CN203732493U - Blood sugar test paper - Google Patents
Blood sugar test paper Download PDFInfo
- Publication number
- CN203732493U CN203732493U CN201320647914.8U CN201320647914U CN203732493U CN 203732493 U CN203732493 U CN 203732493U CN 201320647914 U CN201320647914 U CN 201320647914U CN 203732493 U CN203732493 U CN 203732493U
- Authority
- CN
- China
- Prior art keywords
- test paper
- electrode
- blood sugar
- working electrode
- polymer film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The utility model relates to the field of blood sugar test by using an electrode method and in particular relates to blood sugar test paper. The blood sugar test paper provided by the utility model comprises a substrate, a working electrode and a counter electrode formed on the substrate, a circuit connected with the working electrode and the counter electrode, and a composite material layer formed on the working electrode and used for reacting with a blood sample, wherein the composite material layer comprises a polymer film and inorganic nanoparticles dispersed and adhered into the polymer film, and an anti-interference ion layer including any one of hydroxyl, sulfydryl, carboxyl, amino and alkyl is formed on the surface of the inorganic nanoparticle. According to the blood sugar test paper, selectivity to different substances can be achieved by changing the density of groups and the ratio of different groups; the blood sugar test paper is strong in anti-interference capacity in a testing process, easy to store and capable of being used repeatedly, and greatly facilitates the use of diabetics; and meanwhile, the test result is high in accuracy, and the test fee is greatly reduced.
Description
Technical field
The utility model relates to electrode method blood sugar test field, relates in particular to a kind of blood sugar test paper.
Background technology
The existing diabetes patient of China approximately 5,000 ten thousand, account for 1/4th of world diabetic sum, and also increasing progressively with 1,200,000 people's quantity every year.Rapid blood sugar instrument, as the indispensable instrument of diabetes monitoring, is popularized and is come in numerous diabetics.Commercially available rapid blood sugar instrument is divided into photochemical method and the large class of electrode method two by principle of work.Wherein electrode method blood glucose meter needs blood volume few, and test result is fast, very easy to use.But, because the supporting test strips of commercially available blood glucose meter itself exists the deficiency in principle, test environment is had relatively high expectations, many patients, even some lack the medical worker of specialized training, all can run into the inaccurate problem of detection, thereby affect the observation of result for the treatment of.
The test philosophy of electrode method blood glucose meter is galvanochemistry three electrodes (or the two electrodes) method of testing of employing standard, and measuring process has been coordinated by blood glucose meter and disposable test strips.In test strips, contain contrast electrode, to electrode and three electrodes of working electrode (wherein, the test paper of two electrodes does not comprise contrast electrode, only uses electrode and two electrodes of working electrode).The biology enzyme that scribbles the reaction of energy catalysis glucose in blood on working electrode, as glucose oxidase or hexokinase, the electric signal producing in course of reaction is read and changes into blood sugar concentration reading by blood glucose meter.Blood glucose meter is as a kind of electronic equipment of maturation, and the probability itself breaking down is less.But the enzyme in test strips is bioactivator, expensive, and is easily subject to the interference of the extraneous factors such as temperature, humidity, light, chemical substance and goes bad, therefore the preservation condition of test strips is had relatively high expectations, the term of validity is shorter, and can only disposablely use, and expense is higher.
Utility model content
For this reason, the technical problems to be solved in the utility model is to provide the blood sugar test paper that a kind of antijamming capability is strong, be easy to preservation and can be repeatedly used.
Described blood sugar test paper, comprise substrate, be formed at this on-chip working electrode and to electrode, with described working electrode and the circuit that electrode is connected and be formed on this working electrode for the composite layer of blood sample reaction, this composite layer comprises: polymer film and disperse and adhere to the inorganic nanoparticles in this polymer film, described inorganic nanoparticles surface is formed with any one the anti-interference sheath comprising in hydroxyl, sulfydryl, carboxyl, amino, alkyl.
Further, described test paper also comprises and disperses and adhere to the carbon nano-tube in described polymer film.
Further, described test paper also comprises a contrast electrode being connected with described circuit.
Further, described test paper also comprises that one is covered in described working electrode and to the hydrophilic membrane as reaction chamber on electrode.
Further, described test paper also comprises a contrast electrode being connected with described circuit, and be covered in described working electrode, contrast electrode, to the hydrophilic membrane as reaction chamber on electrode.
Further, the thickness of described polymer film is 1～300 micron.
Further, described inorganic nanoparticles is sheet, bar-shaped or needle-like form.
In terms of existing technologies, the employing-polymer composites the utility model proposes prepare without enzyme test peper bar, there is anti-interference sheath on inorganic nanoparticles surface, can the organism of opposed polarity be produced and be attracted or repulsive interaction.By changing density and the not isoplastic proportioning of group, can realize the selectivity to different material, its antijamming capability in test process is strong, test strips is easy to preserve, and can be repeatedly used, greatly facilitate diabetic's use, test result accuracy rate is high simultaneously, greatly reduces testing cost.
Brief description of the drawings
Fig. 1 is the structural representation of blood sugar test paper of the present utility model.
Fig. 2 is the STRUCTURE DECOMPOSITION schematic diagram of blood sugar test paper of the present utility model.
Embodiment
In order to make the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the utility model is further elaborated.Should be appreciated that specific embodiment described herein is only for explaining the utility model, and be not used in restriction the utility model.
Referring to Fig. 1 and Fig. 2, a kind of blood sugar test paper that the utility model embodiment provides, comprise substrate 10, be formed at on-chip working electrode 20, contrast electrode 30, to electrode 40 (being loop electrode), with described working electrode 20, contrast electrode 30 and circuit 50 that electrode 40 is connected.
On this working electrode, be formed with a composite layer 60, for reacting with blood sample.This composite layer 60 comprises: a polymer film, and adhere to and be scattered in the inorganic nanoparticles in this polymer film.Inorganic nanoparticles is the forms such as sheet, bar-shaped, flower-shaped or needle-like form, the groups such as hydroxyl, sulfydryl, carboxyl, amino, alkyl are contained on its surface, these groups have different polarity, can form the anti-interference sheath that interfering ion is produced to resistance effect on inorganic nanoparticles surface, the effect that can the organism of opposed polarity be produced absorption or be repelled.By changing the proportioning between density and the different group of these groups, can realize the selectivity to different material.
In general, the thickness of polymer film does not have particular requirement, is preferably 1-300 micron.Particularly, this polymer film can be perfluorinated sulfonic resin, teflon, Kynoar, polyvinyl alcohol (PVA), cyclodextrin polymer, polythiophene, polythiaether, polyolefins, polyaniline etc.
It should be noted that defined inorganic nanoparticles also comprises the nano material for shapes such as nanometer rods, nanometer sheet on microcosmic herein.This inorganic nanoparticles does not have specific particle size range requirement, but should be within nanoscale scope, i.e. 0.1～100 nanometer.Because in nanoscale, the particle of different sizes or sheet, rod all have required activity, so, the nano particle of different-grain diameter, just activity varies in size, and can change according to real needs.This nano particle can directly disperse and adhere in polymer film.In the present embodiment, this inorganic nanoparticles is nano-sized nickel hydroxide, reacts with glucose in blood for the enzyme substituting in conventional test strips.In addition, this inorganic nanoparticles can also be Nanometer Copper, nano cupric oxide, nano nickel, Platinum Nanoparticles, Technique of Nano Pd, and one or more of the inorganic nano material such as nm of gold.
This test paper can further comprise the carbon nano-tube being scattered in this polymer film, for increasing electric signal, improves measurement sensitivity.Certainly not high to accuracy requirement in the situation that, also can not need carbon nano-tube.
This polymer film is for dispersing Nano carbon tubes, and dispersion and stabilized nanoscale nickel hydroxide, gets rid of other electroactive materials in blood as the interference of ascorbic acid etc. simultaneously, reduces the error in blood sugar test process.
This test paper further comprises that one is covered in working electrode 20, contrast electrode 30, and to the hydrophilic membrane 70 as reaction chamber on electrode 40.
It should be pointed out that the utility model also comprises the test paper of two electrode classes, for two electrode blood glucose monitoring systems.In the embodiment of two pole reagent papers, on this substrate 10, do not form contrast electrode 30.60 of composite layers are formed on working electrode 20, and 70 of hydrophilic membranes are covered in working electrode 20, and on electrode 40 as reaction chamber.
This employing inorganic nanoparticles-carbon nano tube-polymer compound substance prepare without enzyme test peper bar, in test process, antijamming capability is strong, test result accuracy rate is high, and can be repeatedly used (as can be in one month Reusability 100 times), greatly reduce testing cost, and test strips is easy to preserve, and greatly facilitates diabetic's use.
The foregoing is only preferred embodiment of the present utility model; not in order to limit the utility model; all any amendments of doing within spirit of the present utility model and principle, be equal to and replace and improvement etc., within all should being included in protection domain of the present utility model.
Claims (7)
1. a blood sugar test paper, comprise substrate, be formed at this on-chip working electrode and to electrode, with described working electrode and the circuit that electrode is connected and be formed on this working electrode for the composite layer of blood sample reaction, it is characterized in that, this composite layer comprises: polymer film and disperse and adhere to the inorganic nanoparticles in this polymer film, described inorganic nanoparticles surface is formed with any one the anti-interference sheath comprising in hydroxyl, sulfydryl, carboxyl, amino, alkyl.
2. test paper as claimed in claim 1, is characterized in that, described test paper also comprises and disperses and adhere to the carbon nano-tube in described polymer film.
3. test paper as claimed in claim 1, is characterized in that, described test paper also comprises a contrast electrode being connected with described circuit.
4. test paper as claimed in claim 1, is characterized in that, described test paper also comprises that one is covered in described working electrode and to the hydrophilic membrane as reaction chamber on electrode.
5. test paper as claimed in claim 1, is characterized in that, described test paper also comprises a contrast electrode being connected with described circuit, and be covered in described working electrode, contrast electrode, to the hydrophilic membrane as reaction chamber on electrode.
6. test paper as claimed in claim 1 or 2, is characterized in that, the thickness of described polymer film is 1～300 micron.
7. test paper as claimed in claim 1, is characterized in that, described inorganic nanoparticles is sheet, bar-shaped or needle-like form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320647914.8U CN203732493U (en) | 2013-10-18 | 2013-10-18 | Blood sugar test paper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320647914.8U CN203732493U (en) | 2013-10-18 | 2013-10-18 | Blood sugar test paper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203732493U true CN203732493U (en) | 2014-07-23 |
Family
ID=51202556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320647914.8U Expired - Fee Related CN203732493U (en) | 2013-10-18 | 2013-10-18 | Blood sugar test paper |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203732493U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105353005A (en) * | 2015-09-29 | 2016-02-24 | 扬中市恒海电子科技有限公司 | blood glucose meter |
| CN112986350A (en) * | 2019-12-16 | 2021-06-18 | 大连大学 | Method for detecting nitrite by using AuNPs/NiNFs/ITO electrode |
| CN113030212A (en) * | 2019-12-24 | 2021-06-25 | 大连大学 | Method for rapidly analyzing and detecting glucose |
| CN113427559A (en) * | 2021-07-02 | 2021-09-24 | 西安交通大学医学院第二附属医院 | Nano fetuin test paper for monitoring diabetic retinopathy and preparation process thereof |
-
2013
- 2013-10-18 CN CN201320647914.8U patent/CN203732493U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105353005A (en) * | 2015-09-29 | 2016-02-24 | 扬中市恒海电子科技有限公司 | blood glucose meter |
| CN112986350A (en) * | 2019-12-16 | 2021-06-18 | 大连大学 | Method for detecting nitrite by using AuNPs/NiNFs/ITO electrode |
| CN112986350B (en) * | 2019-12-16 | 2022-05-13 | 大连大学 | Method for detecting nitrite by using AuNPs/NiNFs/ITO electrode |
| CN113030212A (en) * | 2019-12-24 | 2021-06-25 | 大连大学 | Method for rapidly analyzing and detecting glucose |
| CN113030212B (en) * | 2019-12-24 | 2022-11-04 | 大连大学 | Method for rapidly analyzing and detecting glucose |
| CN113427559A (en) * | 2021-07-02 | 2021-09-24 | 西安交通大学医学院第二附属医院 | Nano fetuin test paper for monitoring diabetic retinopathy and preparation process thereof |
| CN113427559B (en) * | 2021-07-02 | 2023-03-10 | 西安交通大学医学院第二附属医院 | Nano fetuin test paper for monitoring diabetic retinopathy and preparation process thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102338765A (en) | Blood sugar testing paper | |
| Lin et al. | Semiconductor metal oxides as chemoresistive sensors for detecting volatile organic compounds | |
| Gao et al. | Application of PEDOT: PSS and its composites in electrochemical and electronic chemosensors | |
| Arman Kuzubasoglu | Recent studies on the humidity sensor: A mini review | |
| CN106770544B (en) | Ni-MOF ultrathin nanometer band, synthetic method and its application | |
| Costa-Rama et al. | based screen-printed electrodes: A new generation of low-cost electroanalytical platforms | |
| Hu et al. | Application of electrochemical sensors based on carbon nanomaterials for detection of flavonoids | |
| CN203732493U (en) | Blood sugar test paper | |
| Mo et al. | Electrochemical determination of nitrite by au nanoparticle/graphene-chitosan modified electrode | |
| Cavallari et al. | A hybrid electronic nose and tongue for the detection of ketones: Improved sensor orthogonality using graphene oxide-based detectors | |
| Kumarage et al. | Low-dimensional nanostructures based on cobalt oxide (Co3O4) in chemical-gas sensing | |
| Patil et al. | An electrochemical electrode to detect theophylline based on copper oxide nanoparticles composited with graphene oxide | |
| Sobahi et al. | Electrochemical sensing of H2O2 by employing a flexible Fe3O4/graphene/carbon cloth as working electrode | |
| Singh et al. | Deposition of Ni/RGO nanocomposite on conductive cotton fabric as non-enzymatic wearable electrode for electrochemical sensing of uric acid in sweat | |
| Yu et al. | Nanomaterials-based ion-imprinted electrochemical sensors for heavy metal ions detection: a review | |
| Kalambate et al. | A portable smartphone-compatible ratiometric electrochemical sensor with ultrahigh sensitivity for anticancer drug mitoxantrone sensing | |
| Shahsavari et al. | Fabrication of Nanostructure Electrochemical Sensor Based on the Carbon Paste Electrode (CPE) Modified With Ionic Liquid and Fe 3 O 4/ZIF-67 for Electrocatalytic Sulfamethoxazole Detection | |
| Zhang et al. | Carbon-based transducers for solid-contact calcium ion-selective electrodes: mesopore and nitrogen-doping effects | |
| Sui et al. | A sensitive pyrimethanil sensor based on electrospun TiC/C Film | |
| Zhu et al. | The polypyrrole/multiwalled carbon nanotube modified au microelectrode for sensitive electrochemical detection of trace levels of Pb2+ | |
| Min et al. | Formaldehyde gas sensors fabricated with polymer-based materials: a review | |
| Alterary et al. | Atropine-phosphotungestate polymeric-based metal oxide nanoparticles for potentiometric detection in pharmaceutical dosage forms | |
| Qi et al. | Nanoporous graphene oxide-based quartz crystal microbalance gas sensor with dual-signal responses for trimethylamine detection | |
| Tan et al. | Production of Ni 7 S 6/NiO hybrids as a highly sensitive amperometric sensor for glucose | |
| Mazurków et al. | Electrochemical characterization of modified glassy Carbon Electrodes for non-enzymatic glucose sensors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140723 Termination date: 20181018 |