CN105498073A - Degradable implantation catheter carrying drug particles - Google Patents
Degradable implantation catheter carrying drug particles Download PDFInfo
- Publication number
- CN105498073A CN105498073A CN201510931618.4A CN201510931618A CN105498073A CN 105498073 A CN105498073 A CN 105498073A CN 201510931618 A CN201510931618 A CN 201510931618A CN 105498073 A CN105498073 A CN 105498073A
- Authority
- CN
- China
- Prior art keywords
- catheter body
- catheter
- drug particle
- degradable implantation
- carrying drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
Abstract
The invention discloses a degradable implantation catheter carrying specific drug particles such as an iodine-125 brachytherapy source and sustained release drug particles such as sustained release fluorouracil particles and the like. The catheter comprises a catheter body for accommodating the drug particles and spacer blocks arranged in the catheter body and used for spacing drugs. The degradable implantation catheter carrying the drug particles can be loaded with sufficient antitumor drugs and carry the drugs to be implanted into a tumor part of a patient together, the antitumor drug particles realize predetermined distribution in the tumor, do not enter a blood vessel to be moved through flushing and can still keep predetermined distribution in fluid-containing and necrotic lacunas of a tumor body, and the implanted drug particles can follow a tumor change part correspondingly instead of being left outside a treated part when the catheter is degraded and the tumor body shrinks.
Description
Technical field
The present invention relates to medical field, particularly relate to a kind of degradable implantation catheter carrying drug particle.
Background technology
It is low that the local dose that can overcome conventional entity oncotherapy mode systemic administration is preferably placed in antitumor drug local, weak effect, the defect that general toxicity is large, dense or the dosage of the medicine of tumor by local can not only be improved, and significantly can reduce general toxic reaction, and medicine is directly positioned over tumor tissues place and distribution meets and plans not only operating difficulties, need to carry out frequently implant procedure, length consuming time, increase wound and Operative risk.
Therefore, need a kind of degradable implantation catheter carrying drug particle, for holding antitumor drug, and then carry the tumor locus of antitumor drug together patients with implantation, in the degradable implantation catheter carrying drug particle, load enough antitumor drug and realize the reasonable layout of drug particle, to reach best therapeutic effect.Degradability contributes to realizing drug particles and can follow tumor with tumor regression and assemble gradually, is unlikely to enter in surrounding tissue.
Summary of the invention
In view of this, the object of this invention is to provide a kind of degradable implantation catheter carrying drug particle, enough antitumor drug can be loaded and carry the tumor cell place of medicine together patients with implantation, realizing long-term treatment by the slow releasing of antitumor drug, save medical expense.
The degradable implantation catheter carrying drug particle of the present invention, comprise catheter body for holding medicine and be located in catheter body for by spacer block spaced apart for medicine.
Further, described catheter body and spacer block are made by degradation material.
Further, the internal diameter of described catheter body is 0.9-1.0mm, and wall thickness is 0.08 ~ 0.12mm.
Further, described catheter body sidewall arranges at least one side opening or catheter body sidewall opening is formed C type tubular construction.
Further, described side opening along catheter body length to spacing be 10 ~ 20mm.
Further, one end of described catheter body is closed, and the other end is bell mouth shape, and its blind end is tack, tip, round end and can be forked.
Further, described degradation material is biological erosion to separate or biodegradable metal, alloy or polymer.
Further, described degradation material be magnesium, ferrum, magnesium base alloy, polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, polyamide, polyester, polyesteramide, polyanhydride, poe, polyphosphazene, false polyamino acid, polyglycereol-sebacate, polycaprolactone, polycaprolactone derivatives, based on amino alcohol polyesteramide, poly-octane glycol citrate, hydrogel or curable biology can resorbent elastomers.
The invention has the beneficial effects as follows: the degradable implantation catheter carrying drug particle of the present invention, enough antitumor drug can be loaded and carried the tumor cell place of medicine together patients with implantation by this degradable implantation catheter carrying drug particle, realize long-term treatment by the slow releasing of antitumor drug, save medical expense.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
Fig. 1 is structural representation of the present invention; As shown in the figure: the degradable implantation catheter carrying drug particle of the present embodiment, comprise the catheter body 2 for holding medicine 1 and be located in catheter body 2 for by spacer block 3 spaced apart for medicine 1; Catheter body 2 is for having the flexible tubular structure of certain degree of hardness, and medicine 1 can be discharged by the mouth of pipe of catheter body 2 end, also can on catheter body 2 sidewall machining hole, medicine 1 is discharged by hole, all can realize object of the present invention; Rationally can arrange length and the interval of spacer block 3 according to disease sites, and then medicine 1 can be made corresponding with disease sites after catheter body 2 implant into body, energy is drug administration 1 dosage reasonably, and ensure therapeutic effect.
In the present embodiment, described catheter body 2 and spacer block 3 are made by degradation material; Catheter body 2 and spacer block 3 can be absorbed by the body after implanting gradually, simplify therapeutic process, reduce the infringement to human body.
In the present embodiment, the internal diameter of described catheter body 2 is 0.9 ~ 1.0mm, and wall thickness is 0.08 ~ 0.12mm; Caliber is little, and wall thickness is thin, is suitable for, through puncture needle implant surgery, being beneficial to degraded and absorbed; Can be used for holding the cylindrical drug particles that diameter is about 0.8mm, and discharge through puncture needle, guarantee to reach medicine ideal distribution state.
In the present embodiment, described catheter body 2 sidewall arranges at least one side opening 4 or catheter body 2 sidewall opening is formed C type tubular construction, namely on the sidewall of catheter body 2, open a partial sidewall arriving several side opening 4 or ablation catheter body 2 form C type tubular construction, size and the density of side opening 4 are rationally set according to medicine 1 absorbability, or the width of C type pipe lateral opening is rationally set according to medicine 1 absorbability, one of them side opening 4 is located at catheter body 2 bottom, when medicine 1 is loaded deaeration be convenient to filling medicine and medicine discharge gradually, act on disease sites, described side opening 4 is bellmouth orifice structure, namely the aperture of side opening 4 becomes large from inside to outside gradually along catheter body 2 radial direction, medicine 1 release duration can be controlled preferably, increase active area simultaneously, improve therapeutic effect, in catheter body 2, corresponding other side openings 4 except least significant end are provided with the diaphragm being sealed in this part side opening 4 outer end, described diaphragm is one-body molded with catheter body 2 and diaphragm is equal with the outer surface of catheter body 2, diaphragm is by can biological erosion separate or biodegradable metal, alloy or polymer are made, side opening 4 can be sealed by diaphragm, avoid implanting prodrug 1 to trickle down, therefore medicine 1 can be powder or liquid, arrange diaphragm makes the outer surface of catheter body 2 become level and smooth simultaneously, be convenient to implant, implant rear film to be preferentially degraded, side opening 4 is opened, realize the release of medicine 1.
In the present embodiment, described side opening 4 along catheter body 2 long to spacing be 10 ~ 20mm; Make medicine 1 can directly act on sufferer position, improve therapeutic effect, reduce dosage, reduce the side effect of medication.
In the present embodiment, one end of described catheter body 2 is closed, and the other end is bell mouth shape, and its blind end is tack, tip, round end and can be forked; Conveniently load in catheter body 2 by medicine 1, blind end is set to forked can increase medicine 1 active area, utilizes bifurcation structure effectively to locate catheter body 2 simultaneously, avoids catheter body 2 to be shifted, and ensures therapeutic effect.
In the present embodiment, described degradation material is biological erosion to separate or biodegradable metal, alloy or polymer; Catheter body 2 can be absorbed by the body after implanting gradually, simplifies therapeutic process, reduces the infringement to human body.
In the present embodiment, described degradation material is magnesium, ferrum, magnesium base alloy, polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, polyamide, polyester, polyesteramide, polyanhydride, poe, polyphosphazene, false polyamino acid, polyglycereol-sebacate, polycaprolactone, polycaprolactone derivatives, based on the polyesteramide of amino alcohol, poly-octane glycol citrate, hydrogel or curable biology can resorbent elastomers, the polymer of Based PC needs extra cross-linking agent such as lysinediisocyanate or 2, two (6-caprolactone-4-base) propane of 2-is to obtain elastomer properties, also the copolymer of above material can be used, mixture and combination, the compositions in weight percentage of described hydrogel comprises corn starch 4.5-4.7, acrylic acid 21.4-22.5, acrylamide 9-9.5, Ammonium persulfate. 3.2-4.5, calcium carbonate 4.5-4.7, sodium hydroxide 9.5-9.9, water surplus, namely except corn starch, acrylic acid, acrylamide, Ammonium persulfate., calcium carbonate, beyond sodium hydroxide, all the other are water, when preparing hydrogel, first that sodium hydroxide is soluble in water, and add acrylic acid and carry out pretreatment, add corn starch, acrylamide and calcium carbonate successively again, after stirring reaction of heating, add initiator and carry out graft polymerization reaction, then reacted liquid is poured in mould, freeze-day with constant temperature, have technique simple, product is nontoxic, biodegradation rate is fast and apply the advantages such as wide.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (8)
1. carry a degradable implantation catheter for drug particle, it is characterized in that: comprise catheter body for holding medicine and be located in catheter body for by spacer block spaced apart for medicine.
2. the degradable implantation catheter carrying drug particle according to claim 1, is characterized in that: described catheter body and spacer block are made by degradation material.
3. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: the internal diameter of described catheter body is 0.9 ~ 1.0mm, and wall thickness is 0.08 ~ 0.12mm.
4. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described catheter body sidewall arranges at least one side opening or catheter body sidewall opening is formed C type tubular construction.
5. the degradable implantation catheter carrying drug particle according to claim 4, is characterized in that: described side opening along catheter body length to spacing be 10 ~ 20mm.
6. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: one end of described catheter body is closed, and the other end is bell mouth shape, and its blind end is tack, tip, round end and can be forked.
7. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described degradation material for separating or biodegradable metal, alloy or polymer in biological erosion.
8. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described degradation material be magnesium, ferrum, magnesium base alloy, polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, polyamide, polyester, polyesteramide, polyanhydride, poe, polyphosphazene, false polyamino acid, polyglycereol-sebacate, polycaprolactone, polycaprolactone derivatives, based on amino alcohol polyesteramide, poly-octane glycol citrate, hydrogel or curable biology can resorbent elastomers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510931618.4A CN105498073A (en) | 2015-12-14 | 2015-12-14 | Degradable implantation catheter carrying drug particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510931618.4A CN105498073A (en) | 2015-12-14 | 2015-12-14 | Degradable implantation catheter carrying drug particles |
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| Publication Number | Publication Date |
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| CN105498073A true CN105498073A (en) | 2016-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510931618.4A Pending CN105498073A (en) | 2015-12-14 | 2015-12-14 | Degradable implantation catheter carrying drug particles |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456665A (en) * | 2017-09-13 | 2017-12-12 | 成都迪康中科生物医学材料有限公司 | A kind of degradable conduit for loading drug particle |
| CN107970522A (en) * | 2017-11-24 | 2018-05-01 | 黑龙江工程学院 | A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof |
| CN108098735A (en) * | 2017-12-12 | 2018-06-01 | 上海大学 | A kind of biological micro-nano robot and its construction method based on biological 3D printing |
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| CN2701461Y (en) * | 2003-12-26 | 2005-05-25 | 冯梅 | Lumen internal metal network bracket for local radiotherapy and chemical therapy particle |
| CN2905096Y (en) * | 2006-01-01 | 2007-05-30 | 张德祥 | Catheter for implanting I125 source into canals |
| CN101069660A (en) * | 2007-06-20 | 2007-11-14 | 中国人民解放军第三军医大学第一附属医院 | Biliary-tract carriage carrying about medicine and preparing method therefor |
| CN102470237A (en) * | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | Solid drug tablets for implantable drug delivery devices |
| CN103300950A (en) * | 2012-03-07 | 2013-09-18 | 常州乐奥医疗科技有限公司 | Pipeline support capable of carrying drug particles |
| CN203710540U (en) * | 2013-12-11 | 2014-07-16 | 天津赛德医药研究院有限公司 | Connecting chain capable of degrading radioactive sealing seed sources |
-
2015
- 2015-12-14 CN CN201510931618.4A patent/CN105498073A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2701461Y (en) * | 2003-12-26 | 2005-05-25 | 冯梅 | Lumen internal metal network bracket for local radiotherapy and chemical therapy particle |
| CN2905096Y (en) * | 2006-01-01 | 2007-05-30 | 张德祥 | Catheter for implanting I125 source into canals |
| CN101069660A (en) * | 2007-06-20 | 2007-11-14 | 中国人民解放军第三军医大学第一附属医院 | Biliary-tract carriage carrying about medicine and preparing method therefor |
| CN102470237A (en) * | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | Solid drug tablets for implantable drug delivery devices |
| CN103300950A (en) * | 2012-03-07 | 2013-09-18 | 常州乐奥医疗科技有限公司 | Pipeline support capable of carrying drug particles |
| CN203710540U (en) * | 2013-12-11 | 2014-07-16 | 天津赛德医药研究院有限公司 | Connecting chain capable of degrading radioactive sealing seed sources |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456665A (en) * | 2017-09-13 | 2017-12-12 | 成都迪康中科生物医学材料有限公司 | A kind of degradable conduit for loading drug particle |
| CN107456665B (en) * | 2017-09-13 | 2018-06-29 | 成都迪康中科生物医学材料有限公司 | A kind of degradable conduit for loading drug particle |
| CN107970522A (en) * | 2017-11-24 | 2018-05-01 | 黑龙江工程学院 | A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof |
| CN108098735A (en) * | 2017-12-12 | 2018-06-01 | 上海大学 | A kind of biological micro-nano robot and its construction method based on biological 3D printing |
| CN108098735B (en) * | 2017-12-12 | 2021-11-05 | 上海大学 | Biological micro-nano robot based on biological 3D printing and construction method thereof |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160420 |