CN203710540U - Connecting chain capable of degrading radioactive sealing seed sources - Google Patents
Connecting chain capable of degrading radioactive sealing seed sources Download PDFInfo
- Publication number
- CN203710540U CN203710540U CN201320813074.8U CN201320813074U CN203710540U CN 203710540 U CN203710540 U CN 203710540U CN 201320813074 U CN201320813074 U CN 201320813074U CN 203710540 U CN203710540 U CN 203710540U
- Authority
- CN
- China
- Prior art keywords
- degradable
- radioactive
- seed source
- connecting chain
- seed sources
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 72
- 238000007789 sealing Methods 0.000 title abstract description 10
- 230000000593 degrading effect Effects 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 abstract description 16
- 238000006065 biodegradation reaction Methods 0.000 abstract description 6
- 238000006073 displacement reaction Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 230000005012 migration Effects 0.000 abstract description 4
- 238000013508 migration Methods 0.000 abstract description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract description 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 8
- 239000007943 implant Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 230000005855 radiation Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 4
- 230000002980 postoperative effect Effects 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 229910000861 Mg alloy Inorganic materials 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Landscapes
- Radiation-Therapy Devices (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The utility model discloses a connecting chain capable of degrading radioactive sealing seed sources. The connecting chain comprises a degradable connecting chain which is of a hollow pipe-shaped structure, wherein the degradable connecting chain is internally at least provided with two radioactive sealing seed sources; at least one degradable seed source is arranged between the two adjacent radioactive sealing seed sources; and the radioactive sealing seed sources and the degradable seed source which are arranged in sequence are connected in an end-to-end manner. The degradable seed source and the degradable connecting chain are made of lactide copolymer respectively. The connecting chain disclosed by the utility model has the advantages that the surface is smooth, the structure is stable during biodegradation, the distribution position of the radioactive sealing seed sources can be ensured when the connecting chain is implanted into a tumor tissue and the radioactive sealing seed sources are uniformly distributed in lesion according to the treatment plan, so that the influence of displacement or migration of the radioactive sealing seed sources on the treating effect is prevented. The connecting chain is mainly applied in treatment of multiple tumors such as prostatic cancer, liver cancer, lung cancer and pancreatic cancer, is improved in the working efficiency of the implanting operation of the radioactive sealing seed sources and is more applicable to clinical implanting operation.
Description
Technical field
This utility model relates to a kind of radioactive sealed seed source connection medical apparatus and instruments for implanted treatment between tumor tissues, specifically degradable radioactive sealed seed source connection chain.
Background technology
Interstitial radiation sealed seed source implanted treatment is that the ray that utilizes seed source to radiate kills cancerous cell by around radioactive sealed seed source implantation tumour or tumor, reaches the object for the treatment of and alleviation disease.This Therapeutic Method has advantages of that wound is little, side effect is little and relapse rate is low, has obtained good therapeutic effect in clinical.Radioactive sealed seed source is as the in-house medicine of implant into body, before clinical use, must formulate treatment plan according to tumor shape, volume, position, according to image-guided clinical operation, implement treatment plan again, radioactive sealed seed source is implanted in tumor tissues, continuing, the lonizing radiation of short distance, low dosage kill tumor cell, normal tissue does not damage or only has the situation of microlesion to be issued to therapeutic purposes simultaneously.
The radioactive sealed seed source shell of current clinical use mostly is minitype titanium metal tube, volume is little, smooth surface, after implanting because in-vivo tissue is wriggled and the situation such as extruding, easily make radioactive sealed seed source be shifted, cause tumor area local radiation DM to cause curative effect to decline, even may cause it to migration at a distance, to cause organ thromboembolism, the taking-up of need to performing the operation when serious.In radioactive sealed seed source implant surgery operating process, be difficult to guarantee that radioactive sealed seed source distribute spacing is even in addition, thereby affect radioactive dosage, distribute and therapeutic effect.So a kind of radioactive sealed seed source can connection by treatment plan interval, can in tumor, during biodegradation, keep again spacer structure stable, make radioactive sealed seed source nonmigratory degradable radioactive sealed seed source connection chain that is not shifted fundamentally solve the problems referred to above.
Publication number is CN101987226A, the Chinese invention patent application that its open day is on March 23rd, 2011 discloses the magnesium of controlled degradable and the radioactive particle chain that magnesium-alloy tube connects, although solved radioactive sealed seed source organize in vivo between displacement or migration problem, but have the following disadvantages: (1) radioactive sealed seed source is for being plugged on connection tube, seed source spacing is wayward, easily produce the dark or shallow result of pegging graft, thereby affect radioactive dosage, distribute and therapeutic effect; (2) degradable magnesium adopting and magnesium alloy ultrathin pipe connection chain material cost is high, processing cost is high, increases patient economy burden.
Notification number is CN201969196U, its day for announcing is that in JIUYUE, 2011 Chinese utility model patent of 14 days discloses a kind of Degradable sealing seed source chain, although also can solve radioactive sealed seed source organize in vivo between displacement or migration problem, but have the following disadvantages: (1) adopts the method for braiding to form the stitching thread pipe complex process of mesh shape, when connecting radioactive particle and column filler, can cause too much radiation to operator; (2) the stitching spool thickness of this mesh shape is inhomogeneous, easily makes network damaged when connecting radioactive sealed seed source and column filler, affects radioactive sealed seed source spacing in vivo, and then affects radioactive dosage distribution and therapeutic effect.
Utility model content
For above-mentioned prior art, this utility model provides a kind of degradable radioactive sealed seed source connection chain, have simple in structure, easy to use, being beneficial to radioactive sealed seed source loading connects, make implant surgery more convenient, during biodegradation in connection chain Stability Analysis of Structures, postoperative dosage keeps being evenly distributed, radioactive seed source is not shifted and does not move.Improve radiation treatment effect in tumor tissues, more applicable clinical implant surgery treatment tumor.
In order to solve the problems of the technologies described above, a kind of degradable radioactive sealed seed source of this utility model connection chain, the degradable connection chain that comprises hollow tubular structure, in described degradable connection chain, be at least placed with two radioactive sealed seed sources, between adjacent two radioactive sealed seed sources, be at least placed with 1 degradable seed source, radioactive sealed seed source and the degradable seed source of placing are successively end to end.
This utility model degradable radioactive sealed seed source connection chain, wherein, the material that described degradable seed source and degradable connection chain adopt is lactide copolymer.
Compared with prior art, the beneficial effects of the utility model are:
(1) this utility model degradable connection chain is hollow tubular structure, one-shot forming, caliber wall thickness is even, can guarantee that radioactive sealed seed source and degradable seed source are pushed to assigned address, simultaneously can be in connection chain in the situation of not stressing fixed position.
(2) degradable seed source specification is consistent with radioactive sealed seed source specification, and in end to end assurance connection chain, radioactive sealed seed source is equidistant arranges evenly, and dose distribution is even.
(3) degradable seed source and degradable connection chain adopt lactide copolymer, and its biological safety is high, and effectively reduces material cost and processing cost.The lactide copolymer mechanical performance adopting is superior, guarantees that degradable radioactive sealed seed source connection chain can not bend, rupture in the process of Operation.Postoperative irradiation sealed seed source is mobile in during biodegradation not to be moved.
(4) in clinical implant surgery process, only single stepping can be implanted to a plurality of radioactive sealed seeds in a connection chain in tumor tissues, greatly shortens operating time, increases work efficiency, more applicable clinical implanted treatment tumor.
Accompanying drawing explanation
Fig. 1 is the perspective view of this utility model degradable radioactive sealed seed source connection chain.
Fig. 2 (a) is that in this utility model degradable radioactive sealed seed source connection chain, schematic diagram is arranged in a seed source;
Fig. 2 (b) is that in this utility model degradable radioactive sealed seed source connection chain, schematic diagram is arranged in another seed source.
In figure: 1-radioactive sealed seed source, 2-degradable seed source, 3-degradable connection chain.
The specific embodiment
Below in conjunction with the specific embodiment, this utility model is described in further detail.
As shown in Figure 1, a kind of degradable radioactive sealed seed source of this utility model connection chain, the degradable connection chain 3 that comprises hollow tubular structure, in described degradable connection chain, be at least placed with two radioactive sealed seed sources 1, between adjacent two radioactive sealed seed sources 1, be at least placed with 1 degradable seed source 2, radioactive sealed seed source 1 and degradable seed source 2 are packed in degradable connection chain one by one with certain arrangement mode, can one or several degradable seed sources 2, interval according to treatment plan between two radioactive sealed seed sources 1, Fig. 1, in Fig. 2 (a) and Fig. 2 (b), show respectively between two radioactive sealed seed sources 1 and be placed with 1, 2 or 3 degradable seed sources 2, the specification in described degradable seed source 2 is consistent with described radioactive sealed seed source 1 specification, with push rod one by one by radioactive sealed seed source 1 and degradable seed source 2 end to end packing in degradable connection chain 3 of being arranged in order, make the degradable radioactive sealed seed source connection chain of certain length.The length of connection chain needs radioactive sealed seed source quantity to determine according to treatment plan, also can be made into long connection chain, preoperatively intercepts as required.In operation, the radioactive sealed seed source connection chain of making is packed into the implantation utensil of coupling, by treatment plan, by puncture needle, be implanted in tumor tissues.
The material that described degradable seed source 2 in this utility model and degradable connection chain 3 adopt is lactide copolymer, its biological safety is high, and can effectively reduce material cost and processing cost, its mechanical performance of lactide copolymer adopting is superior, guarantees that degradable radioactive sealed seed source connection chain can not bend, rupture in the process of Operation.Postoperative irradiation sealed seed source 1 is mobile in during biodegradation not to be moved.
This utility model degradable radioactive sealed seed source connection chain smooth surface, during biodegradation, inner structure is stable, be implanted in tumor tissues and can guarantee radioactive sealed seed source distributing position, make radioactive sealed seed source be evenly distributed on intralesional by treatment plan, prevent from because of radioactive sealed seed source displacement or move affecting therapeutic effect.Degradable radioactive sealed seed source connection chain is mainly used in the treatment of the kinds of tumors such as carcinoma of prostate, hepatocarcinoma, pulmonary carcinoma, cancer of pancreas, improves the work efficiency of radioactive sealed seed source implant surgery, is more applicable for clinical implant surgery.
Although this utility model is described in conjunction with figure above; but this utility model is not limited to the above-mentioned specific embodiment; the above-mentioned specific embodiment is only schematic; rather than restrictive; those of ordinary skill in the art is under enlightenment of the present utility model; in the situation that not departing from this utility model aim, can also make a lot of distortion, within these all belong to protection of the present utility model.
Claims (2)
1. a degradable radioactive sealed seed source connection chain, the degradable connection chain (3) that comprises hollow tubular structure, it is characterized in that, in described degradable connection chain, be at least placed with two radioactive sealed seed sources (1), between adjacent two radioactive sealed seed sources (1), be at least placed with 1 degradable seed source (2), the specification in described degradable seed source (2) is consistent with described radioactive sealed seed source (1) specification, and radioactive sealed seed source (1) and the degradable seed source (2) of placing are successively end to end.
2. degradable radioactive sealed seed source connection chain according to claim 1, is characterized in that, the material that described degradable seed source (2) and degradable connection chain (3) adopt is lactide copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320813074.8U CN203710540U (en) | 2013-12-11 | 2013-12-11 | Connecting chain capable of degrading radioactive sealing seed sources |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320813074.8U CN203710540U (en) | 2013-12-11 | 2013-12-11 | Connecting chain capable of degrading radioactive sealing seed sources |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203710540U true CN203710540U (en) | 2014-07-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320813074.8U Expired - Lifetime CN203710540U (en) | 2013-12-11 | 2013-12-11 | Connecting chain capable of degrading radioactive sealing seed sources |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203710540U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105498073A (en) * | 2015-12-14 | 2016-04-20 | 中国人民解放军第三军医大学第一附属医院 | Degradable implantation catheter carrying drug particles |
| CN107233662A (en) * | 2017-06-23 | 2017-10-10 | 宁波君安药业科技有限公司 | A kind of radioactive particle chain of use high molecular polymer connecting tube connection |
-
2013
- 2013-12-11 CN CN201320813074.8U patent/CN203710540U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105498073A (en) * | 2015-12-14 | 2016-04-20 | 中国人民解放军第三军医大学第一附属医院 | Degradable implantation catheter carrying drug particles |
| CN107233662A (en) * | 2017-06-23 | 2017-10-10 | 宁波君安药业科技有限公司 | A kind of radioactive particle chain of use high molecular polymer connecting tube connection |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140716 |
|
| CX01 | Expiry of patent term |