CN203720157U - High performance liquid chromatographic column - Google Patents
High performance liquid chromatographic column Download PDFInfo
- Publication number
- CN203720157U CN203720157U CN201420083724.2U CN201420083724U CN203720157U CN 203720157 U CN203720157 U CN 203720157U CN 201420083724 U CN201420083724 U CN 201420083724U CN 203720157 U CN203720157 U CN 203720157U
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- CN
- China
- Prior art keywords
- pressure cap
- sieve plate
- column
- chromatographic column
- performance liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 238000012856 packing Methods 0.000 claims abstract description 12
- 239000000945 filler Substances 0.000 claims description 24
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model provides a high performance liquid chromatographic column comprising a column pipe, packing filled in the column pipe, an external pressing cap, an internal pressing cap and a sieve plate, wherein the inner side wall of the external pressing cap is provided with an internal thread; two ends of the column pipe are provided with openings; the opening close to one end of the outer side wall of the column pipe is provided with an external thread matched with the internal thread; the inner top wall of the external pressing cap is provided with a blind hole; one end of the internal pressing cap extends into the corresponding opening to seal the packing, and the other end of the internal pressing cap extends into the blind hole; the sieve plate is arranged between the packing and the internal pressing cap and is in tight contact with the packing and the internal pressing cap. By using the high performance liquid chromatographic column provided by the utility model, the length of the internal pressing cap extending into the column pipe can be changed, so that the distance between the sieve plate and the packing in the column pipe is changed. When the packing collapses, the sieve plate can be in tight contact with the packing again through the regulation, so that the dead volume in the column pipe is filled up, the phenomenon that the column efficiency is lowered is avoided, the service life of the chromatographic column is prolonged, and the experimental cost is greatly reduced.
Description
Technical field
The utility model relates to chromatographic resolution field of analytic instrument, relates in particular to a kind of performance liquid chromatographic column.
Background technology
Liquid chromatograph mainly comprises: several part-structures such as high pressure pump, injector, chromatographic column, detecting device, and wherein chromatographic column is called as chromatographic heart, and the quality of column performance has directly affected separation, the analyzing and testing effect of whole chromatographic system.One brace has the chromatographic column of high separation, Gao Zhuxiao to occupy very important status in the separation of liquid chromatograph, analyzing and testing, is the most important condition that guarantees good separation, analyzing and testing result.Yet at present, in the use procedure of chromatographic column, chromatographic column column cap collapse phenomenon is of common occurrence, and chromatographic column causes dead volume significantly to increase after subsiding, peak type variation, degree of separation obviously declines, and post effect significantly reduces.
The occurrence cause of chromatographic column collapse phenomenon mainly contains the following aspects: one, chromatographic column filling technological deficiency, and hypotony during filling, chromatograph packing material loads not consolidation and produces space; Two, high pressure pump pressure is excessive, the crushed generation of filler space; Three, mobile phase improper use, the dissolved chromatographic column that causes of filler is subsided.Above many reasons shows that the in use generation of collapse phenomenon of chromatographic column is inevitably, and the post effect of therefore how improving after chromatographic column is subsided is a mission critical.
At present, the measure of taking after chromatographic column is subsided mainly comprises: the chromatographic column one, more renewing, two, again load chromatographic column.Wherein, change a chromatographic column important expenditure beyond doubt, making to test consumables cost significantly increases; And again load chromatographic column, need on the one hand professional chromatographic column filling technology, also increased on the other hand consumables cost.
For the problems referred to above, be necessary to provide a kind of performance liquid chromatographic column of improvement.
Utility model content
The purpose of this utility model is to provide a kind of performance liquid chromatographic column.
For realizing above-mentioned utility model object, a kind of performance liquid chromatographic column of the present utility model, it comprises column jecket, is filled in the filler in described column jecket, outer pressure cap, interior pressure cap and sieve plate, described column jecket two ends have opening, on the madial wall of described outer pressure cap, be provided with internal thread, the opening that closes on one end on the lateral wall of described column jecket is formed with the external thread matching with described internal thread; On the inner roof wall of described outer pressure cap, be formed with blind hole, one end of described interior pressure cap is stretched in respective openings, seals described filler, and the other end stretches in described blind hole, described sieve plate is arranged between described filler and interior pressure cap, and with described filler and interior pressure cap close contact.
As further improvement of the utility model, the edge of the opening of described column jecket and described sieve plate opposite side is formed with an annular groove, in described annular groove, is provided with packing washer.
As further improvement of the utility model, described interior pressure cap comprises connecting portion and press section, the diameter of described connecting portion is identical with the diameter of described blind hole, described connecting portion stretches in described blind hole, the diameter of described press section is identical with the internal diameter of described column jecket, and described press section is stretched in described column jecket by respective openings.
As further improvement of the utility model, the axial direction of described interior pressure cap offers through hole.
As further improvement of the utility model, described interior pressure cap is formed with described sieve plate opposite side the accepting groove matching with described sieve plate shape, when described sieve plate and interior pressure cap close contact, is contained in described accepting groove.
Compared with prior art, the beneficial effects of the utility model are: the length that performance liquid chromatographic column of the present utility model can make interior pressure cap extend in column jecket changes, thereby change the distance between the filler in sieve plate and column jecket.When filler subsides, by above-mentioned adjusting, can make sieve plate and filler close contact again, filled up the dead volume in column jecket, avoided post effect to reduce phenomenon, extended the serviceable life of chromatographic column, greatly reduce experimental cost.
Accompanying drawing explanation
Fig. 1 is the decomposing schematic representation of an embodiment of performance liquid chromatographic column of the present utility model.
Embodiment
Below in conjunction with each embodiment shown in the drawings, the utility model is elaborated; but should be noted that; these embodiments are not limitation of the utility model; those of ordinary skills are according to these embodiment institute work energy, method or structural equivalent transformation or alternative, within all belonging to protection domain of the present utility model.
As shown in Figure 1, performance liquid chromatographic column 100 of the present utility model comprises column jecket 10 and is filled in the filler 20 in described column jecket 10.Described column jecket 10 two ends have opening.
Described performance liquid chromatographic column 100 also comprises: outer pressure cap 30, interior pressure cap 40 and sieve plate 50, on the madial wall of described outer pressure cap 30, be provided with internal thread 60, the opening that closes on one end on the lateral wall of described column jecket 10 is formed with the external thread 70 matching with described internal thread.Thereby column jecket 10 can screw in outer pressure cap 30 by the coordinating of internal thread 60 and external thread 70, when column jecket 10 is during with the relative rotation of outer pressure cap 30 generation, can change the degree of depth of the outer pressure cap 30 of column jecket 10 screw-in.In addition, be formed with blind hole 80 on the inner roof wall of described outer pressure cap 30, one end of described interior pressure cap 40 is stretched in described blind hole 80, thus embedded connection the between pressure cap 40 and outer pressure cap 30 in realizing.In addition, the other end of described interior pressure cap 40 stretches in the respective openings of column jecket 10, and described sieve plate 50 is arranged between described interior pressure cap 40 and filler 20, and with described filler 20 and interior pressure cap 40 close contacts, thereby sieve plate 50 is by filler 20 compactings.
In above-mentioned embodiment, interior pressure cap 40 side relative to sieve plate 50 is formed with the accepting groove matching with described sieve plate 50 shapes, and when described sieve plate 50 and interior pressure cap 40 close contact, it is contained in described accepting groove.So be conducive to the fixing of sieve plate 50 positions.Further, the edge of the opening relative with sieve plate 50 of described column jecket 10 is formed with an annular groove 101, in this annular groove 101, be provided with packing washer, when sieve plate 50 and filler 20 close contact, packing washer can carry out close contact with interior pressure cap 40, thereby realizes the excellent sealing between interior pressure cap 40 and column jecket 10.
Particularly, described interior pressure cap 40 comprises connecting portion 401 and press section 402, the diameter of described connecting portion 401 is identical with the diameter of described blind hole 80, described connecting portion 401 stretches in described blind hole 80, the diameter of described press section 402 is identical with the internal diameter of described column jecket 10, and described press section 402 is stretched in described column jecket by respective openings.Thereby when regulating column jecket to stretch into the distance in outer pressure cap, press section can apply different pressure to filler by sieve plate.When filler subsides, the relatively outer pressure cap of column jecket is rotated, make the Distance Shortened between the two, thereby make sieve plate and filler again realize close contact.
In addition, on described interior pressure cap 40, offer vertically through hole.This through hole can supply mobile phase process, and flows into or outflow chromatographic column.
In sum, the length that performance liquid chromatographic column of the present utility model can make interior pressure cap extend in column jecket changes, thereby changes the distance between the filler in sieve plate and column jecket.When filler subsides, by above-mentioned adjusting, can make sieve plate and filler close contact again, filled up the dead volume in column jecket, avoided post effect to reduce phenomenon, extended the serviceable life of chromatographic column, greatly reduce experimental cost.
To those skilled in the art, obviously the utility model is not limited to the details of above-mentioned one exemplary embodiment, and in the situation that not deviating from spirit of the present utility model or essential characteristic, can realize the utility model with other concrete form.Therefore, no matter from which point, all should regard embodiment as exemplary, and be nonrestrictive, scope of the present utility model is limited by claims rather than above-mentioned explanation, is therefore intended to include in the utility model dropping on the implication that is equal to important document of claim and all changes in scope.Any Reference numeral in claim should be considered as limiting related claim.
In addition, be to be understood that, although this instructions is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of instructions is only for clarity sake, those skilled in the art should make instructions as a whole, and the technical scheme in each embodiment also can, through appropriately combined, form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. a performance liquid chromatographic column, it comprises column jecket and is filled in the filler in described column jecket, described column jecket two ends have opening, it is characterized in that, described performance liquid chromatographic column also comprises: outer pressure cap, interior pressure cap and sieve plate, on the madial wall of described outer pressure cap, be provided with internal thread, the opening that closes on one end on the lateral wall of described column jecket is formed with the external thread matching with described internal thread; On the inner roof wall of described outer pressure cap, be formed with blind hole, one end of described interior pressure cap is stretched in respective openings, seals described filler, and the other end stretches in described blind hole, described sieve plate is arranged between described filler and interior pressure cap, and with described filler and interior pressure cap close contact.
2. performance liquid chromatographic column according to claim 1, is characterized in that, the edge of the opening of described column jecket and described sieve plate opposite side is formed with an annular groove, in described annular groove, is provided with packing washer.
3. performance liquid chromatographic column according to claim 1, it is characterized in that, described interior pressure cap comprises connecting portion and press section, the diameter of described connecting portion is identical with the diameter of described blind hole, described connecting portion stretches in described blind hole, the diameter of described press section is identical with the internal diameter of described column jecket, and described press section is stretched in described column jecket by respective openings.
4. according to the performance liquid chromatographic column described in claim 1 or 3, it is characterized in that, the axial direction of described interior pressure cap offers through hole.
5. performance liquid chromatographic column according to claim 1, is characterized in that, described interior pressure cap is formed with described sieve plate opposite side the accepting groove matching with described sieve plate shape, when described sieve plate and interior pressure cap close contact, is contained in described accepting groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420083724.2U CN203720157U (en) | 2014-02-26 | 2014-02-26 | High performance liquid chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420083724.2U CN203720157U (en) | 2014-02-26 | 2014-02-26 | High performance liquid chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203720157U true CN203720157U (en) | 2014-07-16 |
Family
ID=51159297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420083724.2U Expired - Fee Related CN203720157U (en) | 2014-02-26 | 2014-02-26 | High performance liquid chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203720157U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781890A (en) * | 2019-02-14 | 2019-05-21 | 李素媛 | A kind of detection of tealeaves monosaccharide components liquid chromatographic detection device and its application method |
| CN110208445A (en) * | 2019-07-09 | 2019-09-06 | 常州三泰科技有限公司 | Liquid-phase chromatographic column column tube and liquid-phase chromatographic column |
| CN111239309A (en) * | 2020-01-20 | 2020-06-05 | 安徽省先锋制药有限公司 | High performance liquid chromatography column |
-
2014
- 2014-02-26 CN CN201420083724.2U patent/CN203720157U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781890A (en) * | 2019-02-14 | 2019-05-21 | 李素媛 | A kind of detection of tealeaves monosaccharide components liquid chromatographic detection device and its application method |
| CN109781890B (en) * | 2019-02-14 | 2021-08-24 | 李素媛 | Liquid chromatography detection device for detecting monosaccharide components of tea leaves and using method thereof |
| CN110208445A (en) * | 2019-07-09 | 2019-09-06 | 常州三泰科技有限公司 | Liquid-phase chromatographic column column tube and liquid-phase chromatographic column |
| CN111239309A (en) * | 2020-01-20 | 2020-06-05 | 安徽省先锋制药有限公司 | High performance liquid chromatography column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140716 |