CN203688566U - Immune coagulation analyzer - Google Patents
Immune coagulation analyzer Download PDFInfo
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- CN203688566U CN203688566U CN201320849665.0U CN201320849665U CN203688566U CN 203688566 U CN203688566 U CN 203688566U CN 201320849665 U CN201320849665 U CN 201320849665U CN 203688566 U CN203688566 U CN 203688566U
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- 230000015271 coagulation Effects 0.000 title abstract 5
- 238000005345 coagulation Methods 0.000 title abstract 5
- 238000003384 imaging method Methods 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000002474 experimental method Methods 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims description 20
- 230000003321 amplification Effects 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 230000035931 haemagglutination Effects 0.000 claims description 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 description 12
- 238000001514 detection method Methods 0.000 description 8
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 230000036039 immunity Effects 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000035800 maturation Effects 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 101710186708 Agglutinin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
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- 230000005484 gravity Effects 0.000 description 1
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- 244000052769 pathogen Species 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
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Abstract
The utility model relates to the technical field of medical extermination and discloses an immune coagulation analyzer which is used in immune coagulation experiments and is used for detecting a microplate for bearing an experimental reaction result and interpreting the result. The immune coagulation analyzer comprises a machine body, wherein the machine body is internally provided with a detecting cavity; the front end of the detecting cavity is provided with an opening; the lower end face of the detecting cavity is provided with an objective table, and the upper end face of the detecting cavity is provided with an imaging structure for receiving image data of the microplate; the imaging structure is opposite to the objective table; the machine body is internally provided with a center control chip for receiving the image data and detecting; the imaging structure is electrically connected to the center control chip. The imaging structure of the immune coagulation analyzer can be used for shooting an experimental result on the microplate and converting an image into data, the result is judged and analyzed through software in the center control chip and is output, and manual interpretation of the experimental result is substituted, so that the precision and efficiency are both relatively high, and labor and cost are also reduced.
Description
Technical field
The technical field that the medical science that the utility model relates to detects, relates in particular to immune coaglation analyzer.
Background technology
Immunity hemagglutination test detection method is the epidemic disease detection method of medically a kind of maturation, it refers to particulate antigen, such as bacterium, red blood cell etc., under the condition existing at appropriate electrolyte with corresponding antibody, after certain hour, be condensed into macroscopic agglutinator, then pass through the detection method of artificial visually examine's mode sentence read result.The particulate antigen of participating in reaction is called agglutinogen, and antibody is called agglutinin.Agglutinating reaction is widely used in the diagnosis of disease and the analysis of various antigenic properties, both can check unknown antigen with known immune serum, also can carry out detection specificity antibody by known antigens.
Due to feature and the detection performance of immune hemagglutination test detection method, now be widely used in the detection of antigen and antibody analysis and human erythrocyte's antigen and the antibody of various pathogenic pathogen, the method maturation, be widely used, with low cost, testing requirements is not high, and existing nearly over one hundred test manufacturer released commercial immune blood clotting both at home and abroad.
Immune hemagglutination test detection method of the prior art, mainly relies on artificial sentence read result, and it has a lot of shortcomings: first, need to train professional person and carry out interpretation, talent's cost is higher; Secondly, in the time that needs judge great amount of samples, speed is slower, and custom and the mode of interpersonal judgement are not identical, sentence read result is not sought unity of standard, often there is assay difference, need secondary interpretation even more times number interpretation could determine, to man power and material all comparatively waste.
Utility model content
The purpose of this utility model is to provide immune coaglation analyzer, and being intended to solve in prior art needs manual analysis interpretation in immune blood coagulation tests, causes that human cost is high, efficiency is low and the problem of poor accuracy.
The utility model is to realize like this, immunity coaglation analyzer, for immune hemagglutination test, microwell plate to carrying experiment reaction result detects, and sentence read result, comprise body, described internal body is provided with test chamber, described test chamber front end has opening, lower surface is provided with objective table, and upper surface is provided with the imaging arrangement for accepting microwell plate view data, and described imaging arrangement and described objective table are just to arranging, described internal body is provided with the control chip for accepting view data and detecting, and described imaging arrangement is electrically connected on described middle control chip.
Further, described imaging arrangement comprises that described stepper motor and described ccd element are electrically connected on described middle control chip for accepting view data and being converted into the ccd element of digital signal and the stepper motor for driving described ccd photographic plate to move.
Further, described middle control chip comprises amplification filtering module, analog-to-digital conversion module, memory module, programmable control module and administration module, and described stepper motor is electrically connected to described administration module, and described ccd element is electrically connected on described amplification filtering module.
Further, described body is provided with for exporting the usb data line of data to computer, and described usb data line is electrically connected on described administration module.
Further, described objective table comprises LED light source, and described microwell plate is positioned on described LED light source.
Further, described objective table comprises the draw-in groove for connecting and fixing described microwell plate, and described draw-in groove is positioned at described LED light source top.。
Compared with prior art, the immune coaglation analyzer in the utility model, its inside is provided with imaging plate, experimental result on microwell plate can be converted into digital picture data, and be delivered to middle control chip, middle control chip preset in advance has software, by image data processing, and sentence read result.Whole testing process relies on machine observation experiment result, and software interpretation, does not need professional person to analyze, and human cost is low, and efficiency is high, and accuracy is high.
Accompanying drawing explanation
The structural representation of the immune coaglation analyzer that Fig. 1 provides for the utility model embodiment;
The imaging arrangement framework schematic diagram of the immune coaglation analyzer that Fig. 2 provides for the utility model embodiment.
Embodiment
In order to make the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the utility model is further elaborated.Should be appreciated that specific embodiment described herein is only in order to explain the utility model, and be not used in restriction the utility model.
Below in conjunction with concrete accompanying drawing, the realization of the present embodiment is described in detail.
As shown in Figure 1, immune coaglation analyzer, for immune hemagglutination test, detects the microwell plate of carrying experiment reaction result, and sentence read result.Immunity coaglation analyzer comprises body 1, is provided with test chamber 11 in body 1, and the front end of this test chamber 11 has opening 111.The lower surface of test chamber 11 is provided with the objective table 15 for placing microwell plate, and its upper surface is provided with the imaging arrangement 12 of the view data for accepting microwell plate, and this imaging arrangement and objective table are just to arranging; Body 1 inside is provided with the middle control chip that on the microwell plate for accepting view data and view data is shown, experimental result detects, and imaging arrangement 12 is electrically connected on middle control chip.
Immune coaglation analyzer in the present embodiment in actual use, microwell plate is put on the objective table 15 of test chamber 11, imaging arrangement 12 is converted into data by the image on microwell plate and controls chip in then inputting, the software that middle control chip arranges by inside, the agglutinator state that experimental result is presented is compared, and then exports sentence read result.
By immune coaglation analyzer, in the whole interpretation process of immune hemagglutination test result, not by professional person, human cost is low, and interpretation speed is fast, can test to great amount of samples easily.And interpretation standard is formulated by software is unified, there will not be the problem of artificial deviation effects sentence read result, accuracy is higher.
Image interpretation software is the software engineering of current a kind of maturation, is common in person's handwriting identification, and recognition of face etc. field, adopts a kind of simple recognizer in the present embodiment, mainly comprise pre-service, feature extraction and the identification of image in algorithm.
1) binaryzation.Binary conversion treatment is that the gray level image obtaining is converted into binary digital image, and native system adopts global threshold method to carry out binary conversion treatment.
2) level and smooth.Owing to smoothly can removing isolated noise, interference, edge that can be level and smooth, the pre-treatment step so this is absolutely necessary.Here use a kind of simple and effective smoothing method---median filter method.
3) cut apart.Cutting apart of image is in the entire image obtaining from image acquisition, to separate the digital picture district of needs identification and useless background image district.
4) standardization.For the ease of the feature extraction to arbitrary image character, also to carry out normalization process.Due to the difference of image size and relative position, can not directly train and identify, so use the location specification method based on center of gravity to carry out standard to dot array data after treatment, make it to become 16 × 16 dot array data form, for follow-up processing used.
5) refinement.Adopt parallel thinning algorithm herein.The method adopts the neighborhood of 16 kind 3 × 3 " to peel off " outermost layer of image as deletion template, adopt again the neighborhood of two kind 3 × 4 to recover as recovering template the successional key point of impact of being left out, can " peel off " outermost layer of image completely and not destroy the successional object of image thereby reach each iteration simultaneously.This method calculated amount is little, and gained skeleton is located substantially on the axis of image, and end points, without obvious contraction, can meet the requirement of recognition methods used herein to refinement result.
The main task of feature extraction is that pretreated binary array data are processed, and extracts the characteristic information about aspects such as skeleton, profile, topological structure, distributions in image, then gives sorter.Extract the discrete cosine feature of image, finally according to relevant medical knowledge, set and judge contrast images data, close rate reaches default numerical value, the interpretation that can whether be, realize from image taking, to identification, then the process of exporting to interpretation, its automaticity is high, standard is unified, and efficiency is high.
As shown in Figure 2, imaging arrangement 12 comprises that stepper motor 122 and ccd element 125 are electrically connected on middle control chip for accepting microwell plate view data and being converted into the ccd element 125 of electronic signal and the stepper motor 122 for driving ccd photographic plate to move.
Need to line by line scan due to ccd element 125, expect image clearly, stepper motor 122 needs uniform motion, and sweep velocity is consistent.Under the control of middle control chip, stepper motor 122 can drive ccd element 125 imaging of lining by line scan, and then the electronic signal of imaging is flowed to middle control chip by ccd element 125.
As shown in Figure 2, middle control chip is made up of multiple modules, comprises amplification filtering module 145, analog-to-digital conversion module 144, memory module 143, programmable control module 141 and administration module 142.Wherein stepper motor 122 is electrically connected to administration module 142, and ccd element 125 is electrically connected on amplification filtering module 145.
As depicted in figs. 1 and 2, body 1 is provided with for exporting the usb data line 13 of data to computer 2, and usb data line 13 is electrically connected on administration module 142.Administration module 142 can be transferred to the result of scan image and data on computer 2 by usb data line 13, is convenient to analyze and storage.
As shown in Figure 1, objective table 15 comprises LED light source 152 and for connecting and fixing the draw-in groove 151 of microwell plate, draw-in groove 151 is positioned at LED light source 152 tops.LED light source 152 emits beam, and light, through microwell plate, is convenient to CCD element 125 scan image clearly.The project organization of draw-in groove 151 can have multiple, for example horizontal chute, or multiple buckles that are arranged side by side etc. all can be realized.
The foregoing is only preferred embodiment of the present utility model; not in order to limit the utility model; all any modifications of doing within spirit of the present utility model and principle, be equal to and replace and improvement etc., within all should being included in protection domain of the present utility model.
Claims (6)
1. immune coaglation analyzer, for immune hemagglutination test, microwell plate to carrying experiment reaction result detects, and sentence read result, it is characterized in that, comprise body, described internal body is provided with test chamber, described test chamber front end has opening, lower surface is provided with objective table, and upper surface is provided with the imaging arrangement for accepting microwell plate view data, and described imaging arrangement and described objective table are just to arranging, described internal body is provided with the control chip for accepting view data and detecting, and described imaging arrangement is electrically connected on described middle control chip.
2. immune coaglation analyzer as claimed in claim 1, it is characterized in that, described imaging arrangement comprises that described stepper motor and described ccd element are electrically connected on described middle control chip for accepting view data and being converted into the ccd element of digital signal and the stepper motor for driving described ccd photographic plate to move.
3. immune coaglation analyzer as claimed in claim 1, it is characterized in that, described middle control chip comprises amplification filtering module, analog-to-digital conversion module, memory module, programmable control module and administration module, described stepper motor is electrically connected to described administration module, and described ccd element is electrically connected on described amplification filtering module.
4. immune coaglation analyzer as claimed in claim 3, is characterized in that, described body is provided with for exporting the usb data line of data to computer, and described usb data line is electrically connected on described administration module.
5. the immune coaglation analyzer as described in claim 1 to 4 any one, is characterized in that, described objective table comprises LED light source, and described microwell plate is positioned on described LED light source.
6. immune coaglation analyzer as claimed in claim 5, is characterized in that, described objective table comprises the draw-in groove for connecting and fixing described microwell plate, and described draw-in groove is positioned at described LED light source top.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320849665.0U CN203688566U (en) | 2013-12-20 | 2013-12-20 | Immune coagulation analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320849665.0U CN203688566U (en) | 2013-12-20 | 2013-12-20 | Immune coagulation analyzer |
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| Publication Number | Publication Date |
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| CN203688566U true CN203688566U (en) | 2014-07-02 |
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| CN201320849665.0U Expired - Lifetime CN203688566U (en) | 2013-12-20 | 2013-12-20 | Immune coagulation analyzer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107091935A (en) * | 2017-04-20 | 2017-08-25 | 陈凡 | Automate General layout Plan of blood clotting Inhibition test work station and application thereof |
| CN108663527A (en) * | 2017-03-27 | 2018-10-16 | 南京市畜牧兽医站 | Blood clotting and hemagglutination-inhibition test readout instrument |
| CN109085368A (en) * | 2018-08-14 | 2018-12-25 | 王振华 | A kind of coagulation analysis device |
| CN109856410A (en) * | 2019-02-15 | 2019-06-07 | 王振华 | A kind of blood clotting test device |
-
2013
- 2013-12-20 CN CN201320849665.0U patent/CN203688566U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108663527A (en) * | 2017-03-27 | 2018-10-16 | 南京市畜牧兽医站 | Blood clotting and hemagglutination-inhibition test readout instrument |
| CN107091935A (en) * | 2017-04-20 | 2017-08-25 | 陈凡 | Automate General layout Plan of blood clotting Inhibition test work station and application thereof |
| CN109085368A (en) * | 2018-08-14 | 2018-12-25 | 王振华 | A kind of coagulation analysis device |
| CN109085368B (en) * | 2018-08-14 | 2022-02-08 | 王振华 | Blood coagulation analysis device |
| CN109856410A (en) * | 2019-02-15 | 2019-06-07 | 王振华 | A kind of blood clotting test device |
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Granted publication date: 20140702 |
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| CX01 | Expiry of patent term |