this patent has been invented Novel ultrasonic extraction element, and its electrical configuration principle as shown in Figure 1.
The high-energy ultrasonic transducer 1 that this device adopts is comprised of multi-disc piezoelectric ceramics, closely fixing with sound wave conducting subassembly 3 and ultrasonic/sonic wave emitter 5 by lead screw 2 and back shroud 4;
Described ultrasonic wave emitter 5 is the trapezoidal cylinder of alloy, and through sound wave conducting subassembly 3, is fixed on stainless steel casing 6 bottoms of device; Ultrasonic wave emitter 5 integral body are in the inside of stainless steel casing 6 centre;
Described stainless steel casing 6 inner chambers are the ultrasonic spaces of energy collecting type, and the reasonable setting of this spatial sound mathematic(al) parameter is the core of this patent.The ultrasonic energy in this space acts on vegetable material, realizes autonomic drug active component high efficiency extraction.
Described stainless steel casing 6 upper right side are connected and communicate with the feed pipe 7 of medicine-liquid mixture; Being connected what communicate with stainless steel casing 6 lower rights is discharge pipe 8;
Described feed pipe 7 is for sending into prefabricated medicine-liquid mixture in the ultrasonic space of energy collecting type; The outside, junction of feed pipe 7 and stainless steel casing 6, is provided with valve 9, controls medicine-liquid mixture and flows into;
Described discharge pipe 8, for the dregs of a decoction-medicine liquid mixture after ultrasonic extraction is sent, enters isolated by filtration flow process; Discharge pipe 8 is provided with valve 10 with the outside, junction of stainless steel casing 6, controls the dregs of a decoction-medicine liquid mixture and flows out.
This patent important technological parameters: adopt transmitting power to be greater than 15 times of above high-energy ultrasonic transducers of conventional transducer, the face sound power density of its emitter can reach 5 ~ 18.6W/cm
2, the spatial sound power density of ultrasonic field is 0.4 ~ 1.5 W/cm
3, supersonic frequency is 25 ± 5kHz.
accompanying drawing explanation
Fig. 1 is the midship section figure of the utility model Vltrasonic device;
Fig. 2 is the outer side elevation view of this Vltrasonic device.
the specific embodiment
Electromechanical structure of the present utility model: with reference to figure 1 and Fig. 2.The high energy transducer 1 that employing is comprised of multi-disc piezoelectric ceramics, and closely fixing with lead screw 2, back shroud 4 and industrial glue and sound wave conducting subassembly 3 and ultrasonic/sonic wave emitter 5; Ultrasonic wave emitter 5, for being mixed with the trapezoidal cylinder of alloy of rare earth material, is fixed on stainless steel casing 6 bottoms of device by sound wave conducting subassembly 3; Ultrasonic wave emitter 5 integral body, in the inside of stainless steel casing 6 centre, form energy collecting type ultrasonic field at stainless steel casing 6 inner chambers; Being connected what communicate with stainless steel casing 6 upper right side is the feed pipe 7 of medicine-liquid mixture; Being connected what communicate with stainless steel casing 6 lower rights is discharge pipe 8; Feed pipe 7 is for sending prefabricated medicine-liquid mixture into energy collecting type ultrasonic field; Discharge pipe 8, for the dregs of a decoction-medicine liquid mixture after ultrasonic extraction is sent, pushes external filter; The outside, junction of described feed pipe 7 and stainless steel casing 6, is provided with valve 9, controls prefabricated medicine-liquid mixture and flows into; The outside, junction of discharge pipe and stainless steel casing 6 is provided with valve 10, controls the dregs of a decoction-medicine liquid mixture and flows out.
Ultrasonic field parameter arranges example: adopting front end face radius 5.5cm, frequency is the novel high-energy ultrasound emission body of 25 ± 5kHz, acoustical power 1200W, and surface of emission sound power density is about 12.6W/cm
2; The stainless steel inside cavity practical space of device is designed to the cylindrical cavity of radius 8cm, long 11cm, and spatial sound power density reaches 0.55W/cm
3, meet the arrange requirement of foregoing invention process conditions to ultrasonic field parameter; With this, calculate, the dimensions of mechanical structures of device stainless steel casing does not change, only the radius of high-energy ultrasonic emitter is brought up to 7.5cm, frequency is constant, transmitting sound power is at 880W ~ 3300W scope continuous setup, meets the parameter area of the claims in the present invention: surface of emission sound power density is 5 ~ 18.6W/cm
2, spatial sound power density is 0.4 ~ 1.5W/cm
3, all can continuous setup.
The treating capacity of extracting for strengthening autonomic drug, for concrete case study on implementation 1, real space in the stainless steel cavity of device is expanded to case 1 volume 4 times.In this cavity, evenly settle 4 ultrasound emission bodies of the same type, launch 880W ~ 3300W ultrasonic wave simultaneously, reach equally the parameters,acoustic scope of the claims in the present invention: face sound power density is 5 ~ 18.6W/cm
2, spatial sound power density is 0.4 ~ 1.5W/cm
3.
Implementation result of the present utility model: for conventional Ultrasound extraction element performance comparison, select each 1kg of 3 plant medicinal material, clean and to dry, be ground into 30 orders, with 10 times of water soaking 40min, complete medicine-liquid mixture prefabricated; Then, mixture is sent into " specific embodiment " described Novel ultrasonic extraction element by feed pipe, and the capacity 90%(of filling stays 10% space); Under 30 ℃ of conditions, acoustical power 1200W, spatial sound power density is 0.55W/cm
3, to medicine-liquid mixture strengthening extraction 12min; The dregs of a decoction-medicine liquid mixture of processing enters centrifugal filter by discharge pipe; Liquid after filtration is after macroporous resin adsorption, alcohol wash-out, then drying, obtains autonomic drug active component extract; Then, utilize HPLC to carry out Content Test to the medicinal active ingredient of extract; Meanwhile, the conventional Ultrasound device that utilizes acoustical power to be fixed as 1000W extracts experiment, and soak time, liquid when temperature are consistent with energy collecting type ultrasonic extraction process, and extraction time is got 25min; Filter gained liquid through resin adsorption purifying, obtain corresponding medicinal active ingredient extract, and test with HPLC.
Finally, the experimental data of two class ultrasonic extraction devices is contrasted, draw the following conclusions: 1. experimental data shows, at gained, extract under the essentially identical prerequisite of purified, the art of this patent is 1.7 times of conventional Ultrasound extractive technique work efficiency; 2. energy saving comparison: the ultrasonic extraction of energy collecting type is energy-conservation than approximately 0.57 with conventional Ultrasound extraction process.
The above; it is only the preferably specific embodiment of the utility model; protection domain of the present utility model is not limited to this; anyly be familiar with those skilled in the art; in the technical scope disclosing at the utility model, the simple change of the technical scheme that can obtain apparently or equivalence are replaced and are all fallen in protection domain of the present utility model.
Claims (2)
1. the Novel ultrasonic device of an autonomic drug active component high efficiency extraction, it is characterized in that, the high energy transducer (1) being comprised of multi-disc piezoelectric ceramics has been installed in this Vltrasonic device inside, and utilizes lead screw (2), back shroud (4) and sound wave conducting subassembly (3) and ultrasonic wave emitter (5) closely fixing; In this device inside, can form the ultrasonic field that spatial sound power density is applicable to active components of plants high efficiency extraction;
Described ultrasonic wave emitter (5) is the trapezoidal cylinder of alloy, and is fixed on stainless steel casing (6) bottom through sound wave conducting subassembly (3); The whole inside centre in stainless steel casing (6) of ultrasonic wave emitter (5);
Described stainless steel casing (6) inner chamber is the ultrasonic space of energy collecting type of extracting for autonomic drug active component; Being connected what communicate with stainless steel casing (6) upper right side is the feed pipe (7) of medicine-liquid mixture; Being connected what communicate with stainless steel casing (6) lower right is discharge pipe (8);
Described feed pipe (7) is for sending into prefabricated medicine-liquid mixture in the ultrasonic space of energy collecting type; Feed pipe (7) has valve (9) with the outside, junction of stainless steel casing (6), controls prefabricated medicine-liquid mixture and flows into;
Described discharge pipe (8), for the dregs of a decoction-medicine liquid mixture after ultrasonic extraction is sent, enters isolated by filtration flow process; Discharge pipe (8) is provided with valve (10) with the outside, junction of stainless steel casing (6), controls the dregs of a decoction-solution mixture and flows out.
2. the Novel ultrasonic device of a kind of autonomic drug active component high efficiency extraction according to claim 1, it is characterized in that, the acoustic condition of described ultrasonic high-efficiency device for extracting inside is: supersonic frequency is 25 ± 5kHz, and the face sound power density of transmitting is 5 ~ 18.6W/cm
2, spatial sound power density is 0.4 ~ 1.5 W/cm
3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320260431.2U CN203750207U (en) | 2013-05-14 | 2013-05-14 | Novel ultrasonic device for extracting botanical drug active ingredients efficiently |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320260431.2U CN203750207U (en) | 2013-05-14 | 2013-05-14 | Novel ultrasonic device for extracting botanical drug active ingredients efficiently |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203750207U true CN203750207U (en) | 2014-08-06 |
Family
ID=51245518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320260431.2U Expired - Fee Related CN203750207U (en) | 2013-05-14 | 2013-05-14 | Novel ultrasonic device for extracting botanical drug active ingredients efficiently |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203750207U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908057A (en) * | 2021-11-15 | 2022-01-11 | 黄欣 | Method and device for decocting traditional Chinese medicine |
-
2013
- 2013-05-14 CN CN201320260431.2U patent/CN203750207U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908057A (en) * | 2021-11-15 | 2022-01-11 | 黄欣 | Method and device for decocting traditional Chinese medicine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2011079404A1 (en) | Device and method for extracting active principles from natural sources, using a counter-flow extractor assisted by a sound transduction system | |
| WO2005056155A1 (en) | An extraction method and the apparatus thereof | |
| CN103191196B (en) | Integrated ultrasonic cyclic extracting and separating technology for cistanche functional ingredient | |
| CN203750207U (en) | Novel ultrasonic device for extracting botanical drug active ingredients efficiently | |
| CN102370713A (en) | Preparation method for momordin | |
| CN102920740B (en) | A kind of middle Tibetan medicine active ingredient energy collecting type ultrasound high efficiency extraction technique | |
| CN204865073U (en) | Dual -frenquency compound ultrasonic extraction element | |
| CN101705183B (en) | Biological cell wall breaking system and biological effective component extracting system based on laser plasma technology | |
| CN106039760A (en) | Ultrasonic extractor special for traditional Chinese medicine materials | |
| CN103990295B (en) | A kind of multiple-frequency supersonic cavitation medicament extracting device | |
| CN204051659U (en) | A kind of ultrasonic cavitation device | |
| CN204563667U (en) | A kind of Chinese medicine ultrasonic extraction device | |
| CN105621529B (en) | One kind strengthens shock flow type waterpower acoustical generator | |
| CN2690024Y (en) | Supersonic reinforced continuous counter flow leaching device | |
| CN207412803U (en) | One kind is based on ultrasonic wave Chinese medicine extractor | |
| RU2397015C1 (en) | Device for cavitation grinding, activation, disinfection of substance | |
| CN207418321U (en) | A kind of consumption-type filled column | |
| CN207267877U (en) | Organic domestic waste processing tandem tunnel methane-generating pit | |
| CN204891849U (en) | Plant active ingredient separator | |
| CN108888990A (en) | A kind of biological extraction element with self-cleaning function | |
| CN103055533A (en) | High-efficiency traditional Chinese medicine extracting tank | |
| CN104307200A (en) | Ultrasonic traditional Chinese medicine extraction equipment | |
| CN202146877U (en) | Spray cleaning tank for raw materials of Chinese herbal medicines | |
| CN204939049U (en) | Horizontal flocculation tempering tank | |
| CN204684239U (en) | Notoginseng injury tablet preparation technology device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140806 Termination date: 20150514 |
|
| EXPY | Termination of patent right or utility model |